无创正压通气救治慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的临床研究

目的 探讨无创正压通气（NIPPV）治疗慢性阻塞性肺疾病（COPD）合并Ⅱ型呼吸衰竭的治疗效果。方法 观察23例NIPPV治疗慢性阻塞性肺疾病（COPD）急性加重期并发Ⅱ型呼吸衰竭患者的血气指标变化（pH值、PaO2、PaC02），住院病程，气管插管率和病死率，并同以往未使用NIPPV治疗的25例COPD相似病例进行比较分析。结果 23例NIPPV治疗前后24h血气指标明显改善，住院病程缩短，气管插管率（P＜0．05～0．01）降低，同非NIPPV治疗的对照组比较差异有统计学意义。结论 NIPPV是治疗慢性阻塞性肺疾病急性加重期并发Ⅱ型呼吸衰竭的一种有效方法。     

无创正压通气治疗慢性阻塞性肺疾病急性加重期并Ⅱ型呼吸衰竭

目的：研究无创正压通气（NIPPV）治疗慢性阻塞性肺疾病（coPD）急性加重期并Ⅱ型呼吸衰竭的临床效果。方法：2002年1月-2006年12月我科收住的COPD急性加重期并Ⅱ型呼吸衰竭病人。治疗组36例，在应用常规药物治疗的基础上应用NIPPV。对照组36例，常规药物治疗。结果：治疗组经治疗后血气指标及临床症状明显改善，住院天数缩短，与对照组比较差异有显著性。结论：NIPPV是治疗慢性阻塞性肺疾病急性加重期并Ⅱ型呼吸衰竭的一种有效方法，早期应用可阻止病情发展，缩短病程。     

无创正压通气治疗慢性阻塞性肺疾病急性加重期并Ⅱ型呼吸衰竭

目的研究无创正压通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)急性加重期并Ⅱ型呼吸衰竭的临床效果.方法2002年1月～2006年12月我科收住的COPD急性加重期并Ⅱ型呼吸衰竭病人.治疗组36例,在应用常规药物治疗的基础上应用NIPPV.对照组36例,常规药物治疗.结果治疗组经治疗后血气指标及临床症状明显改善,住院天数缩短,与对照组比较差异有显著性.结论NIPPV是治疗慢性阻塞性肺疾病急性加重期并Ⅱ型呼吸衰竭的一种有效方法,早期应用可阻止病情发展,缩短病程.     

无创正压通气治疗COPD急性加重期并Ⅱ型呼吸衰竭

目的 探讨无创正压通气(NIPPV)在治疗慢性阻塞性肺疾病急性加重期(AECOPD)并Ⅱ型呼吸衰竭的疗效.方法 收集2006年3月～2008年12月本院呼吸内科住院的94例AECOPD患者,随机分为观察组(NIPPV)60例和对照组(非机械通气,NMV组)34例,观察二组治疗前后的动脉血气、住院病程及需气管插管率的变化.结果 两组患者治疗前的基础情况差异无显著性(P>0.05),治疗组和对照组在治疗结束时pH、PaCO2、PaO2与治疗前均有明显改善(P<0.05).治疗组住院病程、气管插管率明显降低,同非NIPPV治疗的对照组比较差异有显著性(P<0.05).结论 NIPPV是治疗COPD急性加重期并发Ⅱ型呼吸衰竭的一种有效方法.     

无创正压通气治疗慢性阻塞性肺疾病急性加重期的临床观察及护理

目的：探讨无创正压通气（NIPPV）治疗慢性阻塞性肺疾病急性加重期的效果及护理方法。方法：将我院2007年3月～2009年3月收治的96例慢性阻塞性肺疾病急性加重期患者分为两组,其中,2007年3月～2008年3月收治的50例患者作为对照组,2008年4月～2009年3月收治的46例患者作为实验组,应用NIPPV治疗。观察两组住院时间、气管插管率和病死率。结果：实验组应用NIPPV治疗,24h后血气指标明显改善,平均住院时间缩短,气管插管率和病死率降低,与对照组比较,有显著性差异（P〈0.01）。结论：NIPPV是治疗慢性阻塞性肺疾病急性加重期的有效方法,早期应用NIPPV并精心护理,可有效缩短病程。     

双水平气道正压通气联用呼吸兴奋剂治疗慢性阻塞性肺病急性加重期并发Ⅱ型呼吸衰竭临床分析

目的评价鼻面罩无创双水平气道正压（BiPAP）通气联用呼吸兴奋剂治疗慢性阻塞性肺病（COPD）急性加重期并发Ⅱ型呼吸衰竭的疗效。方法将32例COPD急性加重期并发Ⅱ型呼吸衰竭患者作为治疗组，采用呼吸兴奋剂、鼻面罩无创双水平气道正压（BiPAP）通气及常规治疗；观察患者血气指标变化（PH值、PaO2，PaCO2）及比较插管率。并同以往使用呼吸兴奋剂治疗的30例COPD急性加重期并发Ⅱ型呼吸衰竭的相似病例作为对照组进行比较分析。结果治疗组32例患者中28例治疗成功，另外4例病情加重需要气管插管机械通气治疗；对照组30例患者中16例治疗成功，14例需气管插管机械通气治疗。治疗组气管插管率明显低于对照组（P〈0.05）。治疗组治疗前pH7．25&#177;0．05、PaCO2为（83&#177;12）mmHg（1mmHg=0.133kPa）、PaO2为（53.9&#177;6.3）mmHg，在平均治疗5d后PH为7．32&#177;0．08（P〈0．01）、PaCO2为（61&#177;9）mmHg（P〈0.05），PaO2为（84&#177;15）mmHg（P〈0.05）。结论双水平气道正压通气联用呼吸兴奋剂治疗慢性阻塞性肺病急性加重期并发Ⅱ型呼吸衰竭患者疗效确切，明显降低插管率。     

无创正压通气治疗慢性阻塞性肺病急性加重期合并呼吸衰竭的疗效观察

目的 探讨无创正压通气（NPPV）治疗慢性阻塞性肺病（COPD）急性加重期合并呼吸衰竭的价值。方法 对46例COPD合并呼吸衰竭病人中23例采用NPPV治疗者（治疗组）与23例采用常规药物治疗者（对照组）进行比较。观察治疗后2h、48h心率、呼吸频率、动脉血气分析的改善情况，比较气管插管率，病死率、住院时间。结果治疗组同期心率、呼吸频率、动脉血气分析较对照组明显改善，住院时间缩短，气管插管率、病死率明显降低。结论 NPPV是治疗COPD急性加重期合并呼吸衰竭的一种有效方法，可提高氧分压、降低二氧化碳分压，缩短病程及降低插管率、病死率。     

无创正压通气治疗慢性阻塞性肺病合并呼吸衰竭疗效观察

目的 评价慢性阻塞性肺病（COPD）合并呼吸衰竭使用无创正压通气（NIPPV）的冶疗价值.方法 回顾分析56例COPD合并呼吸衰竭患者行NIPPV治疗（NIPPV组）,另有同期42例COPD合并呼吸衰竭患者采用标准治疗方法（标准组）,比较两组患者的气管插管率、住院时间及病死率.结果 NIPPV组较标准组气管插管率、平均住院时间、死亡率明显减少,两组差异有统计学意义（P＜0.05）.结论 NIPPV可明显改善COPD合并呼吸衰竭患者呼吸状况,疗效显著.     

无创正压通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的疗效观察

目的探讨无创正压通气（NIPPV）治疗慢性阻塞性肺疾病（COPD）急性加重合并Ⅱ型呼吸衰竭的临床治疗作用。方法将COPD合并Ⅱ型呼吸衰竭患者58例,随机分为治疗组30例,对照组28例,两组均行常规抗感染、激素、平喘、祛痰、呼吸兴奋剂和持续低流量吸氧等治疗。治疗组在此基础上进行NIPPV治疗,观察两组的临床疗效。结果两组患者治疗前的基本情况差异无统计学意义（P〉0.05）,治疗组NIPPV治疗前、后（6 h）PaCO2、PaO2、心率和呼吸频率指标明显改善,平均住院日、气管插管率和住院病死率明显减低,同对照组比较差异有统计学意义（P〈0.05）。结论NIPPV治疗COPD急性加重合并Ⅱ型呼吸衰竭疗效肯定,可明显缩短住院时间,降低插管率、病死率,值得推广应用。     

无创正压通气治疗慢性阻塞性肺病并Ⅱ型呼吸衰竭的疗效分析

目的：探讨无创正压通气治疗慢性阻塞性肺病急性加重期（ AECOPD ）并Ⅱ型呼吸衰竭患者的效果。方法观察39例在常规治疗基础上给予无创正压通气治疗AECOPD并Ⅱ型呼吸衰竭患者的动脉血气变化、有效率及住院天数,并与40例常规治疗组进行比较。结果39例无创正压通气治疗24、72 h血气指标明显改善,住院时间缩短,气管插管和病死率降低,与对照组比较差异有统计学意义（P＜0．05）。结论无创正压通气治疗AECOPD并Ⅱ型呼吸衰竭疗效肯定,早期应用可阻止病情进一步加重,避免有创机械通气,缩短病程。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…