首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 46 毫秒
1.
对164例CCPD患者的CV/VC%与MMEF作了相关分析,两者呈负相关(r=-0.6965,P〈0.01),说明CV/VC%随着MMEF的降低而增高。对另一组172例COPD患者的FEV1.0%、MMEF及计算和实测的CV%VC(%)的异常率也进行了分析。结果表明,MMEF异常率均高于CV/VC%的计算值和实测值,关FEV1.0%≥80%的患者中,MMEF的敏感性也高于FEV1.0%,作者认为,  相似文献   

2.
目的:探讨联合检测孕中晚期母血清βhCG、AFP、uE3预测早产、妊高征(PIH)的可行性,方法:用放射免疫法检测早产16例、中重度PIH28例、正常对照组164例产妇孕13~17周间血清β-hCG、AFP、uE3水平,将各值与正常组相应每两孕周中位数的倍数相比较,并作统计学分析。结果:(1)三标记物水平随孕周增加呈规律性波动;(2)单指标预测PIH,βhCG有意义,当βhCG≥1.5MOM时灵敏度、特异度较好,分别为50%、81.71%;而AFP、uE3不论以何界点预测均无意义,故联合预测意义不大。(3)单指标预测早产,当βhCG≥1.52、2.0MOM、AFP≥1.5、2.0、2.5MOM,uE3≤0.6MOM时均具统计学意义,其中以β-h  相似文献   

3.
目的探讨地氟醚的交感兴奋作用及其机理。方法择期手术病人30例,ASAⅠ~Ⅱ级,随机分为地氟醚(15例)、异氟醚(15例)两组。不用术前药。气管插管后观察不同地氟醚和异氟醚水平(0.5MAC、OMAC和1.5MAC)对平均动脉压(MAP)和心率(HR)、心率变异性(HRV)和用改良荧光法测定血浆中肾上腺素(E)、去甲肾上腺素(NE)浓度的影响。结果二组MAP、HR、E和NE在麻醉前、0.5MAC和1.0MAC时无差异(P>0.05),达1.5MAC后地氟醚组则出现2~4min的MAP增高和HR增快,且血浆E和NE浓度升高,明显高于异氟醚组(P<0.05),而异氟醚组无变化。HRV的总功率(TP)、低频(LF)和高频(HF)二组都随着MAC的增加逐渐降低,但在1.5MAC时与异氟醚组相比,地氟醚组HF明显降低,LF/HF明显升高(P<0.05)。结论快速增加地氟醚浓度至1.5MAC可出现交感兴奋作用,其作用机制可能是迷走神经受抑制超过交感神经的抑制程度。  相似文献   

4.
利用地高辛标记的cDNA探针,原位检测DDPH[1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙胺基)丙烷酸盐]对缺氧内皮细胞条件培养液致猪PASMCPDGF基因表达的影响。实验分6组:常氧、低氧无血清培养液组(N、H组),常氧、低氧内皮细胞条件培养液组(NECCM、HECCM组),NECCM+DDPH、HECCM+DDPH组。用自动图像分析仪检测各组细胞PDGF-A和-B链杂交产物的平均光密度(OD)值。结果:HECCM组PDGF-A和-B链mRNA表达量分别是NECCM组的1.40、1.49倍(P<0.01),分别是N组的1.8倍、1.7倍(P<0.01),HECCM+DDPH组PDGF-A、-B链mRNA表达量分别为HECCM的0.73倍、0.65倍(P<0.01),与NECCM组相比,均无显著差异。提示DDPH在PDGF基因转录水平抑制HECCM诱导的PASMC的增殖。  相似文献   

5.
目的:了解笑气与其它麻醉药合用时所产生的麻醉强度。方法:56例择期手术病人,随机分成8组,各组病人分别应用不同浓度的笑气(N_2O)和异氟醚(ISO),保证每组病人的呼气末麻醉药浓度达到1.0MAC,脑电功率谱及95%边缘频率(SpectralEdgeFrequency,SEF)。结果:应用70%N_2O组病人的SEF值最大,单纯ISO组的SEF值最小(P<0.05)。结论:70%、60%、50%、40%的麻醉效能达不到0.7、0.6、0.5、0.4MACISO的麻醉强度,临床麻醉中应适当增加其它麻醉药的用量。  相似文献   

6.
择期24例ASAⅠ~Ⅱ级胸内手术患者,随机分为两组(静脉组13例,静吸组11例),于麻醉后5min、15min、30min、60min测定PR、SV、CO、SI、CI、VPE、MAP、TPR分析比较。结果表明:静脉组PR前30min稳定,60min增快(P<0.01),MAP下降4%(p>0.05),SV、CO、SI、CI、VPE进行性下降(p<0.01);静吸组PR前30min增快7%(P>0.05),60min时正常,MAP稳定,其他指标前30min呈下降趋势(P<0.05),60min恢复正常。两组TPR增高幅度近似(67.2%~70.1%)。  相似文献   

7.
目的:探讨精神分裂症阴性和阳性症状在脑电地形图(BEAM)检测中的特点。方法:应用丹麦SEEG-16道脑电地形图仪,对符合CCMD-Ⅱ标准的13例阴性症状组、15例阳性症状组和40名正常成人对照组作BEAM检查。结果:精神分裂症阴性症状组、阳性症状组及正常对照组在δ频带Fp1、F7、O1、O2,θ频带Fp1、F7、F8、T3、T4、O、,α频带O1,β频带T6脑区上有显著性差异(P<0.05 ̄0.  相似文献   

8.
胡艳萍  周新华 《河北医学》1996,2(4):317-318
74例经病理学证实的小细胞肺癌,局限期35例,广泛期39例,均为初治病例。主要以ACO、CE、COME和COP方案治疗。其中ACO方案有效率75%,CE方案有效率84%,AOE方案有效率100%,COME方案有效率85%,COP方案有效率50%,其它方案有效率55%,结果表明,含ADM、CBP和VP-16的联合方案优于其它方案(P〈0.05)。毒副反应主要是胃肠道反应和胃髓抑制。  相似文献   

9.
目的:检测不同程度糖尿病肾病(DN)病人炎性因子及氧化应激指标水平,探讨炎症反应及氧化应 激反应在 DN 进展中的作用及意义。方法:将 2017-01~ 2018-06 就治的 DN 病人 132 例,根据 Mogensen 分期分 为Ⅰ~Ⅱ期组 41 例,Ⅲ期组 50 例,Ⅳ~Ⅴ期组 56 例,检测 3 组高敏 C 反应蛋白(hs-CRP)、白介素-6(IL-6)、肿 瘤坏死因子-α(TNF-α)及丙二醛(MDA)、髓过氧化物酶(MPO)、8-羟化脱氧鸟苷(8-OHdG)、氧化物歧化酶 (SOD)水平,分析炎性因子及氧化应激指标与尿蛋白排泄率(UAER)的相关性。结果:3 组 hs-CRP、IL-6、TNF- α 水平两两比较差异均有统计学意义(P<0.05);3 组 MDA、MPO、8-OHdG 水平两两比较差异均有统计学意义(P <0.05);hs-CRP、MDA、8-OHdG 与 UAER 呈线性相关关系(P<0.05)。结论:炎症反应及氧化应激反应与 DN 的 进展密切相关,监测 hs-CRP、IL-6、TNF-α 等炎性因子及 MDA、MPO、8-OHdG 等氧化应激指标对于判断 DN 病 情有一定的辅助作用。  相似文献   

10.
用简易的髓鞘碱性蛋白(MBP)及其抗体(Anti-MBP)酶联免疫吸附定量测定(ELISA)法对6组共337例神经系统疾病患者进行检测,其中脊髓压迫症(CMP)36例,多发性硬化(MS)33例,脑血管疾病(CVD)34例,中枢神经系统感染性疾病(ID)31例,癫痫(EP)161例和其他神经系统疾病(OND)42例。结果显示:CMP、MS.CVD、ID和EP5组血清MBP均值明显高于OND组(P<0.01),其中又以急性外伤所致脊柱骨折伴截瘫为主(33例)的CMP患者血清MBP值最高,与MS组比较P<0.05,与CVD、ID和EP组比较P<0.01。CVD患者CSFMBP均值也明显高于OND组(P<0.05)。本法检测6组血清和CSF的Anti-MBP含量差异不显著(P>0.05)。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号