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1.
目的:观察前列地尔联合丹红注射液治疗早期糖尿病肾病的临床效果。方法将67例早期糖尿病肾病患者随机分为3组,常规组22例行常规治疗,前列地尔组21例为前列地尔注射液加常规治疗,联合组24例为前列地尔与丹红注射液加常规治疗。疗程2周,并监测尿微量白蛋白、β2微球蛋白、血尿素氮、肌酐。结果前列地尔组及联合治疗组尿微量白蛋白、β2微球蛋白在治疗后明显下降,与常规治疗组比较差异有统计学意义(P<0.01);联合组与前列地尔组比较,差异有统计学意义(P<0.01)。结论前列地尔联用丹红注射液可明显降低早期糖尿病肾病患者的尿白蛋白,防止病情进展。  相似文献   

2.
缬沙坦联合灯盏花素治疗糖尿病肾病64例临床观察   总被引:1,自引:0,他引:1  
目的观察缬沙坦联合灯盏花素对糖尿病肾病的疗效。方法将64例糖尿病肾病患者分为对照组和治疗组,在糖尿病治疗方案的基础上,比较缬沙坦联合灯盏花素与香丹注射液对尿微量白蛋白排泄率和血B2微球蛋白的影响。结果缬沙坦联合灯盏花素可使尿微量白蛋白排泄率显著下降(P〈0.05),同时血液高凝状态也有明显改善(P〈0.05)。结论缬沙坦联合灯盏花素对糖尿病肾病有明显疗效。  相似文献   

3.
目的观察前列地尔联合阿魏酸钠治疗糖尿病肾病的疗效。方法收集70例糖尿病肾病患者,并将其分成常规治疗组和联合治疗组。在常规降糖治疗的基础上,常规治疗组加用前列地尔,联合治疗组加用前列地尔和阿魏酸钠,经过3个月的治疗,观察治疗前后两组患者相关指标的变化。结果常规治疗组和联合治疗组治疗后尿微量白蛋白、尿总蛋白、血肌酐均明显降低,与治疗前比较差异有统计学意义(P〈0.001),治疗后尿蛋白变化与常规治疗组比较差异也有统计学意义(P〈0.05)。结论前列地尔联合阿魏酸钠治疗糖尿病肾病有确切疗效,能明显减少尿白蛋白的排出,值得在临床推广。  相似文献   

4.
目的:观察褪黑素与缬沙坦联合治疗2型糖尿病早期肾病的临床疗效。方法:选择2型糖尿病早期肾病患者60例,均维持原有抗糖尿病药物控制高血糖,饮食、活动量不变,将患者随机分为两组,常规治疗组应用缬沙坦80mg/d,联合治疗组用缬沙坦80mg/d,同时加用褪黑素10mg/d。应用6个月后观察两组患者肾功能及24h尿微量白蛋白的变化。结果:6个月后,两组患者24h尿微量白蛋白均有降低,联合治疗组较单缬沙坦治疗组24h尿白蛋白降低更明显,两组比较差异显著(P〈0.05)。结论:褪黑素与撷沙坦联合治疗2型糖尿病早期肾病安全、有效,可以更好地降低24h尿微量白蛋白,延缓糖尿病早期肾病的进程。  相似文献   

5.
沈元丽  陈凯 《中原医刊》2011,(2):124-125
目的观察百令胶囊联合缬沙坦胶囊治疗糖尿病肾病的疗效。方法将80例糖尿病肾病患者随机分为对照组40例和治疗组40例,两组患者在良好控制血糖、血压基础上,治疗组给予百令胶囊5糊次,3次/d,口服,缬沙坦胶囊80~160mg/d,口服;对照组单用缬沙坦胶囊,80~160mg/d,口服,共12周;治疗前后观察24h尿蛋白定量、血浆白蛋白(ALB)、尿β2微球蛋白(β2-MG)指标。结果治疗组与对照组比较,24h尿蛋白定量降低(P〈0.01),血浆白蛋白明显升高(P〈0.05),尿(β2-MG)明显降低(P〈0.05)。结论百令胶囊联合缬沙坦胶囊治疗糖尿病肾病能明显的减少蛋白尿,升高血浆白蛋白。  相似文献   

6.
目的:探讨阿魏酸钠联合缬沙坦治疗对糖尿病肾病患者血浆内皮素(ET)、一氧化氮(NO)、尿白蛋白排泄率(UAER)的影响。方法将123例糖尿病肾病患者随机分为阿魏酸钠治疗组(A 组)、缬沙坦治疗组(B 组)、阿魏酸钠+缬沙坦联合治疗组(C 组),测定3组治疗前后血浆 ET、NO 及 UAER 的变化。结果 A组、B 组、C 组治疗前各项指标差异无统计学(P 〉0.05);A 组、B 组治疗后血浆 ET 和 UAER 较治疗前均降低(P 〈0.05),血浆 NO 较治疗前均升高(P 〈0.05),C 组血浆 ET 和 UAER 较治疗前明显降低(P 〈0.01),血浆NO 较治疗前明显升高(P 〈0.01)。结论阿魏酸钠联合缬沙坦治疗可有效降低糖尿病肾病患者血浆 ET、UAER,升高 NO,对治疗糖尿病肾病有一定的作用。  相似文献   

7.
目的探讨前列地尔联合缬沙坦治疗早期糖尿病肾病的临床疗效。方法回顾性分析我院68例早期糖尿病肾病患者,随机分为观察组和对照组。在常规治疗的同时,对照组服用缬沙坦,观察组采用前列地尔联合缬沙坦进行浩疗。治疗时间为2周,比较二组患者的尿素氮、血肌酐和24h尿微量白蛋白等指标。结果观察组患者血肌酐和24h尿微量白蛋白的结果明显优于对照组,统计结果差异有统计学意义(P〈0.05)。结论前列地尔联合缬沙坦疗法是一种安全、有效的早期糖尿病肾病治疗方法,值得临床应用推广。  相似文献   

8.
张文学 《中国乡村医生》2010,12(18):136-137
目的:探讨以滋阴补肾、活血祛瘀法治疗早期糖尿病肾病的治疗效果及作用机制。方法:采用随机对照方法,将符合标准的60例患者分为治疗组和对照组相。治疗组30例基础治疗、血管紧张素受体拮抗剂(缬沙坦)加益肾合剂,对照组30例基础治疗加血管紧张素受体拮抗剂(缬沙坦)。治疗前经过4周调整阶段,以后8周为1个治疗疗程。以临床症状、血脂、脂蛋白α、糖化血红蛋白、尿微量白蛋白、尿β2微球蛋白等为观察指标。结果:益肾合剂不仅可明显改善早期糖尿病肾病患者的临床症状,而且可明显降低患者脂蛋白α、糖化血红蛋白、尿微量白蛋白、尿β2微球蛋白。结论:益肾合剂能显著改善早期糖尿病肾病患者血脂、尿微量白蛋白、尿β2微球蛋白异常,能较好地保护肾功能。说明益肾合剂治疗早期糖尿病肾病疗效可靠,值得进一步研究。  相似文献   

9.
尿微量蛋白联合检测在糖尿病肾病诊断中的意义   总被引:1,自引:0,他引:1  
目的 探讨尿微量蛋白检测在糖尿病性肾病诊断中的价值。方法 应用时间分辨荧光免疫分析技术测定糖尿病患者及糖尿病肾病患者尿微量白蛋白(Alb),β2微球蛋白(β2-MG),尿Tamm-Horsfall蛋白(THP),尿免疫球蛋白(IgG)含量。结果 无肾病的糖尿病患者尿Alb、β2-MG,THP、IgG变化不明显(p〉0.05);糖尿病肾病早期(尿白蛋白阴性)Alb、β2-MG、THP、IgG有明显升高(P〈0.05);糖尿病肾病尿白蛋白阳性(肾功能不全)患者的Alb、β2-MG、THP、IgG明显高于其他两组(p〈0.01)。结论 尿微量蛋白检测在糖尿病肾病早期尿白蛋白阴性时,就可以判定糖尿病肾脏受损程度,为早期诊断糖尿病肾病提供可靠依据。  相似文献   

10.
目的观察凯时注射液(前列腺素E1脂微球载体制剂)治疗早期糖尿病肾病的临床疗效。方法根据24h尿白蛋白的排泄率(UAER)将84例2型糖尿病早期肾病患者分成常规治疗组和加用凯时治疗组。结果联用凯时治疗组24h尿白蛋白明显减少(P〈0.01)。凯时注射液治疗早期糖尿病肾病疗效良好。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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