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1.
(1)目的 观察肝动脉化疗加内照射治疗肝癌的效果。(2)方法 随机选择100例原发性肝病病人,其中50例采用肝动脉化疗加^32P内照射治疗,另50例采用单纯介入治疗。比较两种方法的治疗效果。(3)结果 肝动脉化疗加内照射组病人1,2,3年累积生存率分别为76.5%,55.7%,36.1%,中位生存期为2.25年。单纯介入组1,2,3年累积生存率分别为65.3%,30.5%,11.8%,中位生存期为  相似文献   

2.
合并门静脉癌栓的原发性肝癌的化学栓塞治疗   总被引:11,自引:0,他引:11  
对40例合并门静脉癌栓(PTT)的原发性肝癌(PHC)行多次化学栓塞治疗。结果治疗总有效率为67.5%,治疗后0.5,1及3年生存率分别为75.0%,12.5%及2.5%,平均生存期9月。合并分支PTT者治疗有效率高于合并其他部位PTT者(P〈0.05)。平均治疗间隔期的长短对疗效的影响差异无显著性(P〉0.05)。提示在掌握适应症的前提下,TAI+TAE是合并PTT的PHC的有效治疗方法;不论P  相似文献   

3.
妊娠期肝内胆汁郁积症(简称ICP)是产科的重要并发症之一。作者对近5年来在本院分娩的46例ICP患者的临床资料进行分析如下。1资料和分析1.1一般资料近5年来我院共有1806例次分娩,其中46例次妊娠合并ICP,发生率为2.54%。根据妊娠中、晚期出...  相似文献   

4.
肝动脉插管治疗晚期肝癌40例分析   总被引:1,自引:0,他引:1  
对40例Ⅲ期原发性肝癌进行了63次肝动脉插管治疗。单纯化疗10例,化疗(TAI)+碘化油栓塞(TAE)30例,其中17例加用明胶海绵栓塞。栓塞30例中,24例肿瘤缩小,其中5例缩小50%以上;未栓塞10例中,仅2例略有缩小.AFP增高的35例中18例下降(51.4%).治后TAE30例中存活>6个月14例(46.7%).>1年5例(16.7%).TAI10例中仅1例存活>6个月,无1例超过1年。结果表明:TAI和TAE是治疗晚期肝癌首选的方法,可以延长生存期,提高生活质量,对门脉癌栓作TAE时要尽可能超选择,减少剩余肝组织的误栓。对A-V分流病例,周围性栓塞与中央型栓塞同时进行,效果会更好。本文对插管治疗晚期肝癌的不足之处作了初步探讨。  相似文献   

5.
肝动脉栓塞化疗治疗大肠癌肝转移35例   总被引:1,自引:1,他引:0  
应用肝动脉栓塞化疗治疗大肠癌肝转移35例,其中高分化腺癌28例,低分化腺癌3例,未分化癌1例,粘液腺癌3例。经治疗达完全缓解12例(34.3%),部分缓解16例(45.7%),稳定5例(14.3%),恶化2例(5.7%),总有效率80.0%。35例均获随访,最短生存时间5个月,1年存活29例(82.8%),3年存活13例(37.1%),5年存活4例(11.4%),平均生存时间为25.5个月。因此,  相似文献   

6.
原发性肝细胞癌组织雌,孕激素受体研究   总被引:1,自引:0,他引:1  
目的:研究原发性肝癌及癌旁组织中ER、PR与临床病理因素的相关性。方法:用免疫组化ABC法检测肝癌及癌旁组织中ER、PR表达。结果:116例肝癌中ER、PR阳性率分别为68.9%和64.6%,而癌旁组织的阳性率分别为83.4%和83.6%(P〈0.05)。80例ER阳性患者中1年和3年生存率为80.5%和55.7%。36例ER阴性患者1年和3年生存率为60.7%和21.3%(P〈0.05)。75例  相似文献   

7.
1975年1月~1992年12月收治卵巢内胚窦瘤30例,为同期卵巢恶性肿瘤529例中的5.67%。30例中现健存14例,1年生存率为63.3%,22年生存率46.7%,30例中13例在1975~1984年发病,其1年生存率46.2%,≥2年生存率15,4%;而1985~1992年的17例中,1年生存率76;5%,≥2年生存率70.6%,两个年度比较差异有极显著意义(P<0.01)。其临床分期、残余瘤灶与预后密切相关(P<O.01),术后不化疗、间歇期延长或过早中断治疗是复发、恶化的主要原因,手术范围的大小与预后无明显差异(P>0.05)。  相似文献   

8.
~(125)I-抗AFP放射免疫治疗原发性肝癌临床观察   总被引:2,自引:0,他引:2  
将纯化抗AFP多抗,用氯胺T氧化法标记 ̄(125)I,得 ̄(125)I-抗AFP抗体进行导向治疗不能切除的肝癌22例。均经静脉滴注。全组 ̄(125)I中位剂量为289.3(100.3~708.9)MBq,抗AFP抗体的IgG量为5.2mg(1.8~12.8mg)。可评价疗效19例,有效率为31.6%(CR5.3%,PR26.3%),总有效率(CR+PR+MR)为42.1%,肿瘤缩小率为63.2%(12/19)、AFP下降率64.7%(11/17),6例转阴,治后1年生存率为47.1%(8/17),7例尚存活,5例存括14~33个月。治疗耐受良好,毒副反应轻微。 ̄(125)I半衰期长,射线穿透力短,对正常组织扰乱少,使用方便,防护较简便,具有显著实用价值。  相似文献   

9.
采用酶联免疫吸附试验检测84例肝癌病人和80例非肝癌病人血清中的戊型肝炎抗体,丙型肝炎抗体和乙肝表面抗原,结果:两种人群相应抗体抗原的阳性率依次为:10.7%,30.0%,0.1%和5.0%,5.0%,10.0%,两组比较,相应阳性率的P值分别为为P〉0.05,P〈0.01,P〈0.01,OR值为1.1.6.8。  相似文献   

10.
根Ⅰ式和根Ⅱ式胃切除术治疗进展期胃癌的比较   总被引:4,自引:0,他引:4  
为评价根Ⅱ(R2)胃切除对胃癌病人的利弊,本文分析比较作根治性切除的进展期胃癌共131例,病人按淋巴结清扫的范围分成两组。64例行R2胃切除,67例行根Ⅰ(RI)胃切除。除R2组(33/64)全胃切除率比R1组(22/67)高(P<0.05)外,两组病人的临床和病理情况基本相似。手术时间R2组明显比R1组长(P<0.01),输血量R2比R1组大(P<0.01)。手术后住院天数两组无显著差别。R2组64例中,5例(7.8%)发生外科并发症,R1组67例中,发生这类并发症者仅1例(1.5%),两者差别有显著意义(P<0.05)。R2和R1组的死亡率为0%和1.5%,无显著差别。3年生存率R2组为54.8%R1组为37.8%,其差别有显著意义(P<0.05)。以上结果提示,R2胃切除是可行的,对能根治病例有提高生存率的作用。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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