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1.
目的 观察调肝运脾化浊方联合电针治疗非酒精性脂肪肝的临床疗效.方法 将非酒精性脂肪肝的120例患者随机均分为对照组和治疗组,各60例.对照组予多烯磷脂酰胆碱胶囊口服,每次456 mg,每日3次;治疗组予调肝运脾化浊方汤药口服,并配合电针治疗.12周为1个疗程,1个疗程后观察中医证候积分、主要临床症状积分、肝脏酶谱指标、血脂检测指标、肝/脾CT比值、生存质量评分的变化.结果 疗程结束后,治疗组临床疗效总有效率(86.7%,52/60)优于对照组(73.3%,44/60)(P< 0.05);治疗组中医症状总积分以及主要中医症状积分改善均较对照组明显(P< 0.05);与对照组比较,治疗组ALT、AST、GGT、TBil、TC、TG、LDL-C水平均明显降低,HDL-C水平明显升高,治疗组肝/脾CT比值好转明显优于对照组(P<0.05);治疗组生存质量评分改善程度优于对照组(P<0.05).结论 调肝运脾化浊方联合电针治疗非酒精性脂肪肝具有显著疗效.  相似文献   

2.
郝泉  刘艳  李明 《中国现代医生》2008,46(30):110-111
目的 探讨二甲双胍治疗非酒精性脂肪肝的临床疗效。方法 非酒精性脂肪肝患者100例,分为两组,治疗组50例给予饮食、运动、控制体重及二甲双胍治疗。对照组50例给予饮食、运动、控制体重及维生素E治疗,疗程均为6个月。治疗前后测定各组患者血清转氨酶(ALT、AST)、血脂(TG、TC、LDL-C及HDL-C)、肝/脾CT比值,同时观察不良反应。结果 治疗后两组患者血清ALT均明显降低,其中尤以试验组降低明显(P〈0.01);试验组患者治疗后各项血脂水平均显著改善;试验组胰岛素抵抗指数于治疗后明显下降(P〈0.05),而对照组无明显改变(P〉0.05);同时试验组治疗后肝/脾CT比值显著升高(P〈0.01)。用药期间两组患者均未出现显著不良反应。结论 二甲双胍对非酒精性脂肪肝有显著疗效且用药安全。  相似文献   

3.
目的探讨中药疏肝消脂方治疗非酒精性脂肪肝的疗效及治疗前后肝脏CT影像学差异。方法 60例确诊为非酒精性脂肪肝患者随机分为治疗组和对照组,每组30例,对照组患者给予调节饮食结合适当运动进行治疗,治疗组在此基础上服用疏肝消脂方,分析比较治疗后3个月后两组CT、临床及生化指标变化情况。结果治疗组临床治疗总有效率93.33%,对照组86.67%,两组比较差异有统计学意义(P0.05);治疗后,与对照组相比,治疗组ALT、AST、TC及TG等肝功能各项指标均有所改善,差异有统计学意义(P0.05);与治疗前比较,治疗组肝CT值及肝/脾CT比值均升高,差异有统计学意义(P0.05);治疗后与对照组相比,治疗组肝CT值及肝/脾CT比值均升高,差异有统计学意义(P0.05)。结论疏肝消脂方治疗非酒精性脂肪肝疗效显著,CT定量技术评估中医药治疗非酒精性脂肪肝疗效方法安全、准确。  相似文献   

4.
目的:探讨复方参草颗粒(CSCG)对酒精性脂肪肝大鼠血清生物化学指标及肝组织形态学变化的影响。方法:60只大鼠随机分为6组,每组10只,即正常对照组、模型组、阳性药脂可清胶囊组及CSCG高、中、低剂量组。正常对照组大鼠喂食普通饲料;其余各组大鼠喂食380 mL?L-1酒精及高脂饲料,连续15 d,制备高脂模型。第16天起,灌胃给予各实验组大鼠相应药物,连续40 d。末次给药12 h后腹主动脉取血,检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、谷丙转氨酶(ALT)及谷草转氨酶(AST)含量,计算TC/HDL-C,LDL-C/HDL-C比值及动脉硬化指数(AI);断头处死大鼠,剖取肝脏,行常规HE染色,光学显微镜下观察。结果:与模型组比较,CSCG高剂量组大鼠血清TC,TG,LDL-C、TC/HDL-C、LDL-C/HDL-C及AI均有不同程度的降低(P<0.05或P<0.01),血清HDL-C含量升高(P<0.01),AI下调(P<0.01);光学显微镜下CSCG高、中剂量组大鼠肝组织内脂滴成分明显减少,肝细胞结构及排列明显改善。结论:CSCG对酒精性脂肪肝具有一定的拮抗作用。  相似文献   

5.
目的:观察排毒降脂合剂对大鼠非酒精性脂肪肝(nonalcoholic steatohepatifis,NASH)动物模型的影响,阐明其作用机制.方法:以高脂饲料喂饲大鼠建立脂肪肝病模型,观察排毒降脂合剂对大鼠肝脏血脂、转氨酶含量以及肝组织病理学变化.结果:与模型组相比,排毒降脂合剂中、大剂量组能降低血清TC、LDL-C、ALT和AST(P<0.01,P<0.05),升高血清HDL-C(P<0.01,P<0.05),以高剂量组效果最显著.结论:排毒降脂合剂治疗脂肪肝的机制可能与其抑制TG、LDL-C、ALT和AST,升高血清HDL-C有关.  相似文献   

6.
目的:探讨苦参素联合多烯磷脂酰胆碱对非酒精性脂肪肝患者心脏舒张功能、血脂和肝功能影响。方法:选自我院于2015年3月至2017年3月期间收治的非酒精性脂肪肝患者102例,依据随机数字表法分为观察组51例与对照组51例。对照组采用多烯磷脂酰胆碱胶囊治疗,观察组在对照组基础上苦参素胶囊治疗。两组疗程均为12周。比较两组治疗疗效,治疗前后CT检查、心脏舒张功能不全、血脂指标、肝功能指标变化,及不良反应发生情况。结果:观察组治疗总有效率(94.12%)高于对照组(72.55%),且有统计学差异(P<0.05)。两组治疗后肝CT值和肝脾CT比值较治疗前升高(观察组:t=12.335、15.149,对照组:t=5.333、7.021,P<0.05);观察组治疗后肝CT值和肝脾CT比值高于对照组(t=8.536、7.390,P<0.05)。两组治疗后心脏舒张功能不全发生率较治疗前降低(观察组:χ2=17.270,对照组:χ2=5.162,P<0.05);观察组治疗后心脏舒张功能不全发生率低于对照组(χ2=4.387,P<0.05)。两组治疗后TG、LDL-C和TC水平较治疗前下降而HDL-C水平较治疗前升高(观察组:t=22.325、12.789、12.970、15.254,对照组:t=10.458、6.453、6.364、8.423,P<0.05);观察组治疗后TG、LDL-C和TC水平低于对照组而HDL-C水平高于对照组(t=13.563、8.086、8.145、7.565,P<0.05)。两组治疗后AST和ALT水平较治疗前降低(观察组:t=20.735、20.817,对照组:t=11.278、9.322,P<0.05);观察组治疗后AST和ALT水平低于对照组(t=15.937、16.799,P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论:苦参素联合多烯磷脂酰胆碱对非酒精性脂肪肝患者疗效明显,可降低心脏舒张功能不全,改善血脂及肝功能,具有重要研究价值。  相似文献   

7.
目的:通过针刺不同腧穴组方对高脂血症大鼠肝脏形态学影响的观察,筛选治疗高脂血症大鼠的最佳腧穴组方。方法:将90只SD大鼠随机分为空白组、模型对照组及针刺7组,每组10只,分别给予电针针刺。连续治疗4 w后观察各组大鼠血脂及肝脏组织形态学的变化。结果:与空白组比较,模型组大鼠血清TC、TG、LDL-C升高,HDL-C降低(P0.01),说明造模成功。电针治疗后,与模型组比较,针刺组LDL-C、HDL-C值均不同程度下降,除曲池组外余各针刺组TC降低,曲池+中院+丰隆组TG、ALT、AST降低(P0.05,P0.01)。模型组肝脏有明显病理学损伤,表现为轻至中度脂肪肝。结论:电针不同腧穴对高脂血症大鼠肝脏有明显的保护作用,以"曲池"、"中脘"、"丰隆"三穴配伍疗效最优。  相似文献   

8.
目的 观察中药清脂颗粒治疗酒精性脂肪肝的临床疗效.方法 将160例酒精性脂肪肝患者随机分为两组,对照组给予东宝肝泰片治疗,治疗组给予中药清脂颗粒治疗.两组均以4周为1个疗程,观察治疗前后临床疗效、血清TG、TC、HDL-C、LDL-C指标,肝功ALT、AST、GGT指标,腹部彩超或CT等指标.结果 治疗组总有效率87.5%,对照组为65.2%,两组比较,差异有统计学意义(P<0.05);治疗组在改善患者血脂、肝功指标、影像学表现方面均优于对照组(P<0.05);两组安全性指标观察比较,差异无统计学意义(P>0.05).结论 中药清脂颗粒对酒精性脂肪肝具有良好的治疗作用.  相似文献   

9.
[目的]观察祛瘀化浊法对酒精加高脂饮食诱导的脂肪肝大鼠血清胰岛素抵抗(IR)、C-反应蛋白(CRP)的影响,探讨其可能作用机制。[方法]将Wistar大鼠52只随机分为空白对照组、脂肪肝模型组、脂肪肝模型易复善治疗组、脂肪肝模型中药调脂积冲剂治疗组、脂肪肝模型中药(六味地黄丸)治疗组。采用酒精合并高脂乳剂建立大鼠脂肪肝模型,以易善复和六味地黄丸为阳性对照,8周后检测TC、TG、HDL-C、LDL-C、ALT、GGT、FBG、血清胰岛素、CRP含量,评价胰岛B细胞功能,光镜观察组织学变化。[结果]模型组大鼠肝组织出现明显的脂肪变.其血清中TC、TG、LDL-C、ALT、GGT、FBG、FINS、HOMA—IR、CRP、肝指数均高于正常组,HDL-C低于正常组。调脂积冲剂能降低肝指数.降低CRP、TC、TG、ALT、GGT、TC、TG、LDL-C、FBG、FINS的含量,升高HDL-C的含量,降低HOMA—IR。[结论]CRP、IR参与酒精合并高脂饮食诱导的大鼠脂肪肝的发生,祛瘀化浊方药能在一定程度上能降低炎症状态,改善胰岛素抵抗,防止肝细胞脂肪变性和肝脏损伤的进一步发展.促进肝内脂质代谢。  相似文献   

10.
本文测定了183名健康人,52名冠心病和56名高血压患者血清总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)含量。冠心病组HDL-C、HDL-C/LDL-C、HDL-C/TC值显著低于健康组(P<0.001)。提示HDL-C为冠心病的“危险降低因子”。高血压病组HDL-C/TC、HDL-C/LDL-C比值显著低于健康组,HDL-C差异不显著。不论TG浓度高、中、低,冠心病发病率均与HDL-C/TC及HDL-C/LDL-C比值呈负相关,与HDL-C呈不规律现象。提示作为冠心病早期预测指标,HDL-C/TC、HDL-C/LDL-C比值比HDL-C及其他脂质水平更有实用价值。  相似文献   

11.
目的探讨应用不同脂肪沉着程度供肝对肝移植患者预后的影响。方法选取64例进行肝移植术患者,依据供肝浸润程度,随机分为轻度脂肪肝组、中度脂肪肝组、重度脂肪肝组、无脂肪肝组共四组,每组各16例,比较四组患者肝功能(主要观察ALT、AST指标)、入住ICU的平均时间、1年移植物成活率、移植物原发无功发生率。结果轻度脂肪肝组入住ICU的平均时间、ALT和AST水平、移植物原发无功发生率与无脂肪肝组接近;中度脂肪肝组入住ICU平均时间、ALT和AST水平均较轻度组和无脂肪肝组明显增高,P0.05;重度脂肪肝组入住ICU平均时间、ALT和AST水平、移植物原发无功发生率明显较前三组为高,P0.05。结论轻、中度肝脏脂肪浸入可作为肝移植供肝,重度脂肪肝不能作为供肝的选择目标。  相似文献   

12.
The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of "tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment" can regulate "the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration"; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.  相似文献   

13.
Liver     
<正>209461 Intraoperative ligation of recipient’s portasystemic shunt in liver transplantation/Chen Litian(,Organ Transplant Center,Tianjin 1st Centr Hosp Tianjin 300192)…∥Chin J Gen Surg.-2009,25(4).-489~491Objective To investigate the clinical significance of ligating the portasystemic shunt confirmed by preoperative CT evaluation during orthotopic liver transplantation.Methods From January 2007 to August 2008,35 patients in Tianjin First Central Hospital underwent preoperative three-dimensional CT scan,among them 23 patients had spontaneous major portasystemic shunts,the other 12 patients did not have portasystemic shunts.16 out of the 23 cases with significant shunts underwent shunt ligation based on portal blood flow volume measured by intraoperative portal vein flowmetry.The shunt of the other 7 patients were left untreated.Results The portal blood flow in the 12 patients without portasystemic shunt judged by preoperative CT scanning were(1 101±70)ml/min.The shunts in 7 patients with portal blood flow greater than 1 000 ml/min were not ligated,that of the 16 patients with portal blood flow volume lower than 1 000 ml/min were ligated.The portal blood flow volume in those 16 patients before and after ligating the shunt were(657±112)ml/min and(1 136±161)ml/min,respectively(P<0.05).Postoperatively 2 patients suffered from portal vein thrombosis,among them 1 patients suffered from intermittent disturbance of consciousness,2 patients died within 3 months,with one died of respiratory failure from pulmonary aspergillus infection,one died of hepatic failure in 2 months after operation because of graft dysfunction.The other 19 patients with normal blood flow and well-functioning graft were alive.Conclusion The ligation of portasytemic shunt is mandatory in patients when pretransplant CT evaluation showing a major porto-systemic shunts and portal blood flow volume was less than 1 000 ml/min.5 refs,2 figs.  相似文献   

14.
Liver     
<正>209293 Probing into indication of living-related Liver Transplantation for Wilson’s disease/Cheng Feng(Liver Transplant Center,1st Hosp Nanjing Med Univ,Key Lab Living Donor Liver Transplant,Minist Public Health,Nangjing 210029)…∥Chin J Surg.-2009,47(6).-437~440Objective To probe into indication of living-related liver transplantation(LRLT)for Wilson’s Disease.Methods From January 2001 to February 2007,thirty-seven living-related liver transplants were performed.A retrospective analysis was carried on outcome of those patients.The indications for LRLT were acute hepatic failure in 3 patients and chronic advanced liver disease in 32 patients including 13 patients with Wilsonian neurological manifestations.Two patients presented with severe Wilsoian neurological manifestations even though their liver functions were stable.According to the scoring system for evaluation of the neurological impairment in Wilsion disease based on neurological signs and functions(total score was 30),the pre-transplantation score of those patients with neurological manifestations was 15.9±4.3(n=15).Results Thirty-seven patients were followed up for 20-93 months.The survival rates of post-transplant patients and grafts at 1,3,and 5 year were 91.9%,83.8%,75.7%,and 86.5%,78.4%,75.7%,respectivly.Postoperative surgical complications occurred in 2 donors with bile leakage required drainage,in 2 recipients with hepatic thormbosis underwent retransplantation of cadeveric liver and in 1 recipient with hepatic stenosis required balloon dilatation.Neurological function was improved in all recipients and the score of posttransplantation at 6,12,18,24,and 30 months was 17.5±3.7(n=13);21.0±4.3(n=12);23.9±3.9(n=10);26.6±2.2(n=10)and 28.1±1.9(n=7)respectively.Conclusion Patients with acute hepatic failure or patients with severe liver disease unresponsive to chelation tratment should be treated with LRLT.Early transplantation in patients with an unsatisfactory response medical tratment may prevent irreversible neurologica  相似文献   

15.
Liver     
Alleviation of ischemia-reperfusion injury in rat liver donors by induction of exogenous hTERT gene;Effects of surgical technique on acute renal failure after orthotopic liver transplantation in patients with end-stage liver disease at high risk: a report of 90 eases;Timing for liver transplantation for chronic severe hepatitis;Analysis of bacterial variance and drug resistance after orthotopic liver transplantation;The influence of splenectomy on orthotopic liver transplantation and its management  相似文献   

16.
Liver     
<正>209087 Clinical analysis of outcome of invasive fungal infection after kidney transplantation/Chen Guodong(陈国栋,Dept Transplant Surg,1st Hosp,Sun Yat sen Univ, Guangzhou 510080)…∥Chin J Organ Transplant. -2009, 30(10). -616~619 Objective To explore the outcome of invasive fungal infection in kidney transplantation and the influencing factors.  相似文献   

17.
目的探讨脂肪肝患者血清肝纤维化指标特点,寻找可能引起脂肪肝肝纤维化改变的相关因素。方法记录脂肪肝组和正常对照组临床资料与血清生化指标以及肝纤维化指标,分析各项指标的异常及脂肪肝组肝纤维化指标及其他指标的相关关系。结果脂肪肝组和正常对照组血清生化指标和肝纤维化指标之间的比较:脂肪肝患者组血清FPG、TG、Tc、ALT、HA、LN、PCⅢ、CIV、CG与对照组比较差异有统计学意义(P〈0.05)。血清肝纤维化指标HA与年龄(≥50岁)、酗酒、男性、CG增高、ALT增高、高血压病有线性回归关系;血清肝纤维化指标LN与酗酒、肥胖、糖尿病有线性回归关系;血清肝纤维化指标CIV与高脂血症,ALT增高有线性回归关系;血清肝纤维化指标PcⅢ与年龄(I〉50岁)、高脂血症、高血压病有线性回归关系。结论通过多元线性回归分析显示:男性,年龄≥50岁,酗酒,肥胖,伴发高血压病、高脂血症、糖尿病,出现CG增高,ALT增高,可能是促进脂肪肝发生肝纤维化的危险因素。  相似文献   

18.
Liver     
<正>209604 The suppressive effect of CD8+ CD28-regulatory T cells from spontaneous tolerance models on the acute rejection responses in rat liver transplantation/Chen Ning(陈宁,Dept Gastroenterol,Peking Univ Peop Hosp,Beijing 100044)…∥Chin J Organ Trans-plant. -2009,30(9). -524 ~526  相似文献   

19.
郝彦开  贾军峰  杨玉巧 《医学综述》2012,18(11):1753-1755
目的观察活血化瘀、软坚散结药配伍治疗肝纤维化时对患者主、次症状改变及肝功能的影响。方法将确诊为酒精性肝纤维化患者90例,随机分为三组,治疗组采用自制方剂化肝汤1号(醋鳖甲、黄芩、柴胡、赤芍等),对照组1采用凯西莱治疗,对照组2采用化肝汤1号和凯西莱联合治疗,疗程3个月。观察三组患者治疗前后主、次症状改善情况,血清天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ谷氨酰转肽酶(γ-GT)变化。结果三组治疗后的临床疗效比较差异无统计学意义(H=2.5897,P>0.05)。三组治疗后肝功能指标均有改善,与治疗前比较,差异有统计学意义(P<0.05)。结论化肝汤1号可有效地降低肝细胞的损害程度,促进受损细胞修复,从而改善肝功能。  相似文献   

20.
Liver     
Prevention and treatment of artery complication after liver transplantation by HBO , Clincal feature of cytomegabvirus pneumonia in orthtopic liver-transplantation and treatments, Risk factors of diabetes mellitus following orthotopic liver transplantation , Re-infection of hepatitis B virus after liver transplantation , Diagnosis and treatment of fungal infection after orthotopic liver transplantation , Two successful adult-to-adult living donor liver transplantation using dual grafts  相似文献   

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