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1.
该文连续观察了19例大肠患者手术前后血清可溶性白细胞介素2受体(SIL-2R),周围血自然杀伤细胞(NK细胞)活性及T细胞亚群的动态变化,结果显示,大肠癌患者术前血清SIL-2R水平明显高于正常对照组(P<0.005),而且Dukes'C期病人血SIL-2R较Dukes'B期病人明显升高(P<0.05)。同时,周围血NK细胞活性及CD4/CD8比值较正常对照组明显下降(P<0.01).术后一周上述免疫指标受到进一步抑制,直至术后2周上述免疫指标逐渐开始恢复。但仍处于抑制状态,结果显示,大肠癌患者术前及术后早期均存在免疫抑制,免疫抑制时出现可能与其体内高水平的SIL-2R浓度有关。因此,大肠癌患者血清SIL-2R及周围血NK细胞活性及T细胞亚群的动态监测,有助于患者疾病和病情时诊断以及预后的估计  相似文献   

2.
对44例Graves病初治患者于治疗前检测外周血T淋巴细胞亚群及NK细胞活性,结果显示CD_3细胞与正常对照组差异无显著性(P>0.05),CD4细胞低于正常对照组(P<0.05),CD_细胞显著低于正常对照组(P<0.01),CD_4/CD_8值及NK细胞则显著高于正常对照组(P<0.01),并发现这些变化与T3、T4无显著相关性。对Graves病的细胞免疫改变作了初步讨论。  相似文献   

3.
原发性高血压患者sIL-2R及细胞免疫活性的变化   总被引:1,自引:0,他引:1  
目的探讨sIL-2R、T淋巴细胞亚群和NK细胞在原发性高血压中的变化与意义。方法分别用酶标双抗体夹心法、碱性磷酸酶抗碱性磷酸酶法和改良的微量细胞毒试验—乳酸脱氢酶释放法检测76例原发性高血压患者的sIL-2R、T淋巴细胞亚群、自然杀伤细胞(NK细胞)的数量与活性。结果原发性高血压患者sIL-2R水平明显增高,CD3、CD4、CD4/CD8、NK细胞活性显著降低,且sIL-2R和CD4/CD8的异常随病情的加重而加重。有家族史的患者较对照组NK细胞数量显著减少。结论原发性高血压患者存在sIL-2R异常和细胞免疫的调节紊乱,终致IL-2的产生与功能障碍,此可能是引起本病的重要环节。sIL-2R和CD4/CD8的异常变化可以反映疾病的严重程度,而NK细胞数量的异常似与本病的遗传因素有关。  相似文献   

4.
许荣  李培成 《华夏医学》1999,12(4):CD56
观察全身性红斑狼疮(SLE)患者的T淋巴细胞亚群、NK细胞及可溶性白介素2受体(sIL-2R)的变化以了解患者细胞免疫调节紊乱的机制。采用流式细胞仪对40例SLE患者和30名正常对照组进行CD3+、CD4+、CD8+、NK等细胞表面标志检测;采用ELISA法检测sIL-2R。结果表明,SLE患者血中CD8+细胞增加,而CD4+细胞和NK细胞均减少,CD3+细胞无明显变化。血浆中sIL-2R明显增高。结论:SLE发病与细胞免疫调节紊乱有关。  相似文献   

5.
报道30例膀胱癌患者和34例正常人的细胞免疫功能检测结果。膀胱癌患者外周血IL-2活性、干扰素水平均显著低于正常人。患者NK活性、IL-2受体表达均显著低于正常人。患者OKT3+细胞比例下降,OKT8+细胞比例升高,OKT4+细胞无明显改变;OKT4/OKT8细胞比值减小。患者NK活性与IL-2活性及干扰素水平呈直线正相关;IL-2活性与T4细胞及T4/T8细胞比值呈直线正相关。  相似文献   

6.
检测柯萨奇B组病毒(CVB)性心肌炎70例,正常人(NC)40例外周血的自然杀伤细胞(NKC)活性和T细胞亚群。结果显示病毒性心肌炎(VMC)组NKC活性显著低于NC组(P〈0.01)。T细胞亚群与NC组比较,急性VMC患者总T细胞(CD3),辅助性T细胞(CD4)和抑制性T细胞(CD8)及CD4/CD8比值均减少,P〈0.05 ̄0.01。慢性VMC患者仅CD8减低明显(P〈0.05),而CD3、  相似文献   

7.
目的:了解慢性肺心病T淋巴细胞亚群、NK细胞活性及红细胞免疫功能变化及临床意义。方法:测定30例肺心病患者急性发作期和缓解期外周血T淋巴细胞亚群、NK细胞活性及红细胞免疫功能,并与25例正常人对照。结果:肺心病患者急性发作期CD3、CD4、CD4/CD8比值、C3bRR及NK细胞活性均明显低于正常人(P〈0.01),CD8则明显高于正常人(P〈0.01),肺心病伴明显缺氧和高碳酸血症者变化最明显。  相似文献   

8.
为探讨病毒性心肌炎(VMC)免疫发病机理及静脉丙种球蛋白(IVIG)治疗VMC的作用机理,将BALB/c小鼠随机分为正常对照组、病毒模型组、IVIG保护组及IVIG治疗组,观察IVIG对小鼠脾脏T细胞亚群、NK细胞、IL-1、IL-2及外周血TNF活性的影响。结果:与正常对照组比较,病毒模型组NKC活性及CD3、CD4、CD8均明显降低,IL-1、IL-2及TNF活性明显升高,而IVIIG保护组一  相似文献   

9.
目的:检测慢性丙型肝炎患者外周血T细胞亚型和NK活性,并与正常人比较,以观察HCV感染对患者细胞免疫功能的影响。方法 采用间接免疫荧光-流式细胞分析法检测外周血T细胞CD3、CD4、CD8表达,采用LDH释放法测定NK活性。结果 慢性丙型肝炎患者外周血CD4、CD4/CD8比值NK活性明显降低,与正常人碾 显著性,而CD8升高;HCV-RNA阳性组一HCV-RNA阴性组比较,CD4/CD8比值、N  相似文献   

10.
CD3AK细胞在体外对体外癌细胞系细胞杀伤活性最强,对自体细胞杀伤活性与TIL细胞接近,且均显著大于LAK细胞,CD3AK细胞IL-2治疗癌症患者30例中,CR+PR14例,有效率为46%,Kernofsky的生活质量标准评分治疗后有显著提高(P〈0.01),血浆IL-2活性治疗后有明显提高(P〈0.05),T4/T8治疗后有所提高。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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