贺菊乔教授治疗慢性前列腺炎用药规律研究

目的 采用数据挖掘软件统计研究贺菊乔教授治疗慢性前列腺炎（CP）的用药规律.方法 收集贺教授治疗CP 患者461 例、共计1 752 诊次的处方资料,使用SPSS 17.0 和Clementine 12.0 软件进行关联分析,探究贺教授治疗CP 的学术经验.结果 分析出各味中药的使用频次及2 味、3 味中药的关联情况,充分体现了贺教授以清热利湿和活血化瘀之法论治CP 的用药特色.结论 基于关联规则得出的结果在一定程度上客观反映了贺教授治疗CP 的学术经验,为今后临床治疗CP 提供了有益的参考和借鉴.     

贺菊乔教授治疗男性不育症用药经验的数据挖掘

目的：研究贺菊乔教授治疗男性不育症的用药经验。方法收集贺教授治疗的229例男性不育症患者,共计1553诊次的处方资料,采用数据挖掘软件对其进行统计和关联分析。结果分析出有关各味中药的使用频次、功效归类及两味中药的关联情况,获取了贺教授治疗男性不育症的常用药物和药对组合。结论数据挖据技术的分析结果,充分体现了贺教授以生精之法为主,辅以固精、通精之法论治男性不育症的用药特色,对提高中医治疗男性不育症的临床疗效大有裨益。     

治疗痛经方药的关联规则分析

目的应用关联规则方法探讨治疗痛经方药的用药规律。方法应用计算机检索中医方剂数据库(源于《中医方剂大辞典》)有关治疗痛经的217首方剂,以EXCEL 2000软件建立数据库,收录每首方剂中的单味药进行统计分析。应用关联规则方法中Apriori算法分析方剂中药对的应用规律。结果在治疗痛经的217首方剂中共使用427种药物2 450频次。其中,使用频次在10次以上的依次为当归、川芎、延胡索、赤芍、香附等56味中药,使用总频次为1 622次;关联规则方法分析出使用频次在10次以上的药对当归-川芎、当归-白芍、当归-香附等389对。结论运用用药频率统计与关联规则等数据挖掘方法,能较好地发现中医临床治疗痛经方药的用药规律,为临床遣方用药提供理论指导。     

基于关联规则的痹证方剂用药规律研究

目的：分析治疗痹证方剂的处方用药及配伍规律,为临床治疗痹证提供参考。方法：筛选《中医方剂大辞典》收录的治疗痹证的方剂,利用SPSS Clementine软件,采用软件内置的Apriori算法对筛选方剂进行处方分析。结果：共筛选1311首痹证方剂,涉及中药672味。对其中使用频率大于100次的42味中药进行关联规则分析,显示常用药对配伍组合为没药、乳香,赤芍、当归和杜仲、牛膝等;常用三味药物组合为牛膝、川芎、当归,肉桂、川芎、当归和羌活、川芎、当归等。结论：通过关联规则等数据挖掘方法对痹证方剂进行挖掘,可以得到痹证治疗的一些常用药物组合以及发现一些新的药物组合,对于开拓痹证临床组方用药思路,提高痹证临床治疗水平和效果具有一定参考意义。     

肾性贫血方剂组方规律中医文献分析

目的 :总结、分析近现代治疗肾性贫血中医文献方剂组方用药的规律。方法 :收集中医肾脏病专著及中医内科专著中有关中-重度肾性贫血的有效方剂,统一中西医诊断,规范中药名称,使用中医传承辅助系统(V2.5)软件逐一录入并进行数据处理,先统计"中-重度"用药频次,再按"中度""重度"贫血方剂分别统计用药频次,分析药物组合规律、常用药物组合的关联规则,最终提取核心药物。结果:共有203首治疗中-重度肾性贫血处方被录入,共计295味中药,提取出核心药物14味:茯苓、大黄、黄芪、白术、丹参、陈皮、半夏、黄连、附子、党参、赤芍、当归、山茱萸、熟地黄;治疗中度肾性贫血方剂144首,计213味中药,归纳出核心药物7味:茯苓、黄芪、大黄、白术、丹参、半夏、陈皮;治疗重度肾性贫血方剂59首,共133味中药,提取出核心药物6味:熟地黄、大黄、茯苓、当归、陈皮、半夏,各组核心药物进行网络展示。结论:治疗中度、重度肾性贫血的核心药物组成明显不同,治疗原则有差异,但补气、化湿法是治疗各阶段肾性贫血的主要方法。     

基于数据挖掘的中医治疗缺血性卒中组方用药分析

目的分析中医药方剂治疗缺血性卒中的用药特点。方法检索中国生物医学文献数据库(CBM),筛选2004-2013年中医药治疗缺血性卒中的临床文献,运用中医传承辅助系统软件V1.1(TCMISS)挖掘中医药治疗缺血性卒中组方的用药特点。结果筛选出治疗缺血性卒中的文献1332篇,治疗缺血性卒中的方剂169首,涉及中药217味,使用频次≥10的药物有35味。得出138种药物组合模式,其中2味药的药对组合模式31种,3、4、5味药的核心组合模式分别为45、35、21种。并展示了9味常用药物关联的网络化图。结论活血化瘀法为缺血性卒中的基本治疗方法,川芎、地龙、黄芪等9味中药为治疗缺血性卒中的常用药物。     

基于数据挖掘探究中药古方治疗肺癌用药规律

[目的]基于数据挖掘技术探究中药古方治疗肺癌的用药规律。[方法]以中国方剂数据库为检索库,检索治疗肺积或息贲的中药方剂,建立中药古方治疗肺癌方剂数据库,并采用Excel、SPSS 22.0及SPSS Modeler 14.0软件进行频数及频率分析、聚类分析、关联分析,进而对中药古方用药规律进行定量、定性分析。[结果]中药古方治疗肺癌涉及方剂40首,中药110种,高频中药38味,甘草、人参、槟榔、木香等较为常用;温里药、补气药、理气药、止咳平喘药较常选用;核心药物聚类分析结果形成5个类别;经关联规则分析,支持度≥10%,得出药对关联规则21条,3味药配伍关联规则60条。[结论]中药古方治疗肺癌以扶正祛邪为主要治则,多采用温阳益气,滋阴养血结合清热、化痰、止咳、解表、行气活血等方法选取相应中药组方治疗。     

基于中医药传承辅助平台研究治疗慢性鼻窦炎方剂的组方用药规律

目的:运用中医药传承辅助平台(V2.5)软件分析治疗慢性鼻窦炎的组方用药规律。方法:筛选万方、维普、中国知网数据库中近15年来治疗慢性鼻窦炎的方剂,通过中医传承辅助平台软件构建方剂数据库,利用该软件的关联规则及熵聚类等数据挖掘算法,将临床证型、药物及剂量等相关信息录入到中医传承辅助平台软件构建数据库,采用软件分析药物频次统计、规则分析及熵聚类等,总结治疗慢性鼻窦炎的组方用药规律。结果:通过对116首治疗慢性鼻窦炎的方剂所含药物频次统计得出常用药物28味;通过药物之间的关联规则分析,得到使用频次较高的药对30个;通过熵层次聚类分析算法发现6个关联系数较高的潜在药对及6个新处方。结论:临床治疗慢性鼻窦炎多选用疏风通窍、清热排脓之品进行遣方用药,统计分析结果与各医家临床辨证论治心得基本吻合,中医传承辅助平台可用于各中医医家临床经验分析与总结。     

金元四大家治疗消渴用药规律探析

目的:整理并总结金元四大家治疗消渴用药规律,以期为临床治疗本病提供文献学证据,并为完善金元四大家学术体系提供统计学依据。方法:收集金元四大家医学著作中与消渴相关的中药处方,对符合纳入标准的中药处方进行统计,利用WPS Excel软件建立方药数据库,应用SPSS 20.0统计软件对中药的频数、相关性进行分析,运用IBM SPSS Modeler 18.0统计软件对治疗消渴的高频药物进行数据挖掘,采用Cytoscpae软件绘制高频药物核心网络图。结果:共获得治疗消渴的中药处方44首,其中涉及中药89味,总计出现频次335次。金元四大家治疗消渴常用高频药物以补气药、清热泻火药、清热燥湿药为主,根据高频药物关联分析,挖掘出23对常用药对和26组常用药组;根据高频药物相关性分析,绘制药物核心网络图,挖掘出3组临床常用核心组方。结论:金元四大家治疗消渴主要从肺、胃、心三脏论治,病机以火热内盛为主,可兼有气虚、阴虚、血虚,治疗上应用清热药和补虚药为主,以清热泻火生津,滋阴润燥,补气升阳为治疗大法,常用方剂有白虎汤、补中益气汤、生津甘露汤、六一散等。本研究结果可为临床治疗消渴提供借鉴,同时为更好地理解金元四大家学术思想提供了数据支持。     

中医治疗失眠处方数据挖掘研究

目的使用关联规则挖掘治疗失眠中药的高频组合以及强关联关系,探讨中药的用药规律。方法本文基于1685篇中医药临床文献,从临床治疗失眠的方剂出发,将Rapidminer 5.2作为数据挖掘软件,使用关联规则挖掘算法FP-growth,找到中药之间的高频组合以及强关联关系,并从中医机理的角度对数据挖掘结果进行解释。结果在1685篇临床文献中,治疗失眠的方剂共有768首,中药407味。使用频次最高的中药为酸枣仁。通过关联规则挖掘得到1234个中药组合,其中甘草和酸枣仁是支持度最高的中药组合,"地黄,桃仁→当归"是置信度最高的中药组合。结论临床上多采用滋阴降火、补脾益气、补脾益心等方法治疗失眠。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.