Endemic arsenism, fluorosis and arsenic fluoride poisoning caused by drinking water in Kuitun, Xinjiang

Endemic arsenism, fluorosis and arsenic fluoride poisoning caused by drinking water in Kuitun, Xinjiang@王国荃 @黄月珍 @冈竞民 @汪师贞 @肖碧玉 @姚华 @胡宇 @顾玉兰 @张晨 @刘开泰     

Primary peripheral blood stem cell transplantation for severe aplastic anemia

Primary peripheral blood stem cell transplantation for severe aplastic anemia@刘元波@赵相印@刘复强@钱筠@崔晶@邓移风@张维娜@刘小超@杨敏@郑佳@李守静@杨晓云@裴蕾@吕秋霜@李援邻@祝瑞全     

Genetic epidemiological survey of esophageal cancer in one-tenth of the population of Yangquan city

Genetic epidemiological survey of esophageal cancer in one-tenth of the population of Yangquan city@李卫东 @王秀琴 @张春林 @韩小友 @陈德权 @张卫华 @潘秀芬 @贾运堂 @毛学正 @张睿 @周传农 @吴旻     

Clinical study on treatment of incipient diabetic nephropathy by integrated traditional chinese and western medicine

Clinical Study on Treatment of Incipient Diabetic Nephropathy by Integrated Traditional Chinese and Western Medicine@边 芳 @赵佩民 @张志深 @李艳英 @吴凤霞 @张红梅 @赵庆梅 @姬淑君 @闫树河 @黄金秀     

Preliminary Study on Therapeutic Effect of Oxymatrine in Treating Patients with Chronic Hepatitis C

Preliminary Study on Therapeutic Effect of Oxymatrine in Treating Patients with Chronic Hepatitis C@李继强@李超群@曾民德@范建高@华静@邱德凯@萧树东@佘祥奎@李国软     

Clinical and experimental studies on clearing away stomach-heat purging fire and nourishing yin principle in treating patients of recurrent aphthae

Clinical and Experimental Studies on Clearing Away Stomach-Heat Purging Fire and Nourishing Yin Principle in Treating Patients of Recurrent Aphthae@过伟峰@王永山@顾勤@汪红@王小琴@尚文斌@周仲瑛@朱翠娣@平雷     

Comparative effects of lovastatin and L-arginine on endothelium-dependent vasodilation and atherosclerosis in hypercholesterolemic rabbit

Comparative effects of lovastatin and L-arginine on endothelium-dependent vasodilation and atherosclerosis in hypercholesterolemic rabbit@张金盈@董建增@李凌@赵洛沙@黄振文@魏经汉@刘瑞云...     

Spectral analysis of breath sounds in asthm atics and chronic asthm aticbronchitis during acute episode

Spectral analysis of breath sounds in asthm atics and chronic asthm aticbronchitis during acute episode@辛晓峰@殷凯生@张希龙@童茂荣@施毅@夏锡荣@黄小平     

Externalization and internalization of cardiac endothelin receptors during different phases of sepsis in rat

Externalization and internalization of cardiac endothelin receptors during different phases of sepsis in rat@王晓红@杨军@董林旺@庞永政@苏静怡@唐朝枢@刘乃奎     

The association of different human leucocyte antigen-DQ with myasthenia gravis

The association of different human leucocyte antigen-DQ with myasthenia gravis@李霞@范玉新@季碧霞@张咸宁@朱定良@庚镇城...     

甲状旁腺切除术对甲状旁腺机能亢进性骨病的远期疗效

为了评价甲状旁腺切除术对原发性甲状旁腺机能亢进（ＰＨＰＴ）所致骨病的远期疗效，回顾分析了１６例术后平均５．１（１．０～１０．５）年患者的临床表现、骨结构和骨密度恢复情况，结果表明手术虽能明显改善患者骨病，但在随访终点有１０／１６例（６２．５％）骨病恢复不全，其中骨病重的Ｙ１组比骨病轻的Ｙ２组恢复不全比例更高（Ｐ＜０．０５），１４／１６例血骨钙素（ＢＧＰ）和尿吡啶并啉（Ｐｙｒ）浓度处于中青年对照组范围内，这意味着其成骨与破骨处于平衡状态。这些结果提示：ＰＨ－ＰＴ患者应尽早诊断治疗，术后应对患者密切随访，重视对骨病恢复不全者的后续治疗     

胰十二指肠切除术后住院时间影响因素分析-回顾性研究

Background. Postoperative hospital stay after pancreaticoduodenectomy (PD) was relatively longer than other gastrointestinal operations, The aim of current study was to investigate the risk factors of postoperative hospital stay after PD. Methods. Patients who were performed PD in Cancer Hospital Chinese Academy of Medical Sciences (CHCAMS) between December 2008 and November 2012 were selected for the retrospective study. The clinical and pathological data was collected and analyzed. The primary outcome was postoperative hospital stay. Normal discharge or recovery was defined as postoperative hospital stay no more than 10 days, otherwise it was defined as delayed discharge or recovery (including hospital death). Results. Finally, 152 patients were enrolled in present study. Postoperative hospital stay was 19.7±7.7 (7-57 d). 67 of 152 patients were normal discharge, and 85 of 152 patients were delayed discharge. The overall morbidity of complications was 62.5% (95/152), and the mortality rate was 3.29% (5/152). Multiple factors analysis showed that complication morbidity (adjusted OR=10.40, 95%CI=3.58-30.22), age (adjusted OR=4.09, 95%CI=1.16-14.39), BMI (body mass index) (adjusted OR=4.40, 95%CI=1.19-16.23), surgical procedure (adjusted OR=26.14, 95%CI=4.94-153.19), blood transfusion (adjusted OR=7.68, 95%CI=2.09-28.27) and fluid input (adjusted OR=3.47, 95%CI=1.24-11.57) were significantly associated with delayed discharge. Conclusions. Postoperative complications affects the postoperative hospital discharge. Furthermore, age, BMI, transfused red blood, surgical procedure and input might prolong LOS (length of hospital stay). Studies with more patients were needed in future.     

甲磺酰胺苯乙胺类化合物抗心律失常活性的定量构效关系研究(Ⅰ)

以ＰＯＬＹＧＥＮ软件中的ＣＨＡＲＭｍ程序和集团坐标轮换法，对合成的１２个甲磺酰胺苯乙胺类化合物的结构进行计算机分子模拟。根据所得化合物的能量最低构象，计算了其ＶＤＷ体积、偶极矩、总键能、总键角能、总非正则能以及氮原子电荷等值，并对这些化合物进行ＣＮＤＯ／２法量化计算，这些计算结果作为结构参数分别与１２个化合物抗心律失常活性进行相关分析，以逐步回归法建立了两个相关性较好的方程：ｌｇｌ／ＭＥＣ＝６．９９９１－０．３８４２Ｘ２＋３．６７９６Ｘ５［ｎ＝１２，ｒ＝０．８５５９７５，ｓ＝０．１８９６７２，Ｆ＝１２．３３４６４＞Ｆ１－０．０５（３，９）＝３．８６］；ｌｇｌ／ＭＥＣ＝１４．７０３８－２１３．２６９２Ｘ４－１０．４８２９Ｘ５［ｎ＝１２，ｒ＝０．９３１９１９，ｓ＝０．１３３０４７，Ｆ＝２９．７１３５４＞Ｆ１－０．０１（３，９）＝６．９９］。结果提示，这类化合物的抗心律失常活性与分子中的原子轨道杂化程度和氮原子对分子ＨＯＭＯ和ＬＵ－ＭＯ的贡献有关，可以看出，氮上的取代不同会引起抗心律失常活性的不同     

欧洲刺柏（Juniper）

活性成分与药理作用欧洲刺柏药用部位是其浆果，具有促水排泄、防腐、抗胃肠胀气和抗风湿作用，还可改善胃功能。用作促水排泄药可增加尿量（水丢失），但不增加钠排泄。成分萜品烯-4-醇可增加肾小球滤过率，但刺激肾。欧洲刺柏浆果对单纯疱疹病毒体外显示抗病毒活性，并具抗真菌活性。动物实验显示，欧洲刺柏浆果提取物具有堕胎、抗生育、抗炎、抗胚胎植入、降血压、升血压和降血糖作用。欧洲刺柏浆果油具有兴奋子宫的活性，以及利尿、胃肠道抗菌和刺激作用，该油对平滑肌有阻止解痉作用。     

基于网络药理学探讨独活-羌活-细辛治疗膝骨关节炎的作用机制*

目的 基于网络药理学的方法分析和预测独活-羌活-细辛治疗膝骨关节炎可能的作用机制。方法 利用TCMSP数据库获取独活、羌活、细辛的活性成分及靶点,与CTD、NCBI等数据库获取的膝骨关节炎疾病基因靶点映射,构建药物-活性成分-疾病靶点网络。进行MCODE聚类分析,通过Omicshare云平台和DAVID数据库GO、KEGG通路富集分析。结果 从3味药中共筛选出了36个活性成分及205个靶点,主要有山柰酚、 β-谷甾醇、芝麻脂素、异紫花前胡苷等关键成分,AKT1、ESR1、JUN、CASP3等为关键靶点,核心基因有NOS3、ESR1、COX1、NR1I2,关键的生物进程和通路有类固醇激素反应性、活性氧代谢过程、AGE-RAGE通路和TNF通路。结论 独活-羌活-细辛可能通过多成分、多靶点网络来治疗膝骨关节炎。