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1.
Background Apelin is an adipokine that contributes to the pathogenesis of type 2 diabetes. The plasma levels of apelin increased in obese patients and diabetic subjects. This study aimed to investigate the effects of apelin genetic variants on type 2 diabetes and related quantitative traits. Methods We selected three single nucleotide polymorphisms (SNPs) that could capture all common variants in APLN gene region and genotyped them in 1892 type 2 diabetic patients and 1808 normal glucose regulation controls. The clinical features related to glucose metabolism were measured in the controls. The comparison of allele and genotype distribution in the cases and controls were performed by using X2 tests. The association between SNPs and quantitative traits were analyzed using Wilcoxon's rank-sum test. Results None of the SNPs or haplotypes showed evidence of association to type 2 diabetes. However, rs2235306 was nominally associated with fasting plasma glucose levels in the male subjects with normal glucose regulation ((4.93±0.03) vs (5.01±0.03) mmol/L, P=0.04). No significant difference was observed between all three SNPs and other variables. Conclusions APLN SNP rs2235306 was associated with fasting plasma glucose levels in males. It suggests that APLN genetic variants may contribute to clinical features related to glucose metabolism in Chinese population.  相似文献   

2.
Objective : To evaluate the changes of serum matrix metalloproteinase-9 (romp-9) in patients of incipient diabetic nephropathy with or without macrovascular disease and to analyze the factors associated with homocysteine(hcy), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α), highly sensitive C-reactive protein (hsCRP), HbAlc and lipid profile in those patients in order to know whether this marker or other factors are more important to induce diabetic macrovascular disease. Methods: Type 2 diabetes mellitus(T2DM) subjects with incipient diabetic nephropathy with or without macrovascular disease were selected for participation and divided into 2 groups. The patients in group 1 (n= 38) used insulin, and patients in group 2 (n=34) were treated with an oral antidiabetic drug. Then serum mmp-9, hey, IL-6 and TNF-α in these patients were measured, and compared to the healthy subjects as control (n= 16). The results were analyzed by SPSS13. Results: Serum romp-9 and hcy of the patients having incipient diabetic nephropathy with macrovascular disease were higher than that of patients without macrovascular disease (P〈0.01). For insulin-injected patients, whether they accompanied with macrovascular diseases or not, the serum levels of romp-9, hcy, IL-6 and TNF-α were all lower, but no significant statistics compared with non-insulin used patients or the healthy subjects. The serum level of romp-9 was more correlated with the serum hcy in antidiabetic drug used patients. (P〈0. 000) Conclusion: The serum level of romp-9 plays an important role of pathogenesis in the macrovascular disease in the incipient diabetic patients, and the serum level of hcy also can reflect the severely degree of macrovascular disease in these patients, insulin can reduce these markers.  相似文献   

3.
Background Dyslipidaemia is a potential independent The aim of this study was to investigate dyslipidaemia, with ischemic stroke in a Chinese hospital. risk factor for cerebrovascular disease in patients with diabetes. treatment and control of dyslipidaemia among diabetic patients Methods A total of 1046 type 2 diabetic patients were assigned to diabetes with (n=-522) and diabetes without stroke groups. The two groups were matched by gender, age and diabetes duration. Lipid and lipoprotein profile were measured. Serum level and control of lipids were assessed and classified according to American Diabetes Association (ADA) guidelines and an intensified low density lipoprotein-cholesterol (LDL-C) target recommended in Chinese dyslipidaemia control criteria. Results Diabetic patients suffering stroke displayed not only poorly-controlled lipid and lipoprotein profiles, including the significantly lower proportion of patients achieving intensified LDL-C target of 〈2.07 mmol/L (80 mg/dl), and high density lipoprotein-cholesterol (HDL-C) target (14.4% vs 21.0%, P=0.005; 45.8% vs 51.9%, P=0.048 respectively), but also less adherence to therapy prescribed for dyslipidaemia (30.8% vs 41.0%, P=0.001), when compared with diabetic patients without stroke. For the diabetic women with stroke, situation of dyslipidaemia was worse, with significantly lower serum level of HDL-C and apoA1, higher LDL-C level and higher ratio of apoB/apoA1 when compared with diabetic counterparts without stroke. Conclusions Many diabetic patients with ischemic stroke remain uncontrolled for dyslipidaemia. Intensified LDL-C and overall lipid lowering clinical goals are potential precautions taken against ischemic stroke among diabetic patients in China.  相似文献   

4.
Background Serum high sensitive C-reactive protein (hs-CRP), adiponectin levels and urine albumin excretion rate (UAER) are probably associated with inflammation and atherosclerosis. The aim of this study was to determine the three markers in coronary artery disease (CAD) subjects with different glucose tolerance status in a Chinese population and further explore the levels of the three markers in these subjects and the possible association of these markers with CAD risk factors and the severity of CAD as well. Methods A total of 242 subjects with angiographically documented CAD were recruited, and then assigned to three groups: the normal glucose tolerance (NGT) + CAD group, including 100 CAD patients with NGT; the impaired glucose tolerance (IGT) + CAD group, 40 CAD patients with IGT; the type 2 diabetes mellitus (T2DM) + CAD group, 102 CAD patients with T2DM. Serum hs-CRP, adiponectin levels as well as UAER were measured in all subjects. Results Serum hs-CRP levels were increased in the T2DM + CAD group compared with the NGT + CAD group (4.71±2.59) vs (3.60±2.46) mg/L, P=0.037. Serum adiponectin levels were gradually decreased from the NGT + CAD to IGT + CAD to T2DM + CAD groups, (5.99±1.84), (5.82±1.72) and (4.65±1.71) mg/L, P=0.002 and 0.040 for NGT + CAD and IGT + CAD groups vs T2DM + CAD group, respectively. While the UAER was gradually increased from the NGT + CAD to IGT + CAD to T2DM + CAD groups, (6.42±2.51), (6.89±2.94) and (15.03±4.22) μg/min (P 〈0.001) for NGT + CAD and IGT + CAD groups vs T2DM + CAD group. Multiple linear stepwise regression analysis showed that waist-hip ratio (WHR) and low density lipoprotein cholesterol (LDL-C) were the significant determinants of serum hs-CRP levels; triglyceride (TG), high density lipoprotein cholesterol (HDL-C), age, WHR, T2DM, 2-hour serum insulin (2hINS), sex, and apolipoprotein B were the significant determinants of serum adiponecti  相似文献   

5.
Oxidative damage to DNA and its relationship with diabetic complications   总被引:2,自引:1,他引:1  
Objective To detect the oxidative DNA damage in diabetic patients and to investigate the relationship of oxidative DNA damage with diabetes and diabetic nephropathy. Methods Single cell gel electrophoresis (SCGE) was used to detect the DNA strand breaks in peripheral blood lymphocytes, and oxidative DNA damage product and serum 8-OHdG were determined by a competitive ELISA in 47 cases, including 25 patients without diabetic complications, 22 patients with diabetic nephropathy and 25 normal control subjects. Results Diabetic patients showed greater oxidative damage to DNA. The percentage of comet cells and the length of DNA migration (comet tail length) of peripheral blood lymphocytes were significantly increased in patients with diabetes, and significantly higher in patients with diabetic nephropathy than in diabetic patients without vascular complications (P〈0.05). There was a significant increase in serum 8-OHdG in diabetic patients compared with normal subjects (P〈0.05). Moreover, serum 8-OHdG was much higher in patients with diabetic nephropathy than in diabetic patients without vascular complications (P〈0.05). Coneluslon There is severe oxidative DNA damage in diabetic patients. Enhanced oxidative stress may be associated with diabetes, especially in patients with diabetic nephropathy.  相似文献   

6.
Wang G  Li Q  Niu T  Chen C  Xu X 《中华医学杂志(英文版)》2002,115(9):1308-1311
Objective To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the β3-adrenergic-receptor (β3-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. Methods Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and β3-AR gene polymorphisms in 102 pairs of case-control Chinese spouses.Results Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P=0.032).The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR=1.67; 95% CI: 0.73-3.81, P=0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P=0.034). The combination of BMI and Arg64 allele carrier of the β3-AR gene increased the diabetic risk over four-fold (adjusted OR=4.00; 95%CI: 1.53-10.45, P=0.005).Conclusions In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose.It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level.The presence of the Arg64 allele in the β3-AR gene may predispose patients to higher serum uric acid level.  相似文献   

7.
The aim of this investigation was to determine whether a PPAR72 Prol2Ala polymorphism was associated with insulin resistance, β-cellfunction and hypertension in Chinese populations. 289 unrelated Chinese subjects first diagnosed Type 2 diabetes (HbAC1〈6.0) were investigated, including 132 hypertensive diabetic (HTD) subjects, 157 normotensive diabetic (NTD) subjects. Blood pressure and anthropometric measurements were collected from all participants, as well as several venous blood samples during oral glucose tolerance test (OGTT). Biochemical measurements (high-density lipoprotein (HDL) and low-density lipoprotein-cholesterol (LDL), triglycerides) and PPARγ2 Pro12Ala genotype were also determined. And insulin resistance and β-cells function was assessed by HOMA-IR and HOMA-β respectively. The frequency of subjects bearing the Pro12Ala was lower in the hypertension group (3. 03 %) than in the non-hypertension group (5.7 %) (P〈0.05) after adjusted for age, BMI and gender. Hypertensive diabetic Pro12Ala subjects had lower fasting plasma glucose level (P=0. 0127), and better glucose tolerance 60 min after oral glucose (P=0. 0361). Moreover, plasma insulin concentrations at 60 min was lower than those without A variant (P = 0. 0275), and both hypertensive Ala/Pro in HOMA-β (P : 0. 0455) and AUC for insulin (P=0. 0473) were higher, and HOMA-IR was lower (P=0. 0375) as compared with hypertensive Pro/Pro subjects. No association was observed between Prol2Ala genotype and BMI, total cholesterol, HDL- cholesterol or triglycerides in either group. Our findings suggested that the Ala 12 allele of the PPARγ2 gene may improve insulin resistance and ameliorate β-cell function reserves in T2DM with hypertension, and protect patients from hypertension in T2DM. As an important thrifty gene, environment factors may exerts an effect of PPARγ2 on glucose homeostasis and insulin resistance.  相似文献   

8.
Background Estrogen might play an important role in type 2 diabetes mellitus pathogenesis. A number of polymorphisms have been reported in the estrogen receptor alpha (ERα) gene (also named ESR1), including the XbaⅠ and PvuⅡ restriction enzyme polymorphisms of ESR1, which may be involved in disease pathogenesis. The aim of this study was to determine whether ER0t gene polymorphisms are associated with type 2 diabetes mellitus and serum lipid level. Methods Two hundred and ninety-nine patients with type 2 diabetes mellitus were compared with three hundred and forty-one health controls of Guangzhou in China, both were male and postmenopausal female residents at 51--70 years. ESR1 genotyping was performed using polymerase chain reaction (PCR) and PvulI and XbaI restriction fragment length polymorphism (PCR-RFLP) analysis. Results ESR1 allelic frequencies of P, p and X, x alleles were 0.408, 0.592; 0.360, 0.640 in the type 2 diabetes mellitus group and 0.318, 0.682; 0.328, 0.672 in the control group, respectively. In case-control study, there was significant difference in PvuⅡ, but not XbaⅠ, allele frequency between the type 2 diabetes mellitus and control groups (P=0.001 and P=0.122). When the group was separated into men and women, the difference was significant in women (P〈0.001) but not in men (P=0.854) with the PvulI genotype, and the effect of PvulI variant on the development of type 2 diabetes mellitus was improved with aging. In addition, PvulI genotype was associated with blood glucose [fasting blood glucose (FBG), postprandial blood glucose (PBG)] and serum lipid [total cholesterol (TC) and low density lipoprotein (LDL)-c] concentration in healthy women. Conclusions PvuII polymorphism of ESRI increases susceptibifity to type 2 diabetes mellitus in Chinese Guangzhou women. ESR1 variants may also impact serum lipid metabolism, which might provide a mechanism connecting ESR1 to type 2 diabetes.  相似文献   

9.
Background The concentration of serum fructosamine is correlated with plasma glucose level. The aim of this study was to determine whether the level of serum fructosamine can be diagnostic for abnormal glucose tolerance in pregnant women.Methods Serum samples were collected from 161 pregnant women between November 2004 and April 2005. The women were divided into three groups according to the gestational age (16-20 weeks group, 56 patients; 28-34 weeks group, 72; and 37-41 weeks group, 33). Each group was subdivided into normal and abnormal glucose tolerance subgroups. The levels of serum fructosamine were measured. Differences among the groups were assessed by ANOVA and Student-Newman-Keuls test. Correlations between the level of fructosamine and other variables including the results of glucose challenge test (GCT), oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) test, and infant’s birth weight were analyzed by Pearson correlation.Results The level of serum fructosamine decreased with gestational age [(223.25±48.90) µmol/L, (98.44±29.57) µmol/L, and (53.99±29.94) µmol/L, respectively. P<0.05]. It was higher in women with abnormal glucose tolerance than that in women with normal glucose tolerance, however, the difference reached statistical significance only in the 28-34 weeks group (P<0.05). In this group, the level of serum fructosamine correlated positively with the GCT result (r=0.28, P<0.05). No correlation was found between fructosamine level and OGTT result, HbA1c level, or neonatal weight.Conclusions Fructosamine can be used to monitor the glucose level of pregnant women with abnormal glucose tolerance, and to identify the patients at high risk of abnormal glucose tolerance, but can not be used to predict gestational diabetes mellitus (GDM) in early stage of pregnancy.  相似文献   

10.
Background Recently, it has been suggested that the serum uric acid (SUA) level decreased in diabetic patients. The aim of this study was to explore the association between SUA level and different state of glucose metabolism and glomerular filtration rate (GFR) reflected by the simplified Modification of Diet in Renal Disease (MDRD) equation and to test the hypothesis that high MDRD is one of the determinants of SUA level.Methods This cross-sectional study included 2373 subjects in Beijing who underwent a 75 g oral glucose tolerance test (OGTT) for screening of diabetes. According to the states of glucose metabolism, they were divided into normal glucose tolerance, impaired glucose regulation and diabetes.Results Multiple stepwise linear regression analysis showed that adjusted by gender, SUA was positively correlated with body mass index (BMI), waist/hippo ratio, systolic blood pressure (SBP) and triglyceride, meanwhile negatively correlated with age, hemoglobin A1c, fasting insulin and MDRD. There was an increasing trend in SUA concentration and a decreasing trend in MDRD when the levels of fasting plasma glucose (FPG) increased from low to high up to the FPG level of 8.0 mmol/L; thereafter, the SUA concentration started to decrease with further increases in FPG levels, and the MDRD started to increase with further increases in FPG levels.Conclusion This study confirmed the previous finding that SUA decreased in diabetes and provided the supporting evidence that the increased MDRD might contribute to the fall of SUA.  相似文献   

11.
目的比较葡萄糖耐量异常和正常孕妇75g口服葡萄糖耐量试验(OGTT)各时段血糖值比值,并探讨其临床意义。方法收集1909例孕24~36周孕妇的75gOGTT资料,按美国糖尿病协会诊断标准,将孕妇分为妊娠期糖尿病组(GDM组,n=60)、妊娠期葡萄糖耐量损害组(GIGT组,n=156)和正常葡萄糖耐量组(NGT组,n=1693)。根据75gOGTT中空腹血糖(FPG)及葡萄糖负荷后1、2、3h血糖值(PG1h、PG2h、PG3h)分别计算各组PG3h/FPG、PG2h/FPG、PG1h/FPG、PG3h/PG1h、PG2h/PG1h、PG3h/PG2h比值,并进行统计学分析。结果GDM组与GIGT组各比值之间以及三组间PG3h/FPG比较均无统计学差异(P>0.05);GDM组和GIGT组PG2h/FPG、PG1h/FPG均明显高于NGT组(P<0.05),而两组PG3h/PG1h、PG2h/PG1h和PG3h/PG2h均小于NGT组(P<0.05)。结论葡萄糖耐量正常与异常孕妇的75gOGTT各时段血糖值比值存在明显差异,这种差异可能与胰岛素抵抗有关。  相似文献   

12.
Li S  Wang C  Zhong XW  Li HQ  Fu XQ  Ran XW 《中华医学杂志》2012,92(4):232-235
目的 探讨影响平均血小板体积(MPV)的危险因素并分析MPV与糖尿病下肢动脉病变的相关关系.方法 纳入研究对象173例,2型糖尿病91例、糖调节受损(IGR)41例和正常糖耐量(NGT)人群41名,测量收缩压、舒张压,甘油三酯、胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇( LDL-C)、空腹血糖(FPG)、血肌酐、血小板计数以及MPV,体重、身高,并计算体质指数.糖尿病患者测量糖化血红蛋白(HbA1c)及其踝肱指数.结果 (1)2型糖尿病患者MPV最高,为(12.3±1.5)fl,高于IGR (9.7±0.9) fl和NGT者(8.0±0.9) fl(P <0.01);在糖尿病患者中,HbA1c≥7%的患者MPV(13.2±1.9)fl明显高于HbA1c<7%的患者(11.8±1.7) fl(P<0.01);(2)多元逐步回归分析显示,患者年龄、血肌酐、LDL-C和FPG水平是影响MPV的重要危险因素,调整R2 =0.891;(3)非条件Logistic回归分析显示MPV(OR=1.648,P=0.042)是周围动脉病变发生的危险因素.结论 年龄、血肌酐、LDL-C和FPG水平是MPV的重要影响因素;MPV是周围动脉病变发生的危险因素.  相似文献   

13.
目的 探讨糖尿病前期(即糖调节受损,impaired glucose regulation,IGR)患者中血尿酸(serum uric acid, SUA)和餐后2 h血糖(2-h PG)水平的相关性。方法 纳入3 588例在我院门诊就诊患者为研究对象,检测SUA、肌酐、胱抑素C(Cystatin, Cys-C)、血脂和糖化血红蛋白(glycosylated hemoglobin A1c, HbA1c)水平,行糖耐量试验(oral glucose tolerance test, OGTT)和胰岛功能试验。根据空腹血糖(fasting plasma glucose, FPG)和HbA1c水平将研究对象分为糖调节正常(normal glucose regulation, NGT)组、IGR组和2型糖尿病(type 2 diabetes mellitus, T2DM)组。对各检测指标进行组间比较,分析各组检查者SUA 与OGTT 中2-h PG相关性,以及其它检测指标与2-h PG相关性,并计算IGR人群2-h PG增高的相对危险度(odds ratio, OR)及95%可信区间(confidence interval, CI)。结果 研究人群中,NGT 556例,IGR 1 019例, T2DM 2 013例。3组间血糖、血清胰岛素、甘油三酯、高密度脂蛋白胆固醇、HbA1c、SUA、肌酐、Cys-C水平比较差异均有统计学意义( P均<0.05)。多元线性回归分析发现NGT和IGR组的SUA水平与2-h PG水平呈正相关( P<0.05),T2DM中SUA水平与2-h PG无相关关系( P=0.156)。在整个研究人群中HbA1c和FPG水平与2-h PG水平呈正相关( P<0.05)。在NGT中FPG水平与2-h PG水平呈正相关( P=0.031)。在IGR和T2DM中,HbA1c水平与2-h PG水平呈正相关( P<0.05)。HbA1c、FPG和SUA水平是IGR患者2-h PG的独立风险因素。结论 糖尿病前期SUA与2-h PG相关,并独立于FPG、HbA1c和其他已知的危险因素;SUA在糖尿病前期患者的病情演变过程中可能起重要作用,因此SUA检测可以作为监测糖尿病前期患者发展成T2DM的风险指标。  相似文献   

14.
目的:探讨妊娠期糖尿病(GDM)患者血清脂肪因子omentin-1、chemerin水平变化及与GDM糖脂代谢、炎症指标等的相关性。方法 ELISA法定量85例GDM及匹配设置的85例糖耐量正常孕妇(NGT)血清omentin-1及chemerin水平,同时检测两组糖脂生化指标、炎症指标、空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR)。以单因素相关分析、多元逐步回归分析处理。结果(1)GDM组孕前BMI、hs-CRP、血脂、血糖、FINS、HOMA-IR、血清chemerin均明显高于NGT组,血清omentin-1明显低于NGT组(P<0.05);(2)血清omentin-1:肥胖GDM<非肥胖GDM≈肥胖NGT<非肥胖NGT(P<0.05);血清chemerin:肥胖GDM>非肥胖GDM≈肥胖NGT>非肥胖NGT(P<0.05);(3)析因分析,产前肥胖和/或HOMA-IR≥2时,血清omentin-1水平明显降低;产前肥胖血清chemerin明显升高,但与HOMA-IR≥2无关联;(4)相关性分析:血清omentin-1与HDL明显正相关,而与孕前BMI、产前BMI、FPG、FINS及HOMA-IR明显负相关;chemerin与TC、TG、hs-CRP及FPG明显正相关;omentin-1和chemerin之间无明显相关性(P=0.301);(5)孕前BMI、TG、FPG、FINS是GDM血清omentin-1的独立影响因素;TG、LDL、hs-CRP是GDM血清chemerin的独立影响因素。结论血清omentin-1可以反映孕妇糖、脂代谢紊乱和胰岛素抵抗程度,血清Chemerin则提示患者的高脂血症和慢性炎症状态。两者与GDM关系密切,可能共同参与了GDM疾病的发生和发展。  相似文献   

15.
新诊断2型糖尿病患者β细胞功能分析   总被引:4,自引:0,他引:4  
Li YB  Zhu DL  Tian HM  Shi LX  Luo ZJ  Yan L  Zeng LY  Zhou ZG  Yang LY  Liu J  Li M  Weng JP 《中华医学杂志》2006,86(36):2537-2541
目的了解新诊断2型糖尿病患者胰岛β细胞功能改变。方法检测352例新诊断2型糖尿病患者空腹血糖、胰岛素及胰岛素原,行静脉葡萄糖耐量试验,评价胰岛素曲线下面积(AUC)、胰岛素急性分泌时相(AIR)及稳态模型β细胞功能指数(Homa β)及胰岛素抵抗指数(HomaIR)。结果糖尿病患者 AUC 较正常者明显减低(834.2 pmol/L vs 7934.7 pmol/L,中位数,P<0.001);AIR 缺失(-33.7 pmol/L vs 6962.0 pmol/L,P<0.001)。分层分析显示当患者空腹血糖>7.0 mmol/L 时其 AIR 即明显减弱(317.3 pmol/L),大于9.0 mmol/L 时消失。糖尿病患者 Homa β约为正常者的30%(3.7±0.9 vs 5.9±0.9,P<0.001),空腹胰岛素原(PI)及其与胰岛素比值(PI/I)显著升高(22.6 pmol/L±14.7 pmol/L vs 11.5 pmol/L±7.1 pmol/L,P<0.001;30.1%±20.5%vs12.1%±9.6%,P<0.001)。结论新诊断2型糖尿病患者胰岛β细胞功能受损主要表现在 AIR 缺失和 AUC 显著下降,Homa β明显降低,以及胰岛素分泌质量下降。  相似文献   

16.
目的探讨2型糖尿病患者血清白介素 23(IL 23)、肿瘤坏死因子 α(TNF α)、干扰素 γ(IFN γ)的水平与胰岛素抵抗相关性。方法将85例观察对象分为:正常对照组(NGT组)20例、新发2型糖尿病组(DM1组)33例、既往2型糖尿病组(DM2组)32例,均监测体质量、身高、腰围、臀围、空腹血糖(FPG)、胰岛素(FINS)、胆固醇(CH)、甘油三酯(TG)、糖化血红蛋白(HbA1c),并测定IL 23、TNF α、IFN γ浓度,简易稳态模型评估胰岛素抵抗指数(HOMA IR)。结果DM1、DM2组的IL 23 水平较NGT组明显升高(P<0.05),而DM1组又较DM2组明显升高(P<0.01);DM1、DM2组的TNF α水平较NGT组明显升高(P<0.05),DM1、DM2组组间比较无统计学差异;三组间IFN γ水平比较无统计学差异(P>0.01)。血清IL 23与HOMA IR(r=0.412,P=0.001)、TNF α(r=0.458,P=0.000)显著相关,与IFN γ无关(P>0.05);TNF α、IFN γ与HOMA IR显著相关(r=0.410,P=0.001;r=0.739, P=0.001)。结论IL 23、 TNF α是2型糖尿病胰岛素抵抗的重要细胞因子,IL 23不能通过参与调节IFN γ发挥作用。  相似文献   

17.
目的 探讨妊娠期糖尿病患者血清中视黄醇结合蛋白4(retinol binding protein 4,RBP4)表达与糖脂代谢指标及新生儿体重的相关性。 方法 选取妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇40例作为研究对象,另选40名正常孕妇做对照,分别测定分娩前空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,Fins)、血脂及血清RBP4水平,计算胰岛素抵抗指数(HOMA-IR),并在分娩后记录新生儿体重(birth weight,BW)、测定脐血RBP4水平。 结果 GDM组血清及脐血中RBP4、FPG、甘油三酯(triglyceride,TG)、HOMA-IR及BW均高于对照组(P<0.05)。2组Fins和总胆固醇(Total cholesterol,TC)比较差异均无统计学意义(均P>0.05)。相关性分析发现孕妇血清中RBP4与TC呈正相关(r=0.489,P<0.01),血清及脐血中RBP4与BW呈正相关(r=0.488,P<0.01;r=0.327,P<0.05)。 结论 RBP4参与了妊娠期血糖、血脂代谢,与胎儿生长发育有一定关联,可能参与了GDM的发病过程。   相似文献   

18.
中国成人不同糖代谢异常的分布特点   总被引:27,自引:3,他引:24  
目的 探讨各种不同的糖代谢异常 (糖调节受损和糖尿病 )在中国人群中的分布和特点。方法 研究对象为 1994年全国糖尿病防治协作组资料库中具有完整口服糖耐量试验 (OGTT)资料的 15 6 37例中国成人 (≥ 2 5岁 )。参考 1999年WHO糖尿病诊断标准将研究对象分为 7组 :正常糖耐量 [NGT ,空腹血糖 (FPG) <6 1mmol/L及OGTT2小时血糖 (PG 2h) <7 8mmol/L]、单纯空腹血糖受损 (i IFG ,6 1≤FPG <7 0mmol/L及PG 2h <7 8mmol/L)、单纯糖耐量异常 (i IGT ,FPG<6 1mmol/L及 7 8≤PG 2h <11 1mmol/L)、同时FPG及PG 2h异常 (IFG/IGT ,6 1≤FPG <7 0mmol/L及 7 8≤PG 2h <11 1mmol/L)、单纯空腹高血糖的糖尿病 (IFH ,FPG≥ 7 0mmol/L及PG 2h <11 1mmol/L)、单纯餐后高血糖的糖尿病 (IPH ,FPG <7 0mmol/L及PG 2h≥ 11 1mmol/L)、同时空腹及餐后高血糖的糖尿病 (IFH/IPH ,PG 2h≥ 11 1mmol/L及FPG≥ 7 0mmol/L)。计算以上各种糖代谢异常在本组人群发生频率并比较其临床特点。结果  (1)NGT、i IFG、i IGT、IFG/IGT、IFH、IPH和IFH/IPH的频率分别为 5 0 8%、8 8%、12 3%、6 1%、6 4 %、5 2 %和 10 4 %。 (2 )i IGT、IFG/IGT、IPH和IFH/IPH的频率有随年龄而增加的趋势 ,但i IFG和IFH频率分别在 2 5~ 34岁和 5 5  相似文献   

19.
目的观察艾塞那肽对2型糖尿病合并早期糖尿病肾病(diabetic nephropathy,DN)患者肾功能等临床指标的影响。方法 58例早期DN患者随机分为艾塞那肽组与格列美脲组,每组各29例,分别给予艾塞那肽和格列美脲治疗,两组均联合二甲双胍治疗。治疗24周后对比两组患者空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 hpostprandial plasma glucose,2 h PG)、糖化血红蛋白(hemoglobin Alc,Hb A1c)、血脂、尿素(blood urea,BUN)、肌酐(creatinine,Cr)、尿白蛋白/肌酐比值(urinary albumin to creatinine ratio,UACR)、血清转化生长因子-β1(transforming growthfactorβ1,TGF-β1)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、体重、体重指数(body mass index,BMI)等变化。结果 24周治疗后,两组FPG、2 h PG、Hb A1c水平均较治疗前降低(P0.05),组间比较差异无统计学意义(P0.05);两组UACR均较治疗前降低(P0.05);艾塞那肽组体重、BMI、SBP较治疗前降低(P0.05),24周治疗后,艾塞那肽组UACR、TGF-β1、SBP、体重、BMI较格列美脲组降低(P0.05)。结论艾塞那肽通过降低血糖、血压,减轻体重,减少尿蛋白排泄及抗纤维化作用保护肾脏。  相似文献   

20.
 目的 观察初发2型糖尿病患者的血清Reg Ⅰα水平,并分析其与其他临床指标的相关性,探讨其可能的临床意义。方法 经口服葡萄糖耐量试验(oral glucose tolerance test,OGTT)入选110名正常糖耐量(normal glucose tolerance,NCT)和46名2型糖尿病患者(type 2 diabetes mellitus,T2DM)酶联免疫吸附测定测定血清Reg Ⅰα和胰岛素、C反应蛋白(hs-CRP)、人脂肪细胞脂肪酸结合蛋白(A-FABP)、脂联素等。结果 NGT组和Y2DM组的血清Reg Ⅰα水平无显著差异[(626.82 ± 359.60)ng/mL vs (610.11 ± 326.01)ng/mL,P = 0.788];在所有研究对象中,血清Reg Ⅰα水平与年龄正相关,同时与腰臀比(WHR)、A-FABP、hs-CRP呈正相关,与高密度脂蛋白(HDL-C)呈负相关,与空腹血糖(FPG)和OGTT 2 h血糖和胰岛素水平无明显相关性。校正年龄因素后,Reg Ⅰα水平与A-FABP正相关,与HDL-C负相关。但在T2DM组,Reg Ⅰα和A-FABP、HOMA-B成正相关(r值分别为0.428,0.424;P值分别为0.042,0.044),和FPG糖化血红蛋白1(HbA1c)呈负相关(r分别为-0.525,-0.425,P值分别为0.01,0.043)。结论 与NGT相比,初发T2DM患者血清Reg Ⅰα水平没有明显差异;在T2DM患者血清Reg Ⅰα与胰岛功能和血糖水平有一定的关系,提示Reg Ⅰα有可能参与T2DM的β细胞代偿,有可能是评价胰岛功能的指标之一。  相似文献   

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