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1.
目的观察多孔磷酸三钙填塞植骨加支持钢板手术治疗塌陷型胫骨平台骨折的疗效。方法分析采用多孔磷酸三钙填塞植骨加支撑钢板手术治疗的25例塌陷型胫骨平台骨折患者的临床资料。全部病例术前均行X线正侧位摄片、CT扫描及三维重建,以准确了解骨折的塌陷和粉碎程度及骨折碎片的翻转方向。凡骨折塌陷〉5mm,且伤前无关节退行性变者,均作为该手术方法的适应证。结果除1例Ⅱ度开放性骨折发生切口浅表感染外,其余患者伤口均Ⅰ期愈合。术后X线片显示所有骨折均达到解剖复位或接近解剖复位。经6个月~3年(平均1.8年)的X线片和功能随访,维持解剖复位者21例(占84%);按Merchant评分标准评定膝关节功能优良22例(88%)。结论多孔磷酸三钙填塞植骨加支撑钢板手术治疗塌陷型胫骨平台骨折能有效避免复位后的再丢失,改善远期疗效;多孔磷酸三钙作为骨移植替代材料,具有良好的临床应用前景。  相似文献   

2.
目的观察复合骨形态发生蛋白(BMP)-2纳米人工骨辅助锁定支撑钢板手术治疗骨质疏松性AO-C型桡骨远端骨折的疗效。方法采用复合BMP-2纳米人工骨辅助锁定支撑钢板手术治疗骨质疏松性桡骨远端骨折患者18例。全部患者在术前均行X线正侧位摄片,以明确骨折的塌陷和粉碎程度以及骨折碎片翻转的方向。按照骨折AO分型标准,C型骨折作为该手术方法的适应证。结果术后X线片示,所有骨折均达到解剖复位或接近解剖复位。按照Gartland和Werley评分,优14例,良4例,优良率为100%。上肢功能评分为0~30分,平均为(6±1)分。所有患者随访6个月~2年,平均随访(12±6)个月。随访时X线片显示,在术后8~18周后均获骨性愈合,完全骨代替。平均愈合时间为(12±3)周。植入骨被完全吸收,被新生骨替代,骨缺损处均得到满意修复,达到临床愈合,人工骨与周围骨组织接触良好,无骨溶解、骨折延期愈合或不愈合,无异物、免疫排斥反应发生。所有患者术后均未出现高热、皮疹等过敏反应。伤口全部愈合,无红肿、渗液等不良反应,心电图及生化指标未因植入物而发生异常变化。结论复合BMP-2纳米人工骨辅助支撑钢板手术治疗骨质疏松性桡骨远端骨折可有效避免复位后骨量再丢失,改善远期疗效;复合BMP-2纳米人工骨作为骨移植替代材料,具有良好的临床应用前景。  相似文献   

3.
目的 观察复合骨形态发生蛋白(BMP)-2纳米人工骨辅助锁定支撑钢板手术治疗骨质疏松性AO-C型桡骨远端骨折的疗效.方法 采用复合BMP-2纳米人工骨辅助锁定支撑钢板手术治疗骨质疏松性桡骨远端骨折患者18例.全部患者在术前均行X线正侧位摄片,以明确骨折的塌陷和粉碎程度以及骨折碎片翻转的方向.按照骨折AO分型标准,C型骨折作为该手术方法的适应证.结果 术后X线片示,所有骨折均达到解剖复位或接近解剖复位.按照Gartland和Werley评分,优14例,良4例,优良率为100%.上肢功能评分为O~30分,平均为(6±1)分.所有患者随访6个月~2年,平均随访(12±6)个月.随访时X线片显示,在术后8~18周后均获骨性愈合,完全骨代替.平均愈合时间为(12±3)周.植入骨被完全吸收,被新生骨替代,骨缺损处均得到满意修复,达到临床愈合,人工骨与周围骨组织接触良好,无骨溶解、骨折延期愈合或不愈合,无异物、免疫排斥反应发生.所有患者术后均未出现高热、皮疹等过敏反应.伤口全部愈合,无红肿、渗液等不良反应,心电图及生化指标未因植入物而发生异常变化.结论 复合BMP-2纳米人工骨辅助支撑钢板手术治疗骨质疏松性桡骨远端骨折可有效避免复位后骨量再丢失,改善远期疗效;复合BMP-2纳米人工骨作为骨移植替代材料,具有良好的临床应用前景.  相似文献   

4.
目的:评价锁定钢板和中空拉力钉治疗胫骨平台粉碎性骨折的疗效。方法:自2006年2月—2009年10月采用锁定钢板和中空拉力钉治疗胫骨平台粉碎性骨折18例,男12例,女6例。骨折类型按Schatzker分型,Ⅲ型5例,Ⅳ型4例,V型4例,Ⅵ型5例。均采用开放复位、中空拉力螺钉辅助钢板内固定、塌陷缺损处自体或同种异体骨植骨。对术后疗效及影响的相关因素进行分析。结果:15例获得随访,平均随访时间20个月(6个月~30个月),术后采用膝关节HSS评分方法,术后膝关节平均评分达90分。结论:手术是治疗胫骨平台骨折十分有效的方法,解剖复位、坚强内固定、塌陷后的复位植骨为胫骨平台骨折复位满意的三要素。  相似文献   

5.
目的 针对SchatzkerⅡ型和Ⅲ型胫骨平台骨折治疗中关节面复位困难及复位不佳的问题,探讨解剖复位的方法.方法 术中劈开外侧骨皮质,连同髂胫束向上翻转骨皮质,显露塌陷关节面,确定其复位范围及高度,水平凿断其下面松质骨,整体抬高,直视下解剖复位关节面,形成的骨缺损残腔,以髂骨块或条或异体骨填塞夯实,微创方法解剖钢板固定.结果 23例胫骨平台塌陷性骨折中,疗效按Merchant等评分标准,优18例,良3例,中2例,优良率为91.3%.结论 对需要手术治疗的塌陷性胫骨平台骨折,采用本方法治疗疗效肯定.  相似文献   

6.
目的 :强调胫骨平台粉碎性骨折应采取AO的分型方法以确定骨折类型 ,尽早进行手术治疗 ,以达到骨折的解剖复位和坚强内固定的目的 ,对预后有着重要的影响。方法 :对 2 0例胫骨平台粉碎性骨折患者按AO分类于伤后当日进行手术治疗。先平关节面复位骨折 ,再用髁钢板和松质骨螺钉固定骨折 ,然后在髂骨取骨植骨 ,对有韧带、半月板、交叉韧带的损伤同时修复固定。结果 :术后 1周内X线或CT检查显示骨折达到或近解剖复位 ,C型 1例因骨折严重 ,内固定困难 ,平台塌陷移位。均于 1年后取钉。术后 15例获得平均 1年随访 ,骨折均临床愈合。结论 :胫骨平台粉碎性骨折归于A3、B3、C型应尽早手术治疗达到对骨折复位满意的三要素对预后有重要意义  相似文献   

7.
徐笑强  查二南 《现代实用医学》2011,23(12):1359-1360
目的探讨螺旋CT三维重建在胫骨平台骨折中的应用价值。方法收集87例术前胫骨平台骨折患者常规X线摄片资料,并与螺旋CT扫描三维重建诊断进行对比。结果 87例胫骨平台骨折螺旋CT三维重建诊断结果为:Ⅰ型(外侧平台单纯劈裂骨折)10例,Ⅱ型(外侧平台单纯塌陷骨折)7例,Ⅲ型(外侧平台劈裂塌陷性骨折)22例,Ⅳ型(内侧平台骨折)8例,Ⅴ型(前后边缘骨折)16例,Ⅵ型(平台粉碎性骨折)24例。结论对于一些在常规X线片上难以显示的较微小的骨折,螺旋CT三维重建在诊断及治疗胫骨平台骨折中起着重要作用。  相似文献   

8.
目的探讨胫骨近端钢板加克氏针联合应用治疗胫骨平台骨折的疗效.方法对22例胫骨平台骨折患者采用胫骨近端钢板加克氏针固定,根据骨折块粉碎程度近端植骨或不植骨,术中透视或术后X线片观察平台塌陷恢复程度;患肢行走活动感觉.结果22例患者随访患者塌陷的关节面恢复,患肢行走活动基本正常.结论辅助克氏针加手术、植骨治疗胫骨平台骨折较单纯手术、植骨治疗胫骨平台骨折疗效满意.  相似文献   

9.
何彦国 《西部医学》2010,22(8):1411-1412
目的总结手术治疗胫骨平台骨折的疗效。方法回顾性分析胫骨平台骨折手术患者34例,骨折类型按Schatzker分型,其中Ⅰ型7例,Ⅱ型9例,Ⅲ型5例,Ⅳ型7例,Ⅴ型6例,Ⅰ型骨折采用切开复位松质骨拉力螺钉固定,其他类型采用切开复位、钢板螺钉内固定,缺损塌陷处自体或同种异体骨植骨。结果 34例患者均获得随访,随访时间为7-38个月,平均18个月,功能评价采用Hohl膝关节功能分级系统,临床结果优良率达85.3%。结论手术内固定是治疗胫骨平台骨折的重要方法 ,术中解剖复位应根据不同分型给予牢固内固定,早期正确功能锻炼能够提高手术效果。  相似文献   

10.
胫骨平台骨折分型的螺旋CT三维重建应用和临床价值   总被引:6,自引:0,他引:6  
华勇  王会根 《中原医刊》2004,31(7):14-15
目的 :探讨螺旋CT三维重建 (3DCT)对胫骨平台骨折分型的影响及在胫骨平台骨折中的临床应用价值。方法 :收集经手术治疗的胫骨平台骨折 2 6例 ,所有患者术前均接受X线片检查 ,同时行螺旋CT扫描和三维重建及多平面重建。根据Schatker分类法对胫骨平台骨折进行分型 ,比较X线片和 3DCT两种方法对胫骨平台骨折分型诊断的正确率 ,并评价 3DCT在胫骨平台骨折治疗中的应用。结果 :经手术证实 ,2 6例胫骨平台骨折按Schatker分类法 :Ⅰ型 :劈裂骨折 (1例 ) ;Ⅱ型 :塌陷骨折 (2例 ) ;Ⅲ型 :劈裂及塌陷 (17例 ) ;Ⅳ型 :涉及胫骨嵴的平台骨折 (3例 ) ;Ⅴ型 :内外侧平台Y型骨折 (2例 ) ;Ⅵ型 :胫骨平台和胫骨上 1/3段联合骨折 (1例 )。普通X线片对胫骨平台骨折分型的正确率为 76 92 % ,螺旋CTSSD、MPR结合二维CT横切面图像对胫骨平台骨折分型的正确率为 10 0 % ,两者比较有显著差异 (P <0 .0 5 ) ,所有 3DCT资料均对治疗具有指导作用。结论 :3DCT对胫骨平台骨折分型及决定治疗方案有重要的指导作用  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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