收治于方舱医院的COVID⁃19患者胸部高分辨CT表现

目的：探讨新型冠状病毒感染的肺炎（corona virus disease 2019,COVID?19）患者的胸部高分辨CT（high resolution CT,HRCT）影像表现。方法：回顾性分析2020年2月21—24日130例收治于方舱医院的COVID?19患者的胸部HRCT影像学表现。结果：130例中15例（11.5%）患者HRCT无异常。肺内阴性表现组年龄明显低于肺内阳性表现组（P=0.011）,而两组间性别构成比差异无统计学意义（P=0.122）。115例患者中,病变累及左肺9例（7.8%）,右肺13例（11.3%）,双肺93例（80.9%）。37例（30.4%）右肺上叶受累,54例（47.0%）右肺中叶受累,90例（78.3%）右肺下叶受累,46例（40%）左肺上叶受累,83例（72.2%）左肺下叶受累。病变呈单发病灶18例（15.7%）,呈多发病灶23例（20.0%）,呈弥漫病灶74例（64.3%）。病变分布于胸膜下61例（53.0%）,支气管血管束2例（1.7%）,胸膜下及支气管血管束52例（45.3%）。100例（87.0%）患者CT图像上可见片絮影,72例（62.6%）可见磨玻璃影,58例（50.4%）可见索条影,20例（17.4%）可见实变影。104例（90.4%）患者CT图像上包含2种或2种以上征象。病灶中合并空气支气管征19例（16.5%）,“铺路石征”9例（7.8%）。纵隔窗图像上观察有纵隔淋巴结肿大6例（5.2%）,所有病例均未见胸腔积液。结论：收治于方舱医院的COVID?19患者影像主要表现为累及双肺、沿胸膜下和支气管血管束分布的多发病灶。除片絮、磨玻璃、实变、空气支气管征和“铺路石”征外,病灶内索条影出现比例较高,可能提示病灶吸收好转。     

新型冠状病毒肺炎患者初次胸部高分辨力CT影像学特征分析

目的探究临床诊断为新型冠状病毒肺炎（COVID-19）患者的初次胸部高分辨力CT（HRCT）影像学特征。方法回顾浙江中医药大学附属杭州西溪医院2020年1月20日至2月6日共61例临床诊断为COVID-19患者的初次胸部HRCT影像学资料,对病灶大小、分布、密度情况进行统计和分析。结果61例患者共发现435个阳性病灶。病灶平均大小（16.5±9.3）mm。病灶分布：单侧肺16例（26.2%）,双侧肺45例（73.8%）,单个肺叶受累11例（18%）,2个肺叶受累16例（26.3%）,多个肺叶受累34例（55.7%）;胸腔积液1例（1.6%）,淋巴结肿大3例（4.9%）;右上肺65个（14.9%）,右肺中叶43个（9.9%）,右下肺127个（29.2%）,左上肺87个（20%）,左下肺113个（23%）;肺野外周354个（81.4%）,肺野中央区域48个（11%）,同时受累33个（7.6%）。病灶密度：单纯磨玻璃密度影169个（38.9%）,磨玻璃密度影伴小叶间隔增厚“铺路石”征88个（20.2%）,磨玻璃密度影伴部分实变146个（33.6%）,实变病灶32个（7.4%）;继发支气管扩张病灶56个（12.9%）,含“充气支气管征”病灶181个（41.6%）。结论COVID-19患者初次胸部HRCT表现具有一定特征,主要表现为两肺下叶胸膜下分布的磨玻璃影或伴铺路石征为特点,胸部HRCT检查在COVID-19的早期诊断中有重要作用。     

新型冠状病毒肺炎首次高分辨率CT影像分析7例

目的探讨新型冠状病毒肺炎（COVID-19）首次胸部高分辨率CT（HRCT）影像的特点及鉴别诊断。方法收集2019年12月至2020年2月确诊的7例COVID-19患者的首次胸部HRCT图像,对病灶分布、形态及周围受累情况进行分析,并结合近期文献报道,总结其影像特点及鉴别诊断要点。结果7例患者均发现磨玻璃阴影（GGO）,单纯性GGO3例,沿肺段分布GGO合并实变2例,GGO合并双侧少许胸腔积液1例,GGO合并双肺多发条索纤维灶1例。双侧肺叶均发现病变6例（所有肺叶、肺段均受累2例）,局限于右肺下叶1例（以胸膜下分布为主）。右肺病变较左肺病变分布广6例,肺下叶病变较上叶病变分布广6例。结论COVID-19患者首次胸部HRCT影像学具有一定的特点,以GGO为典型表现,以胸膜下、肺下叶及右肺分布明显,双侧肺门及纵隔淋巴结肿大少见。     

高分辨螺旋CT对系统性红斑狼疮胸部表现的诊断及其临床意义的探讨

目的探讨系统性红斑狼疮（SLE）患者胸部CT征象及其临床意义。方法回顾性分析44例SLE 患者胸部CT征象,结合临床表现,探讨其临床意义。结果SLE 患者常见CT征象中肺实变（12例）、磨玻璃样影（37例）,小叶间隔增厚（35例）、界面征（23例）、胸膜下线征（20例）、胸膜肥厚（39例）、心包肥厚（10例）、肺内蜂窝样改变9例、肺囊肿样改变4例、肺粟粒样结节1例、胸膜腔积液8例、心包积液5例、纵隔及两侧腋下肿大淋巴结（大于10mm）19例、肺动脉主干增粗2例。SLE肺部小叶间隔增厚、界面征、胸膜下线征、胸膜肥厚和心包肥厚等为常见病变CT征象。结论通过分析HRCT可以有效检查出SLE胸部侵犯的表现征象,有利于临床医生及时诊断,尽早治疗,减少并发症等。     

69例新型冠状病毒肺炎的胸部CT影像学特征分析

目的 探讨海南地区新型冠状病毒肺炎（coronavirus disease 2019,COVID-19）的首诊胸部CT表现和临床特点,以期提高对该病的认识。方法 回顾性分析2020年1月22日—3月7日海南省人民医院收治的69例COVID-19确诊患者的临床胸部CT资料。结果 69例患者临床表现主要为发热56例,咳嗽、咳痰59例,乏力32例。临床分型,轻型3例（4.35%）,普通型病例54例（78.26%）,重型和危重型12例（17.39%）。69例患者中,5例（7.25%）首诊胸部CT阴性,64例（92.75%）胸部CT有异常病灶,13例（20.31%）单侧肺叶病变,51例（79.69%）为双肺受累;9例（14.06%）肺内单发病灶,55例（85.94%）肺内多发病灶。病灶的CT影像学特征为肺内磨玻璃密度影,37例（57.81%）呈胸膜下及肺外带分布为主;伴病灶中心或节段性肺实变23例（33.33%）,伴支气管充气征19例（27.54%）,合并病灶内血管束增粗50例（72.46%）,伴小叶间隔增厚38例（55.07%）,胸膜下纤维条索影9例（13.04%）,2例（2.90%）伴有胸腔积液。结论 海南地区COVID-19患者以输入性病例为主,部分为本地散发病例,临床以轻型和普通型病例为主。首诊胸部CT主要表现为胸膜下及肺外带分布磨玻璃密度影,伴血管束增粗及间质性改变,胸腔积液少见。     

胸部高分辨率CT技术的临床应用

目的：进一步研究，掌握胸部高分辨率CT（HRCT）技术，观察和认识肺内细微结构，细小病变影像特征及病理改变。方法：正常胸部组50例，各类肺疾患者100例，常规螺旋CT全胸扫描，运用HRCT对局部或病灶扫描，然后对比分析。结果：HRCT能清晰显示肺小叶间隔，小支气管分支结构及形态，能观察到蜂窝状网影，胸膜下小结，胸膜下线影，毛玻璃样征；小毛刺征，小结节堆砌征，脐样征，印戒征，双轨征，支气管囊柱状改变征等反映肺间质病变，癌结节病变及支气管扩张的病变征象，结论：HRCT是研究认识肺间质病变，肺内小结节以及支气管扩张的方法，薄层扫描，高千伏，高分辨率重建算法是HRCT技术的三大要素，适当的图像显示技术，病员的正确体位及呼吸控制也是HRCT影像质量的可靠保证。     

普通型与重型新型冠状病毒肺炎的HRCT征象对照研究

目的：探讨普通型与重型新型冠状病毒肺炎（coronavirus disease 2019,COVID?19）患者的一般资料及胸部CT征象在鉴别诊断中的价值。方法：回顾性分析2020年1月1日—2月20日武汉市中心医院127例COVID?19确诊患者的一般资料、胸部CT征象及随访CT影像变化规律。其中普通型101例（79.53%）、重型26例（20.47%）。一般资料、胸部CT征象的组间比较采用χ2或Fisher确切概率法统计分析,并总结各型COVID?19患者的随访CT影像演变规律。结果：127例中,男73例（57.48%）,女54例（42.52%）,性别差异无统计学意义（χ2=1.847,P=0.174）。与普通型患者比较,重型患者发病年龄偏高（χ2=4.547,P=0.033）。合并基础性疾病者32例（25.20%）,普通型15例（14.85%）,重型17例（65.38%）,组间差异有统计学意义（χ2=28.014,P＜0.001）。CT表现中,普通型患者CT征象以磨玻璃密度影（67例）、混合磨玻璃密度影（45例）为主,重型患者CT征象以混合磨玻璃密度影（19例）、铺路石征（10例）为主,组间差异有统计学意义（χ2=11.330,P=0.010）。重型患者发现纵隔淋巴结肿大1例（3.85%）（P=0.205）,胸腔积液4例（15.38%）（P=0.001）。重型患者病灶CT评级普遍高于普通型,其病程较普通型更长且肺部受累高峰时间较普通型延后。结论：COVID?19患者胸部CT征象演变规律存在差异,其不仅能评估病情严重程度,还能对重型COVID?19做出早期预警。     

肺泡蛋白沉积症的影像学表现4例报道并文献复习

目的 分析肺泡蛋白沉积症（PAP）的胸部平片、CT影像表现,旨在提高对本病的认识.方法 回顾性分析浙江省台州医院4例经病理证实的PAP患者的胸部影像资料,其中男3例,女1例,年龄29～61岁;4例患者均行螺旋CT、高分辨率CT（HRCT）检查,1例行胸部平片;其中3例肺泡灌洗,1例肺穿刺证实.结果 ①原发型3例,胸部平片表现为双肺弥漫性分布斑片状密度增高影,边界不清,两侧肋膈角锐利,心影未见增大.1例胸部CT示病变弥漫呈片状分布,边缘锐利,与周围正常肺组织界限清晰,并在其衬托下呈“地图样”分布,同时可显示磨玻璃影中的网格状影（铺路石征）.2例胸部CT示两肺弥漫分布磨玻璃影,肺尖及肺基底部均累及,部分胸膜下区未累及,边界不清,部分肺组织实变,见空气支气管征.②继发型l例,CT显现左下肺散在片状磨玻璃样高密度影,与周围正常组织分界清楚;右下肺大片状高密度影,内见支气管走形,周围见晕征.③1例原发型PAP纵隔内见肿大淋巴结影,短径未超过1.5 cm.4例均未见胸腔积液和心影增大.结论 弥漫、区域性磨玻璃样阴影,地图或铺路石样改变,胸膜下区未累及,临床与影像表现不符等征象是PAP具有特征性的表现;若有基础疾病合并上述影像表现,应考虑合并PAP可能.     

家庭群居爆发型新型冠状病毒肺炎的临床与胸部HRCT表现

目的 探讨家庭群居爆发型新型冠状病毒肺炎（简称"新冠肺炎"）（novel coronavirus pneumonia，NCP）的临床与胸部HRCT表现特点。方法 收集2020年2月3所医院经核酸检测阳性确诊的新冠肺炎患者10例（4个家庭），其中男性6例（中位年龄60.5岁），女性4例（中位年龄59岁）。所有患者均接受胸部CT扫描并行薄层HRCT重建，由两名10年以上工作经验放射科医生共同阅片分析新冠肺炎HRCT病变发生部位、形态、分布、密度等特点，以及治疗前后HRCT征象变化。并收集临床和实验室指标进行分析和总结。结果 本组4个家庭中首例确诊病例均有武汉确诊病例或武汉疫区接触史，4例为输入型病例（占40%），平均潜伏期5 d。实验室检查中5例（50%）外周血白细胞总数降低，4例（40%）淋巴细胞明显降低；8例（80%）C-反应蛋白增高，10例（100%）乳酸脱氢酶增高。10例（100%）患者胸部CT均有阳性表现，其中7例（70%）表现为双肺散在分布磨玻璃密度影（ground glass opacity，GGO），病变界限大多清楚。8例（80%）累及多个肺叶，2例（20%）为单肺叶病变。绝大多数病灶位于胸膜下和肺外周处，以双肺下叶为著。5例患者（50%）病变内可见细支气管充气征，9例患者（90%）病变内可见增粗细小血管影。7例患者（70%）治疗后复查胸部CT，3例（30%）原肺内胸膜下病变出现不同程度实变及纤维化，2例（20%）实变影转变为GGO，1例（10%）原肺内GGO消失，又出现新发GGO，1例（10%）病变范围有增大。结论 新冠肺炎具有家庭群居爆发的特点，均可有输入性病例，潜伏期较短，其胸部HRCT表现具有一定特征性，且有助于治疗后患者病变动态观察；结合流行病学和实验室检查有助于对NCP做出临床诊断和提供疫情防控的可靠依据。     

普通型新型冠状病毒肺炎患者康复期胸部CT表现

目的：探讨普通型新型冠状病毒肺炎（coronavirus disease 2019,COVID-19）康复期患者胸部影像学表现。方法：收集2020年1月21日至2月23日孝感市第一人民医院确诊为普通型COVID-19的80例患者临床及影像资料,以体温恢复正常3 d以上、呼吸道症状明显好转、肺部影像学显示炎症明显吸收及连续2次呼吸道病原核酸检测阴性（采样时间至少间隔1 d）作为康复期出院标准,通过动态观察COVID-19康复期患者HRCT表现,与入院时进行对比分析,观察COVID-19患者典型征象及康复期出院时病变分布、病变形态等表现。结果：动态观察COVID-19康复期患者HRCT表现“破苍蝇拍征”及“包水管征”吸收减少,以“包水管征”吸收较早且明显。对比入院时HRCT,康复期表现以双肺下叶背段或后基底段局限斑片状磨玻璃灶、多叶多段磨玻璃样密度灶及弥漫分布的磨玻璃灶,部分患者残存小叶内间质及小叶间隔增厚、胸膜下弧线影及不规则纤维索条影灶,康复期患者未见明显纵隔淋巴结肿大和胸腔积液。结论：动态观察显示“破苍蝇拍征”及“包水管征”吸收减少是普通型COVID-19康复期病情好转的典型表现,康复期出院患者多遗留磨玻璃样改变、小叶内间隔和（或）小叶间隔增厚、胸膜下弧线影并残存间质炎症,临床随访应推广HRCT检查才能有效观察残存病灶的动态改变,降低残存病灶发生为间质纤维化的风险。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.