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1.
目的:的发性开角型青光眼(POAG)眼压,视野与图形视网膜电流图(PERG)q波幅值之间的关系。通过改变空间频率(120′,60′,30′)选择青光眼电生理学诊断最佳刺激参数。方法对24例(30只眼)POAG病人进行眼压、定量静态视野及PERG检测。分析眼压、定量静态视野与PERGq波幅值关系。检测结果进行统计学分析。结果眼压与PERGq波幅值变化呈负相关,定量静态视野缺损程度与PERGq波幅值变  相似文献   

2.
樊映川  张国辉 《四川医学》1995,16(2):109-110
视神经病变的P—VEP和P—ERG四川省人民医院(610072)樊映川,张国辉图形视诱发电位(P—VEP)的检测在视神经病变的诊断中有着肯定的价值。自70年代以来,已广泛用于临床。近年来,联合检测图形视网膜电图(P-ERG)已引起许多学者的关注。联合...  相似文献   

3.
对原发开角青光眼和高眼压症患者进行了稳态图形视网膜电流图(p-ERG)及图形翻转视觉诱发电位(P-VEP)检查。从电生理方面探讨青光眼的早期损害,及这一损害与视野缺损和视盘损害的相关性。结果表明,青光眼和高眼压症患者稳态P-ERG各空间频率振幅均下降,与对照组比较其差异有高度显著性(P<0.01)。除最低空间频率(0.07周/度)外,其余各空间频率P-ERG振幅与视野平均丢失呈负相关;P-ERG振幅与杯盘比值未显示相关性。青光眼组和高眼压症组的P-VEP检测结果与对照组差异无显著性。  相似文献   

4.
原发开角青光眼和高眼压症的稳态图形视网膜电流图   总被引:2,自引:0,他引:2  
对原发开角青光眼和高眼压症患者进行了稳态图形视网膜电流图(P-ERG)及图形翻转视觉诱发电位(P-VEP)检查。从电生理方面探讨青光眼的早期损害,及这一损害与视野缺损和视盘损害的相关性。结果表明,青光眼和高眼压症患者稳态P-ERG各空间频率振幅均下降,与对照组比较其差异有高度显著性(P〈0.01)。除最低空间频率(0.07周/度)外,其余各空间频率P-ERG振幅与视野平均丢失呈负相关;P-ERG振  相似文献   

5.
次声作用对大鼠视觉电生理功能的影响   总被引:10,自引:0,他引:10  
探讨次声作用对大鼠视觉电生理的影响。方法:42只大鼠按暴露时间随机分为7组,每组6只,暴露于8Hz,130dB的次声压力仓中,2h/d,分别暴露1,4,7,11,14,18及21d,暴露前后分别行闪光视觉诱发电位(FVEP)、视网膜电图(ERG)、振荡电位(OPs)的检测。结果:动物在次声暴露1d后,即有明显FVEP-P波、ERG-a波、ERG-b波振幅下降,而且随着暴露时间延长,有明显的适应现象  相似文献   

6.
目的:了解血小板源性生长因子(PDGF)和碱性成纤维细胞生长因子(bFGF)在视网膜增殖膜细胞的表达及其与增殖性玻璃体视网膜病变(PVR)的关系。方法:免疫组化法研究PDGF和bFGF在20例视网膜前膜和1例视网膜下膜(视网膜脱离术后继发)细胞中的表达情况。结果:①15/21(71.4%)例标本对抗PDGF抗体呈阳性反应,14/21(66.7%)例对抗bFGF呈阳性反应;②Eales病和增殖性糖尿病视网膜病引起的血管增殖性前膜(≥61个细胞/视野,1000×)较PVR引起的非血管增殖性前膜(31~60个细胞/视野)内细胞密度高,黄斑前膜(≤30个细胞/视野)最低。结论:PDGF和bFGF在PVR发展过程中起重要作用;PVR膜上增殖细胞可产生bFGF,它是导致严重PVR时玻璃体内bFGF含量异常升高的主要原因。  相似文献   

7.
采用光镜酶组织化学和电镜细胞化学方法,对家兔急性高眼压后视网膜内与糖代谢及分解代谢有关的葡萄糖-6-磷酸酶(G-6-Pase)、磷酸化酶和酸性磷酸酶(ACP)进行了研究。结果显示:高眼压后7~15d磷酸化酶活性明显下降(P<0.05),ACP活性明显增强,色素上皮(RPE)溶酶体内容物有释放现象。提示急性高眼压后存在糖原代谢障碍;ACP参与了视网膜损伤过程。  相似文献   

8.
玻璃体中碱性成纤维细胞生长因子的定量   总被引:5,自引:2,他引:3  
目的:定量研究增殖性玻璃体视网膜病变(PVR)患者玻璃体中碱性成纤维细胞生长因子(bFGF)的含量,阐明bFGF在PVR中的作用和影响。方法:双夹心酶联免疫吸附技术测定正常对照组20只眼、PVR-C组35只眼、PVR-D组26只眼和单纯玻璃体出血组25只眼患者玻璃体内bFGF含量,以及PVR-D病人(15例)血清内bFGF含量。结果:①玻璃体内bFGF含量:对照组median5.20ng/L,qu  相似文献   

9.
目的:研究家兔糖皮质激素受体(GR)与激素性青光眼(SIG)的关系。方法:实验前测定家兔外周血白细胞糖皮质激素受体(GR)、血浆皮质醇,实验中隔日给家兔结膜下注射地塞米松0.5mg,共15次30天,每周测量家兔眼压、房水流畅系数C值一次,分析GR、血浆皮质醇与眼压、C值的改变值间的关系。结果:GR与眼压、C值的改变值间具有相关性(P〈0.025,P〈0.01),血浆皮质醇与眼压、C值的改变值间无相  相似文献   

10.
白内障术前眼电生理检测的临床意义   总被引:1,自引:0,他引:1  
钱晓娃 《浙江医学》1995,17(6):332-333,337
对132例(148只眼)白内障患者,行术前闪光视网膜电图(F-ERG)和闪光视皮层诱发电位(F-VER)记录,以及光这下位、辨色力的检查。比较两类方法预测术后视力的准确性。结果眼电生理检测的符合率92.57%(137只眼),光这下位、辨色力检查符合率72.98%(108只眼)经统计学处理有显著性差异(P〈0.05)。表明对白内障术前患者作闪光视网膜电衅和闪光视皮层诱发电位检查,能客观地预测术后视力  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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