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1.
目的:探讨后腹腔镜下对一侧肾盂、输尿管癌的治疗效果。方法:2004年10月~2008年6月在我院行后腹腔镜下治疗肾盂癌、输尿管癌31例患者。膀胱袖带状电切,后腹腔镜行患肾、输尿管切除,下腹部小切口切除患肾及输尿管全长。结果:31例手术均取得成功,手术时间2.5~6h,平均4.7h,出血量50~200ml,平均80ml,引流量40~200ml,平均110ml,引流管术后36~72h拔除,住院时间12~15d,平均13.4d。20例为肾盂移行细胞癌,11例为输尿管移行细胞癌。术后随访1~36个月,平均20个月,1例发生膀胱移行细胞癌行电切术。余均未复发。结论:后腹腔镜下治疗Ⅰ、Ⅱ期肾盂、输尿管癌,手术创伤小,术后恢复快,并且可取得满意的效果,值得推广。  相似文献   

2.
目的探讨后腹腔镜联合经尿道电切镜治疗上尿路肿瘤的疗效。方法采用后腹腔镜手术治疗上尿路移行细胞癌12例。其中肾盂癌8例,输尿管癌4例;右侧5例,左侧7例;男性9例,女性3例;年龄42~70岁,平均年龄54岁;病理分期:T1期4例,T2期4例,T3期4例,T4期0例。结果 12例均获成功。手术时间125~210min。平均170min。术中出血60~150mL,平均110mL,术中均未输血。患者术后1~3d排气并进食。术后住院时间4~8d,平均6d。术后羟基喜树碱膀胱灌注,随访1~24个月,发生膀胱癌1例,局部复发骨盆转移1例,复发率16.7%。结论后腹腔镜联合经尿道电切镜治疗上尿路肿瘤具有创伤小、疼痛轻、恢复快等优点,是一种安全、可行的手术方法。  相似文献   

3.
目的探讨后腹腔镜根治性肾输尿管切除术治疗上尿路恶性肿瘤的疗效。方法2005年10月至2009年5月对11例肾盂或输尿管移行细胞癌患者行后腹腔镜根治性肾输尿管切除术,其中肾盂癌6例,输尿管癌5例。Hem-O-lock夹处理肾动静脉,不更改手术体位行下腹部斜切口处理输尿管下段与膀胱。结果手术时间120~180min,平均150min;出血量40~200ml,平均70ml;术中、术后未发生明显并发症。随访2~40个月,1例发生膀胱移行细胞癌。结论后腹腔镜根治性肾输尿管切除术具有损伤小、恢复快等优点,Hem-O-lock夹处理肾动静脉安全可靠,经济实用。不更改手术体位行下腹部斜切口处理输尿管下段与膀胱节约手术时间,不增加创伤,疗效可靠。  相似文献   

4.
目的探讨后腹腔镜肾输尿管全切并膀胱袖套状切除治疗上尿路移行细胞癌的疗效。方法对6例上尿路移行细胞癌患者行后腹腔镜下肾脏切除术,经同侧下腹直肌旁切口切除下段输尿管并行膀胱袖套状切除,完整取出切除的肾输尿管标本。术后常规用表柔比星膀胱灌注。结果手术时间180~300min;术中出血量50~100ml;术后7d出院,无严重并发症发生。随访6~32个月,未见复发。结论后腹腔镜肾输尿管全切并膀胱袖套状切除治疗上尿路移行细胞癌,是一种安全有效的术式,具有痛苦小、并发症少及患者恢复快等优点。  相似文献   

5.
目的:介绍后腹腔镜肾输尿管切除术结合经腹腔下腹正中切口治疗移植肾同侧原上尿路移行细胞癌的最初经验。方法:选取2005年11月至2009年1月间,北京大学第三医院15例肾移植后因移植肾同侧原上尿路移行细胞癌而接受结合经腹腔下腹正中切口的后腹腔镜肾输尿管切除术的患者。后腹腔镜下将肾切除后,经膀胱镜行同侧输尿管口及膀胱袖状切除术,于下腹正中做6~8 cm切口,经腹腔途径将远端输尿管切至膀胱壁内段后,将输尿管完整取出,并经此切口完整取出标本。结果:平均手术时间为253 min,平均术中出血245 mL,3例患者接受输血治疗。后腹腔镜肾切除术中无1例中转开放,2例患者出现轻微并发症。病理结果显示:3例肾盂、1例肾盂和输尿管、3例肾盂和膀胱、1例双侧肾盂、4例输尿管、2例输尿管和膀胱和1例双侧输尿管内可见移行细胞癌。平均随访35个月,无1例患者后腹腔内复发或远处转移。5例并发膀胱癌患者中在随访时发现有2例复发膀胱癌,4例行单侧肾输尿管切除的患者在随访中发现对侧原上尿路移行细胞癌。结论:后腹腔镜肾输尿管切除术结合下腹正中经腹腔切口的方法可能是一个治疗移植肾同侧原上尿路移行细胞癌的安全且有效的选择。  相似文献   

6.
目的:探讨后腹腔镜技术在上尿路肿瘤临床手术应用的可行性。方法:应用后腹腔镜技术手术治疗肾癌11例,肾盂、输尿管癌16例。结果:26例手术获得成功,1例中转开放完成。手术时间90~180min,平均130 min,出血50~400 ml,平均100 ml,术后住院7~10 d,平均8 d。随访1~24个月,无肿瘤复发及术区、切口种植转移。结论:后腹腔镜根治性手术治疗上尿路肿瘤安全可行,疗效可靠。  相似文献   

7.
目的:评价后腹腔镜肾部分切除术(RLPN)治疗T1a期肾细胞癌的安全性和临床效果.方法:回顾性分析32例行后腹腔镜肾部分切除术的T1a期肾细胞癌患者的临床资料.观察手术时间、术中出血量、热缺血时间、术后住院天数.结果:31例手术均顺利完成,1例术中出血较多转开放性手术.手术时间90~155 min(平均115 min);热缺血时间15~34 min(平均23 min);术中出血40~280 mL(平均105 mL);术后住院8~l0d(平均9d).术后1例发生漏尿.患者均康复出院.术后病理:肾透明细胞癌24例,嫌色细胞癌6例,乳头状癌2例.随访3~79个月,患者均未见肿瘤局部复发、远处转移及切口种植等.结论:后腹腔镜肾部分切除术治疗T1a期肾细胞癌安全可行,是≤4.0cm的Tta期肾细胞癌的首选治疗术式,值得在具备条件的医院临床推广.  相似文献   

8.
完全腹腔镜下上尿路尿路上皮癌根治术12例分析   总被引:1,自引:0,他引:1  
目的:探讨完全腹腔镜肾、输尿管全长切除+膀胱部分切除术治疗上尿路尿路上皮癌的疗效及临床价值。方法12例上尿路尿路上皮癌患者在我院接受完全腹腔镜下肾盂、输尿管癌根治术,肾盂癌8例,输尿管癌4例,其中2例输尿管癌突入膀胱内。术中采用70°健侧卧位,建立人工气腹,置5枚套管,首先在肾周筋膜外行患侧肾切除,再游离输尿管至膀胱,其中肾盂癌或输尿管癌未侵入膀胱病例切开部分逼尿肌,将输尿管开口及部分膀胱黏膜拉出膀胱壁外,Hem-o-lock夹毕切断;输尿管癌侵入膀胱病例术前膀胱内保留灌注100 mL稀释后的50 mg羟基喜树碱,切开膀胱前将灌注液自导尿管放出,沿输尿管膀胱入口处周围2 cm环形切除膀胱壁及输尿管开口处肿瘤,2-0可吸收线缝合膀胱。结果该组病例均成功完成手术,无中转开放手术。手术时间150~200 min,平均170 min;术中出血80~150 mL,平均95 mL;无严重围手术期并发症。术后住院时间6~9 d,平均7 d,术后病理均为尿路上皮癌。8例患者术后辅以4次GC方案全身化疗。术后随访2~30个月,1例术后7个月因膀胱内肿瘤复发行经尿道膀胱肿瘤电切术,其余患者未见肿瘤复发、转移。结论完全腹腔镜下上尿路尿路上皮癌根治术临床疗效满意,同时具有创伤小、不需要术中更换体位、术后恢复快等优点,值得临床推广应用。  相似文献   

9.
目的:探讨长期服用马兜铃酸伴发尿路移行细胞癌患者的临床特点。方法:分析15例有长期服用含有马兜铃酸中药史并在我院确诊为尿路移行细胞癌患者的临床资料,其服药时间为1.0~25.0年,平均6.1年。结果:11例患者首发症状为间歇性无痛肉眼血尿,2例镜下血尿,1例腰痛,1例体检时超声检查偶然发现输尿管肿瘤。经尿脱落细胞检查、B超、泌尿系三维CT、磁共振尿路造影、静脉肾盂造影、逆行肾盂输尿管造影、膀胱镜、输尿管镜等明确诊断。15例患者均在我院手术治疗:采用经尿道膀胱肿瘤电切术或根治性膀胱全切术,腹腔镜行肾/输尿管全长加膀胱内输尿管口电切术,姑息性单纯肿瘤切除术。15例患者术后病理诊断均为尿路移行细胞癌,其中11例为多发或多中心肿瘤。全部随访6~36个月,平均13个月。2例分别于术后23、33个月死于多发转移。结论:长期服用含马兜铃酸中药的患者出现血尿时应高度怀疑尿路发生移行细胞癌的可能性,马兜铃酸与尿路多发或多中心肿瘤是否相关尚需进一步研究。  相似文献   

10.
目的比较开放手术与后腹腔镜手术治疗腔静脉后输尿管的疗效。方法回顾性分析14例腔静脉后输尿管患者的临床资料,术前均经静脉尿路造影(IVU)、多层螺旋CT、三维尿路成像(MSCTU)等检查而明确诊断。14例中开放手术9例,应用传统的输尿管切断复位矫形术;腹腔镜手术5例,采用后腹腔径路,3个穿刺通道做输尿管切断、复位,移至下腔静脉前方,做端端吻合术。结果开放手术9例均成功,无并发症。手术时间48~100rain,平均(65.5±2.6)min。术中出血量190~260ml,平均(208.6±4.5)ml。住院时间14~17天,平均(14.8±1.1)天。术后康复时间45—60天,平均(52.8±1.3)天。后腹腔镜手术5例均成功,无中转手术及并发症。手术时间85~115min,平均(102.3±3.8)min。术中出血量30~70ml,平均(45.3±1.1)nll。住院时间6~9天,平均(7.3±0.9)天。术后康复时间16~32天,平均(23.6±2.4)天。后腹腔镜手术患者术后复查B超与IVU,输尿管梗阻均明显缓解,无吻合口狭窄等远期并发症发生。结论与开放手术比较,后腹腔镜手术治疗下腔静脉后输尿管安全、有效,具有微创、康复快等优点,值得临床上推广。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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