养肝益水颗粒对高血压病早期肾损害尿微量蛋白影响

目的观察养肝益水颗粒对原发性高血压早期肾损害患者尿微量蛋白[尿微量白蛋白（MA）、转铁蛋白（TRF）、免疫球蛋白G（IgGu）、α1-微球蛋白（α1-MG）、β2-微球蛋白（β2-MG）]的影响。方法将60例患者随机分为治疗组、对照组各30例,2组均给予西医常规降压治疗,治疗组加服养肝益水颗粒,疗程均1个月。观察治疗前后尿微量蛋白指标的变化。结果2组治疗后MA、TRF、IgGu、α1-MG、和β2-MG均显著下降（P〈0.01）,且治疗后治疗组MA、α1-MG、β2-MG与对照组比较差异有统计学意义（P〈0.01-0.05）。结论在西医治疗基础上加服养肝益水颗粒可更有效减少原发性高血压早期肾损害患者尿微量蛋白的排泄。     

尿微量蛋白检测对儿童过敏性紫癜的意义

目的探讨过敏性紫癜（HSP）患儿肾损害早期诊断的实验室指标。方法对53例多次尿常规检查正常的HSP患儿通过检测尿免疫球蛋白（IgG）、尿微量白蛋白（MA）、尿液转铁蛋白（TRF）、尿α1微球蛋白（α1-MG）、尿β2微球蛋白（β2-MG），同时检测血尿素氮（BUN）肌酐（Scr）。结果53例多次尿常规检查正常的HSP患儿，尿高分子量蛋白（IgG、MA、TRF）检测异常者占73．58％。尿低分子量蛋白（α1-MG、β2-MG）检测异常者占75．47％。尿微量蛋白（IgG、MA、TRF、α1-MG、β2-MG）5项指标综合检测异常者占86．79％。结论尿微量蛋白是早期诊断HSP肾损害的良好指标。尿微量蛋白（IgG、MA、TRF、α1-MG、β2-MG）5项指标综合检测，因其检测简易、安全、费用少，可作为临床早期诊断、早期治疗、早期干预治疗以降低肾损伤程度的依据。     

尿微量蛋白在原发性高血压肾损害早期诊断中的意义

目的:探讨尿微量蛋白在诊断原发性高血压早期肾损害的意义.方法:选取原发性高血压Ⅰ、Ⅱ期患者( EHⅠ、EHⅡ)及正常健康人(对照组),采用免疫速率散射比浊法检测其尿液中微量白蛋白(MA)、转铁蛋白(TRF)、α1-微球蛋白(α1-MG)和免疫球蛋白G(IgG)的含量.结果:与正常对照组比较,原发性高血压Ⅰ期组尿MA、TRF、α1-MG均明显升高(P<0.05),而尿IgG无显著差异;原发性高血压Ⅱ期组尿MA、TRF、α1-MG显著升高(P<0.01),尿IgG明显升高.结论:尿微量蛋白的测定是发现早期肾损害的敏感指标.     

尿微量蛋白在早期糖尿病肾病中的诊断意义

目的探讨尿微量白蛋白（MA）、尿转铁蛋白（TRF）、尿β2-微球蛋白（β2-MG）和尿α1-微球蛋白（α1-MG）在糖尿病肾病早期诊断中的意义。方法采用免疫比浊法测定82例2型糖尿病患者及80名健康人24h尿中MA、TRF、β2-MG、α1-MG含量,比较四者在糖尿病肾病筛选中的价值。结果糖尿病病程小于5年组,尿24hα1-MG、β2-MG含量与健康对照组相比明显增加;糖尿病病程5～10年组,尿24hMA、TRF、β2-MG和α1-MG含量与健康对照组相比明显增加;在尿微量白蛋白正常的糖尿病患者中,尿24hTRF、β2-MG和α1-MG含量增高的百分比分别为29.23%,50.77%,61.54%。结论糖尿病肾病早期肾小球和肾小管都有-定程度的损害,尿TRF、β2-MG和α1-MG较尿MA出现更早,测定尿TRF较尿MA更敏感,测定尿TRF、α1-MG、β2-MG和MA,有助于全面评估糖尿病肾病（DN）的肾损害,早期诊断DN。     

尿微量蛋白在原发性高血压肾损害早期诊断中的意义

目的 :探讨尿微量蛋白在诊断原发性高血压早期肾损害的意义。方法 :选取原发性高血压 、 期患者 (EH 、EH )及正常健康人 (对照组 ) ,采用免疫速率散射比浊法检测其尿液中微量白蛋白 (MA)、转铁蛋白 (TRF)、α1 -微球蛋白 (α1 - MG)和免疫球蛋白 G(Ig G)的含量。结果 :与正常对照组比较 ,原发性高血压 期组尿 MA、TRF、α1 -MG均明显升高 (P<0 .0 5 ) ,而尿 Ig G无显著差异 ;原发性高血压 期组尿 MA、TRF、α1 - MG显著升高 (P<0 .0 1) ,尿Ig G明显升高。结论 :尿微量蛋白的测定是发现早期肾损害的敏感指标     

尿微量蛋白联合检验在高血压肾损害中的检验价值探究

目的:探讨分析尿微量蛋白联合检验在高血压肾损害中的检验价值.方法:将我院2015年3月至2016年11月收治的96例原发性高血压患者作为研究对象,按照原发性高血压诊断标准将其分为观察组、研究组和治疗组,观察组为Ⅰ期患者,研究组为Ⅱ期患者,治疗组为Ⅲ期患者,并选取本院体检健康患者作为对照组,每组各为24例,比较四组患者的尿尿转铁蛋白(TRF)、α1微球蛋白(α1-MG)及尿微量白蛋白(MA)水平.结果:观察组、研究组和治疗组TRF、α1-MG及MA水平均有一定的提高,其中观察组患者α1-MG水平显著高于对照组(P<0.05),比较差异有显著性;研究组和治疗组TRF、α1-MG及MA水平均明显高于对照组(P<0.05),比较差异有显著性.结论:尿微量蛋白联合检验对高血压肾损伤能显著提高阳性率的检测,值得在临床上应用推广.     

尿微量蛋白和血β2微球蛋白测定在高血压患者早期肾损害中的意义

目的 研究尿微量蛋白和血β2微球蛋白测定在高血压患者早期肾损害中所起的作用.方法对350例高血压患者和150例正常对照者,采用散射比浊法检测2组的尿微量ALB、TRF、α1-MG、VIgG、β2-MG进行分析比较.结果 正常对照组ALB为(7.01±2.58)mg/L,TRF为(1.21±0.25)mg/L,α1.MG为(8.53±1.87)mg/L,UIgG为(6.23±1.32)mg/L.,血β2-MG为(0.08±0.02)mg/L;观察组(即高血压患者组)ALB为(23.45±5.15)mg/L,TRF为(1.54±0.19)mg/L,α1-MG为(15.79±4.26)mg/L,UIgG为(13.52±2.87)mg/L,血肛β2-MG为(0.79±0.12)mg/L.两组之间差异有统计学意义.结论 α1-MG、ALB及血β2-MG为高血压病早期肾损害的敏感指标,与高血压分级呈正相关.     

脑外伤尿微量蛋白变化与GCS评分的关系

目的：评价脑外伤患者尿微量蛋白测定的临床意义。方法：根据GCS评分将急性脑外伤患者分为特重型组、重型组、中型组、轻型组，检测尿α1-微球蛋白(α1-MG)，微量白蛋白(MA)，转铁蛋白(TRF)和免疫球蛋白G(IgG)。结果：相关分析显示，α1-MG、MA、TRF和IgG与GCS均呈负相关。应用多元逐步回归分析法显示，α1-MG和IgG值与GCS计分值密切相关。结论：脑伤后早期尿α1-MG，MA，TRF和IgG检测可作为脑外伤程度诊断的辅助指标，对诊断脑外伤与肾损害的程度有一定参考价值。     

检测尿微量蛋白对高血压早期肾损害的评估

目的探讨尿微量蛋白在高血压早期对肾损害的临床意义.方法本文采用免疫速率散射比浊法对152例高血压病人尿液中微白蛋白(MA)、转铁蛋白(TRF)、α1-微球蛋白(α1-MG)和IgG进行检测,结果显示,α1-MG在高血压早期就有明显改变(P＜0.01)随着病情的进展,其它三项指标也呈不同程度的改变.结论尿微量蛋白的检测,可较早的反映高血压患者早期肾功能的损害,在临床上具有一定的预防及诊治意义.     

尿微量蛋白在糖尿病早期肾损害中的临床应用

目的 :探讨尿蛋白定性阴性的糖尿病肾病 (DN)患者随机尿中三种微量蛋白检测对发现糖尿病早期肾损害的意义。方法 :尿微量白蛋白 (MA)、α1-微球蛋白 (α1-MG)和转铁蛋白 (TRF)用速率散射比浊法 ,尿肌酐 (Cr)采用Jaffe比色法进行测定。结果 :尿蛋白定性阴性的DN组尿MA/Cr为(3.4 10± 2 .36 6 )mg/mmol ,TRF/Cr为 (0 .342± 0 .2 72 )mg/mmol,α1-MG/Cr为 (3.2 0 6± 2 .75 1)mg/mmol,对照组MA/C为 (0 .713± 0 .12 6 )mg/mmol,TRF/Cr为 (0 .137± 0 .0 84 )mg/mmol,α1-MG/Cr为 (0 .915± 0 .36 6 )mg/mmol。两组比较具有极显著性差异 (P <0 .0 1)。结论 :尿MA、TRF及α1-MG可作为发现糖尿病早期肾损害敏感而又可靠的常规指标。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.