子宫动脉灌注新辅助化疗治疗子宫颈癌38例

目的:评价子宫动脉灌注新辅助化疗在巨块型子宫颈癌和Ⅱ,Ⅲ期宫颈癌患者治疗中的作用。方法:临床观察巨块型ⅠB2期,Ⅱb择期和Ⅲ期子宫颈鳞状细胞癌患者38例,术前采用Seldinger技术子宫动脉插管灌注化疗,化疗后施行子宫广泛切除术及盆腔淋巴结清扫术或根治性放疗。结果:子宫动脉灌注化疗治疗ⅠB2期,Ⅱb期和Ⅲ期子宫颈癌有效率为65.78%。结论:选择性子宫动脉灌注化疗可有效缩小局部肿瘤、改善宫旁情况。明显减少ⅠB2期宫颈癌患者术中出血;明显降低了Ⅱb期和部分Ⅲ期子宫颈癌患者临床分期,提高了手术可切除率,近期疗效明显。     

连续性动脉灌注化疗在Ib_2～Ⅲ期宫颈癌手术前的应用

目的 :观察连续性动脉灌注化疗联合手术治疗Ib2 ～Ⅲ期宫颈癌的效果。方法 :对 34例手术困难的Ib2 ～Ⅲ期宫颈癌患者经髂内动脉插管连续灌注化疗后 ,再行宫颈癌根治术治疗。结果 :1 1例Ib2 期及 1 7例Ⅱb期患者经1～ 2次介入治疗后病灶明显缩小 ,宫旁浸润情况改善 ,顺利完成宫颈癌根治术及盆腔淋巴结清扫术。 6例Ⅲ期患者经 2～ 3次介入治疗后阴道浸润灶消失 ,4例部分缓解 ,顺利完成根治术 ,2例改为放疗。结论 :对晚期宫颈癌患者 ,连续性动脉灌注化疗联合手术治疗能够有效地杀灭肿瘤细胞 ,使部分病例临床分期得到逆转而获得手术机会     

宫颈癌术前介入治疗57例

目的：探讨子宫颈癌术前骼内动脉灌注化疗疗效及其临床意义。方法：宫颈癌57例中Ⅰ期巨块型11例，Ⅱa期8例，Ⅱb期29例，Ⅲ期5例，Ⅳ期4例，术前均行2疗程介入化疗。化疗方案：顺铂100mg，阿霉素50mg。结果：近期有效率为85．9％，其中Ⅰb期2例，Ⅱa期1例，经2次介入治疗后属病理完全缓解，同时经介入治疗后提高了Ⅱb、Ⅲ期手术率，分别为78．1％和40．0％。其中Ⅱb期29例经介入治疗后23例手术，术后病理证实，宫旁浸润1例，盆腔淋巴结转移6例，脉管癌栓1例，手术彻底性也较高。结论：宫颈癌术前介入治疗使病灶缩小，提高了Ⅱb、Ⅲ期手术切除率。Ⅱb期手术也较彻底。     

宫颈癌术前子宫动脉化疗栓塞治疗的临床疗效观察

目的探讨术前子宫动脉化疗栓塞在宫颈癌治疗方面的临床价值.方法对12例宫颈癌患者在手术前行子宫动脉化疗栓塞,观察症状缓解的程度、疗效和近期不良反应.化疗栓塞后3～4周行子宫根治术及盆腔淋巴结清扫术.结果宫颈癌患者临床症状明显缓解,近期疗效观察有效10例,无效2例,各期次疗效没有显著差别.不良反应经对症处理后均缓解.2例Ⅱ期根治手术后阴道切除缘癌细胞阳性,3例ⅠB期清扫下的淋巴结中发现转移.结论宫颈癌术前子宫动脉化疗栓塞是治疗宫颈癌安全有效的的治疗宫颈癌安方法,值得临床进一步推广使用.     

连续性动脉灌注化疗在Ib2—Ⅲ期宫颈癌手术前的应用

目的：观察连续性动脉灌注化疗联合手术治疗Ib2-Ⅲ期宫颈癌的效果。方法：对34例手术困难的Ib2－Ⅲ期宫颈癌患者经髂内动脉插管连续灌注化疗后，再行宫颈癌根治术治疗。结果：11例Ib2期及17例Ⅱb期患者经1－2次介入治疗后病灶明显缩小，宫旁浸润情况改善，顺利完成宫颈癌根治术及盆腔淋巴结清扫术。6例Ⅲ期患者经2－3次介入治疗后阴道浸润灶消失，4例部分缓解，顺利完成根治术，2例改为放疗。结论：对晚期宫颈癌患者，连续性动脉灌注化疗联合手术治疗能够有效地杀灭肿瘤细胞，使部分病例临床分期得到逆转而获得手术机会。     

选择性动脉化疗及栓塞在宫颈癌术前的临床研究

目的评价动脉灌注化疗及栓塞在宫颈癌术前的应用价值。方法对30例Ⅰb～Ⅲb期宫颈癌患者术前分别行1～2次选择性动脉灌注化疗及栓塞,并分析其临床资料。结果全部病灶获得手术切除。介入治疗后至术前宫颈直径缩小约0．8～13cm,且质地变软,术中宫旁组织易剥离,出血少。术后病理Ⅱb期以下病例各断端均未见癌细胞。结论术前介入化疗栓塞明显提高中晚期宫颈癌患者的手术切除率,还有助于杀灭肿瘤周围微小转移灶,可作为宫颈癌综合治疗的一种有效方法。     

宫颈癌先期介入化疗八例临床分析

目的探讨髂内动脉或子宫动脉栓塞化疗在宫颈癌治疗中的近期临床疗效.方法对8例(Ⅰb2期1例,Ⅱa期5例,Ⅱb期2例)宫颈癌患者实施新辅助化疗.选择卡铂、博莱霉素经子宫动脉或髂内动脉栓塞化疗,异环磷酰胺静脉化疗.介入性化疗后3～4wk行子宫根治术及盆腔淋巴结清扫术,进行疗效、毒副作用的观察和评定.结果 8例患者症状均明显缓解,近期有效率100%(部分缓解75%,完全缓解25%).术后病理检查各断端均未见癌细胞,淋巴结转移2例.治疗后毒副作用有恶心、呕吐、发热及白细胞减少等.其中有4例患者出现臀部及下肢疼痛.结论宫颈癌术前介入性化疗近期疗效好,毒副作用轻,且增加根治手术的机会,是宫颈癌辅助治疗的有效方法.     

宫颈癌的介入治疗

目的探讨宫颈癌的较佳治疗方法 ,方法利用Seldinger技术经股动脉插管,超选到双侧髂内动脉—子宫动脉,灌注化疗药物、栓塞子宫动脉2-4次;结果 12例Ⅱ-Ⅳ期宫颈癌患者,CR10例,PR2例,随访观察均超过2年,疗效显著。结论髂内动脉灌注化疗,子宫动脉栓塞治疗宫颈癌,创伤小,疗效高,结合手术、放疗可以根治部分病例。     

术前介入性化疗结合手术治疗在宫颈癌治疗中的应用效果观察

目的：探讨术前应用顺铂(DDP)或卡铂(Carboplatin)、表阿霉素(EPI)介入性化疗结合手术治疗宫颈癌的方法和临床疗效。方法：17例(ⅠA期3例、ⅠB期4例、ⅡA期5例、ⅡB期5例)宫颈癌患于术前实施经股动脉插管至子宫动脉．髂内动脉前干，先后分别灌注DDP(90mg／m^2．或Carboplatin 300mg／m^2)、表阿霉素(60mg／m^2)和明胶海绵颗粒栓塞剂进行栓塞肿瘤供血动脉。对适合手术治疗，于介入性化疗后3～4周行广泛性全子宫切除盆腔淋巴结清扫术。结果：介入性化疗满3周后病人子宫颈癌灶缩小21．0％～100％，平均88．2％。其中有14例病人顺利地接受了广泛性全子宫切除治疗盆腔淋巴结清扫术，3例(ⅠA期2例及ⅠB期1例)病人介入治疗满3周后于术前检查发现宫颈病灶完全消失，手术切除标本送病理检查未找到癌细胞。3例病人(ⅡA期1例，ⅡB期2例)宫颈病灶缩小不明显，未能进行手术治疗。结论：对于宫颈癌ⅠA～ⅡB期病人，应用本方法化疗可有效地缩小肿瘤体积，结合手术治疗后14例患达到CR的效果。     

宫颈癌手术前超选择性动脉化疗-栓塞45例疗效探讨

目的:探讨宫颈癌手术前超选择性动脉化疗-栓塞的疗效及其临床意义。方法:宫颈癌45例中Ⅰb期巨块型11例,Ⅱa期6例,Ⅱb期19例,Ⅲ期5例,Ⅳ期4例,术前均行介入化疗-栓塞。化疗-栓塞药物为顺铂80mg,表阿霉素60mg、丝裂霉素10mg~20mg、超液化碘油、明胶海绵少量。结果:近期有效率为86.2%,其中Ⅰb期2例,Ⅱa期2例,介入治疗后属病理完全缓解,同时经介入治疗后提高了Ⅱb期、Ⅲ期手术率,分别为78.2%和40.1%。其中34例经介入治疗后手术,术后病理证实,手术彻底性较高。结论:宫颈癌术前介入治疗使病灶缩小,提高了Ⅱb期、Ⅲ期手术切除率。Ⅱb期手术较彻底。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.