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1.
韩利畴  王栋 《医学综述》2011,17(18):2845-2846
目的研究使用辛伐他汀对初发2型糖尿病(T2DM)患者颈动脉内膜中层及血管内皮舒张功能的影响。方法 120例初发T2DM患者在应用正规胰岛素降糖治疗基础上,随机分为辛伐他汀治疗组70例,对照组50例。治疗4个月测量颈动脉内膜中层厚度和测定血管内皮舒张功能。结果与治疗前比较,治疗组颈动脉内膜中层厚度变薄,肱动脉内皮依赖性舒张功能及非内皮依赖性舒张功能有显著性改善(均P<0.05)。结论早期应用辛伐他汀可减少初发T2DM患者颈动脉内膜中层厚度,对其血管内皮舒张功能亦有明显改善。  相似文献   

2.
单纯性肥胖患者外周胰岛素抵抗与β细胞功能的研究   总被引:3,自引:0,他引:3  
目的研究血糖"正常"的单纯性肥胖患者胰岛素抵抗与β细胞功能的关系,探讨游离脂肪酸(FFA)在2型糖尿病(T2DM)发病中的作用.方法 10例血糖"正常"的单纯性肥胖患者和10例年龄、生活习惯相匹配的非肥胖者(对照),均不吸烟、血压及血胆固醇正常.所有研究对象均完成以下检查①空腹血脂及FFA.②血清免疫活性胰岛素(IRI)、前胰岛素(PI)及真胰岛素(TI);③静脉注射葡萄糖后早相胰岛素分泌反应(AIR);④正常血糖高胰岛素钳夹试验,评价外周组织葡萄糖的摄取率(GDR).结果肥胖患者IRI、PI和TI增高,PI/(PI+TI)比值也高于对照组(P<0.01).肥胖患者AIR增高,曲线下面积也高于对照组(P<0.05),但肥胖患者在3、5及10min的血糖也高于对照组(P<0.05).肥胖组达到稳态时GDR明显降低(P<0.05).肥胖组血脂除TG增高(P<0.05)外,其余正常.血FFA浓度高于正常组(P<0.05).肥胖组血FFA与GDR成负相关(r=-0.767,P<0.01).结论血糖"正常"的单纯性肥胖患者存在外周胰岛素抵抗与β细胞功能异常,且二者可能同时发生.高FFA血症可导致外周胰岛素抵抗与β细胞功能异常.  相似文献   

3.
目的 研究血糖“正常”的单纯性肥胖患者胰岛素抵抗与β细胞功能的关系,探讨游离脂肪酸(FFA)在2型糖尿病(T2 DM)发病中的作用。方法 10例血糖“正常”的单纯性肥胖患者和10例年龄、生活习惯相匹配的非肥胖者(对照) ,均不吸烟、血压及血胆固醇正常。所有研究对象均完成以下检查:1空腹血脂及FFA。2血清免疫活性胰岛素(IRI)、前胰岛素(PI)及真胰岛素(TI) ;3静脉注射葡萄糖后早相胰岛素分泌反应(AIR) ;4正常血糖高胰岛素钳夹试验,评价外周组织葡萄糖的摄取率(GDR)。结果 肥胖患者IRI、PI和TI增高,PI/ (PI TI)比值也高于对照组(P<0 .0 1)。肥胖患者AIR增高,曲线下面积也高于对照组(P<0 .0 5 ) ,但肥胖患者在3、5及10 min的血糖也高于对照组(P<0 .0 5 )。肥胖组达到稳态时GDR明显降低(P<0 .0 5 )。肥胖组血脂除TG增高(P<0 .0 5 )外,其余正常。血FFA浓度高于正常组(P<0 .0 5 )。肥胖组血FFA与GDR成负相关(r=- 0 .76 7,P<0 .0 1)。结论 血糖“正常”的单纯性肥胖患者存在外周胰岛素抵抗与β细胞功能异常,且二者可能同时发生。高FFA血症可导致外周胰岛素抵抗与β细胞功能异常。  相似文献   

4.
目的研究黄芪对高脂饲料喂养的肥胖大鼠离体胸主动脉内皮依赖性血管舒张功能的影响。方法(1)在体研究,SD大鼠随机分为正常对照组、肥胖组、黄芪干预组(高脂饲料喂养同时每天灌胃黄芪液),6周后处死所有大鼠,留取并称量所有大鼠的腹腔内脂肪。采用离体血管环灌流方法,观察各组大鼠离体主动脉环对乙酰胆碱或硝普钠的舒张反应;(2)离体研究,正常对照组和肥胖组各5只,以黄芪液孵育离体血管环,并与空白对照比较,观察黄芪对离体血管环舒张功能的影响。结果肥胖组体脂比较正常组明显增加,黄芪液灌胃6周明显减少肥胖组动物腹部脂肪堆积。肥胖组内皮依赖性血管舒张功能较正常对照组明显下降,黄芪液灌胃6周可部分改善肥胖组动物内皮依赖性血管舒张功能,各组非内皮依赖性血管舒张功能无明显差别。肥胖组离体血管环经黄芪液孵育3h后,其受损的内皮依赖性血管舒张功能可明显改善。结论黄芪可改善高脂饲养喂养的肥胖大鼠受损的内皮依赖性血管舒张功能,其机制可能与缓解胰岛素抵抗以及直接促使内皮细胞NO产生增多有关。  相似文献   

5.
目的 研究肽类肠道激素高血糖素样肽1(GLP-1)类似物艾塞那肽(exendin-4,Ex 4)对高脂饲料诱导的肥胖大鼠内皮依赖性血管舒张功能的影响.方法 将20只雄性Wistar大鼠随机分成2组(每组10只),正常对照组给予普通饲料喂养,肥胖组给予高脂饲料.观察各组动物体质量变化,10周后处死大鼠,采集心脏血液,检测血浆生化指标,计算体脂比,分离出主动脉置于器官浴槽中,肥胖组血管环分为肥胖Ex-4组与空白对照组两亚组(每组10个血血管环).肥胖EX-4组血管环以Ex-4加Krebs-Henseleit液(K-H液)孵育,正常对照组及肥胖空白对照组以K-H液孵育,加入不同浓度的乙酰胆碱和硝普钠,观察各组血管环内皮依赖性与非内皮依赖性血管舒张功能.结果 肥胖组动物脂代谢紊乱,血浆甘油三酯、总胆固醇及游离脂肪酸浓度较正常对照组升高(P<0.01),腹腔脂肪质量及体脂比均高于正常对照组(P<0.05).与正常对照组相比,肥胖大鼠内皮依赖性血管舒张功能受损(P<0.05).肥胖EX-4组大鼠内皮依赖性血管舒张功能较肥胖空白对照组改善(P<0.05).3组间非内皮依赖性血管舒张功能差异无统计学意义(P>0.05).结论 Ex-4对肥胖大鼠血管受损的内皮细胞具有确切的保护作用.  相似文献   

6.
引言 研究表明,2型糖尿病患者一级亲属(FDR)在发生糖尿病之前已经出现胰岛素抵抗(IR)^[1]和内皮依赖性血管舒张功能异常。本研究我们检测了FDR不同腰围组血清胰岛素、血脂、血清脂联素的水平及血管内皮功能和颈总动脉内膜中层厚度(IMT),探讨了脂联素、IR与动脉粥样硬化病变程度的关系。  相似文献   

7.
 目的 探讨胰岛素抵抗大鼠脂肪组织中脂肪因子chemerin mRNA的表达情况,探讨其与胰岛素抵抗之间的关系及意义。 方法 采用高脂饲料喂养建立胰岛素抵抗大鼠模型,将30只雄性SD大鼠随机分为正常饮食组(NC,n=15)和高脂饮食组(HF,n=15),喂养10周后,以大鼠清醒状态下正常血糖-高血浆胰岛素钳夹技术进行评估,处死后取肾周脂肪组织,应用Real-time PCR方法检测大鼠脂肪组织中chemerin mRNA的表达水平。结果 (1)与NC组比较,HF组60~120 min的平均葡萄糖输注率(GIR60~120)明显降低[(13.87±1.45) mg·kg-1·min-1 vs (24.10±2.87) mg·kg-1·min-1,P<0.05]。(2)与NC组比较,HF组大鼠脂肪组织中chemerin mRNA的表达明显升高[(1.86±1.02) vs (0.92±0.32),P<0.01]。结论 胰岛素抵抗大鼠脂肪组织chemerin mRNA升高,提示脂肪因子chemerin可能参与胰岛素抵抗的发生。  相似文献   

8.
黄佩  李锡明  张荣林 《医学研究生学报》2005,18(12):1102-1104,1107
目的:观察缬沙坦和氨氯地平对老年原发性高血压的降压作用及对左心室舒张功能,血管内皮舒张功能,胰岛素抵抗的改善作用. 方法:选择1~2级老年高血压患者40例,随机分为缬沙坦治疗组和氨氯地平治疗组,分别治疗12周,每周测血压2次,观察两组患者治疗前后血压、心率及胰岛素敏感性的变化,左心室舒张功能以及内皮依赖性血管舒张功能的变化. 结果和结论:缬沙坦组和氨氯地平组均可有效地降低1~2级老年原发性高血压患者的血压,改善左心室舒张功能、胰岛素抵抗及内皮依赖性血管舒张功能.  相似文献   

9.
目的:探讨非洛地平对原发性高血压患者内皮功能及胰岛素抵抗的影响。方法:对42例原发性高血压于口服非洛地平8周,并服药前后测定空腹血糖及胰岛素,然后计算胰岛素敏感性;采用血管外超声法检测治疗前后肱动脉内皮依赖性血管舒张功能。结果:经非洛地平治疗8周后患者收缩压、舒张压均降低,分别为(158.0±18.0)mmHg/(120.0±6.0)mmHg、(102.0±12.0)mmHg/(79.0±7.0)mmHg,P<0.001;空腹胰岛素水平较前降低,胰岛素敏感性指数较前升高,分别为(12.29±6.08)/(9.20±5.28)、(-4.46±0.51)/(-3.55±0.43),P<0.001;肱动脉内径的基础值及血流介导的内皮依赖性血管舒张功能明显改善,分别为(3.26±0.48)mm/(3.92±0.38)mm、(3.88±1·98%)/(5.72±2.44%),P<0.001。结论:非洛地平在有效降压的同时,能改善原发性高血压患者胰岛素抵抗及肱动脉内皮依赖性血管舒张功能。  相似文献   

10.
Hong J  Gu WQ  Zhang YF  Guo Y  Chen HM  Zhang LZ  Zhao YJ  Ning G 《中华医学杂志》2003,83(22):1952-1956
目的 研究正常人、糖耐量正常肥胖 (肥胖 )、肥胖伴糖耐量减退 (IGT)和肥胖伴 2型糖尿病 (T2DM)患者的胰岛素抵抗和胰岛 β细胞 1相胰岛素分泌功能。 方法  15 1位受试者接受了口服 75 g葡萄糖耐量试验 (OGTT)和胰岛素改良的减少样本数 (n =12 )的Bergman微小模型技术 ,结合多样本静脉葡萄糖耐量试验 (FSIGTT) ,前者用以诊断糖耐量有无异常 ,后者用以测定机体的胰岛素敏感性指数 (SI)、葡萄糖自身代谢效能 (SG)和机体对FSIGTT中葡萄糖负荷后的胰岛素分泌反应(AIRg) ,应用处理指数 (DI =AIRg×SI)评价AIRg是否足以代偿机体的胰岛素抵抗。 结果 正常组的SI 显著高于肥胖、IGT和T2DM组 (P <0 0 1) ,后 3组间差异无显著意义。正常组与肥胖组的SG无明显差异 ,但显著大于IGT和T2DM组 (P <0 0 1) ,后 2组间差异无显著意义 ;正常组与IGT组的AIRg(2 6 1mU·L-1·min-1± 0 13mU·L-1·min-1vs 2 5 6mU·L-1·min-1± 0 2 5mU·L-1·min-1)差异无显著意义 ,但小于肥胖组 (3 0 2mU·L-1·min-1± 0 2 7mU·L-1·min-1,P <0 0 1)而大于T2DM组 (1 5 4mU·L-1·min-1± 0 5 5mU·L-1·min-1,P <0 0 1) ;DI值则由正常组 (3 4 4± 0 17)向肥胖组、IGT和T2DM组依次降低 (3 16± 0 31、2 6 5± 0 5 0、1  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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