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1.
曲美他嗪治疗冠心病心绞痛合并糖尿病患者疗效观察   总被引:1,自引:0,他引:1  
罗群 《中国现代医生》2009,47(36):53-53,69
目的探讨曲美他嗪对冠心病合并糖尿病患者的临床治疗效果。方法84例冠心病合并糖尿病患者随机分为观察组和对照组,对照组采用常规方法治疗,观察组在常规治疗的基础上加用曲美他嗪,比较两组治疗效果。结果治疗组加用曲美他嗪后心绞痛发作次数、心绞痛持续时间和硝酸甘油用量均明显下降,而且无明显不良反应,血糖稳定。结论曲美他嗪可明显改善心功能,减少心绞痛发作频率、心绞痛持续时间和硝酸甘油用量,安全有效。  相似文献   

2.
韩献  文迎  韦正群 《医学综述》2012,18(14):2299-2301
目的观察曲美他嗪联合地尔硫对稳定型心绞痛的临床疗效。方法 120例稳定型心绞痛患者随机分为对照组和观察组,各60例。对照组在常规治疗的基础上加用曲美他嗪;观察组在常规治疗的基础上加用曲美他嗪和地尔硫。观察两组患者心绞痛发作频率、持续时间、硝酸甘油消耗量及心电图的改变。结果观察组的心绞痛和心电图治疗效果明显优于对照组(P<0.05);与治疗前比较,两组患者治疗后心绞痛发作频率、持续时间及硝酸甘油消耗量均明显降低(P<0.05),且观察组治疗后心绞痛发作频率、持续时间及硝酸甘油消耗量均明显低于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论曲美他嗪联合地尔硫较单一采用曲美他嗪治疗效果好,可明显降低心绞痛发作频率、持续时间及硝酸甘油量,缩小心肌缺血范围,减轻心肌缺血程度。  相似文献   

3.
目的 :探讨曲美他嗪治疗冠心病心绞痛的疗效。方法 :70例冠心病心绞痛患者随机分为曲美他嗪治疗组和对照组 ,在常规治疗包括硝酸盐、β -阻滞剂和钙拮抗剂基础上 ,治疗组加用曲美他嗪治疗 8周。观察用药前后下述指标变化 :(1)用药前后每天的心绞痛发作次数 ,(2 )每天硝酸甘油片的用量 ,(3)心绞痛每次发作持续时间 ,(4) 12导联中ST段下降的导联数 ,(5 ) 12导联中ST段压低的总和。结果 :曲美他嗪治疗后每天心绞痛发作次数和硝酸甘油片用量及心绞痛每次持续时间均明显下降 (P <0 .0 1)。 12导联中ST段下降的导联数和ST段压低的总和明显改善 (P <0 .0 1)。结论 :曲美他嗪能改善心肌缺血 ,对心绞痛患者有明显疗效  相似文献   

4.
目的 :观察曲美他嗪治疗冠心病心绞痛的临床疗效。方法 :将 6 2例冠心病心绞痛患者随机分为曲美他嗪治疗组和对照组。在常规治疗包括硝酸盐、β 阻滞剂和钙拮抗剂的基础上 ,治疗组加用曲美他嗪治疗 4周。观察用药前后下述指标变化 :(1)心绞痛发作次数 ;(2 )硝酸甘油消耗量 ;(3)心电图的ST T改变情况 ;(4)血压、心率的变化。结果 :用曲美他嗪治疗后 ,冠心病患者的心绞痛发作次数、硝酸甘油消耗量及心电图均有明显改善 ,两组比较差异有显著性 (P <0 .0 5 )。结论 :曲美他嗪能改善心肌缺血 ,对冠心病心绞痛患者有明显疗效。  相似文献   

5.
曲美他嗪治疗冠心病心绞痛临床观察   总被引:3,自引:0,他引:3  
目的观察曲美他嗪治疗冠心病心绞痛的临床疗效。方法选取86例冠心病心绞痛患者随机分为曲美他嗪治疗组和对照组,对照组常规给予硝酸盐制剂、β-受体阻滞剂、钙离子拮抗剂、他汀类制剂和小剂量阿司匹林;治疗组在此基础上加用曲美他嗪治疗,比较两组心绞痛发作次数、持续时间、硝酸甘油用量、心电图、血压、心率变化等指标。结果与对照组相比,治疗组冠心病患者的心绞痛发作次数、持续时间、硝酸甘油用量及心电图有明显改善,两组比较有显著性差异(P<0.05),而血压、心率无明显变化,两组比较无显著性差异(P>0.05),并无明显不良反应。结论加用曲美他嗪治疗冠心病心绞痛效果明显,且安全方便。  相似文献   

6.
曲美他嗪治疗糖尿病合并冠心病102例临床观察   总被引:1,自引:1,他引:1  
侯明英 《重庆医学》2008,37(10):1098-1099
目的观察曲美他嗪治疗糖尿病伴冠心病治疗效果。方法102例糖尿病合并冠心病患者,随机分成常规口服药物组52例(对照组)和曲美他嗪组50例(治疗组)。治疗组在常规口服药物治疗的基础上加用曲美他嗪20mg口服,每日3次。治疗6个月观察患者心绞痛发作的次数、血糖水平、超声心动图指标的变化。结果治疗组治疗后心绞痛发作次数减少,左心室射血分数与治疗前相比较,差异有统计学意义(P<0.01),而对照组病情稳定无变化。结论糖尿病合并冠心病患者在常规药物治疗基础上加用曲美他嗪,可以明显提高心肌收缩和舒张功能,减少心绞痛发作次数,而且是安全的。  相似文献   

7.
目的 探讨曲美他嗪治疗稳定型心绞痛的临床疗效。方法  80例稳定型心绞痛患者随机分为治疗组 (40例 )和对照组 (40例 )。对照组予常规药物治疗 ,治疗组加服曲美他嗪对比两组治疗前后心绞痛发作及活动平板运动试验指标。结果 治疗组治疗后心绞痛发作次数、持续时间、硝酸甘油消耗量与活动平板运动试验中总工作量、运动持续时间、至心绞痛发作时间及运动终点时心率×收缩压各项指标均较治疗前显著改善 ,并显著优于对照组 (P <0 .0 5或P <0 .0 1)。结论 曲美他嗪治疗稳定型心绞痛疗效显著 ,安全、耐受性好。  相似文献   

8.
目的 研究旨在观察曲美他嗪治疗冠心病心力衰竭的疗效。方法 选择冠心病心力衰竭患者76人,随机分为A组即常规治疗组和B组即在常规治疗组基础上加用曲美他嗪,分别比较两组病人治疗前后及两组间治疗后心功能变化情况;结果 两组病人治疗前后心功能改善,心绞痛发作次数有显著性差异P〈0.05。结论 曲美他嗪对冠心病心力衰竭有治疗作用。  相似文献   

9.
彭志坚  蔡建生  李继锋  章少波 《河北医学》2009,15(12):1416-1419
目的:探讨曲美他嗪对稳定性劳力型心绞痛患者缺血预适应保护作用的影响。方法:64例稳定性劳力型心绞痛患者随机分为A组(n=32)及B组(n=32):A组为常规药物治疗;B组为常规药物治疗基础上,加用曲美他嗪20mg每日3次,治疗12周。观察两组治疗前后运动平板试验结果,比较两组的疗效。结果:两组治疗前后自身比较每周心绞痛发作次数、运动耐量、运动诱发心绞痛所需时间、运动至ST段压低1 mm所需时间及运动持续时间均有显著统计学差异(P〈0.05);治疗后组间比较运动耐量、每周心绞痛发作次数、运动诱发心绞痛所需时间、运动至ST段压低1 mm所需时间及运动持续时间B组明显优于A组(P〈0.05)。结论:曲美他嗪能提高稳定性劳力型心绞痛患者的缺血阈值,增加缺血预适应保护作用。  相似文献   

10.
曲美他嗪治疗老年人冠心病心绞痛疗效观察   总被引:2,自引:1,他引:2  
张海红 《海南医学》2006,17(4):72-72,40
目的评价曲美他嗪在治疗老年人冠心病心绞痛中的临床疗效及安全性.方法采用分组对照的方法,103例冠心病心绞痛患者随机分为治疗组和对照组,对照组常规给予硝酸脂类及抗凝药物,治疗组在常规治疗同时加用曲美他嗪,比较两组心绞痛发作次数、程度、硝酸甘油用量、心电图变化等指标.结果治疗组总有效率90.4%高于对照组(62.7%)(P<0.05),并无明显不良反应.结论曲美他嗪与硝酸甘油合用,能减轻心绞痛发作次数,减少硝酸甘油用量,改善临床症状,安全有效.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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