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1.
Development of sympathetic ophthalmia following globe injury   总被引:2,自引:0,他引:2  
Background Sympathetic ophthalmia (SO), a rare, bilateral, diffuse granulomatous uveitis, usually occurs after open globe injury or intraocular surgery. We sought to identify the risk factors for the development of SO after open globe injury and describe their demographic and clinical features and outcomes of treatments. Methods A retrospective study of inpatients with globe injury in 15 tertiary referral hospitals of China from January 2001 to December 2005 was conducted. The information of demography, nature and mechanism of injury, time and ways of treatments and outcomes was reviewed. Diagnosis of SO was made based on a history of ocular trauma or surgery and subsequent development of bilateral or contralateral uveitis consistent with SO. Any association between related parameters and development of SO was analyzed. Results Among 9103 patients (9776 eyes) of globe injury, SO occurred after open globe injury in 18 cases with an occurrence rate of 0.37%, vitrectomy of closed globe injury in 2 (0.37%) and perforation of burned eyes in another 2. For open globe injury, the median age ((36.72±13.59) years, P=0.01) was higher in patients with SO; there were no significant effects of sexes, injury type, uvea proplaps, once or multi-intraocular surgery, once or multi-vitrectomy and endophthalmitis on incidence of SO; 0.70% endophthalmitis concurred with SO; 83.33% of SO occurred within 1 year after injury or last ocular surgery. SO developed in a fellow eye one week after evisceration of the perforating burned eye. Good final visual acuity was obtained in sympathizing eyes with prompt treatment. Conclusions For open globe injuries, SO sufferers were relatively older and any injury type could induce SO with equal possibility. The initial open globe injury was more likely to be the trigger of SO than subsequent intraocular surgeries including vitrectomy. Prophylactic enucleation after injury is not recommended.  相似文献   

2.
Surgical treatment and outcome of 102 casesof congenital heart diseases associated withsecondary pulmonary hypertension (PH) arereported in the paper. Most patients were schoolaged children while the disease spectrum con-sisted primarily of VSD or/and PDA. Compa-rison and analysis of cardiac catheterization  相似文献   

3.
Nephrolithiasis is a common clinical problem, and its cause is often classified as idiopathic. Primary hyperoxaluria, mostly type 1, constitutes one of the rare causes of recurrent nephrolithiasis, but its diagnosis is often missed or delayed. The exact prevalence of primary hyperoxaluria type 1 ( PH1 ), therefore, has been unclear. The reported prevalence varies in different countries. No Chinese PH1 has ever been reported in the literature. We report a rare case of late-onset primary hyperoxaluria, which was diagnosed only after the development of end-stage renal failure. To our knowledge, this case is the first confirmed Chinese PH1.  相似文献   

4.
Nephrolithiasis is a common clinical problem, and its cause is often classified as idiopathic. Primary hyperoxaluria, mostly type 1, constitutes one of the rare causes of recurrent nephrolithiasis, but its diagnosis is often missed or delayed. The exact prevalence of primary hyperoxaluria type 1 (PH1), therefore, has been unclear. The reported prevalence varies in different countries. No Chinese PH1 has ever been reported in the literature. We report a rare case of late-onset primary hyperoxaluria, which was diagnosed only after the development of end-stage renal failure. To our knowledge, this case is the first confirmed Chinese PH1.  相似文献   

5.
Late hepatic allograft dysfunction (LHAD) is common after liver transplantation (LT) and can cause graft failure ,retransplantation ,or even death. A variety of etiologies including rejection ,vascular complications, bile duct complications, recurrent diseases ,infections ,de novo diseases, neoplasms and drug toxicity can result in LHAD. The recurrent diseases have the potential to become the most serious problems facing LT in the future. It is difficult to differentiate late acute rejection from recurrent viral or autoimmune hepatitis. Accurate diagnosis of the cause of LHAD has therapeutic importance.  相似文献   

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7.
The present study attempted to examine the effects of bile acid pool size on liver regeneration after hepatectomy.The rats were fed on 0.2% cholic acid(CA)or 2% cholestyramine for 7 days to induce a change in the bile acid size,and then a partial hepatectomy(PH)was performed.Rats fed on the normal diet served as the controls.Measurements were made on the rate of liver regeneration,the labeling indices of PCNA,the plasma total bile acids(TBA),and the mRNA expression of cholesterol 7alpha-hydroxylase(CYP7A1),...  相似文献   

8.
Objective. To investigate the effects or cold preservation on rat ratty liver. Methods. We observed the changes of portal perfusion pressure, endothelin-1, enzymes relesase in the effluent and mortality of sinusoid lining cell after 0h, 6h, or 12h preservation respectively and a subsequent 30 min reperfusion in rat fatty liver groups and control groups by using isolated perfused rat liver model.And we compared fatty liver groups with control groups by these indices. Results. There was no obvious difference between mildly fatty liver group and control group after long time (12h)preservation, between moderately fatty liver group and control group after short time( 6h)preservation, between severely ratty liver group and control group without preservation(0h), while preservation reperfusion injury was more severe in moderately fatty liver group than in control group after long time (12h) preservation and in severely ratty liver group than in control group after short time (6h)preservation. Conclusions. The authors suggested that a mildly ratty liver donor could be used in the same way as nonfatty liver and a moderately fatty liver donor could he used depending on the time of preservation and the balance of the emergent needs of recipient and donor organ supply, while severely fatty liver doncr should be discarded without hesitation.  相似文献   

9.
10.
The appearance of abnormal growths on the planarian,Dugesia dorotocephala,in response to cadmium with and without pre-exposure to L-buthionine-R,S-sulfoximine(BSO)and concurrent exposure to the polychlorinated biphenyls(PCBs) Aroclor 1254,PCB28,PCB110 or PCB126 is described,Pigmented rose thorn(PRT) lesions were non-invasive and appeared in response to PCBs.Post-head(PH)lesions developed in up to 100% of the animals within 6- 20 days post-dosing,progressed rather rapidly and were highly invasive.Roung tail tip(RTT) lesions appeared in lower frequencies within 10-30 days,but progressed extremely rapidly resulting in tail loss within 48h.We have referred to these types of lesions as“tumors”,bt they are not necessarily characteristic of vertebrate neoplasms.PCBs interacted with cadmium in a complex way,in some cases increasing totoal lesions and decreasing time-to-lesion and in other cases having the opposite effects.A three-factor(PCB, PCB dose,Cd dose)nested analysis of variance model was used to determine lesion rates in order to compare PCB potencies as potentiators or antagonists.The Aroclor mixture was always the least potent co-toxicant but appeared to be the most potent antagonist;the coplanar PCB 126 was the most potent co-toxicant.The complex response surfaces and the lack of stoichiometry in dose-response relstionships indicate that multiple mechanisms are responsible for PH and RTT lesions in planarians.Thes results emphasize the complexity of PCB toxictities and suggest further studies to validate the planarian model as a screen for combinations or environmental mixtures which may have altered biological potency in other species.  相似文献   

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