HCV－Infektion und Viramie bei Patienten mit Posttransfusionshepatitis in China

ＨＣＶ－ＩｎｆｅｋｔｉｏｎｕｎｄＶｉｒａｍｉｅｂｅｉＰａｔｉｅｎｔｅｎｍｉｔＰｏｓｔｔｒａｎｓｆｕｓｉｏｎｓｈｅｐａｔｉｔｉｓｉｎＣｈｉｎａＴＡＮＧＺｈｅｎ－ｙａ（唐振亚）；ＹＡＮＧＤｏｎｇ－ｌｉａｎｇ（杨东亮）；ＹＵＺｈｉ－ｑｕｎ（喻埴群）；ＨＡＯ...     

Analysis of Plasma Fibrinolysis in the Patients with Acute Cerebral Infarction

ＡｎａｌｙｓｉｓｏｆＰｌａｓｍａＦｉｂｒｉｎｏｌｙｓｉｓｉｎｔｈｅＰａｔｉｅｎｔｓｗｉｔｈＡｃｕｔｅＣｅｒｅｂｒａｌＩｎｆａｒｃｔｉｏｎＺＨＡＮＧＹｉｎｇ－ｄｏｎｇ（张颖冬）；ＬＩＵＸｉ－ｍｉｎ（刘锡民）；ＣＡＩＺｈｕａｎ（蔡转）；ＹＡＮＧＭｉｎｇ－...     

Diagnostic and Therapeutic Radiological Intervention for Fallopian Tube Obstruction

ＤｉａｇｎｏｓｔｉｃａｎｄＴｈｅｒａｐｅｕｔｉｃＲａｄｉｏｌｏｇｉｃａｌＩｎｔｅｒｖｅｎｔｉｏｎｆｏｒＦａｌｌｏｐｉａｎＴｕｂｅＯｂｓｔｒｕｃｔｉｏｎＬＩＨｏｎｇｆａ（李红发）；ＬＩＨｏｎｇｘｉａ（李红霞）；ＹＥＨｕａｉｙｉｎｇ（叶怀英）；ＹＡＮＧＪ...     

Clinical Study on Jiang Tang San（降糖散）in Treating Non－Insulin Dependent Diabetes Mellitus Patiente

ＣｌｉｎｉｃａｌＳｔｕｄｙｏｎＪｉａｎｇＴａｎｇＳａｎ（降糖散）ｉｎＴｒｅａｔｉｎｇＮｏｎ－ＩｎｓｕｌｉｎＤｅｐｅｎｄｅｎｔＤｉａｂｅｔｅｓＭｅｌｌｉｔｕｓＰａｔｉｅｎｔｅＮＩＹａｎ－ｘｉａ（倪艳霞）；ＹＡＮＧＪｕｎ（杨军）；ＦＡＮＳｏｎｇ（樊嵩）ａ...     

Effect of Tetramethylpyrazine on Platelet Aggregation of Experimental Hyperlipoidemia Rabbits

ＥｆｆｅｃｔｏｆＴｅｔｒａｍｅｔｈｙｌｐｙｒａｚｉｎｅｏｎＰｌａｔｅｌｅｔＡｇｇｒｅｇａｔｉｏｎｏｆＥｘｐｅｒｉｍｅｎｔａｌＨｙｐｅｒｌｉｐｏｉｄｅｍｉａＲａｂｂｉｔｓＹＡＮＧＬｉｎ－ｈｕａ（杨林花）；ＳＨＥＮＤｉ（沈迪）；ＬＵＯＸｉａｎｇ（罗湘）；...     

ANTITUMOR ACTIVITY OF IMMUNOCONJUGATES COMPOSED OF BOANMYCIN AND MONOCLONAL ANTIBODY

ＡＮＴＩＴＵＭＯＲＡＣＴＩＶＩＴＹＯＦＩＭＭＵＮＯＣＯＮＪＵＧＡＴＥＳＣＯＭＰＯＳＥＤＯＦＢＯＡＮＭＹＣＩＮＡＮＤＭＯＮＯＣＬＯＮＡＬＡＮＴＩＢＯＤＹ￥ＺｈｅｎＹｏｎｇｓｕ；（甄永苏）；ＰｅｎｇＺｅ（彭泽）；ＤｅｎｇＹｏｎｇｃｈｕａｎ；（邓甬川）Ｘｕ...     

Study of HCV Infection and Viremia in Patients with Posttransfusion Hepatitis in China

ＳｔｕｄｙｏｆＨＣＶＩｎｆｅｃｔｉｏｎａｎｄＶｉｒｅｍｉａｉｎＰａｔｉｅｎｔｓｗｉｔｈＰｏｓｔｔｒａｎｓｆｕｓｉｏｎＨｅｐａｔｉｔｉｓｉｎＣｈｉｎａＴＡＮＧＺｈｅｎ－ｙａ；ＹＡＮＧＤｏｎｇ－ｌｉａｎｇ；ＹＵＺｈｉ－ｑｕｎ；ＨＡＯＬｉａｎ－ｊｉｅ（Ｃｌ...     

Study on the p53 Protein Expression in Gastric Cancer and Precancerous Lesions by Flow Cytometry

Ｓｔｕｄｙｏｎｔｈｅｐ５３ＰｒｏｔｅｉｎＥｘｐｒｅｓｓｉｏｎｉｎＧａｓｔｒｉｃＣａｎｃｅｒａｎｄＰｒｅｃａｎｃｅｒｏｕｓＬｅｓｉｏｎｓｂｙＦｌｏｗＣｙｔｏｍｅｔｒｙＨＡＯＹｉｎｇ（郝莹）；ＺＨＡＮＧＪｉｎｋｕｎ（张锦坤）ＹＩＣｕｉｑｉｏｎｇ（易粹琼）...     

Construction of Eukaryotic Expression Vector pBlacz and Its Expression Both in Vitro and In Vivo

（屈伸）（杨仕林）（尤颖健）（刘绍春）（何善述）ＣｏｎｓｔｒｕｃｔｉｏｎｏｆＥｕｋａｒｙｏｔｉｃＥｘｐｒｅｓｓｉｏｎＶｅｃｔｏｒｐＢｌａｃｚａｎｄＩｔｓＥｘｐｒｅｓｓｉｏｎＢｏｔｈｉｎＶｉｔｒｏａｎｄＩｎＶｉｖｏＱＵＳｈｅｎ；ＹＡＮＧＳｈｉｌｉｎ；Ｙ...     

Application of Anticancer Agent Embolism in Miles'Operation

ＡｐｐｌｉｃａｔｉｏｎｏｆＡｎｔｉｃａｎｃｅｒＡｇｅｎｔＥｍｂｏｌｉｓｍｉｎＭｉｌｅｓ＇ＯｐｅｒａｔｉｏｎＬＩＵＦｅｉ－ｌｏｎｇ（刘飞龙）；ＹＩＥＱｉ－ｆａ（叶启发）；ＹＡＮＧＣｈｕａｎ－ｙｕａｎ（杨传勇）；ＺＨＡＯＣｕｉ－ｌａｎｇ（赵翠兰）；Ｄａｉ...     

门脉高压性血管病变研究

采用免疫组化技术，辅以形态观察，研究３０例肝硬变患者胃冠状静脉的病理变化。发现其内膜受损，组织炎性水肿，中膜平滑肌增殖肥大，细胞外基质增多，管壁因而纤维化、硬化并增厚。表明肝硬变门静脉高压症可合并“门脉高压性血管病变。”     

介入断流术在门静脉高压症致上消化道出血治疗中的临床应用

目的:探讨经皮肝穿刺胃冠状静脉、胃短静脉栓塞术(GCVE)联合部分脾动脉栓塞术(PSAE)在门静脉高压症致上消化道出血治疗中的临床应用价值。方法:2004-01～2011-12我科共收治肝硬化门静脉高压合并急性食管胃底静脉曲张破裂出血患者40例。其中27例患者为消化内科经食管静脉套扎及硬化治疗内科对症治疗后再次出血,13例患者急诊行介入断流术。40例患者中A组25例行经皮肝穿刺胃冠状静脉、胃短静脉栓塞术后,病情稳定后再次行经股动脉穿刺部分脾动脉栓塞术。B组15例单纯行经皮肝穿刺胃冠状静脉、胃短静脉栓塞术。术前、术后分别采用多普勒超声检查门静脉侧支循环情况,对两组进行比较。结果 40例患者曲张出血静脉全部得到栓塞,A组25例患者门静脉管径变小,流速减低,流量下降,奇静脉内径变小,血流量下降,血流速度减低;脾功能亢进症状得到缓解。B组15例患者门静脉管径、血流速、血流量无明显改变,奇静脉内径变小,血流量下降,血流速度减低。40例患者胃冠状静脉超选择插管、栓塞成功。胃短静脉超选择栓塞成功95%。术后随访6～18个月,40例患者出血静脉完全栓塞,其中B组有2例患者2个月后再次出血,再次栓塞后无再出血。结论:经皮肝穿刺胃冠状静脉、胃短静脉栓塞术(GCVE)联合部分脾动脉栓塞术(PSAE)在门静脉高压症致上消化道出血治疗中操作简单,创伤小、止血效果肯定,在急诊止血方面更具有优势,尤其在肝功能较差难以耐受外科分流及断流手术的患者止血治疗中更具有临床应用价值。     

Immunohistochemical Analysis of Growth Factor Expression and Localization in Gastric Coronary Vein of Cirrhotic Patients

ＩｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌＡｎａｌｙｓｉｓｏｆＧｒｏｗｔｈＦａｃｔｏｒＥｘｐｒｅｓｓｉｏｎａｎｄＬｏｃａｌｉｚａｔｉｏｎｉｎＧａｓｔｒｉｃＣｏｒｏｎａｒｙＶｅｉｎｏｆＣｉｒｒｈｏｔｉｃＰａｔｉｅｎｔｓ￥ＹＡＮＧＺｈｅｎ；ＴＩＡＮＬｅｉ；Ｐ...     

双介入治疗肝硬化上消化道出血的临床观察

目的 探讨应用胃冠状静脉、胃短静脉栓塞术联合部分脾动脉栓塞术治疗肝硬化门静脉高压症上消化道出血的疗效.方法 27例肝硬化门静脉高压症并脾功能亢进患者,先行胃冠状静脉、胃短静脉超选栓塞,再行部分脾动脉栓塞,随访食管胃底静脉曲张变化程度,再出血情况、脾脏缩小程度及并发症等.结果 27例患者手术成功,食管胃底静脉曲张程度明显好转.结论 双介入栓塞术治疗门脉高压性食管胃底静脉曲张和脾功能亢进疗效确切,值得临床应用推广.     

胃冠状静脉栓塞联合脾栓塞治疗肝硬化消化道出血

目的 探讨经皮经肝胃冠状静脉栓塞(PTVE)联合选择性脾红髓小动脉栓塞(PSAE)治疗肝硬化消化道出血的疗效. 方法 26例肝硬化、门静脉高压并胃底静脉重度曲张出血的患者,经皮经肝穿刺门静脉,造影后找到胃冠状静脉、胃短静脉,并栓塞该静脉;再择期行选择性脾红髓栓塞,以降低门静脉压力、缓解脾功能亢进.并术后随访15月,同时胃镜复查. 结果 术后26例患者当时急性出血均被控制,术后造影示胃冠状静脉、胃短静脉闭塞,随访期间,22例(84.62％)患者上消化道出血症状消失,19例(73.08％)胃底静脉曲张完全消失,3例(11.54％)胃底静脉曲张复发,4例(15.38％)再发食道胃底破裂出血.但所有患者脾功能亢进症状均明显改善.结论 经皮经肝胃冠状静脉栓塞联合选择性脾红髓小动脉栓塞治疗肝硬化消化道出血,不但可以控制消化道出血,还可以降低门静脉压力,缓解脾功能亢进,且复发率低,长期疗效确切.值得推广.     

肝硬化非曲张静脉破裂出血与血清促胃液素、胃液酸度及门静脉内径关系探讨

目的　探讨肝硬化非曲张静脉破裂出血与血清促胃液素、胃液酸度及门静脉内径的关系。②方法采用放射免疫法测定血清促胃液素含量 ;胃酸直接滴定法测定胃液酸度 ;B型超声法测量门静脉内径。③结果肝硬化非曲张静脉破裂出血者血清促胃液素、胃液酸度及门静脉内径与对照组比较 ,差异有显著性 (t =2 .87～4.95 ,P <0 .0 1)。门静脉压力与胃液酸度存在负相关关系 (r=- 0 .712 ,P <0 .0 1)。④结论　血清促胃液素的升高并非是造成肝硬化非曲张静脉破裂的原因 ;门静脉压力的升高是导致非曲张静脉破裂出血的根本原因 ;即使低胃酸状态也会对胃黏膜屏障构成损害 ,故抑制胃酸治疗是必要的。     

特立加压素和垂体后叶素对肝硬化大鼠门脉压力及胃粘膜血流量的影响

为探讨特立加压素和垂体后叶素对肝硬化大鼠门脉压力、平均动脉压及胃粘膜血流量的影响，采用美国BIOPAC公司生产的MP100型多导生理记录仪测定肝硬化大鼠门脉压力和胃粘膜血流量，并观察给予特立加压素和垂体后叶素前后门压力及胃粘膜血流量的变化。发现特立加压素和垂体后叶素均可显著降低肝硬化大鼠门脉压力及胃粘膜血流量，但特立加压素对动脉压力的影响较垂体后叶素小，且降低胃粘膜血流量的速度快，结果表明特立加压素对于降低肝硬化门脉高压较垂体后叶素为优，对门脉高压性胃病的治疗具有一定的疗效。     

Intraoperative coronary venography in observing changes of portal blood flow after portal-azygos disconnection.

Intraoperative coronary venography was performed in 24 patients before and after portal-azygos disconnection for portal hypertension. Before the procedure the portal vein was found to be communicated with cardial and esophageal veins by two pathways, i,e., from the esophageal and gastric branches of the coronary vein to the esophageal varices, with the latter branches by way of the gastric intramural venula. The portal blood flow was postulated to be hepatofugal because the portal trunk could not be seen venographically. Coronary venography done after the disconnection revealed no pericardial and esophageal varices and the portal vein with hepatopetal blood flow. We conclude that the operation had the advantage of complete disconnection between the portal vein and the cardio-esophageal varices, thus preventing the bleeding from the varix and increasing hepatopetal blood flow.

     

Pathological morphology alteration of the splanchnic vascular wall in portal h ypertensive patients

目的：研究门静脉高压症患内脏血管壁的病理形态学改变。方法：50例门静脉高压症患在行脾切除和贲门周围血管离断术时,取脾动脉、静脉和胃冠状静脉,行光镜和电镜观察。免疫组化法分析脾动脉壁诱导型一氧化氮合成酶（iNOS）的表达。结果：脾动脉的内弹力膜和中膜内弹力纤维断裂和变性。脾动脉平滑肌细胞可见萎缩、凋亡和表型改变。平滑肌细胞的胞浆内可见iNOS阳性表达。肝硬化患可见内脏静脉内膜增生,静脉壁有广泛的附壁血栓,类粥样硬化斑块形成,平滑肌细胞肥大,静脉肌纤维明显增粗和增厚,管壁细胞外基质增加。结论：门静脉高压症可合并内脏动脉和静脉的血管病变,在门静脉高压症的发病机制中,门静脉高压、内脏高动力循环和内脏血管病变之间具有相互影响的关系。     

Changes in serum ammonia concentration in cirrhotic patients with Helicobacter pylori infection

Objective To study whether liver cirrhosis associated with Helicobacter pylori (H. pylori) infection will induce increased serum ammonia and whether the peripher al serum ammonia reflects the level of portal vein serum ammonia. Methods Blood was taken from the portal vein and the cubital vein in cirrhotic patients with and without H. pylori infection and non-cirrhotic patients (splenic rupture) with and without H. pylori infection, and the serum ammonia was measured.Results The mean levels of serum ammonia in the group of cirrhotic patients with H. pylori infection were 167.82±8.97 μmol/L (portal vein) and 142.2±13.35 μmol/L (cubital vein). They were increased significantly as compared with cirrhotic patients without H. pylori infection (47.68±12.03 μmol/L portal vein and 37.23±7.04 μmol/L cubital vein), and also compared with the groups of splenic rupture patients with and without H. pylori infection ( P &lt;0.01). There was no significant difference between the serum ammonia level of the cubital vein and portal vein (P&gt;0.05).Conclusions H. pylori infection can induce an increase in serum ammonia in patients with liver dysfunction, and the peripheral serum ammonia measurement may replace the portal vein serum ammonia as a monitoring method. Eradication of H. pylori in cirrhotic patients may prevent hepatic encephalopathy (HE).