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1.
高金波 《黑龙江医学》2021,45(19):2127-2128
药物性牙龈增生主要指的是由于服用药物所引起的牙龈体积增大和牙龈增生,对于药物性牙龈增生的发病机制尚不清楚.本研究主要针对诱发药物性牙龈增生诱发的炎症、胶原合成降解等方面展开叙述,为药物性牙龈增生发病机制的研究提供相应的参考意义.  相似文献   

2.
参麦对环孢霉素A急性肾毒性的影响   总被引:1,自引:1,他引:0  
目的 观察参麦对环孢霉素A所致肾小管细胞毒性损伤的影响。方法利用体外培养的环孢霉素A中毒模型,测定细胞培养上清液LDH活性及参麦对环孢霉素A中毒后肾小管细胞增殖活性的影响。结果环孢霉素A中毒细胞胞浆内出现空泡变性,细胞增殖活性明显降低,上清液LDH活性明显升高。参麦可明显减轻环孢霉素抑制细胞增殖的作用,上清液中LDH活性明显降低。结论参麦可对抗环孢霉素A的肾毒性作用,促进损伤的肾小管上皮细胞增生。  相似文献   

3.
目的探讨环孢霉素A处理对大鼠横断脊髓cdk4表达的影响.方法成年SD大鼠分SCT组(T9横断),和SCT后给予环孢霉素A处理组.每组13只动物.动物于环孢霉素A处理7 d后处死,其中每组5只用免疫组化染色确定cdk4在脊髓的定位分布,另8只动物用RT-PCR技术确定cdk4在损伤脊髓的表达变化.结果与手术组比较(0.99±0.11),环孢霉素A处理(1.12±0.15)导致cdk4在损伤脊髓的表达明显上调(P〈0.05);免疫组化染色显示cdk4主要分布在脊髓灰质神经元.结论环孢霉素A处理能有效上调损伤脊髓cdk4表达水平,提示环孢霉素A发挥免疫抑制作用可能与cdk4的调节有关.  相似文献   

4.
姚向超  王延东  梁光江 《当代医学》2011,17(27):151-152
目的探讨环孢霉素A在眼科中的应用,以供临床参考。方法分析环孢霉素A在眼科干眼病、防止翼状胬肉复发、角膜移植以及带状疱疹引起的角膜炎的应用效果,对环孢霉素A进行研究,总结其药物应用。结果环孢霉素A在眼科干眼病、防止翼状胬肉复发、角膜移植以及带状疱疹引起的角膜炎的应用效果均较为显著,患者不良反应较少,疗效较好,安全性较高。临床应用时可采用滴眼液、脂质体、眼膏等制剂。结论环孢霉素A在眼科中的应用范围较为广泛,如何研制新的载体材料,减少其毒副作用,是该药物研究的方向。  相似文献   

5.
目的探讨环孢霉素A处理对脊髓损伤大鼠后肢骨骼肌RAF-1 mRNA表达的影响.方法成年SD大鼠分SCT组(T9横断),和SCT后给予环孢霉素A处理组.脊髓横断组用环孢霉素A处理(1 mg/200 g)7 d后处死动物.取后肢骨骼肌用免疫组化染色(n=5)确定RAF-1 mRNA在后肢骨骼肌的定位分布.RT-PCR技术检测RAF-1 mRNA在损伤脊髓大鼠后肢骨骼肌的表达变化(n=8).结果与手术组比较(0.95±0.13),环孢霉素A处理(0.75±0.14)导致RAF-1 mRNA在损伤脊髓大鼠后肢骨骼肌的表达明显下调(P〈0.05);RAF-1蛋白产物主要分布在细胞浆.结论环孢霉素A处理能有效下调脊髓损伤大鼠后肢骨骼肌RAF-1 mRNA表达水平.  相似文献   

6.
环孢霉素A作为一种免疫抑制剂,在临床上广泛应用在移植排斥反应的预防和治疗等.环孢霉素A已有报告不仅有免疫抑制作用,还作用于脑下垂体、副肾皮质、睾丸、胰岛等内分泌器官,并可以影响这些器官的功能.环孢霉素A作用在生殖系统中,可以减少睾丸重量以及性辅助器官的重量,精子数量的减少,导致异常精子的形成,精子超微结构的改变等,还可以降低血清睾酮水平等.  相似文献   

7.
环孢霉素A在移植过程中是一种很重要的药物,但并非尽善尽美。在明尼阿波利斯的明尼苏达大学附属医院外科教授和主任John Najarian说,环孢霉素A可使好的移植方案更好,但是不能使不好的移植方案奏效。他的中心是美国4个中心之一,正在对环孢霉素A进行临床试验。他在全国肾基金会的讨论会上回顾了肾移植中用环孢霉素A的经验后,作出对环孢霉素A的评述。  相似文献   

8.
目的:对神经钙蛋白抑制剂引起的头痛综合征进行分类,并探讨神经钙蛋白抑制剂对脑微血管细胞(H BM EC)NO合成的影响。背景:报道1例环孢霉素A引起头痛的病例。神经钙蛋白抑制剂可影响肾脏NO的代谢,而NO在紧张型头痛和偏头痛中起一定的作用。本研究旨在了解神经钙蛋白抑制剂是否对H BM EC中NO的代谢产生影响。设计和方法:回顾性评估74例因器官移植而接受环孢霉素A和他克莫司治疗的头痛综合征患者。进行培养后,进一步研究环孢霉素A和他克莫司对大脑微血管内皮细胞NO产量的影响。结果:74例接受肝、肺或骨髓移植的患者在行移植手术后的1…  相似文献   

9.
目的评价环孢霉素A治疗支气管哮喘的疗效.方法将39例支气管哮喘患者随机分为两组,治疗组给环孢霉素A口服,对照组给予地塞米松常规治疗,治疗前后观察患者肺活量(VC)及1秒钟用力呼气容积(FEV1)的变化.结果两组患者在治疗前VC及FEV1无显著差异,而治疗后则有.结论环孢霉素A是治疗支气管哮喘的安全有效药物.  相似文献   

10.
目的比较康力龙和环孢霉素A治疗重型再生障碍性贫血的临床疗效,为临床选择有效的治疗方法提供依据。方法采用临床疗效观察的方法,对6例重型再生障碍性贫血进行康力龙治疗,4例采用环孢霉素A治疗,观察其疗效状况。结果采用环孢霉素A治疗的有效率为75%,采用康力龙的治疗有效率为33.33%,差异具有统计学意义(P<0.05)。结论对于重型再生障碍性贫血的治疗,环孢霉素A治疗的有效率明显优于康力龙,值得推广。  相似文献   

11.

Objective

A calcium antagonist, nifedipine, causes gingival overgrowth as a side effect. It has been confirmed that the Japanese traditional medicine, Saireito, inhibits the nifedipine-induced proliferation of gingival fibroblasts in vitro. We performed an in vivo experiment to determine whether Saireito has a therapeutic use in the treatment of nifedipine-induced gingival overgrowth.

Methods

The rats had significant gingival overgrowth induced by the administration of nifedipine. The space between the submandibular incisors and the width of buccal gingiva of maxillary left first molar were macroscopically measured. The buccal gingiva was microscopically examined.

Results

Eight weeks after Saireito was administrated together with nifedipine, Saireito decreased both the incisor space and the gingiva width which had been enlarged by nifedipine and furthermore, the area of connective tissue of nifedipine + Saireito group was significantly smaller than that of nifedipine alone.

Conclusion

In conclusion, Saireito may be clinically effective in therapy for calcium antagonist-induced gingival overgrowth.  相似文献   

12.
Some kinds of drugs such as calcium (Ca(2+)) channel antagonists, antiepileptics and immunosuppressants cause gingival overgrowth as a side effect, the mechanism of which is still unclear. We have examined the effects of isradipine, one of the dihydropyridine-derivative Ca(2+) channel antagonists, on cultured human gingival fibroblast Gin-1 cells. In the present study, to elucidate the mechanism by which isradipine causes gingival overgrowth, we examined whether tyrosine kinase (TK) and phopholipase Cgamma (PLCgamma) are involved in the isradipine-induced proliferation of gingival fibroblasts. Herbimycin A (1 microM) remarkably inhibited the isradipime (10 microM)-induced proliferation. Both U73122 (5 microM), a PLCgamma inhibitor, and xestospongin C (5 microM), an antagonist of a receptor of inositol 1,4,5-trisphosphate in Ca(2+) stores, significantly reduced the [Ca(2+)]i raised by isradipine (10 microM). Thus, the findings obtained here indicate that TK and PLCgamma are closely involved in the isradipine-induced [Ca(2+)]i rise to elicit gingival overgrowth.  相似文献   

13.
目的研究吸烟对钙拮抗剂致牙龈增生的牙周非手术治疗的影响。方法对18例因钙拮抗剂致牙龈增生患者进行牙周非手术治疗,分别选取吸烟组(58个位点)与非吸烟组(46个位点)患者的多个位点观察菌斑指数(PLI)、龈沟出血指数(SBI)、牙龈增生指数(GO)、附着丧失(AL)和探诊深度(probing depth,PD),分析吸烟对治疗效果的影响。结果治疗前,吸烟组SBI明显小于非吸烟组(P<0.05),PD、PLI、GO、AL的差异无统计学意义;治疗后,吸烟组与非吸烟组PLI、PD、SBI较治疗前均有减少,且差异有统计学意义(P<0.05);未吸烟组的改变量明显高于吸烟组,且差异有统计学意义(P<0.05)。结论非吸烟组钙拮抗剂致牙龈增生患者的牙周非手术治疗效果好于吸烟组。  相似文献   

14.
目的研究MMP1基因单核苷酸多态(-1607)1G/2G与环孢素诱导牙龈增生(CsA-GO)发生风险的关系。方法以聚合酶链反应和限制性片段长度多态性(PCR-RFLP)分析方法,分别检测42例环孢素诱导牙龈增生病人和118位正常对照者MMP1(-1607)1G/2G多态的基因型;以Logistic回归模型计算不同基因型与环孢素诱导牙龈增生风险的关系。结果环孢素诱导牙龈增生病例组的MMP1(-1607)3种基因型频率分布与对照组无显著差异(P=0.37)。携带MMP1(-1607)2G基因型者发生环孢素诱导牙龈增生的风险比携带1G基因型者高1.38倍(95%CI=0.81-2.36,P=0.24),而1G基因型与环孢素诱导牙龈增生风险无关。结论 MMP1基因启动子区(-1607)1G/2G单核苷酸多态性可能并非环孢素诱导牙龈增生的遗传易感因素,携带2G基因型的患者发生CsA-GO的风险有增高趋势。  相似文献   

15.
Objective:To investigate the effect of nifedipine(calciumchannel blocker)on the expression of collagen in gingival fibroblasts invitro.Methods:Primarily gingival fibroblasts were cultured and incubated with various concentrations of nifedipine(108μg/L,360μg/L and 1200μg/L)for 5 days.Gingival fibroblasts were primarily cultured derived from nifedipine responders and non-responders in the presence of 360μg/L nifedipine.Enzyme-linked immunosorbent assay was used to evaluate the amount of type I collagen.Cell proliferation was measured by cell counting with evaluating MTT value.Results:The expressions of collagen and cell proliferation were significantly different among the high concentration groups and the others on the fifth day,especially higher in 360μg/L and 1200μg/L groups and also different among nifedipine responders and non-responders.Conclusion:The expression of collagen and cell proliferation may be concerned with the biological mechanism for gingival overgrowth.  相似文献   

16.
应用排龈技术获取精细模型   总被引:1,自引:0,他引:1  
目的:应用排龈技术获取更加清晰的印模及模型,为以后制作代型及精确修复提供基础。方法:对57例门诊患者行冠桥修复时,于备牙前预排龈,取印模前排龈膏再排龈。结果:94.15%的模型颈缘及肩台可被明显分辨。结论:该方法可减少牙体预备时对牙龈组织的损伤,并可获得精细模型,为提高冠边缘密合性提供了可能。  相似文献   

17.
As it was reported earlier that isradipine, a Ca superset 2+ antagonist of dihydropyridine derivative class, caused regression of nifedipine-induced hyperplasia of human gingiva, experiments were performed to examine whether or not isradipine would solely inhibit the proliferation of cultured gingival fibroblasts. Normal human gingival fibroblast Gin-1 cells were used to test the impact of this medication. Fibroblast proliferation in the presence of isradipine (10 microM) was examined by using the reagent water-soluble tetrazolium-1 (WST-1). The level of basic fibroblast growth factor (bFGF) in the cell-free supernatant of each well was determined by using an enzyme-linked immunosorvent assay (ELISA) kit. The production of type I collagen was assayed by ELISA. Isradipine significantly enhanced the cell proliferation from the second day of the culture period. Also, isradipine raised the level of bFGF in the culture medium. The same concentration, also significantly enhanced the production of type I collagen. In conclusion, we were able to prove that isradipine causes the proliferation of cultured gingival fibroblasts as well as other dihydropyridine-derivative Ca superset 2+ antagonists do. In order to prevent the gingival overgrowth, it is advisable to be very careful in the use of isradipine as a therapy for hypertension and other indications.  相似文献   

18.
目的 研究整合素α2(ITGA2)基因+807位基因多态性与环孢素诱导牙龈增生(CsA-GO)发生风险的关系.方法 以聚合酶链反应和限制性片段长度多态性(PCR-RFLP)分析方法,分别检测99例CsA-GO患者和101例正常对照者ITGA2(+807)C/T多态的基因型,以Logistic回归模型计算不同基因型与CsA-GO风险的关系.结果 两组ITGA2(+807)CC、CT及TT3种基因型差异有统计学意义(P<0.01);C为CsA-GO的高风险位点,带有C位点的患者发生CsA-Go的风险是T位点患者的3.61倍(GR=3.61,95%CI=2.14~6.10).结论 ITGA2基因+807单核苷酸多态是CsA-GO的遗传易感因素.  相似文献   

19.
使用CM型氢气微分析仪,对37例肝硬化腹水及3例血吸虫性肝病伴腹水作氢气呼吸法葡萄糖试验,并与30例正常成人的检测结果进行列照,目的是测定小肠细菌过度生长。结果9例阳性,发生率为22.5%。经使用抗生素后转阴。分析肝硬化腹水并发小肠细菌过度生长的机理。及时诊断及治疗,不仅可增强患者对营养物质的吸收,而且能防止可能由肠道细菌引起的严重感染及并发症。  相似文献   

20.
以往口腔医学生临床前期实习使用模型的牙龈部分用无弹性的石膏制作,不能很好地模拟患者口腔内的真实情况,影响了学生对口腔修复学理论的理解和基本技能的训练,是教学中一个亟待解决的难题。采用弹性人工牙龈材料改进了实习模型,解决了这个问题,有效地提高了学生的实际操作能力。此方法对口腔修复学及其他口腔修复学科实习教学均有帮助,值得推广。  相似文献   

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