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1.
目的:了解广州献血人群中丙型肝炎病毒( HCV)感染者自然转归与HLA多态性的相关性,为HCV治疗策略的制定、预后的评估及疫苗的研制提供科学依据。方法选取广州献血人群中373例HCV感染者,分为两组:自发清除组(133例)和慢性感染者(240例),利用HLA-SBT方法对373份感染者进行HLA-Ⅱ类等位基因分型,用χ2检验分析每个HLA等位基因频率在自发清除组和慢性感染组的分布是否存在差异,并应用多因素Logistic回归对可能影响HCV自然转归的多种因素进行分析。结果自发清除组与慢性感染组相比年龄较小[(28.2±9.9)岁vs(31.3±9.0)岁,t=-2.998,P=0.003],HCV自发清除组女性比例较高(34.6% vs 17.9%,χ2=13.090,P<0.01)。 DQB1*05:02(P=0.002,OR=0.411,95%CI=0.232~0.727)和DRB1*14:54(P=0.027, OR=0.350,95%CI=0.132~0.926)在慢性感染组中更为多见,DRB1*11:01在自发清除组较为常见( P=0.007, OR=2.169,95%CI=1.223~3.848)。多因素logistic回归分析发现,年龄( P<0.01,OR=1.035,95%CI=1.018~1.053)、性别(P<0.01,OR=0.423,95%CI=0.297~0.603)和DQB1*05:02(P=0.016,OR=0.480,95%CI=0.264~0.873)、DRB1*11:01(P=0.016,OR=2.072,95%CI=1.142~3.758)等位基因是HCV感染自然转归的独立相关因素。结论女性、较年轻的HCV感染者比较容易发生自发清除,携带DQB1*05:02等位基因的人群在感染HCV后更易发生慢性化,携带DRB1*11:01基因则容易发生自发清除。  相似文献   

2.
目的:探讨甲状腺癌MHC基因频率分布与可溶性主要组织复合物Ⅰ链相关蛋白A( sMⅠCA)表达的关系。方法采用直接测序法对44例经术后病理证实为甲状腺癌的患者及87例甲状腺良性肿瘤患者、133例健康体检者全血进行MHC( HLA、MⅠCA、MⅠCB)高分辨分型,采用PypopWin32进行MHC系统频率分析,SPSS 20.0统计软件分析甲状腺癌与MⅠCA/B及HLA等位基因频率的相关性,运用ELISA对上述对象血清进行sMⅠCA半定量检测。结果(1)MⅠCB*004:01为甲状腺癌的保护等位基因[P=0.014,RR(95%CI)=0.122(0.016~0.91)];(2)DRB1*15:01和DRB1*04:03为甲状腺良性肿瘤的保护等位基因(P<0.05,RR<1);(3)甲状腺癌患者与甲状腺良性肿瘤及健康体检者比较,血清sMⅠCA水平差异无统计学意义,其中甲状腺癌患者血清sMⅠCA水平为(0.2331±0.2445)ng/mL。结论 MHC系统基因与甲状腺癌存在关联,MⅠCB*004:01与患甲状腺癌风险相关。  相似文献   

3.
目的 探讨儿童急性淋巴细胞白血病(儿童-ALL)易感笥与HLA-DRB1基因多态性的关联性,找出儿童急性淋巴细胞白血病的易感基因。方法 采用序列特异性引物聚合酶链反应(PCR-SSP)DNA分型技术对30例儿童-ALL患者及53便健康对照进行了HLA-DRB1基因分型。结果 儿童-ALL患者与HLA-DRB1*15基因关联,基因频率为25.0%,RR=3.08,x^2=5.56,P<0.025。其他等位基因频率与对照组之间无显著性差异。结论 提示在华北汉族人群中,HLA-DRB1*15与儿童急性淋巴细胞白血病有关联。  相似文献   

4.
目的:探讨蒙古族儿童过敏性紫癜(AP)的遗传背景及免疫学发病机制,为明确AP的病因学及预后提供免疫学方面的资料。方法:采用分析性研究策略和聚合酶链反应-序列特异性引物分型技术(PCR—SSP)对57例内蒙古地区蒙古族儿童过敏性紫癜病人和102例正常蒙古族儿童进行HLA—DRB1等位基因型别分析。结果:HLA—DRB1*110x的基因频率在AP组较正常对照组明显升高(P〈0.05);HLA—DRB1*120x的基因频率在AP组较正常对照组明显降低(P〈0.05)。其它HLA—DRB1等位基因频率在两组间的分布则无明显差异(P〉0.05)。站论:HLA—DRB1*110x与AP的易感性呈正相关,可能是AP的易感基因。HLA—DRB1*120x与AP的易感性呈负相关,可能是AP的保护基因。  相似文献   

5.
目的:探讨等位基因HLA-DQA1及DQB1在国人Graves‘病(gravs‘ disease,GD)发病中的作用。方法:选择汉族GD患者103例及正常人100例。采用PCR-SSP方法,检验HLA-DQA1*051,DQB1*0201及DQB1*0303的出现频率。结果:HLA-DQA1*0501及DQB1 0201GD组均低于对照组(分别P-0.002,RR=0.38及P=0.001,RR=0.27),DQB1*0303GD组与对照组之间无差异(P=0.189RR=0.64),研究提示DQA1*0501,DQB1*020为中国汉族人群GD的保护因素,以上3种基因在不同性别GD患者之间未见差异,结论:HLA-DQ与国人GD的发病有关。GD患者DQA1*0501及DQB1*0201出现频率减少。  相似文献   

6.
目的:分析人类白细胞抗原(HLA)-DRB1等位基因与Ⅰ型自身免疫性肝炎(AIH)的相关性。方法:采用序列特异性多聚酶链反应(PCR-SSP),对32例Ⅰ型AIH型患者和48例健康对照者进行HLA-DRB1等位基因及有关基因亚型分析。结果:HLA-DR4基因频率在Ⅰ型AIH型患者中较健康对照组显著增高(相对危险度=3.35,P=0.014)。对HLA-DR等位基因型的分析表明,Ⅰ型AIH型患者组DRB1*0405的基因频率较健康对照有增加趋势(P=0.04,但Pc=0.08)。HLA-DRβ分子的第三等位基因高变区第71位精氨酸残基的频率在Ⅰ型AIH型患者中显著增高(相对危险度=3.82,P=0.008)。结论:Ⅰ型AIH的发病与HIA-DR4相关。  相似文献   

7.
目的:探讨过敏性紫癜(AP)的遗传背景及免疫学发病机制,为明确AP的病因学及预后提供免疲学方面的资料,同时也为探索其免疫治疗提供有价值的线索。方法:采用分析性研究策略和聚合酶链反应——序列特异性引物分型技术(PCR--SSP)对80例内蒙古地区汉族儿童AP病人和108倒正常汉族儿童进行HLA—DRB1等位基因型别分析。结果:汉族儿童HLA—DRB1各等位基因均被检出。HLA—DRB1*010x、HLA—DRB1*120x的基因频率在AP患儿组较正常对照组明显升高(分别为13.75%vs4.16%、12.50%VS5.56%,),HLA—DRB1*080x的基因频率在AP患儿组较正常对照组明显降低(2.50%VS8.33OA)。这些基因频率在两组间的分布经统计学检验差异有显著性。其它HLA--DRB1等位基因频率在两组间的分布经统计学检验差异无显著性。结论:HLA~DRB1*010x、HLA--DRB1*120x与AP的易感性呈正相关。可能是AP的易感基因。HLA—DRB1*080x与AP的易感性呈负相关,可能是AP的保护基因。  相似文献   

8.
目的:探讨人类白细胞抗原-DQA1(HLA-DQA1)基因多态性与新疆维吾尔族(以下简称维族)、汉族慢性乙型肝炎患者遗传易感性的关系,找寻新疆维族与汉族慢性乙型肝炎患者乙型肝炎病毒(HBV)感染的易感基因和拮抗基因及维、汉族之间 HLA-DQA1基因型差异。方法选择乙型肝炎组患者182例(维族102例,汉族80例),健康对照组163例(维族85例,汉族78例);根据乙型肝炎患者血清 HBV DNA 病毒载量的不同分为高复制组和低复制组;根据血清丙氨酸氨基转移酶(ALT )水平分为 ALT 正常组和 ALT 异常组。 PCR-序列特异性引物(PCR-SSP)法检测 HLA-DQA1*0102、-DQA1*0104、-DQA1*0201、-DQA1*0301、-DQA1*0302、-DQA1*0501等6个等位基因的频率分布;采用酶促反应法检测 ALT ;PCR 检测 HBV DNA 。结果维族乙型肝炎患者组、ALT 异常组、HBV DNA 高复制组与健康对照组比较-DQA1*0301、-DQA1*0501基因频率差异有统计学意义(P<0.05)。汉族乙型肝炎患者 ALT 异常组、HBV DNA 高复制组与健康对照组基因频率比较-DQA1*0102、-DQA1*0201、-DQA1*0301差异有统计学意义(P<0.05),HBV DNA 高复制组与低复制组等位基因-DQA1*0102比较差异有统计学意义(P<0.05);HBV DNA 低复制组、ALT 正常组与健康对照组中 HLA-DQA1*0201位点基因比较,差异有统计学意义(P<0.05)。维族与汉族慢性乙型肝炎患者 HLA-DQA1等位基因频率比较,-DQA1*0102、-DQA1*0301基因频率差异有统计学意义(P<0.05)。维族与汉族健康对照 HLA-DQA1等位基因频率比较,-DQA1*0201、-DQA1*0501基因频率差异有统计学意义(P<0.05)。结论维族人群中 HLA-DQA1*0501为 HBV 感染拮抗基因,-DQA1*0301为易感基因。汉族人群中 HLA-DQA1*0102、-DQA1*0301、-DQA1*0302为 HBV 感染易感基因,-DQA1*0201为拮抗基因。  相似文献   

9.
HLA-DR2与中国人1型糖尿病相关性的探讨   总被引:1,自引:0,他引:1  
目的 研究HLA-DR2与中国人Ⅰ型糖尿病的相关性。方法 应用序列特异引物PCR(PCR-SSP)技术检测华南地区汉族64例1型糖尿病(1型DM)患者(包括15岁前起病组17例,15-30岁起病组30例以及30岁后起病组17例)和72例健康对照者的HLA-DR2等位基因。结果 1型DM组和对照组HLA-DR2等位基因频率分别为31.3%和36.6%,差异无显著性(P>0.05)。15岁前起病组、15-30岁起病组和30岁后起病组中HLA-DR2频率分别为17.6%、30.0%和47.1%,各组间比较及分别与对照组比较差异均无显著性,但15岁前起病组与30岁后起病组比较P=0.058。HLA-DR2 1型DM组与非HLA-DR2 1型DM组比较DK及/或DKA发生率较低(55%及84%,RR=0.65)。对包括本组的5份华人资料的联合分析显示HLA-DR2与IDDM呈弱负相关(P<0.025,RR=0.65)。结论 HLA-DR2与中国人1型DM发病的关系仍有待大样本研究的证实,尤应增加儿童起病1型糖尿病的研究。HLA-DR2与1型糖尿病患者DK及/或DKA发生的关系亦有待阐明。  相似文献   

10.
子宫内膜异位症合并不孕与HLA—DQA1、DRB1的相关性   总被引:2,自引:1,他引:1  
目的 探讨HLA-DQA1、DRB1等位基因与子宫内膜异位症患者不孕的相关性。方法 用聚合酶链反应-序列特异性引物(PCR-SSP)对102例经腹腔镜或外科手术证实的子宫内膜异位症患者(其中35名患者合并不孕)进行HLA-DQA1、DRB1等位基因的基因分型并与对照组进行比较。结果 子宫内膜异位症患者HLA1-DQA1*0401等位基因频率显著高于正常对照,HLA1*0301等位基因频率显著低于正常对照。其中,合并不孕者HLA1-DQA1*0301、DRB1*07、DRB1*08/12等位基因频率低于正常对照,HLA1-DRB1*07、DRB1*08/12等位基因频率低于无合并不孕者;而无合并孕者HLA-DQA1*0301,HLA-DRB1*07*08/12可能与子宫内膜异位症的不孕机制相关,HLA1*0401与子宫内膜异位症的发病机制相关,但不参与子宫内膜异位症的不孕机制。]  相似文献   

11.
目的探讨中国北方汉族人群白细胞抗原(HLA)DRB1及DQA1区等位基因多态性与乙型肝炎病毒(HBV)感染不同结局的关系,分析基因—环境交互在慢性乙肝发生中的作用。方法采用病例—对照研究(慢性乙肝患者207人,HBV携带者212人,自限性HBV感染者148人)方法,比较3组人群检测的HLA等位基因频率并应用交互相乘模型分析基因—环境交互作用。结果慢性乙肝组HLA-DQA1*0301等位基因频率(14·81%)显著低于HBV携带组(25·24%)和自限性HBV感染组(25·00%)(Pc=0·002;Pc=0·007);自限性HBV感染组HLA-DQA1*0102等位基因频率(8·78%)显著高于HBV携带组(1·89%)和慢性乙肝组(2·18%)(Pc=0·000;Pc=0·000);自限性HBV感染组HLA-DQA1*0302等位基因频率(4·05%)显著低于慢性乙肝组(11·41%)(Pc=0·005)。经多元logistic回归分析调整年龄、性别、吸烟和饮酒的混杂效应后,HLA-DQA1*0302仍是发展为慢性乙肝的危险因素(OR=3·913,P=0·0006),HLA-DQA1*0102和HLA-DQA1*0301是HBV感染后的保护因素(OR=0·200,P=0·0004;OR=0·258,P=0·0000)。饮酒与HLA-DQA1*0102[交互指数(Ⅱ)=1·49]、HLA-DQA1*0302(Ⅱ=12·12)在慢性乙肝的发生中可能存在正交互作用,与DQA1*0301存在负交互作用(Ⅱ=0·78)。结论携带HLA-DQA1*0302等位基因者感染HBV后可能增加慢性乙肝发生的风险,而携带HLA-DQA1*0301和HLA-DQA1*0102者可能降低慢性乙肝发生的风险;基因—环境交互作用可能影响HBV感染的结局。  相似文献   

12.
Gao J  Lin Y  Qiu C  Liu Y  Ma Y  Liu Y 《中华医学杂志(英文版)》2003,116(7):1078-1082
Objective Human leukocyte antigen (HLA) class Ⅱ genes, especially HLA-DQ genes, which are highly polymorphic, have been thought to be candidate loci for the etiology of asthma, and shown to be involved in antigenic presentation. This study was conducted to investigate whether susceptibility or resistance to asthma is associated with HLA-DQA1 and DQB1 genes polymorphism.Methods Venous blood samples were collected from northern Chinese population with Han ethnic. (1) One hundred and twenty-five unrelated asthmatic individuals and 52 subjects from 12 asthmatic pedigrees. (2) Ninety-six healthy controls without asthma and atopy with the same ethnic. Genomic DNA was extracted using standard phenol-chloroform method. The second exon of HLA-DQA1 and DQB1 genes were amplified by sequence-specific primer-polymerase chain reaction (SSP-PCR) method. All asthmatics had their serum IgE (total and specific) antibody or skin-prick test measured, bronchial reactivity to methacholine (Mch) and bronchial reversibility by β2-agonist evaluated.Results HLA-DQA1*0104 allele and HLA-DQB1*0201 allele were significantly higher in asthmatics than those in healthy controls (0.408 vs 0.177, P<0.01; 0.568 vs 0.198, P<0.01). Odds ratios (ORs) were 3.203 (95% CI 1.699-6.037), 5.328 (95% CI 2.883-9.849) respectively. Conversely, HLA-DQA1*0301 allele and HLA-DQB1*0301 were significantly decreased in asthmatics compared to healthy controls (0.296 vs 0.50, P<0.01; 0.4 vs 0.563, P<0.05); Logistic regression analysis showed that HLA-DQA1*0104 allele was associated independently with asthma etiology, OR [represented by Exp(B)] was 5.0942 with 95% CI 2.2520-21.1813; Spearman’s analysis showed that HLA-DQA1*0104 allele and HLA-DQB1*0201 allele were positively associated with atopy, the correlation coefficient were 0.183 and 0.289 respectively, P<0.01. By contrast, HLA-DQA1*0301 allele was negatively related to atopy, the correlation coefficient was -0.168, P<0.05; linkage analysis did not support the view that HLA-DQA1/DQB1 genes were linked to asthma with LOD value being 0.72.Conclusions HLA-DQA1*0104 allele and HLA-DQB1*0201 allele were implicated in susceptibility to asthma and atopy, HLA-DQA1*0301 allele and HLA-DQB1*0301 might be protective factor against asthma. Asthma and atopy are multifactorial disorders, HLA-DQA1 and DQB1 genes are involved in the regulation of immune specific response to common allergen.  相似文献   

13.
OBJECTIVE To investigate the association of the absence or presence of aspartic acid at position 57 of the HLA-DQ beta chain (NA or A) with susceptibility or resistance to insulin-dependent diabetes mellitus (IDDM) in a Southern Chinese population.
METHODS Sixty-nine IDDM patients and 47 healthy controls in a Southern Chinese population were HLA-DQB1 genotyped by one-step sequence specific polymerase chain reaction (ssPCR).
RESULTS The frequencies of NA and A were 64.5% and 35.5% in the IDDM patients, and 40.4% and 59.6% in the control subjects respectively (RR for NA was 2.68, P < 0.01). The frequencies of NA/NA, NA/A and A/A phenotypes were 47.8%, 33.3% and 18.8% in the IDDM patients, and 31.9%, 17.0% and 51.1% in the controls respectively (P < 0.01). The frequency of A/A phenotype was significantly lower in the IDDM patients than in the control subjects (RR = 0.22, P < 0.01). DQB1* 0302 and DQB1* 0201 were more frequent in IDDM patients than in control subjects. The younger the age of IDDM onset, the higher the allele frequencies of DQB1* 0201 and DQB1* 0302.
CONCLUSIONS The present study suggests that the NA confers the susceptibility to IDDM, while the A confers the protection against IDDM in patients of Southern Chinese origin. These associations are more clearcut in childhood-onset IDDM patients.
  相似文献   

14.
目的:探讨抗精子抗体阳性的免疫性不育症患者与人类白细胞抗原-DQA1(Human LeococyteAntigen-DQA1,HLA-DQA1)基因的相关性及不同中医证型与HLA-DQAl等位基因的相关性。方法:采用聚合酶链反应序列特异性引物(polymerase chain reaction-sequence specific primer,PCR-SSP)技术,将51例抗精子抗体阳性的免疫性不育症中医分型为肾阴不足型、湿热内蕴型和瘀血阻滞型的患者与60名正常健康人的HLA-DQA1基因进行分型研究。结果:免疫性不育症组HLA-DQA1*0401等位基因频率明显高于正常对照组(χ2=29.869,P<0.01),免疫性不育症组DQA1*0301等位基因频率较正常对照组显著降低(P<0.01)。肾阴不足型免疫性不育症组HLA-DQA1*0301基因频率较正常对照组显著降低(P<0.01)。HLA-DQA1*0401基因频率较正常对照组显著升高(P<0.01)。结论:HLA-DQA1*0401等位基因可能是抗精子抗体阳性的免疫性不育症的易感基因,DQA1*0301可能是安徽汉族免疫性不育症的保护基因;免疫性不育症患者的中医证型肾阴不足型可能与DQA1*0401有关。  相似文献   

15.
目的:研究人类白细胞抗原(HLA)Ⅱ-DQA1、DQB1基因多态性与咳嗽变异型哮喘的相关性。方法:采用序列特异性引物聚合酶链反应的方法,对HLAⅡ-DQA1、DQB1进行基因分型,对无血缘关系的30例咳嗽变异型哮喘患者、32例典型支气管哮喘患者和33例健康人进行了HLAII-DQA1、DQB1基因型检测。结果:①3组间,典型支气管哮喘患者组HLA-DQA1*0201*0301*0501基因频率明显高于咳嗽变异型哮喘患者组与健康对照组(P〈0.05),而咳嗽变异型哮喘患者组与健康对照组之间无统计学意义(P〉0.05);咳嗽变异型哮喘患者组与典型支气管哮喘患者组HLA-DQA1*0302基因频率明显高于健康对照组(P〈0.05),但咳嗽变异型哮喘患者组与典型支气管哮喘患者组比较,咳嗽变异型哮喘患者组HLA-DQA1*0302基因频率明显低于典型支气管哮喘患者组(P〈0.05)。②咳嗽变异型哮喘患者组与典型支气管哮喘患者组HLA-DQB1*0301基因频率明显低于健康对照组(P〈0.05),咳嗽变异型哮喘患者组与典型支气管哮喘患者组之间无统计学意义(P〉0.05)。结论:本研究结果显示,咳嗽变异型哮喘与典型支气管哮喘一样,属多基因遗传疾病,在HLA-DQA1、DQB1等位基因表达上有共性,二者存在着部分相同的免疫遗传机制;但本研究结果同时显示,咳嗽变异型哮喘在HLA-DQA1等位基因的表达上与典型支气管哮喘又有所区别,其基因频率表达介于正常健康人与典型支气管哮喘患者之间,这为咳嗽变异型性哮喘与典型支气管哮喘在临床表现及治疗上的异同提供了免疫遗传依据,同时将为今后通过转基因彻底根治咳嗽变异型哮喘提供免疫遗传学依据。  相似文献   

16.
HLA-DQA1, -DQB1, and -DRB1 gene polymorphism were analyzed to study type 1 DM susceptibility in Malay patients from Southeast Asia (Malaysia and Singapore). Patients showed significant increases in the occurrence of DQA1*0501 (50.7% vs. 20.4%; RR = 3.97; Pc < 0.01), DQB1*0201 (48% vs. 19.1%; RR = 3.86; Pc < 0.05), and DRB1*0301 (38.7 vs. 6.8%; RR = 8.36; 95% Pc < 0.05). Conversely, significant decreases were noted in the occurrence of DQA1*0601 (14.7% vs. 35.2%; RR = 0.33; Pc = 0.008) and DQB1*0601 (4% vs. 23.5%; RR = 0.16; Pc < 0.05) in type 1 DM patients. Using a logistic regression model, we derived a risk prediction model for type 1 DM in our indigenous Malay population based on the identified HLA genotypes. The RR for type 1 DM increases by a factor of 5.68 for every unit increase in the number of DRB1*0301 allele (P < 0.001), and decreases by a factor of 0.18 per unit increase in the number of DQB1*0601 allele (P < 0.001). After adjusting for these two HLA genotypes, DQA1*0501, DQB1*0201 and DQA1*0601 were not statistically significant as risk predictors. The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles.  相似文献   

17.
Objective To investigate the association of the absence or presence of aspartic acid at position 57 of the HLA-DQ β chain (NA or A) with susceptibility or resistance to insulin-dependent diabetes mellitus (IDDM) in a Southern Chinese population.Methods Sixty-nine IDDM patients and 47 healthy controls in a Southern Chinese population were HLA-DQB1 genotyped by one-step sequence specific polymerase chain reaction (ssPCR).Results The frequencies of NA and A were 64.5% and 35.5% in the IDDM patients, and 40.4% and 59.6% in the control subjects respectively (RR for NA was 2.68, P<0.01). The frequencies of NA/NA, NA/A and A/A phenotypes were 47.8%, 33.3% and 18.8% in the IDDM patients, and 31.9%, 17.0% and 51.1% in the controls respectively (P<0.01). The frequency of A/A phenotype was significantly lower in the IDDM patients than in the control subjects (RR=0.22, P<0.01). DQB1* 0302 and DQB1* 0201 were more frequent in IDDM patients than in control subjects. The younger the age of IDDM onset, the higher the allele frequencies of DQB1* 0201 and DQB1* 0302.Conclusion The present study suggests that the NA confers the susceptibility to IDDM, while the A confers the protection against IDDM in patients of Southern Chinese origin. These associations are more clearcut in childhood-onset IDDM patients.  相似文献   

18.
目的:探讨HLA-DQA1-DQB1连锁基因单倍体与成人缓慢进展型1型糖尿病(SPIDDM)和速发型1型糖尿病(FPIDDM)的相关性。方法:采用PCR/SSP技术检测本组1型糖尿病中102例SPIDDM患者和130例FPIDDM患者频率。结果:①HLA-DQA1*0301-DQB1*0201和DQA1*0501-DQB1*0201连锁基因单倍体与SPIDDM(Pc〈0.001)和FPIDDM(Pc〈0.001)均呈显著正相关。②HLA-DQA1*0301-DQB1*0301和DQA1*0301-DQB1*0602连锁基因单倍体与SPIDDM呈显著正相关(Pc〈0.001)。③HLA-DQA1*0301-DQB1*0302、DQA1*0301-DQB1*0303及DRB1*0301-DQA1*0301-DQB1*0201连锁基因单倍体与FPIDDM呈显著正相关(均Pc〈0.05);DQA1*0102等位基因中SPIDDM组16例(15.69%);FPIDDM组10例(7.69%)(P〈0.05);DQA1*03基因SPIDDM组47例(46.08%),FPIDDM组79例(60.77%)(P〈0.05);DQB1*0601基因SPIDDM组10例(9.8%),FPIDDM组4例(3.08%)(P〈0.01)。结论:SPIDDM和FPIDDM虽然均为自身免疫性糖尿病,但其HLA表型并不完全相同,不同的HLA表型可能是决定患者起病方式及病情发展不同的因素之一。  相似文献   

19.
HLA alleles in patients with Guillain-Barre syndrome   总被引:1,自引:0,他引:1  
GuillainBarresyndrome(GBS)isacommonneurologicaldiseasewithcharacteristicsofflaccidparalysisTheetiologyofGBSisthoughttobedemyelinationandaxonaldamagesafterinfectionTheexactmechanismisstillunclearMolecularmimicryhypothesisofGBSisthemostcitedexplanationT…  相似文献   

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