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1.
目的探讨细针吸取细胞学检查中联合应用细胞块切片技术对体表淋巴结肿块诊断的价值。方法选取经活检组织学对照且细针吸取细胞学常规涂片阳性的患者60例,均行二次细针吸取细胞制做细胞块石蜡切片检查,疑难病例加做免疫细胞化学染色,比较联合细胞块切片诊断结果与单纯常规涂片细胞学检查结果,分析两者诊断准确性。结果单纯常规细针吸取细胞学涂片,诊断腺癌与活检组织学诊断符合率为65.4%(17/26),诊断鳞癌符合率为70.O%(14/20);联合细胞块切片诊断腺癌与组织学诊断符合率为96.2%(25/26),诊断鳞癌符合率为95.O%(19/20),两者比较差异有统计学意义(P〈0.05)。常规细胞学分类不明确诊断20例,占33.33%,联合细胞块分类不明确诊断7例,占11.7%。结论细针吸取细胞学检查中联合应用细胞块切片技术能明显提高转移癌尤其腺癌和鳞癌的诊断正确率,并能进行免疫细胞化学染色,在肿瘤分型和分类中具有较高的应用价值,但该技术对恶性淋巴瘤及少见疑难肿瘤的诊断仍存局限性。  相似文献   

2.
唐应成  梁利斌  杨瑞仙 《重庆医学》2004,33(9):1393-1394
目的探讨细针吸取细胞学(FAN)对头颈部炎性淋巴结的诊断价值.方法回顾性观察分析146例头颈部炎性淋巴结的细针吸取细胞学切片,并用组织学作对照.结果 146例头颈部炎性淋巴结的细针吸取细胞学诊断中,定性诊断准确率99.3%;分类诊断准确率:化脓性炎为40/43、反应性增生为50/52、结核性淋巴结炎为41/45、坏死性淋巴结炎为3/4、肺吸虫病为2/2.结论在头颈部炎性淋巴结的细针吸取细胞学诊断中,只要做到选准部位、正确操作、然后进行仔细的镜下观察,就能够进行较为准确的分类诊断.其中仔细的镜下观察对分类诊断非常重要,误诊多与观察不够仔细有关.  相似文献   

3.
对28例恶性淋巴瘤(ML)的细针吸取细胞学诊断发现27例诊断是正确的。22例ML经组织学检查分类21例为ML(95.5%),其中15例进行免疫组化对比分型,准确率为68.2%。着重探索细针吸取细胞学检查诊断ML程序和标准,并能获得较高的诊断准确率。  相似文献   

4.
目的:分析细针吸取细胞学技术在乳腺肿瘤诊断中的临床价值。方法:资料随机选取2013年2月-2014年2月在本院诊治的70例乳腺肿瘤患者,均予细针吸取细胞学技术诊断,对照分析细针吸取细胞学诊断结果与病理组织学结果。结果:细针吸取细胞学技术确诊率91.43%,与病理组织学检验率100%无明显差异;且两种诊断方法中各病情分类无明显差异(P0.05),结论:细针吸取细胞学技术在乳腺肿瘤诊断中有较高的准确性,可以作为乳腺肿瘤的常规诊断方式,但对疑难病症也存在漏诊及误诊的可能,不能完全代替病理组织学诊断。  相似文献   

5.
目的:通过细针吸取细胞学(FNAC)检查探讨骨郎格汉斯细胞组织细胞增生症(LCH)的细胞病理学特点,并结合文献对本疾病进行再认识.方法:使用一次性注射器,在骨肿瘤病灶内作穿刺检查,抽吸物涂片,瑞氏染色,3例作免疫细胞化学染色,光镜观察.结果:细胞学诊断骨LCH10例,其中9例经术后病理组织学证实,诊断准确率达90%.结...  相似文献   

6.
目的:探讨肺黏膜相关淋巴组织恶性淋巴瘤(MALT-ML)细胞学、组织学及免疫组化特点及鉴别诊断要点。方法:对4例肺MALT-ML患者的穿刺组织及支气管镜刷检物进行细胞学、组织学及免疫组化对比分析。结果:4例肺MALT-ML患者中,细胞学诊断提示3例淋巴瘤,1例疑为小细胞未分化癌,MALT-ML不能排除;组织学提示4例患者为黏膜相关B细胞淋巴瘤;免疫表型瘤细胞CD20、CD79 a为阳性,CD3、CD5、CD10、CD45RO、Ckpan、EMA为阴性。结论:肺部MALT-ML极其少见,鉴别诊断十分困难。细针穿刺、支气管刷检细胞学、组织学及免疫组化标记技术等多种方法综合分析,可得出准确的结果。  相似文献   

7.
目的 探讨细针吸取细胞学检查在体表以及经体表可触及肿物的诊断价值.方法 对158例行细针吸取细胞学检查患者的结果与组织学诊断结果进行对照.结果 68例恶性肿瘤的敏感性为(63/68)92.6%,90例良性病变的特异性为(85/90)94.4%,148例获得正确诊断,10例病变虽未明确诊断,但均未因诊断意见不一致造成过度...  相似文献   

8.
季洪爱  周晓军  虞伟 《现代医学》2001,29(6):375-377
目的检测体表肿物细针吸取细胞标本中端粒酶的活性,探讨其在体表肿瘤细胞学诊断中的临床意义.方法采用端粒重复序列扩增(TRAP) -银染色技术检测47例体表肿块细针吸取标本中的端粒酶活性.结果 23例细针吸取恶性肿瘤标本中,端粒酶阳性率为86.9%(20/23),而在19例炎性病变及良性增生组织中阳性率为5.3%(1/19),5例正常组织中未发现有端粒酶活性表达.结论体表肿瘤细针吸取标本端粒酶检测可提高单纯细胞学诊断的准确性、敏感性和特异性,为细胞学诊断体表肿瘤提供可靠依据.  相似文献   

9.
目的:探讨细针吸取细胞学检查乳腺肿块的准确性及临床应用价值.方法:采用10ml 7号针头一次性注射器针吸乳腺肿块4384例,其中1100例有病理组织学诊断对照.结果:细针吸取细胞学阳性确诊率92.26%,假阳性率0.27%;阴性确诊率99.19%.结论:细针吸取细胞学检查乳腺肿块准确性较高,10ml7号针头一次性注射器取材对组织损伤极小,一次取材成功率98.49%,具有较大的实用价值.  相似文献   

10.
目的探讨超声内镜引导下细针穿刺活检术(EUS-FNA)诊断和鉴别诊断胰腺肿瘤的价值。方法采用Olympus GF-UM30P穿刺超声内镜对62例胰腺肿瘤进行细针穿刺活检检查,而后将采集到的标本送病理检查。结果62例胰腺肿瘤中胰腺癌36例,胰管内肿瘤7例,假性囊肿8例,囊腺瘤5例,淋巴瘤3例,炎性假瘤2例,转移性淋巴瘤1例。经EUS-FNA 56例获得成功,其中穿刺成功的实性病灶均获得满意的细胞学和组织学标本,良恶性肿瘤穿刺成功率分别为100%、90%,诊断准确率为100%、87%。仅1例发生急性胰腺炎。结论EUS-FNA诊断胰腺肿瘤的准确率高,穿刺成功率高,且并发症极低,值得在临床推广。  相似文献   

11.
[目的]探讨术前细针穿刺细胞学检查和术中冰冻活组织检查在腮腺肿瘤诊断中意义.[方法]在277例腮腺肿瘤患者中,给141例进行了术前细针穿刺细胞学检查,138例行术中冰冻活组织检查,将2种检查结果与术后常规病理检查结果进行比较分析.[结果]良、恶性肿瘤术前细针穿刺细胞学检查定性诊断率为88.65%,与术后病理检查结果诊断符合率为85.82%,其中良、恶性肿瘤诊断符合率分别为92.00%,37.50%;良、恶性肿瘤术中冰冻活组织检查定性诊断率为99.28%,与术后病理检查结果诊断符合率为97.10%,其中良、恶性肿瘤诊断符合率分别为98.45%,77.78%.[结论]术前细针穿刺细胞学检查和术中冰冻活组织检查可作为腮腺肿瘤常规检查方法.  相似文献   

12.
Fine needle aspiration biopsy cytology was done in 215 lymph nodes involving cervical, submandibular, supraclavicular, axillary and inguinal regions. One hundred and forty of these were diagnosed by histopathology after excisional biopsy or surgery, including 46 cases of metastatic tumor, 57 of lymphoma (46 were non-Hodgkin's lymphoma and 11 were Hodgkin's disease), and 37 of benign lymphadenopathy. Diagnosis of metastatic malignancy was easily made by aspiration biopsy cytology with a total sensitivity of 95.7% (44/46). The diagnosis of lymphoma was less satisfactory with a total sensitivity of 82.5% (47/57). The specificity for diagnosis of benign lymphadenopathy was 97.3% (36/37) with one false positive. The concordance of cell type in aspiration biopsy cytology and histopathology was 75% (33/44) in metastatic malignancy, and 73.5% (28/38) in lymphoma. Typical Reed-Sternberg giant cells were detected in 4 of 11 cases of Hodgkin's disease by aspiration cytology. Out of the 37 cases of benign lymphadenopathy diagnosed by aspiration cytology, 7 were cases of tuberculous lymphadenitis, of which typical Langhans' giant cells were found in 2, and acid fast stain bacilli in 3 cases. There was no complication or needle tract spreading throughout the procedure. We concluded that aspiration biopsy cytology is a simple, safe, reliable, and quick diagnostic method.  相似文献   

13.
Fine needle aspiration cytology (FNAC) is widely accepted as the accurate, sensitive, specific and cost-effective procedure in the diagnosis of lymphadenopathy. The purpose of the study was to evaluate the results of FNAC of lymph nodes in our institutions comparing with results of histopathology. We performed 117 FNAC of lymph node in a period between November 2001 to April 2002, of which, histological results were available in 81 (69.23%). Cervical lymph nodes were 102 (87.18%) and axillary lymph nodes were 15 (12.82%). Male to female ratio of the patients was 1:0.65. Patients' age ranged from 3-80 years with a median age of 23 years. FNAC diagnosis was found to be as follows: granulomatous inflammation 46 (40.35%), reactive hyperplasia 31 (27.19%), metastatic carcinoma 20 (17.54%), Non-Hodgkin's lymphoma 6(5.26%), tubercular lymphadenitis 4(3.51%), acute non-specific lymphadenitis 3(2.63%), Hodgkin's lymphoma 3(2.63%) and chronic non-specific lymphadenitis 1(0.88%). Out of 81 cases of FNAC 71(87.65%) were consisted with histopathological diagnosis of granulomatous lymphadenitis. In the malignancy of lymph node sensitivity and specificity of FNAC were 82.76% and 97.92%, respectively. So, the investigators reasonably conclude that before resort to surgical intervention FNAC may be a helpful procedure in the diagnosis of both neoplastic and non-neoplastic lesion of lymph nodes.  相似文献   

14.
Objective: The aim of this study is to find out the common causes of breast lump and to determine the sensitivity and specificity of FNAC of breast lump. Materials and methods: This is a retrospective study of FNAC of breast done in pathology department of NMCTH from January 2003 to December 2005. FNAC findings were correlated with data from histopathology records to determine the sensitivity and specificity of FNAC. Results: FNAC of breast constituted 16% of all the FNACs. Age group of the patients ranged from 17 to 56 years with mean of 32 years. Fibroadenoma was the most common diagnosis. Malignancy was diagnosed in only 6.6% of the cases. Histological correlation was done in 21 cases. Sensitivity and specificity of FNAC of breast was found to be 83.3% and 100% respectively. Conclusion: FNAC of breast is simple, cost effective and less traumatic method for diagnosis of breast lump. It is highly sensitive and specific also, and can reduce the needs for open biopsies. So FNAC should be used as a routine method for determining the nature of breast lumps. Key words: FNAC, breast lump, neoplasm.  相似文献   

15.
目的探讨针吸细胞学检查在乳腺肿块诊断中的临床应用价值。方法针吸细胞学检查乳腺肿块682例,其中500例与病理组织学检查结果对照。结果与组织病理学对照分析,针吸细胞学检查恶性肿瘤诊断的敏感性为98.7%,良性肿瘤诊断的特异性为95.5%,总准确率为97.4%。结论针吸细胞学检查对于临床诊断乳腺病变有独到价值,而且对恶性病例诊断更为可靠,此诊断技术简便,安全快速,特异性高,临床应用前景广阔。  相似文献   

16.
Salivary gland swelling is a common and important problem. Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling. Imaging technique is not so helpful in pre-operative diagnosis; microscopical examination is required for diagnosis. Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding. Fine needle aspiration cytology (FNAC) is however virtually risk-free. The study was done to assess the utility of FNAC and its accuracy and pitfalls with respect to histopathology and advantages of immunohistochemistry. The study was done with 40 cases of salivary gland swelling. After clinical examination, FNAC and histopathological examination along with immunohistochemistry was done and the results were correlated. Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3. Out of 40 cases 37 cases were cytologically and histopathologically correlated and rest 3 cases were different. Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma). One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma. The sensitivity of this study was found to be 71.43%, specificity 100% and accuracy was 93.10%. This study corroborates well with other studies including immunohistochemical findings. p53 expression was found to be related with nature of the neoplasm. FNAC is an important tool for early diagnosis of salivary gland lesions.  相似文献   

17.
Thyroid swelling is a common problem in India. Early and systematic evaluation of a nodular thyroid swelling is necessary as it is a frequent presentation of thyroid neoplasia. The objective of this study was to evaluate the efficacy of fine needle aspiration cytology (FNAC) in diagnosis and management of thyroid nodules. With the help of statistical parameters, the significance of FNAC in surgical decision making protocol has been evaluated. A comparison between final histopathological findings with initial FNAC findings is done and sensitivity, specificity, positive and negative predictive value and accuracy of FNAC is calculated and compared to already existing studies. A total of 120 cases of nodular thyroid were included, among which 12 cases were excluded from statistical analysis as they were managed conservatively. Total operated cases were 108 and study period was from November 2006 to October 2009. Analysis revealed sensitivity, specificity and accuracy of FNAC as 90%, 84.6% and 86.1% respectively. There were 12 FNAC false positive cases among which 9 were follicular neoplasm and 3 were Hurthle cell neoplasm which ultimately came as benign in histopathology. Only 3 cases of adenomatous nodule as per FNAC report proved to be papillary carcinoma on histology (ie, false negative). This study concludes that FNAC is an important diagnostic tool in early and cost effective evaluation of thyroid nodules. It helps in decision making for appropriate surgical/non-surgical management.  相似文献   

18.
目的 提高人乳头瘤病毒(HPV)感染的阴道细胞病理学诊断水平。方法 对157例外阴、宫颈活体组织及宫颈/阴道细胞涂片进行组织病理及细胞病理诊断,并对其中的112例进行了6B/11型DNA原位杂交及HPV16、18型DNA PCR检测。结果HPV DNA阳性者82例。组织病理和宫颈/阴道细胞病理检查为HPV感染者,HPV DNA均为阳性,组织病理检查为HPV感染,62.50%可经阴道细胞病理检查发  相似文献   

19.
Breast carcinoma is the most common malignant tumour and the leading cause of death from cancer in women. A large number of patients in Bangladesh have been suffering from breast cancer. Now-a-days, Fine needle aspiration cytology (FNAC) is being performed as a pre-operative test to evaluate breast lump. FNAC is cost effective and can prevent unnecessary surgery. As FNAC became more reliable in diagnosing malignancy and thereby the use of frozen-section histology had been reduced by about 80%. But erroneous diagnosis is more common with FNAC than with histopathology. However, mammography can identify breast cancers too small to palpate on physical examination and theoretically beneficial to diagnose even noninvasive lesions. Present study aimed to see the accuracy of FNAC and mammography in the diagnosis of palpable breast lumps and to study their correlation. In this study 222 patients were included in the study and FNAC was done in all the patients. Mammography was done in 112 cases. Among these 112 patients 32 cases were found malignant. Histopathology was done in total 89 cases. Among 112 patients who were underwent mammography only 43 were found for histopathology. Finally, 36 cases were found malignant. Fibroadenoma is mostly found in below 20 years group and malignancy is mostly occurring in older age group. Mammography shows total 8 false positive and 5 false negative cases. FNAC shows only 1 false positive and 1 false negative case. On analysis mammography showed 82.76% sensitivity, 90.36% specificity, 75% Positive predictive value (PPV), 93.75% Negative predictive value (NPV) and 88.39% accuracy. FNAC showed 97.22% sensitivity, 99.46% specificity, 97.220% PPV, 99.46% NPV and 99.095% accuracy. Mammography was found to be less sensitive, specific and accurate in the diagnosis of breast lump though there is highly significant correlation among them. However, the study has shown a much higher performance of FNAC than other previous studies indicating the improved skill in cytological diagnosis to a satisfactory level.  相似文献   

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