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1.
Background Maxillary anterior segmental distraction osteogenesis (MASDO) is a recently used method for correction of severe maxillary retrusion in cleft lip and palate (CLP) patients.In this article,we evaluated the feasibility of MASDO using rigid external distraction (RED) and rapid orthodontic tooth movement to correct severe maxillary retrusion in CLP patients.Methods Fourteen male and five female complete CLP patients between the ages of 18 and 22 years (mean age 19.7 years) at the time of distraction,with severe maxillary retrusion,were treated with the rigid external distraction (RED) device after maxillary anterior osteotomy.Rapid orthodontic tooth movement was started one week after the MASDO.Standard profile photographic,cephalometric films were obtained preoperatively and after therapy.Sella-nasion-point A (SNA) and Sella-nasion-point B (SNB) angles were measured to reflect changes in maxillary and mandibular position,and the distance between anterior nasal spine and posterior nasal spine (ANS-PNS) was measured to represent the maxillary dental arch length.Results The SNA angle increased from an average of 74.6° (range 73.0°-78.0°),preoperatively,to 83.4° (range 78.6°-88.0°) after the RED was removed (P <0.01).All cases of severe maxillary retrusion were improved.Nine patients' profiles became harmonious after therapy.One patient had a bimaxillary protrusion deformity and needed further surgery.The regenerate alveolar crest and edentulous space on both segments was almost completely eliminated after rapid orthodontic tooth movement.Conclusion MASDO with the RED system and rapid orthodontic tooth movement is a successful way of correcting severe maxillary retrusion in CLP patients.  相似文献   

2.
精、神、气、血、津、液是中医理论中6个非常重要的概念,有关术语在《WHO西太区传统医学国际标准名词术语》中一共收录了59条,“世界中医药学会联合会”(以下简称世中联)《中医基本名词术语中英对照国际标准》中收录了58条。血、津、液的内涵较为具体,有一定的物质基础,理解并不困难。翻译上虽有差异,但亦不难统一。精、神、  相似文献   

3.
目的观察益智健脑颗粒联合针灸对阿尔茨海默病(Alzheimers disease,AD)大鼠学习记忆的影响。方法将大鼠随机分为假手术组(A组)、模型组(B组)、针灸组(C组)、益智+针灸组(D组)各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35(Aβ25-35)造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义(P〈0.05);与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义(P〈0.05,P〈0.01);与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义(P〈0.05)。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。  相似文献   

4.
Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome (MetS) and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio (RR):1.06,95% confidence interval (C/):0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia (RR:0.50,95% CI:0.39-0.64,P <0.01).Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension (RR:0.91,95% CI:0.83-1.00,P=0.06) after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation (RR:1.79,95% CI:0.98-3.27,P=0.06) compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.  相似文献   

5.
The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus (Trg) based on Cytochrome P450 isozymes (CYPs) in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.  相似文献   

6.
钟文昭  吴一龙 《循证医学》2008,8(4):193-197
以表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI)分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,  相似文献   

7.
OBJECTIVE: To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang (LWDH), a traditional Chinese herbal formula, in obese rats. METHODS: After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived (OP-CD) rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water (n=12 rats per group). Twelve obese-resistant-CD (OR-CD) rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS: After 9 weeks of treatment, LWDH lowered serum C-reactive protein (CRP) and tumour necrosis factor-α (TNF-α) levels. Serum interleukin-6 (IL-6) levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase (SOD) activity was increased in response to all three doses of LWDH, while the levels of reduced (GSH) and oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION: The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as  相似文献   

8.
Choroidal hemangiomas (CHs) are relatively rare,benign,vascular,hamartomatous tumors.They are categorized to circumscribed choroidal hemangiomas (CCHs) or diffuse choroidal hemangiomas (DCHs) clinically and histologically.Although circumscribed CHs (CCHs) are often asymptomatic,they can affect visual acuity (VA) if they are situated beneath the fovea,where they can cause accumulation of secondary subretinal fluid and/or cystic retinal degeneration.Due to its minimal invasiveness and negligible toxicity to the normal retina,photodynamic therapy (PDT) with verteporfin has been applied widely in the treatment of CCH.1 Treatment strategies for CCHs should take into account tumor size,anatomic location,VA,and presence/absence of complications.The present study was conducted to identify potential predictors of successful PDT treatment other than those previously reported.We also present alternative treatment modalities for larger,more complicated CCHs.Keywords:circumscribed choroidalhemangiomas; photodynamic therapy; tumor height; predictors and outcomes;success rate;fluorescence angiography; indocyanine green angiography  相似文献   

9.
Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are the major cause of in-stent restenosis (ISR). Intervention proliferation and migration of VSMCs is an im- portant strategy for antirestenotic therapy. Roscovitine, a second-generation cyclin-dependent kinase in- hibitor, can inhibit cell cycle of multiple cell types. We studied the effects of roscovitine on cell cycle distribution, proliferation and migration of VSMCs in vitro by flow cytometry, BrdU incorporation and wound healing assay, respectively. Our results showed that roscovitine increased the proportion of Go/G1 phase cells after 12 h (69.57±3.65 vs. 92.50±1.68, P=0.000), 24 h (80.87±2.24 vs. 90.25±0.79, P=0.000) and 48 h (88.08±3.86 vs. 88.87±2.43, P=-0.427) as compared with control group. Roscovifine inhibited proliferation and migration of VSMCs in a concentration-dependent way. With the increase of concen- tration, roscovitine showed increased capacity for growth and migration inhibition. Roscovitine (30 μmol/L) led to an almost complete VSMCs growth and migration arrest. Combined with its low toxicity and selective inhibition to ISR-VSMCs, roscovitine may be a potential drug in the treatment of vascular stenosis diseases and particularly useful in the prevention and treatment of ISR.  相似文献   

10.
Background The bacterial endotoxins test (BET) is a method used to detect or quantify endotoxins (lipo-polysaccharide,LPS) and is widely used in the quality control of parenteral medicines/vaccines and clinical dialysis fluid.It is also used in the diagnosis of endotoxemia and in detection of environment air quality control.Although BET has been adopted by most pharmacopoeias,result judgment algorithms (RJAs) of the test for interfering factors in the BET still differ between certain pharmacopoeias.We have evaluated RJAs of the test for interfering factors for the revision of BET described in the Chinese Pharmacopoeia 2010 (CHP2010).Methods Original data from 1 748 samples were judged by RJAs of the Chinese Pharmacopoeia 2010,the Japanese Pharmacopoeia 2011 (JP2011),the European Pharmacopoeia 7.0 (EP7.0),the United States Pharmacopoeia 36 (USP36),and the Indian Pharmacopoeia 2010 (IP2010),respectively.A SAS software package was used in the statistical analysis.Results The results using CHP2010 and USP36,JP2011,EP7.0,and IP2010 had no significant difference (P=-0.7740).The results using CHP2010 of 1 748 samples showed that 132 samples (7.6%) required an additional step; nevertheless there was no such requirement when using the other pharmacopeias.The kappa value of two RJAs (CHP2010 and EP7.0) was 0.6900 (0.6297-0.7504) indicating that the CHP2010 and other pharmacopoeias have good consistency.Conclusions The results using CHP2010 and USP36,JP2011,EP7.0,and IP2010 have different characteristics.CHP2010 method shows a good performance in Specificity,mistake diagnostic rate,agreement rate,predictive value for suspicious rate,and predictive value for passed rate.The CHP2010 method only had disadvantages in sensitivity compared with other pharmacopeias.We suggest that the Chinese pharmacopoeia interference test be revised in accordance with the USP36,JP2011,EP7.0,and IP2010 judgment model.  相似文献   

11.
The aim of this study is to analyze how patients with chronic diseases from Shanghai interpret their disease, and how these interpretations influence patients' life satisfaction, intention to escape from their illness and their ability to reflect on the implications of their illness. METHODS: A cross-sectional study enrolling 142 patients (mean age (50 ±16) years; 63% men, 37% women) with chronic diseases (60% cancer) was recruited in the Changhai Hospital of Traditional Chinese Medicine, Shanghai, China and surveyed using standardized questionnaires. RESULTS: Patients with chronic diseases from Shanghai interpreted their illness mostly as an Adverse Interruption of Life (55%), as a Threat/Enemy (50%), but also as a Challenge (49%), and only rarely as a Call for Help (18%) or as a Punishment (13%). Particularly fatalistic negative (i.e., Threat/Enemy, Adverse Interruption of Life) and strategy-associated disease interpretations (i.e., Relieving Break, Call for Help) were moderately associated with patients' intention to escape from illness. In contrast, positive interpretations (i.e., something of Value, Challenge) and also the guilt-associated negative interpretation Failure were moderately related with patients' ability to reflect on their illness. However, life satisfaction was weakly associated only with the view that illness might be a Challenge. Interestingly, 58% of those who would see their illness as an Adverse Interruption (AI+) could see it also as a Challenge (Ch+). Detailed analyses showed that AI+Ch+ patients differ from their AI+Chcounterparts significantly with respect to their ability to reflect life and implications of illness (F=9.1 ; P=-0.004).  相似文献   

12.
Inflammation and lung function decline are the main pathophysiological features of chronic obstructive pulmonary disease (COPD). Acupuncture can improve lung function in patients with COPD, but the underlying mechanisms are not well understood. Orexins (OXs), which are found in peripheral plasma, are neuropeptides that regulate respiration and their levels are related to COPD. Therefore, we hypothesized that acupuncture might alter OXs, reduce lung inflammation and improve lung function in COPD. METHODS: COPD was induced in rats by exposure to cigarette smoke for 8 weeks and injecting with lipopolysaccharide twice. Electroacupuncture (EA) was performed at Feishu (BL13) and Zusanli (ST36) for 30 min/d for 2 weeks. Rat lung function and morphology were assessed after EA. The levels of tumor necrosis factor-α (TNF-a) and intedeukin-1β (IL-16) in bronchoalveolar lavage fluid (BALF) and orexin A and B levels in the lung tissue were detected by enzyme-linked immunosorbent assay. OX receptor mRNA levels and immunopositive cells were assessed with real-time polymerase chain reaction and immunohistochemical methods, respectively. The relationships among lung function, cell factors, and OX levels were analyzed by Pearson correlation analyses. RESULTS: Compared with the control group, lung function was significantly decreased in the rats with COPD (P〈0.05). There were obvious increases in TNF-α and IL-1β levels in BALF (P〈0.05 and P〈0.01, respectively), orexin A level in lung tissue (P〈0.01; but not orexin B) and mRNA expressions of OX 1 type receptor (OXR1) and OX 2 type receptor (OXR2) in lung tissue (P〈0.05 and P〈0.01, respectively); the integrative optical densities (IODs) of both receptors were greater in the COPD group (P〈0.05). For rats with COPD subjected to EA, lung function was improved (P〈0.05). There were notable decreases in TNF-a and IL-1β levels (P〈0.05 and 〈0.01, respectively) in BALF. Orexin A, but not orexi  相似文献   

13.
Multiple-treatments meta-analysis is thought to be a feasible method to compare the efficacy and safety among different treatments, especially when there was no head-to-head research among some treatments. But sometimes some conclusions are inconsistent with the clinical experience. Recently, we read a multiple-treatment meta-analysis finished by Stefen Leucht et al, which was published in Lancet) The authors summarized the results of the RCT studies on 15 antipsychotics commonly used in practice; they also horizontally compared the efficacy and safety profile by the recta-analysis. We believe that the results provide more solid evidence for the rational usage of antipsychotics to the psychiatrists, also for the government to distribute health resources in a more reasonable way.  相似文献   

14.
在中医名词术语的英语翻译中,与经络学说相关的术语,其翻译一般都比较统一。在中医药的对外交流中,针灸是率先走出国门并为西方世界所接受的中医疗法。其传入西方的历史远远早于中医药学的其他领域。正因为如此,其用语的英语翻译在国际上相对比较一致。在《WHO西太区传统医学国际标准名词术语》中共收录了有关经络学说的术语43条。“世界中医药学会联合会”(以下简称“世中联”)《中医基本名词术语中英对照国际标准》中则收录了87条。下面试根据WHO的标准并结合“世中联”的方案,对这些术语的翻译问题加以简要的比较分析。  相似文献   

15.
16.
BACKGROUND: Analgesic and wound-healing effects of cinnamon, a widely used spice, have been shown in laboratory rats. However, we found no human studies in this area. OBJECTIVE: The aim of this study was to assess the effect of cinnamon on perineal pain and healing of episiotomy incision. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: In this double-blind, randomized, placebo-controlled trial, 144 postpartum women were allocated into two groups, using stratified block randomization, 1 h after completion of episiotomy repair. They received cinnamon or placebo ointment, 2 mL every 12 h for 10 d. MAIN OUTCOME MEASURES: Perineal pain and wound healing were assessed using visual analogue scale (0-10)and Redness, Edema, Ecchymosis, Discharge, Approximation scale (0-15), respectively. General linear model was used to compare the groups on the outcomes adjusted for baseline values and stratified factors. RESULTS: Follow-up rate was 100% up to the 8 h time point in both groups, and 86% (62 of 72) in the cinnamon group and 85% (61 of 72) in the placebo group at day 10-11 after delivery. Pain score in the cinnamon group was significantly lower than that in the placebo group at (4±1) h (adjusted difference: -0.6, 95% confidence interval: -1.0 to -0.2) and (8+1) h (-0.9, -1.4 to -0.3) after intervention, and on the 10-11th day after delivery (-1.4, -2.0 to -0.7). Also the cinnamon group showed significantly more improvement than the control group in healing score at (8±1) h (-0.2, -0.4 to -0.04) and the 10-11th day after delivery (-1.6, -2.0 to -1.1). CONCLUSION: Cinnamon can be used for reducing perineal pain and improving healing of episiotomy incision.  相似文献   

17.
Objective To provide basic microsurgical anatomy parameters for the far lateral transcondylar approach. Methods Thirty dry skulls were measured around foramen magnum. Twenty formalin fixed Chinese adult cadaveric heads were employed by microsurgical dissection and the vital anatomical structure was delineated and measured. The dissection was performed imitating the far-lateral transcondylar approach. In addition, among 20 formalin fixed cadaveric heads, 10 adult cadaveric heads were scanned with Spiral CT thin tomographic scanner. Some structures of foramen magnum were measured by CT thin tomographic scan. The 3D-CT (three dimensional computed tomography) reconstruction was performed in 4 adult cadaveric heads including preoperative and post-operative. Results Occipital condyle (OC) was an important sign in the far lateral transcondylar approach and its long axis was 24.47±3.32 (18.19-30.30)mm (left,L); 25.16±2.39 (20.66-29.02)mm (right, R) (standard deviation). The distance from the posterior midline of the foramen magnum (FM) to the medial border of the OC was 27.66±2.45 (23.00-31.48)mm (left); 26.27±1.83 (23.68-29.64)mm (right). Inferior occipital triangle was formed by three muscles, which was rectus capitis posterior major, superior oblique and inferior oblique. The distance of vertebral artery from lateral side of transverse foramen of atlas to its dural entry was 16.87±2.08 (12.64-20.1)mm (left), 16.79±1.90 (12.44-20.22)mm (right). Some vital bone structures such as jugular foramen, hypoglossal canal, condylar canal, transverse foramen of atlas could be showed clearly on the three-dimensional reconstruction CT image. Conclusion In this study, the authors provided some anatomic parameters for far lateral transcondylar approach. They documented the structures of inferior occipital triangle and the course of vertebral artery. Rare variation of VA should be paid more attention to. The thin tomographic scan and three-dimensional construction  相似文献   

18.
与对抗医学(allopathic medicine)的诊疗理念和实践有着重大区别的补充替代医学(complementary and alternative medicine.CAM)于20世纪70年代在美国达到第一个高峰。并且“替代医学”这个名词在此期间开始使用。此后.随着非常规医学在美国使用人数的迅速增多以及所治病种的不断增加.相关的基础研究和临床试验也相继展开,并且开始设立专门的CAM研究机构。  相似文献   

19.
程丑夫教授运用六君子汤加减治疗疑难杂症验案举隅   总被引:1,自引:0,他引:1  
程丑夫教授出身中医世家,是全国第五批名老中医学术继承指导老师,主任医师,博士研究生导师,享受国务院特殊津贴。从医40余年来,善于治疗心脑血管疾病、呼吸系统疾病、脾胃病等,在治疗疑难杂症方面尤为突出。笔者有幸跟师门诊,观程师运用六君子汤加减治疗疑难杂症效果显著,现举验案4则来阐述程丑夫教授从脾胃入手治疗疑难杂病的经验。  相似文献   

20.
中医疗法治疗运动性疲劳的研究进展   总被引:1,自引:0,他引:1  
随着竞技体育的发展,运动员经常承受着大负荷、超强度的体力训练,因此极易产生运动性疲劳。疲劳的出现使肌内压增高,局部缺血,造成氧化代谢、H^+排出率与pH值降低,血乳酸增高,从而影响肌纤维神经传导速度和肌内收缩力量,减弱了肌肉保护能力。致使较多的冲击力传到骨骼上,故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩,对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。  相似文献   

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