试探中药注射剂的品质与安全性

中药注射剂是中医临床治疗危急重症的一种较好的速效剂型。目前,中药注射剂的质量和疗效还存在一些问题,有待解决。随着中药注射剂在临床的广泛应用,安全性问题越来越突出。解决中药注射剂的安全性问题极为迫切。     

试探中药注射剂的品质与安全性

中药注射剂是中医临床治疗危急重症的一种较好的速效剂型。目前，中药注射剂的质量和疗效还存在一些问题，有待解决。随着中药注射剂在临床的广泛应用，安全性问题越来越突出。解决中药注射剂的安全性问题极为迫切。     

中药注射剂安全性问题的相关探讨

目的 针对目前临床使用中药注射剂发生的安全问题进行总结分析,找出与安全性问题相关的因素并提出相应的解决措施.方法 选取我院接收的使用中药注射剂治疗疾病的患者456例,回顾性分析患者的临床资料,总结导致安全性问题的相关因素并提出相应的解决措施.结果 过敏反应和胃肠道不良反应是临床上常见的中药注射剂引发的不良反应类型,引发安全性问题的因素主要有五点,分别是研发、生产、运输、使用及监督管理.结论 只有充分了解中药注射剂引发安全性问题的相关因素及原因,才能制定更为合理科学的防范措施,达到更为显著的防治效果,解决好中药注射剂安全问题才能有效的保障患者的生命健康安全,临床价值高,值得推广应用.     

利用免疫芯片技术筛查中药注射剂致敏成分

中药注射剂的安全性问题已引起社会的广泛关注。建立分析确认从中药注射剂中分离过敏成分的方法,以及相应的特异性诊断方法,是中药注射剂需要解决的一个重要方法学问题。提出了利用免疫芯片技术从中药注射剂多组分体系中,鉴定、判断及分离寻找小分子半抗原或致敏成分的新思路。     

关于中药注射剂安全性问题的探讨

随着中药注射剂在临床上的广泛使用，其安全性问题已经成为近年来国内外关注的焦点。总结了近年来关于中药注射剂安全性问题的相关文献，总结并提出了“用好药，好好用药”的新观点，为中药注射剂安全性评价工作的推广提供新的思路和方法。     

中药注射剂安全性的技术思考

中药注射剂的安全性依然是业界关心的重大问题。从分析中药注射剂的不良反应特点及中药作用物质基础的特点入手,认为中药注射剂的疗效主要来自小分子,而大分子成分可能是导致中药注射剂不良反应的主要原因,并建议中药注射剂要加强大分子杂质检查和监控,以增强安全性。     

中药注射剂发展问题的思考

近年来中药注射剂的发展面临着很大的问题,中药注射剂的安全性问题引起了社会广泛的关注,中药注射剂未来发展过程中亟待解决的问题值得我们思考,本文从中药注射剂自身存在的问题出发,探讨怎样应对中药注射剂发展中所遇到的问题.     

中药注射剂安全性的分析与思考

中药注射剂安全性是社会关注的热点问题,正确认识中药注射剂不良反应,将能避免社会民众产生误解或认识错位。目前中药注射剂的生产原料、生产工艺以及突出安全性的质量监控是影响中药注射剂安全性的关键所在,针对各品种临床存在的问题,加强中药注射剂安全性的基础研究,在说明书明确临床药物配伍及使用规范,强化相关物质、不溶性微粒、热原、过敏物质等注射剂安全性质控,确实保证中药注射剂用药安全。      

中药注射剂安全性研究现状

简要介绍中药注射剂安全性研究的分类及研究方式,根据研究现状指出目前中药注射剂安全性研究存在的缺陷和问题,提出中药注射液安全性研究的研究思路及应对措施。     

关于中药注射剂研究开发及安全性问题的思考

中药注射剂是我国独具特色的剂型,在临床治疗中发挥了独特的作用,但由于质量问题或临床使用不科学,几乎所有中药注射剂都出现过不良反应报道,多个品种出现严重不良反应,使中药注射剂安全性问题成为了民众最关注的话题之一。分析阐述了中药注射剂研究开发现状、临床使用及不良反应情况,并从我国政策法规、立项思路及安全性应对对策3个方面为今后中药注射剂研究开发提供思路。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.