Treatment of respiratory failure in metastatic pulmonary choriocarcinoma: an experience at Peking Union Medical College Hospital, China

Background  Respiratory failure caused by metastatic pulmonary choriocarcinoma usually develops rapidly and is associated with a high mortality. The clinical management strategy is important in choriocarcinoma patients with acute respiratory failure. The objective of this study was to evaluate the clinical characteristics, treatment outcome and potential risk factors in patients with acute respiratory failure from metastatic pulmonary choriocarcinoma.

Methods  Sixteen patients with acute respiratory failure from pulmonary metastases choriocarcinoma were enrolled and treated at Peking Union Medical College Hospital from 1995 to 2010. Clinical characteristics, causes of pulmonary failure, treatment profiles and outcomes were analyzed retrospectively.

Results  The presence of respiratory infection or hemorrhage was associated with acute respiratory failure in patients with metastatic choriocarcinoma. Fifteen (93.8%) patients presented with pulmonary infection, 8 (50.0%) patients with pulmonary hemorrhage. All patients were treated with face mask or mechanical ventilation. Fourteen (87.5%) patients received initial chemotherapy at a low dosage or with modified regimens, with a median of 2 cycles (range 1 to 4). Seven patients achieved a complete remission (CR), two had a partial remission. Six CR patients remained alive with a median follow-up of 59 months (range 16 to 120). Seven patients developed progressive diseases and subsequently died.

Conclusions  Respiratory infection and hemorrhage were associated with acute respiratory failure in metastatic pulmonary choriocarcinoma. The initial administration of gentle chemotherapy regimens, accompanied with mechanical ventilation, is feasible and effective in attenuating respiratory failure in patients with metastatic pulmonary choriocarcinoma.

     

A single institution, retrospective study of treatment experience in primary mediastinal germ cell tumors: elucidating the significance of systemic chemotherapy

Background  Primary malignant germ cell tumors (GCTs) of mediastinum are rare neoplasms. We introduce our institutional experience in managing patients with primary malignant GCTs of the mediastinum, focusing on the analysis of therapeutic modalities.

Methods  A retrospective review was done in 39 consecutive patients with mediastinal malignant GCTs treated in our institution between 1991 and 2007.

Results  A total of 39 patients were enrolled in this study with a median age of 27 years. The 5-year overall survival (OS) and progression-free survival (PFS) rates of the whole population were 60.2% and 57.7%, respectively. Stratified by the histology, 18 patients (46.2%) had seminoma and 21 patients (53.8%) had nonseminomatous germ cell tumors (NSGCTs). The 5-year OS rate of patients with seminoma was 87.4% as compared with 36.7% in patients with NSGCTs (P=0.0004). The 5-year PFS rate was also significantly higher in seminoma patients (87.4% vs. 31.6%, P=0.003). For 19 patients with NSGCTs managed with multi-modality treatment, chemotherapy exposure appeared to impact the prognosis. The 5-year OS rate was 44.9% in patients with chemotherapy exposure as compared with 20.0% in patients without it (P=0.43).

Conclusion  Our study confirmed the significance of systemic chemotherapy in the treatment of primary mediastinal GCTs.

     

Congenital quadricuspid aortic valve: analysis of 11 surgical cases

Background  Congenital quadricuspid aortic valve is rarely seen during aortic valve replacement (AVR). The diagnosis and treatment of the disease were reported in 11 cases.

Methods  Eleven patients (nine men and two women, mean age 33.4 years) with quadricuspid aortic valve were retrospectively evaluated. Medical records, echocardiograms and surgical treatment were reviewed.

Results  In accordance with the Hurwitz and Roberts classification, the patients were classified as type A (n=2), type B (n=7), type F (n=1) and type G (n=1). Three patients were associated with other heart diseases, including infective endocarditis and mitral prolaps, left superior vena cava, aortic aneurysm. All had aortic regurgitation (AR) except two with aortic stenosis (AS), detected by color-flow Doppler echocardiography. The congenital quadricuspid aortic valve deformity in seven patients was diagnosed by echocardiography. All patients underwent successful aortic valve replacement.

Conclusion  Quadricuspid aortic valve is a rare cause of aortic insufficiency, while echocardiography plays an important role in diagnosing the disease. Aortic valve replacement is the major therapy for the disease.

     

Radical treatment strategies improve the long-term outcome of recurrent atypical meningiomas

Background  Atypical meningioma is one of the rare subtypes of meningioma, which is lacking of optimal consensus on treatment strategies. This study aimed to investigate the radical treatment strategies to improve the long-term outcome of recurrent atypical meningiomas.

Methods  The prognostic factors including the age and gender of patients; the location, histology, recurrence pattern and mitotic cell rate of the tumors; and the resection extents, surgical strategies and adjuvant therapies of 15 cases of recurrent atypical meningiomas were analyzed retrospectively.

Results  The age and gender of patients were not associated with tumor recurrence. However, high recurrence rates and poor prognosis for atypical meningiomas were associated with the high mitotic cell rate, failure to achieve Simpson grade I-II resection, and without the dura and bone flap replacement intraoperatively. Post-operative radiotherapy improved the outcomes of tumors in patients after the second surgery.

Conclusion  Radical treatment strategies such as dura and bone flap replacements and radiotherapy should be considered in patients diagnosed with atypical meningiomas.

     

Application of echocardiography in resynchronization treatment of heart failure patients

Objective  To review the updated research progress about the application of echocardiography in resynchronization treatment of chronic heart failure patients.

Data sources  The data used in this review were from PubMed, published in English and using the key terms “heart failure”, “echocardiography” and “cardiac resynchronization therapy”.

Study selection  Relevant articles were reviewed and selected to address the stated purpose.

Results Increasing numbers of studies have suggested the importance of echocardiography in resynchronization treatment of chronic heart failure patients. Echocardiography can evaluate atrioventricular, inter- and intra-ventricular mechanical dyssynchrony before cardiac resynchronization therapy (CRT), as a guidance to assess the optimal left ventricular (LV) pacing location, optimize the atrioventricular and interventricular delays and predict response to CRT.

Conclusions  Echocardiography is both non invasive and easily repeatable, and plays a crucial role in appraisal of heart synchronism, instruction of actuator placement, optimization of the device procedure, and prediction of the response to CRT.

     

Effect of periodontal treatment on glycosylated hemoglobin levels in elderly patients with periodontal disease and type 2 diabetes

Background  Periodontal disease is closely related to type 2 diabetes and is an important complication of diabetes. This study aimed to investigate the effect of periodontal treatment on levels of blood glucose (Glu) and glycosylated hemoglobin (HbA1c) among elderly patients with type 2 diabetes and periodontal disease.

Methods  A total of 107 elderly patients with type 2 diabetes and periodontal disease were selected and divided into two groups according to their HbA1c levels. Group A was a well-controlled diabetic group and group B was uncontrolled. Their probing depth (PD), attachment loss (AL), the value of Glu and HbA1c were analyzed before periodontal treatment and 4 months later.

Results  There was a significant difference in periodontal condition between groups A and B (P <0.01). The periodontal condition for both groups was significantly (P <0.01) improved after periodontal therapy. The effect of treatment in group A was more pronounced than group B, and the difference was significant (P <0.01). After the periodontal treatment, Glu and HbA1c were reduced significantly in both groups (P <0.05).

Conclusions  Periodontal condition is related to the control of Glu level among elderly patients with type 2 diabetes and periodontal disease. Periodontal treatment can effectively reduce the level of Glu and HbA1c as well as improve the periodontal condition in elderly type-2 diabetes patients with periodontal disease.

     

Expression of interleukin-2 in Candidal balanoposthitis and its clinical significance

Background  Candidal balanoposthitis (CB) is a common male genital infection. Autoimmune mechanisms may play an important role in the pathogenesis of CB. Interleukin-2 (IL-2) is an important molecule in cell-mediated immunity.

Methods  One hundred and one patients were diagnosed with CB using mycology culture in the dermatology and urology clinics in our hospital. Ninety-four healthy males were randomly selected as controls. We studied serum levels of IL-2 of patients with CB using ELISA and analyzed the correlations between serum IL-2 and clinical data.

Results  Serum IL-2 concentrations in CB patients were significantly lower than that in the control group ((7.80±4.78) vs. (15.44±7.90) ng/L; t=2.27, P <0.05). The incidence of CB in the low-level group was significantly higher than that in the high-level group (70% (71/101) vs. 36% (30/84), P <0.05). Low levels of serum IL-2, comorbidity with other sexually transmitted diseases (STDs), and sexual partners with vulvovaginal candidiasis (VVC) increased the risk of CB.

Conclusion  The pathogenesis of CB is a complex procedure that includes internal autoimmune factors.

     

Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure

Background  Impaired exercise capacity is one of the most common clinical manifestations in patients with chronic heart failure (CHF). The severity of reduced exercise capacity is an indicator of disease prognosis. The aim of the current study was to investigate the association between left heart size and mass with exercise capacity.

Methods  A total of 74 patients were enrolled in the study, with 37 having congestive heart failure (left ventricular ejection fraction (LVEF) <0.45) and the other 37 with coronary heart disease (by coronary angiography) serving as the control group (LVEF >0.55). Echocardiography and cardiopulmonary exercise test were performed. The multiply linear regression model was used to evaluate the association between echocardiogrphic indices and exercise capacities.

Results  The study showed that left ventricular end diastolic / systolic diameter (LVEDD/LVESD), left atrial diameter (LAD) and left ventricular mass index (LVMI) were significantly enlarged in patients with chronic heart failure compared with controls (P <0.01). The VO₂AT, Peak VO₂, Load AT, and Load Peak in chronic heart failure patients were also significantly reduced compared with controls (P <0.05), VE/VCO₂ slope was increased in patients with chronic heart failure (P <0.01). Multivariate linear regression analysis indicated that the patients’ exercise capacity was significantly associated with the left heart size and mass, however, the direction and/or strength of the associations sometimes varied in chronic heart failure patients and controls. Load AT correlated negatively with LVEDD in chronic heart failure patients (P=0.012), while Load AT correlated positively with LVEDD in control patients (P=0.006). VE/VCO₂ slope correlated positively with LAD (B=0.477, P <0.0001) in chronic heart failure patients, while the VE/VCO₂ slope correlated negatively with LAD in control patients (P=0.009).

Conclusion  The study indicates that the size of LVEDD and LAD are important determinants of exercise capacity in patients with CHF, which may be helpful to identify exercise tolerance for routine monitoring of systolic heart failure.

     

A multi-center, double-blind, randomized, parallel group study to evaluate the effects of two different doses of losartan on morbidity and mortality in Chinese patients with symptomatic heart failure intolerant of angiotensin converting enzyme inhibitor treatment

Background  There have been no mortality/morbidity endpoint studies with losartan in Chinese heart failure patients. The objective was to evaluate the effects of high-dose vs. low-dose losartan on clinical outcomes in Chinese subjects with heart failure.

Methods  This study was a post hoc analysis of the Heart failure Endpoint evaluation of Angiotensin II Antagonist losartan (HEAAL) trial (n=545). Chinese adults with symptomatic heart failure (New York Heart Association (NYHA) II–IV) intolerant of treatment with angiotensin converting enzyme (ACE) inhibitors were randomized to losartan 150 mg or 50 mg daily. The primary endpoint was the composite event rate of all-cause death or hospitalization for heart failure. Safety and tolerability were assessed.

Results  Median follow-up was 4.8 years. Baseline characteristics were generally similar to the overall HEAAL cohort. Overall, 120 (44.1%) subjects in the losartan 150 mg group and 137 (50.2%) subjects in the losartan 50 mg group died (any cause) or were hospitalized for heart failure (hazard ratio (OR) 0.807, 95% CI 0.631–1.031). There were no notable differences between treatment groups in the proportion of subjects with adverse experiences.

Conclusion  The results of this post hoc analysis in Chinese subjects, although not powered to show significance, were generally consistent with the main study results, which demonstrated a significantly reduced risk of all cause death or hospitalization for heart failure with daily losartan 150 mg vs. losartan 50 mg in subjects with symptomatic heart failure and intolerance to ACE inhibitors, supporting the use of the higher dose for optimum clinical benefit.

     

Cryoglobulinemia is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients

Background  Mixed cryoglobulinemia (MC) is one of the most common and severe symptoms in chronic hepatitis C patients. The aim of this study was to investigate whether mixed cryoglobulinemia is a factor associated with sustained virological response in chronic hepatitis C patients treated with combination therapy of pegylated interferon alpha-2a and ribavirin.

Methods  This is a single-center study including 57 chronic hepatitis C patients who received combination treatments of pegylated interferon alfa-2a and ribavirin. Serum cryoglobulin was detected by cryoprecipitation prior to treatment. Serum hepatitis C virus (HCV) RNA levels were checked before treatment, during the fourth and 12th week of treatment, and during the 24th week after cessation of treatment. The genotype of HCV was determined at baseline. Logistic regression analysis was used to assess the factors associated with sustained virological response.

Results  Twenty-five patients were with MC (43.9%). Twenty-four weeks after cessation of antiviral treatment, sustained virological response achievement in MC⁺ patients was significantly lower than that in MC^- patients (32.0% vs. 75.0%, P=0.001). Univariate Logistic regression analysis and multivariate Logistic regression analysis found that only MC (odds ratio: 6.375; 95% CI: 1.998–20.343, P=0.002) was negatively associated with sustained virological response achievement.

Conclusion  MC is an independent factor negatively associated with sustained virological response in chronic hepatitis C patients treated with pegylated interferon alpha-2a and ribavirin.

     

头孢曲松联合匹多莫德对血清固定梅毒病人的效果

目的观察研究头孢曲松联合匹多莫德对血清固定的梅毒病人的治疗效果。方法 59例血清固定的梅毒病人随机分为实验组31例和对照组28例,实验组给予头孢曲松2.0 g静脉滴注,每日1次,连用15 d,同时口服匹多莫德口服液800 mg,每日1次,连用15 d。对照组单用头孢曲松2.0 g静脉滴注,每日1次,连用15 d。治疗后3、6个月复查快速血浆反应素环状卡片试验滴度并判断疗效。结果治疗后3个月两组疗效比较差异无显著性(P>0.05)。治疗后6个月,两组疗效比较差异有显著性(u=2.02,P<0.05)。结论头孢曲松联合匹多莫德治疗血清固定的梅毒病人具有良好的效果。     

Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre,Malawi, 2000–2004

Objectives

We aimed to evaluate socio-demographic factors associated with HIV and syphilis seroreactivity in pregnant Malawians presenting for antenatal care in late third trimester of pregnancy.

Methods

Between December 2000 and March 2004 at Queen Elizabeth Central Hospital Blantyre, Malawi, we collected cross-sectional clinical and socioeconomic data from consenting women. HIV-1 status was determined using rapid HIV antibody tests and syphilis seroreactivity was determined using Rapid Plasma Reagin (RPR) and confirmed with Treponema pallidum hemagglutination assay (TPHA).

Results

Of 3,824 women screened for HIV, 1156 (30%) were HIV seropositive and 198 (5%) were RPR and TPHA seroreactive. In the multivariate analysis, HIV infection was positively associated with elevated socio-economic status, being formerly married, and age, but not with education level. HIV prevalence was lower in women of Yao ethnicity than in other women (OR: 0.78, 95%CI: 0.64 – 0.95). Increased maternal education was negatively associated with syphilis seroreactivity.

Conclusions

The seroprevalence of HIV and syphilis among women attending the antenatal ward in Blantyre remains unacceptably high. Demographic correlates of HIV and syphilis infections were different. Our results demonstrate the need for better strategies to prevent HIV and syphilis in women and calls for optimizing antenatal syphilis screening and treatment in Malawi.     

梅毒血清固定患者外周血中Th17/Treg细胞、Foxp3和ROR-γt的表达水平及相关性研究

目的 通过检测梅毒血清固定患者外周血Th 17/Treg细胞比例及其特异性转录因子叉头状转录因子3(Foxp3)和维甲酸相关核孤儿受体(ROR-γt)的mRNA表达水平以及相关的细胞因子水平,探讨其与梅毒血清固定免疫机制的关系.方法 采集60例梅毒血清固定患者(观察组)和60例健康对照者(对照组)的外周血,分离单一核细胞(PBMCs),采用流式细胞仪检测Th17和Treg细胞比例;提取总RNA,采用实时荧光定量PCR(QRT-PCR)法检测Foxp3和ROR-γt的mRNA表达水平;采用ELISA法测定PBMCs上清液中IL-17和转化生长因子-β(TGF-β)水平.结果 观察组外周血中的Treg细胞比例[(9.68±1.54)％]、Foxp3的mRNA[(2.85±0.16)％]和TGF-3[(275.15±20.89) pg/ml]的表达水平明显高于对照组[(5.96±1.27)％、(1.96±0.14)％、(156.33 ±41.49) pg/ml];观察组中的Thl7细胞比例[(1.13±0.31)％]、ROR-γt的mRNA[(0.98±0.16)％]和IL-17的表达水平[(12.21 ±4.73) pg/ml]明显低于对照组[(1.98±0.17)％、(1.85±0.15)％、(18.98±6.89) pg/ml],差异有统计学意义(P＜0.05).结论 外周血中Treg和Th17细胞比例的变化、Foxp3和ROR-γtmRNA表达水平的异常与梅毒血清固定的免疫机制相关,梅毒血清固定患者可能存在Treg/Th17的失衡,且向Treg细胞漂移.     

Impact of HIV/sexually transmitted infection testing on risky sexual behaviors among men who have sex with men in Langfang, China

Background Men who have sex with men (MSM) in China remain at high risk for HIV infection,the proportion of reported HIV/AIDS cases that occurred among MSM rose greatly from 2005 to 2011.HIV testing an...     

深圳市南山区MSM个体性网络大小对感染梅毒的影响

目的了解深圳市男男性行为者(men who have sex with men,MSM)个体性网络大小及其对感染梅毒的影响,为男男性行为者采取干预措施降低梅毒感染风险提供新的视角。方法 2014—2016年深圳市南山区慢性病防治院采用外展干预和男同彩虹门诊相结合的方式对男男性行为者开展匿名自填式问卷调查,收集男男性行为者基本人口学、行为学、性网络特征及梅毒知识知晓情况,开展HIV、梅毒检测,通过卡方检验、Logistic回归探索该人群性行为、性网络与梅毒的相关性。结果共调查429名男男性行为者,梅毒检测阳性率9.1%。平均年龄(27.2±5.8)岁;汉族占98.1%;文化程度大专以上占70%;户籍是外省的占一半以上;约50%在深圳居住时间在半年以内;梅毒预防知识知晓率较低,仅70.2%。个体性网络大小做单因素分析,年龄(P=0.009)、文化程度(P=0.012)、在深居住时间(P=0.002)、最近6月与男性发生肛交时安全套的使用情况(P=0.041)、梅毒知识知晓情况(P=0.047)均与最近6月个体性网络大小情况有统计学意义。梅毒感染单因素分析文化程度、最近6月个体性网络大小、最近6月与男性发生肛交时安全套使用情况与感染梅毒有统计学意义;多因素分析显示个体性网络大小为15人以上(adjusted OR=3.383,95%CI=0.997~23.030)是感染梅毒的危险因素;最近6月与男性发生肛交时每次使用安全套(adjusted OR=0.059,95%CI=0.011~0.305)是感染梅毒的保护因素。结论 MSM人群是梅毒的一个易感人群,感染梅毒会增加感染HIV的风险,预防HIV和梅毒需同步。性网络作为传播HIV/STI桥梁的同时也是预防的关键,通过性网络建立同伴健康教育干预方法是预防性病的重要措施。     

HIV infection among new synthetic drug abusers: a pilot study in Beijing

Background  Following the increased human immunodeficiency virus (HIV) notification (infection) rates via sexual transmission and increased abuse of new synthetic drugs instead of heroin in China, a study on HIV infections and risk factors among synthetic drugs and heroin users in Beijing was conducted to provide a cue for further development of targets and strategies of HIV/AIDS control and prevention for different drug populations.

Methods  A total of 428 subjects including 224 heroin users and 204 new synthetic drug users was recruited from communities in Beijing by convenience sampling. A c² test was used to compare HIV and syphilis infections between the two subpopulations. Logistic regression models were used to evaluate factors related to HIV, syphilis infections and abuse of synthetic drugs.

Results  Unbalanced distributions of demographics were detected between the two subpopulations. Compared with heroin users, most users of synthetic drugs were migrants, single and of younger age (age £30 years). Ten HIV infections and twenty-four syphilis infections were confirmed among 428 subjects. No significant difference in HIV infection was found between the two subpopulations (crude odds ratio (OR) =0.46, 95% confidence interval (CI): 0.07–15.80 and adjusted odds ratio (AOR) =1.26, 95% CI: 0.09–18.28) while four times as many syphilis infections were identified among users of synthetics drugs (AOR=3.92, 95% CI: 1.06–14.56). HIV and syphilis infections appeared to work synergistically. The migrants who were of Han ethnicity, single and who had stayed in Beijing for more than six months were more likely to abuse synthetics drugs.

Conclusions  The new synthetic drug users and heroin users are different subpopulations. We optimistically speculate that HIV has not yet been introduced into the former in Beijing, but considering higher syphilis infections in synthetic drug users and the role of syphilis in HIV infection, synthetic drug users, as a possible and important driver of the HIV/AIDS epidemic in Beijing, should be paid more attention in HIV prevention and control strategies.

     

南京地区HIV/AIDS患者一线抗病毒治疗失败相关因素分析

目的: 分析南京地区人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者一线抗病毒治疗失败的危险因素,提前预警以降低一线治疗的失败率。方法：回顾性分析2016年1月至2019年9月在南京市第二医院感染科门诊启动一线抗病毒治疗并随访至2020年3月的HIV/AIDS患者基线人口学和随访资料,在此期间有耐药基因检测证实一线抗HIV治疗失败、更换含有洛匹那韦/利托那韦（LPV/r）的免费二线方案患者为治疗失败组,以同期病毒持续抑制患者作为对照,通过 Logistic 回归分析治疗失败的相关危险因素。结果：纳入的1 739例HIV/AIDS患者中有44例（2.5%）因病毒学失败更换含LPV/r的二线治疗方案。基线CD4⁺ T淋巴细胞计数<200个/μL (OR=13.105,95% CI：5.025~34.176)和基线病毒载量≥1×10⁵ 拷贝/mL (OR=2.491,95% CI：1.210~5.128)是一线治疗失败的危险因素;一线治疗失败与性别、年龄、婚姻状况、体重指数、传播途径、从确诊到治疗间隔时长、是否有基本医疗保险无关。结论：一线治疗失败的发生与低基线CD4⁺ T淋巴细胞计数和高基线病毒载量有关,具有危险因素的患者需重点关注。     

IL-15、IL-18、IL-21和NK细胞在梅毒血清固定患者外周血中的含量及临床意义

目的： 探讨梅毒血清固定患者外周血IL-15、IL-18、IL-21和NK细胞变化及其临床意义。方法： 选取2018年10月至2020年9月徐州医科大学附属连云港医院皮肤性病科收治的梅毒血清固定患者24例为血清固定组,24例健康体检者为健康对照组。应用流式细胞仪检测两组外周血NK细胞水平,采用双抗体夹心ELISA法检测两组外周血IL-15、IL-18、IL-21。检索全网数据库,纳入有关NK细胞与梅毒血清固定相关性且符合既定标准的研究,进行Meta分析。结果： 梅毒血清固定组外周血IL-18、IL-21水平和NK细胞百分比显著低于健康对照组（P均＜0.05）,两组IL 15水平差异无统计学意义（P=0.173）。Meta分析显示与健康对照组相比,血清固定患者外周血NK细胞百分比明显减低［SMD=-0.64,95%CI（-1.08,-0.21）,P＜0.001］。结论： 梅毒血清固定患者外周血IL-18、IL-21和NK细胞水平降低,可能与血清固定的形成相关,有望成为血清固定诊断的辅助指标。     

Health-related attitudes and risk factors for sexually transmitted infections of Chinese women who have sex with women

Background  Previous studies have shown evidence of health-related risk behaviors among women who have sex with women (WSW), such as sex with men, multiple bisexual partners, and drug use. Women who have sex with women have also been known to avoid routine physical examinations and conceal their same-sex history from physicians, which can affect their ability to receive an accurate diagnosis and treatment. No previous research has targeted women who have sex with women in China. We sought to describe women who have sex with women in China and explore risk factors for their reproductive tract infections (RTI)/sexually transmitted infections (STI).

Methods  Participants were recruited through outreach in venues and online for a cross-sectional study. Data were collected using interviews and laboratory tests.

Results  We recruited 224 women who have sex with women. In the year preceding their participation in the study, 92% (206/224) of women reported sexual relations with women. The RTI rates were: gonorrhea (15.8%), chlamydia (3.5%), syphilis (0.5%), bacterial vaginosis (14.4%), hepatitis B virus (HBV) (0.9%), hepatitis C virus (HCV) (0.5%), and candidiasis (6.9%). No HIV or herpes simplex virus (HSV) positive cases were detected. Factors associated with gonorrhea infection were non-Beijing local residency (odds ratio (OR)=2.1, 95% confidence interval (CI): 1.2–3.8) and genital-genital contact (OR=3.1, 95% CI: 1.3–7.2); factors associated with curable STI (excluding bacterial vaginosis, candidiasis, HBV and HCV) were non-Beijing local residency (OR=1.9; 95% CI: 1.2–3.0) and bleeding during or after sex (OR=18.1; 95% CI: 5.2–62.6); and the factor associated with RTI (including all the infections tested) was bleeding during or after sex (OR=37.8, 95% CI: 11.2–127.4).

Conclusions  Behaviors that may cause RTI/STI exist among Chinese women who have sex with women. Researchers should consider these behaviors when planning corresponding prevention and interventions.

     

277例梅毒患者规范驱梅后血清TRUST转阴影响因素分析

目的探索梅毒患者血清TRUST转归的影响因素。方法对2011年4月—2014年6月深圳市南山区慢性病防治院首次确诊及治疗并随访24个月的277例梅毒患者进行调查,使用Cox比例风险回归模型分析梅毒患者血清TRUST转归的影响因素。结果不同性别、年龄、婚姻、文化程度和是否合并HIV感染的梅毒患者血清TRUST转阴情况之间差异均无统计学意义(P0.05);不同诊断分期和初始TRUST滴度梅毒患者转阴情况之间差异均有统计学意义(P0.05)。Cox比例风险回归模型分析结果显示:一期梅毒患者比隐性梅毒患者血清TRUST更易转阴(RR=3.04,95%CI:1.95~4.73;P0.05),初始TRUST滴度≤1∶8患者比滴度1∶8患者血清TRUST更易转阴(RR=2.34,95%CI:1.40~3.91;P0.05)。结论梅毒的诊断分期和初始血清TRUST滴度是影响梅毒预后的独立影响因素。