姿势对忽视患者垂直感觉的影响

背景与目的:已知右半球损伤患者发生的逆时针(A CW)视觉偏离和视触觉主观垂直(SVs)被空间忽视(N)所扩大,这些患者只在坐位时被评估。本研究旨在探讨姿势改变调节视触觉SV偏离的假说。方法:8例表现为右半球损伤和空间N的患者与6例相匹配的对照(C)受试者进行比较。在黑暗中,受试者必须在4种条件下旋转一个光柱以使其垂直:①以足底支撑坐位;②不靠足底支撑坐位;③伸腿支撑坐位;④仰卧位。结果:与C受试者(+0.01°)相比,N患者(-4.5°)表现出明显SV的ACW偏离。体位的影响取决于组别(P=0.022),因为N组的姿势变化产生明显影响而C组的影响则…     

卡通表情自动加工的失匹配负波研究

目的 采用事件相关电位(Event-related potential,ERP)技术探讨人脑对卡通表情自动加工的脑电生理机制.方法 受试者为16名健康人(男7,女9).要求受试者观看卡通表情图片并计数靶刺激绿色图片的呈现次数,而忽略非靶刺激红色图片(包括作为标准刺激的中性表情及作为偏差刺激的情绪性表情).记录32导脑电,对受试者的视觉失匹配负波(Mismatch negativity,MMN)的波幅进行分析.结果 (1)MMN1:波幅分另为(-0.570±0.076)μV(TP7/TP8)、(-0.840±0.119)μV(A1/A2)、(-1.199±0.105)μV(T5/T6)、(-1.184±0.102)μV(O1/O2).波幅的电极位置主效应显著(F(3,45)=8.340,P＜0.05).方向与半球存在交互效应显著(F(1,15)=11.977,P＜0.05).(2)MMN2:波幅分别为(-0.469±0.126)μV(TP7/TP8)、(-1.014±0.255)μV(A1/A2)、(-1.071±0.182)μV(T5/T6)、(-0.915±0.178)μV(O1/O2).方向主效应差异有显著性(F(1,15)=7.232,P＜0.05),且方向与表情交互效应显著(F(1,15)=6.458,P＜0.05),方向与半球交互效应显著(F(1,15)=11.907,P＜0.05).结论 人脑对正、负性卡通表情均可进行自动加工,而负性表情自动加工较正性表情更强;表情信息自动加工存在右侧偏侧化效应.     

两种亚型注意缺陷多动障碍儿童干扰控制能力的半球不对称性

目的:考察两种亚型注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童大脑左右半球干扰控制功能的表现.方法:采用跨通道干扰的方式,在儿童的左耳或右耳呈现分心刺激,分别与视觉呈现的靶刺激构成一致、不一致和中性关系.结果:当分心刺激在左耳呈现时,ADHD儿童与正常儿童在错误率上的模式明显不同,ADHD儿童表现出显著的冲突效应(效应量为4%),F(1,110)=18.16,P＜0.001,即冲突条件下的错误率明显高于一致条件下的错误率,而正常儿童的冲突效应不显著(效应量为1.2%),F(1,110)=1.59,P＞0.1;ADHD儿童的抑制效应呈现翻转趋势(效应量为-1.7%),F(1,110)=3.16,0.05＜P＜0.1,混合型ADHD儿童的抑制效应翻转显著(效应量为-4.1%),F(1,54)=8.31,P＜0.01,即中性条件的错误率高于冲突条件的错误率,正常儿童的抑制效应不显著F(1,110)=1.53,P＞0.1.结论:ADHD儿童的右半球控制冲突干扰的功能异常,混合型ADHD儿童右半球的功能异常模式还需进一步研究.     

四种诱发大鼠运动病刺激模式的比较

目的 :比较 4种刺激模式对运动病的诱发效应。方法 :将 60只雄性 SD大鼠随机分为对照组、三角形 组、三角形 组、梯形 组和梯形 组。以刺激前后食高岭土量为指标 ,对三角形 组和 组分别采用三角形刺激模式 (频率 0 .1 Hz,峰速 2 4 0°/ s)刺激 1 h和 1 .5 h,对梯形 组和 组分别采用梯形刺激模式 (加速度 1 0°/ s2 ,峰速 2 4 0°/ s,持续 5 min,减速至 0 )刺激 1 h和 1 .5 h,诱发运动病。结果 :在所用的 4种刺激模式中 ,三角形 组和梯形 组高岭土摄入量与对照组相比差异有显著性 ( P<0 .0 1 ) ,梯形 组与对照组相比差异有显著性 ( P<0 .0 5 )。同时三角形 组和梯形 组高岭土摄入量与三角形 组比差异也有显著性 ( P<0 .0 5 )。结论 :用三角形 组或梯形 组的刺激模式诱发运动病的效果较好     

进行性核上性麻痹患者视动性眼球震颤异常

目的:检测视觉运动(OK)刺激时眼球的水平和垂直位相反应,并研究进行性核上性麻痹(PSP)患者眼球快相运动的方向异常。方法:对6例PSP患者、5例帕金森病(PD)患者和10例对照的扫视眼动和视动眼震进行研究。在水平72°,垂直60°的范围内,由黑白两色条带组成的视动刺激以10°～50°/s的速度进行移动。结果:与PD组和对照组比较,PSP患者均有缓慢自主垂直的扫视眼动和快相的眼球震颤。凝视时PSP患者细小、成对的水平扫视运动(SWJ)更频繁且振幅更大。PSP患者垂直扫视眼动则在SWJ和水平扫视时一过性加快。在垂直眼震期的所有患者中,小快相常…     

大学生视觉突出性目标加工的神经机制

目的 利用事件相关电位(ERP)时空模式探讨视觉突出性目标加工的神经机制.方法 16名受试者执行视觉搜索任务,按键判定4个项目中是否存在1个目标,其中目标和1个分心物可能具备颜色突出性.行为绩效和ERP数据应用2(分心物突出性:有、无)×3(目标:缺失、低突出性、高突出性)双因素重复测量方差分析.结果 反应时间交互效应显著(F(1.99,29.79)=21.56,P=0.00).低突出性目标的搜索反应时间在分心物突出性存在[ (552.57 ±82.32) ms]和缺乏[(540.47±75.68)ms]条件下差异显著(t(15)=-2.489,P=0.025).高突出性目标的搜索反应时间在分心物突出性存在[(527.14±77.84) ms]和缺乏[(527.77±78.31)ms]条件下无显著差异(l(15)=0.162,P=0.873).ERP的F值统计参数映像提示:在知觉阶段(350 ～450 ms),分心物和目标的突出性效应分别出现在处理刺激新奇性的右额顶颞区和视觉加工相关的顶枕区,两者的交互效应存在于刺激熟悉性加工及分类相关的左颞区(450～ 600 ms).结论 高突出性目标的迅捷加工得益于早期其与分心物的并行处理以及后期左颞区熟悉性网络对其的有效分类.     

不同全视野图形翻转及彩色图形视觉诱发电位在评价青光眼视功能中的应用

目的:探讨16°×16°和32°×32°全视野图形翻转视觉诱发电位(patternreversalvisualevokedpotential,PR-VEP)和彩色图形翻转视觉诱发电位(colorpatternreversalvisualevokedpotential,CPR-VEP)在评估青光眼视神经功能损害中的应用。方法:应用RolandRETI视觉电生理仪对32例青光眼和30例正常眼分别进行全视野16°×16°和32°×32°的PR-VEP和CPR-VEP检测,记录各眼P100潜伏期和N75-P100波幅的数值,并作统计学分析。结果:在刺激野分别为16°×16°和32°×32°时,PR-VEP和CPR-VEP中,青光眼组的P100潜伏期均较正常对照组明显延长,N75-P100波幅降低;其潜伏期和波幅的改变有显著的统计学意义(P<0.001)。不同刺激野间,青光眼组P100潜伏期和N75-P100波幅的变化比较差异无统计学意义(P>0.05)。青光眼组PR-VEP的P100潜伏期和N75-P100波幅的改变与相应的CPR-VEP结果的比较差异无统计学意义(P>0.05)。结论:16°×16°和32°×32°两种全视野刺激PR-VEP评价青光眼视神经功能作为常规的临床检测程序,增强了结果的可靠性;CPR-VEP可作为评价青光眼色觉异常的一项客观指标。     

后天性上斜肌麻痹手术治疗一例

1 临床资料 患者,男,32岁,工人。主诉自幼右眼上斜视,无头痛、恶心、呕吐;无高热史;无复视。检查:视力为右0.7-1.0D.S.→1.5,左0.4-8.0D.S.→1.5。有代偿头位,头向左侧倾斜,面转向右。左眼固视时,右眼内斜22°,上斜18°。右眼固视时,左眼内斜18°,下斜20°。眼球向各方向转动均不受限。右眼遮盖红玻璃试验无复像。入院诊断:右眼先天性上斜肌麻痹。于1989年7月27日施行右眼下斜肌后徒术,术后左眼固视时,右眼仍上斜5°,内斜10°。于同年8月10日施行左眼下直肌后徙术,垂直性斜视度为0,内     

经皮穴位电刺激对下肢术后患者硬膜外自控镇痛效应的影响

目的研究经皮穴位电刺激联合硬膜外布托啡诺对下肢骨科手术患者自控镇痛(PCA)效应的影响。方法择期下肢骨科手术患者60例,ASAⅠ~Ⅱ级,随机分成两组:Ⅰ组(n=30)0.75%左旋布比卡因25ml 布托啡诺1mg 生理盐水稀释至50ml;采用LCP模式,负荷剂量5ml,持续剂量1ml/h,单次给药剂量2ml,锁定时间10min。全程镇痛48h。Ⅱ组(n=30)采用韩氏穴位神经刺激仪经皮穴位电刺激手术同侧合谷穴和足三里穴及手术切口两侧皮肤,同时联合Ⅰ组方案。术毕,在患者VAS=0时开启PCA泵,记录开机后4,8,16,24和48h共5个时点(T1,T2,T3,T4,T5)患者按压PCA次数(D1)与实际进药次数(D2),同时行VAS评分及记录肛门排气时间和恶心呕吐等不良反应情况。结果两组患者的一般状况(年龄、体重)、出血量、补液量、每组开启PCA泵开启距最后一次硬膜外注局麻药的时间均差异无显著性(P>0.05);T2,T3,T4时点VAS评分Ⅱ组虽略低于Ⅰ组,但差异无显著性(P>0.05);T2,T3时点D1/D2比值Ⅱ组低于Ⅰ组,并有统计学意义(P<0.05);Ⅱ组镇痛期间应用布托啡诺总量明显少于Ⅰ组,差异有显著性(P<0.05)。术后4h无运动阻滞的患者数量及恶心呕吐等不良反应的发生率与肛门排气时间两组相似(P>0.05)。结论经皮穴位电刺激联合硬膜外布托啡诺行下肢骨科手术后镇痛可提供满意的术后镇痛效果,并且可以明显减少镇痛药用量。     

曲马多用于神经外科患者术后自控镇痛的效果

目的 评价曲马多用于神经外科患者术后静脉自控镇痛(PCIA)的效果.方法 60例择期开颅手术患者随机平均分为3组:T F组,曲马多10 mg/ml 氟哌利多3 mg.T组,曲马多10 mg/ml.N组,未行镇痛组.前2组术中即经静脉注入曲马多负荷量1.5 mg/kg,接一次性使用镇痛泵2 ml/h持续静脉输注.记录术前及术后6,18,24 h的心率(HR)、平均动脉压(MAP)、呼吸频率(RR)和瞳孔大小,术后各时点的疼痛视觉模拟评分(VAS)、Ramsay镇静评分、恶心呕吐评分.结果 术后6 h,T F、T两组VAS评分均显著低于N组(P＜0.01及P＜0.05),术后18 h T F组VAS评分较T、N两组显著为低(P＜0.05),但24 h各组VAS评分差异无显著性(P＞0.05).术后各时点T、N组镇静评分显著低于T F组(P＜0.05).各组术后瞳孔大小差异无显著性(P＞0.05).无一例出现呼吸抑制.各组及各时点RR差异无显著性,各组间MAP及术后各时点MAP与术前相比差异无显著性.N组患者术后6,18 h的HR较术前显著增加(P＜0.01),T组患者术后6,18 h的HR与术前相比差异有显著性(P＜0.05),但T F组患者HR在术前与术后变化不大(P＞0.05),术后24 h各组HR与术前相比差异无显著性.3组患者术后恶心呕吐发生率分别为37.50%,50.00%,43.75%,差异无显著性,恶心呕吐评分及呕吐程度差异也无显著性.结论 曲马多伍用氟哌利多用于神经外科患者术后自控镇痛是一种比较理想的选择.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.