阿奇霉素三种方案治疗小儿支原体肺炎疗效观察

目的 探讨阿奇霉素不同给药方案治疗小儿肺炎支原体肺炎的疗效.方法 94例支原体肺炎患儿随机分成A、B、C三组,A组32例、B组31例、C组31例.A组应用阿奇霉素10mg/(kg·d)静滴,连用5～7d;B组先应用阿奇霉素10mg/(kg·d)静滴,连用3d,然后改用阿奇霉素10mg/(kg·d)口服,连用3～4 d;C组应用阿奇霉素10mg/(kg·d)口服,连用5～7d.结果 A、B、C三组均有良好治疗效果,三组之间治愈率没有显著差异(P＞0.05).结论 治疗轻、中型小儿支原体肺炎,口服阿奇霉素治疗效果良好,值得推广应用.     

小儿肺炎支原体肺炎抗生素序贯疗法的临床观察

目的探讨抗生素序贯疗法对小儿肺炎支原体肺炎的治疗效果。方法将68例肺炎支原体肺炎住院患儿分为2组,34例为序贯治疗组(A组),开始以红霉素30 mg.kg-1.d-1静脉滴注,1次/d,连用3 d,病情较重者,连用5 d,改口服阿奇霉素10 mg.kg-1.d-1,1次/d,连服3 d停4 d。34例为常规治疗组(B组),采用单纯红霉素30 mg.kg-1.d-1静脉滴注,1次/d,连用10 d。10 d疗程结束后根据疗效评定标准比较2组疗效及不良反应。结果临床有效率:序贯治疗组为97.1%,常规治疗组为67.6%,2组间有显著性差异(P<0.05),不良反应在开始治疗前3 d无显著性差异(P>0.05),在治疗后7 d有显著性差异(P<0.05)。结论小儿肺炎支原体肺炎采用抗生素序贯疗法优于单纯用红霉素治疗,不良反应发生率低,且安全、有效、方便、依从性好,可缩短住院时间,减少住院费用,减少患儿家长的陪伴时间,减轻家长的精神负担。     

3种方案治疗小儿肺炎支原体肺炎的成本-效果分析

目的 评价3种方案治疗小儿肺炎支原体肺炎的成本-效果.方法 A组:乳糖红霉素每日2次,静脉滴注5 d.热退、症状控制后改用阿奇霉素,连服3 d,停4d,如此服用3个周期.B组:阿奇霉素静脉滴注,一日一次,连续使用5d;热退、症状控制后改用阿奇霉素连服3 d,停4d,如此服用3个周期.C组:乳糖红霉素每日2次,静脉滴注10d.结果 A组(红霉素+阿奇霉素序贯治疗方案)成本最低.结论 红霉素+阿奇霉素序贯治疗方案是治疗小儿肺炎支原体肺炎的最佳方案.     

红霉素、阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的价值分析

目的:分析红霉素、阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的临床价值。方法:抽取我院2017年1月—2018年3月收治的92例肺炎支原体肺炎患儿作为观察对象,将其分为对照组和观察组,各46例。对照组接受阿奇霉素治疗方法,观察组接受红霉素、阿奇霉素序贯疗法,对比分析两组临床效果和不良反应发生情况。结果:观察组总有效率(97. 83%)高于对照组(91. 30%),其不良反应发生率(2. 17%)则低于对照组(17. 39%),组间比较差异有统计学意义(P <0. 05)。结论:红霉素、阿奇霉素序贯疗法在小儿支原体肺炎治疗中能够提高临床疗效,降低不良反应发生率,值得推广和应用。     

小儿肺炎支原体感染60例临床分析

目的 探讨小儿肺炎支原体感染的诊断与治疗.方法 收集我科2005年1月～2006年12月小儿肺炎支原体感染60例的临床资料进行分析.60例均做血、尿、大便常规,血清MP-IGM检测及胸部x线照片检查.治疗上使用阿奇霉素10mg/(kg·d),静脉给药,每日1次,连用7～10d;症状控制后或使用阿奇霉素序贯疗法,即阿奇霉素10mg/(kg·d)口服,每日1次,连用3d,停药4d,疗程14～21d.结果 60例小儿肺炎支原体感染全部治愈.结论 对于疑似患者及使用青霉素类或头孢类抗生素无效者,及时行肺炎支原体感染检查.阿奇霉素可作为治疗支原体肺炎的首选药物.     

阿奇霉素治疗小儿支原体肺炎的临床疗效观察

目的　探讨小儿肺炎支原体肺炎 (MP)的治疗方法。方法　将诊断为MP的 174例患儿随机分成 2组 ,治疗组 88例给予阿奇霉素粉针剂 6～ 10mg·kg- 1 ·d- 1 ,溶于 5 %葡萄糖溶液 2 5 0ml中 ,60min内静脉滴注 ,每日 1次 ,疗程 3～ 5天 ;对照组给予红霉素粉针剂 2 0～ 3 0mg·kg- 1 ·d- 1 ,溶于 5 %葡萄糖溶液中 ,静脉滴注 ,疗程 7～ 14天。结果　阿奇霉素治疗肺炎支原体肺炎退热时间、3个月时随访复发率与红霉素对照组无显著性差异 (P >0 .0 5 ) ,咳嗽消失时间、肺部罗音消失时间、X线吸收消散时间 ,治疗组均明显短于对照组 ,两组比较有显著性差异 (P <0 .0 1或 <0 .0 5 )。结论　阿奇霉素治疗小儿肺炎支原体肺炎疗效确切 ,值得推广。     

阿奇霉素与红霉素治疗肺炎支原体肺炎的比较

目的:探讨小儿支原体肺炎的临床治疗方法及疗效。方法:将确诊为肺炎支原体肺炎的84例患儿随机分为治疗组和对照组各42例,治疗组采用阿奇霉素10 mg/(kg·d)静脉滴注,1次/d,3⁵ d为一个疗程,后口服阿奇霉素分散片10 mg/(kg·d)序贯治疗,服3 d停4 d,连用25 d为一个疗程,后口服阿奇霉素分散片10 mg/(kg·d)序贯治疗,服3 d停4 d,连用2³个疗程;对照组采用红霉素203个疗程;对照组采用红霉素20³0 mg/(kg·d)静脉滴注,1次/d,730 mg/(kg·d)静脉滴注,1次/d,7¹4 d为一个疗程,后口服阿奇霉素分散片序贯治疗214 d为一个疗程,后口服阿奇霉素分散片序贯治疗2³个疗程。两组均给予对症治疗,比较两组临床疗效和症状、体征消失时间、住院天数及不良反应。结果:治疗组和对照组总显效率分别为97.61%和95.23%,两组比较差异无统计学意义。治疗组的体温复常时间、咳嗽消失时间、啰音消失时间及平均住院天数比对照组明显缩短,存在的差异有统计学意义(P<0.05);且治疗组的局部静脉疼痛、胃肠道反应等不良反应发生率较对照组明显减低(P<0.05)。结论:阿奇霉素序贯治疗小儿支原体肺炎具有临床疗效确切、安全、经济方便、依从性好等优点,值得临床推广使用。     

阿奇霉素三种方案治疗小儿支原体肺炎疗效观察

目的探讨阿奇霉素不同给药方案治疗小儿肺炎支原体肺炎的疗效。方法94例支原体肺炎患儿随机分成A、B、C三组,A组32例、B组31例、C组31例。A组应用阿奇霉素10mg/(kg·d)静滴,连用5～7d;B组先应用阿奇霉素10mg/(kg·d)静滴,连用3d,然后改用阿奇霉素10mg/(kg·d)口服,连用3～4d;C组应用阿奇霉素10mg/(kg·d)口服,连用5～7d。结果A、B、C三组均有良好治疗效果,三组之间治愈率没有显著差异(P>0.05)。结论治疗轻、中型小儿支原体肺炎,口服阿奇霉素治疗效果良好,值得推广应用。     

采用阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎40例的疗效与安全性分析

目的：分析采用阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的疗效与安全性。方法：于2014年9月至2015年9月期间选取小儿肺炎支原体肺炎患者80例,随机分为对照组和观察组两组,分别采取红霉素、阿奇霉素序贯疗法治疗,后比较两组患者的临床疗效。结果：观察组患儿的住院时间、疾病症状消失时间、不良反应发生率等均优于对照组,P ＜0．05。结论：采取阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎,疗效显著且安全性较好。     

阿奇霉素和红霉素治疗儿童支原体肺炎用法和疗效比较

目的:比较红霉素序贯阿奇霉素与阿奇霉素治疗儿童支原体肺炎的疗效.方法:符合诊断标准的支原体肺炎患儿58例,依先后分为两组,30例采用红霉素30mg/㎏·d,分2次静脉滴入,连用3天,改用阿奇霉素10mg/㎏·d,静脉滴入5天,停4天,以静滴量再口服3天.28例采用阿奇霉素10mg/㎏·d,静脉滴入5天,停4天,以静滴量再口服3天停药.结果:红霉素序贯阿奇霉素组的痊愈率93.3%,明显高于阿奇霉素组85.7%(P＜0.05),症状、体征消失较快.结论:儿童支原体肺炎时应首选红霉素控制支原体血症,然后再用新一代大环内酯类抗生素阿奇霉素序贯治疗,比开始采用阿奇霉素的疗效好,显效快,值得推广.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.