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1.
目的:总结60岁以上老年人心脏手术的围术期影响因素,提高老年人心脏手术治疗水平.方法:老年心脏病患者40例,单纯冠状动脉病变15例,冠状动脉病变合并瓣膜病变2例,单纯瓣膜病变17例,23例冠状动脉搭桥术(CABG)中,有2例同期行二尖瓣置换术,2例同期行左心室室壁瘤切除术及左心室成形术.单纯二尖瓣置换9例,二尖瓣合并主动脉瓣置换5例,主动脉瓣置换3例.21例体外循环时间平均为(116±32.23)min,主动脉阻断时间平均(80.21 ± 36.27)min.结果:在40例手术中,术后出现严重并发症6例(15%),其中低心排综合征3例,肺功能不全致低氧血症1例,肾功能衰竭1例,脑血栓1例,围术期死亡3例(7.5%).结论:60岁以上老年人心脏手术,围手术期出现低心排综合征,肺功能不全和肾功能衰竭是影响手术效果的主要因素.  相似文献   

2.
杨蕴 《中国民康医学》2009,21(3):237-239
目的:总结60岁以上老年人心脏手术的围术期影响因素,提高老年人心脏手术治疗水平。方法:老年心脏病患者40例,单纯冠状动脉病变15例,冠状动脉病变合并瓣膜病变2例,单纯瓣膜病变17例,23例冠状动脉搭桥术(CABG)中,有2例同期行二尖瓣置换术,2例同期行左心室室壁瘤切除术及左心室成形术。单纯二尖瓣置换9例,二尖瓣合并主动脉瓣置换5例,主动脉瓣置换3例。21例体外循环时间平均为(116±32.23)min,主动脉阻断时间平均(80.21±36.27)min。结果:在40例手术中,术后出现严重并发症6例(15%),其中低心排综合征3例,肺功能不全致低氧血症1例,肾功能衰竭1例,脑血栓1例,围术期死亡3例(7.5%)。结论:60岁以上老年人心脏手术,围手术期出现低心排综合征,肺功能不全和肾功能衰竭是影响手术效果的主要因素。  相似文献   

3.
目的探讨心脏瓣膜病合并冠心病患者同期行心脏瓣膜手术及冠状动脉搭桥的方法及临床效果。方法回顾性分析2013年2月—2017年1月海南省人民医院心脏外科施行心脏瓣膜病置换术同期行冠状动脉搭桥手术患者116例,分析术后相关心脏功能状态指标及相关并发症情况。结果同期行二尖瓣置换、三尖瓣成形术、冠状动脉搭桥46例;二尖瓣成形术、冠状动脉搭桥31例;主动脉瓣置换术、冠状动脉搭桥30例;二尖瓣联合主动脉瓣置换术、冠状动脉搭桥9例,术后复查心脏彩色超声,结果显示瓣膜功能良好,心功能明显改善,左室射血分数较术前明显好转;术后并发低心排出量综合征(低心排)10例,2次开胸止血5例,急性肾功能衰竭7例,脑梗死5例:因出现多器官功能衰竭(MOF)死亡3例,因突发脑出血死亡1例。结论对高危老年心脏瓣膜病合并严重冠心病(冠状动脉血管超过50%以上狭窄)的患者,应该行心脏瓣膜手术治疗同期冠状动脉搭桥、手术前积极治疗改善心肺功能,术中合理的心肌保护,减少体外循环时间,可有效降低病死率以及并发症,提高手术的治疗效果。  相似文献   

4.
重症心脏瓣膜病外科治疗   总被引:1,自引:0,他引:1  
目的:探讨危重心脏瓣膜病手术治疗和围手术期处理的经验。方法:2001年1月~2005年12月危重心脏瓣膜病患者38例接受手术治疗,其中男性15例,女性23例,年龄16~75岁。术前心功能Ⅲ级26例,心功能Ⅳ级12例。其中,二尖瓣置换术19例,主动脉瓣置换术8例,双瓣膜置换11例。行三尖瓣成形术13例,左房血栓清除术8例,冠状动脉搭桥术9例。结果:早期主要并发症为室性心律失常、低心排血量综合征、呼吸衰竭和多器官功能衰竭。死亡2例,其中室性心律失常1例,肾功能衰竭1例。结论:危重心脏瓣膜病的外科治疗应选择适当手术时机,合理纠正病变,加强术后并发症的防治,同时,充分的术前准备也至美重要。  相似文献   

5.
目的回顾性分析我科同期行瓣膜置换及冠状动脉旁路移植手术的临床经验。方法 2002年2月至2009年12月我科同期施行心脏瓣膜置换及冠状动脉旁路移植术(coronary artery bypass grafting,CABG)73例。其中男性41例,女性32例。冠状动脉造影显示:单支血管病变31例,双支血管病变24例,多支血管病变18例。同期施行二尖瓣置换31例,主动脉瓣置换21例,二尖瓣及主动脉瓣病变20例,二尖瓣、主动脉瓣及三尖瓣置换1例。人均冠状动脉远端吻合(2.52±1.21)个。前降支采用左内乳动脉15例,余血管桥均采用静脉桥。术中有2例因低心排血量综合征植入主动脉内球囊反搏支持。结果术后早期(30 d内)死亡3例,病死率4.1%。1例同期行3个瓣膜置换及1支血管移植的53岁男性患者死于室颤;1例同期行二尖瓣置换及3支血管移植的62岁女性患者死于低心输出量综合征;1例同期行二尖瓣置换及1支血管移植的66岁男性患者死于脑梗塞;余病人顺利出院,无围术期心肌梗死发生。随访51例,随访时间3个月至8年,平均随访3.8年,患者心衰改善,心绞痛消失。结论同期施行心脏瓣膜置换及冠状动脉旁路移植手术治疗风湿性心脏病合并冠心病,技术可行,疗效可靠。可靠的瓣膜置换,完全的再血管化,良好的心肌保护,正确的围术期处理是成功的关键。  相似文献   

6.
目的总结老年人心脏瓣膜置换围术期处理经验。方法对本院123例接受心脏瓣膜置换60岁以上老年患者围术期处理的特点进行回顾性分析。结果二尖瓣置换66例,主动脉瓣置换39例,二尖瓣+主动脉瓣置换15例,三尖瓣置换2例,同期进行其他手术共105例,早期死亡率8.9%(11/123),并发症出现率41.5%(50/123),晚期死亡3例,其中与心脏有关死亡1例,死于反复心力衰竭。随访6个月~14年,96例存活,失访13例,随访率88.4%(96/112)。结论重视老年人心脏瓣膜置换围术期的处理措施,合理的手术方法和心肌保护,可以减少围术期并发症,降低手术围术期的死亡率。  相似文献   

7.
目的 分析心脏瓣膜置换术后再次瓣膜手术的原因,探讨手术方法及对结果的影响因素.方法 对1986年1月~2006年6月瓣膜置换后行再次瓣膜手术的病例进行回顾性研究,用同期同类病例做对照进行分析.结果 共52例再次手术中,生物瓣衰败18例,继发其他瓣膜病变13例,瓣周漏6例,非机械性瓣膜功能障碍10例,机械性功能障碍2例,心内膜炎伴赘生物形成3例;手术方式:单独行二尖瓣置换术(MVR)15倒,主动脉瓣置换(AVR)12例,二尖瓣置换加主动脉瓣置换术(DVR)14例,瓣膜修复7例,同期三尖瓣成形术(TVP)共40例,三尖瓣置换术(TVR)1例;手术难度明显大于首次手术,并发症增多,围术期死亡率5.77%.结论 注意术前心功能的改善,术中体外循环尽早建立,完善术中心肌保护、手术技巧的掌握,术后积极纠正低心排出量综合征(低心排)、防止并发症的发生是减少手术死亡的关键因素.  相似文献   

8.
目的探讨心脏瓣膜置换手术治疗心脏瓣膜病变的临床疗效,总结治疗体会。方法回顾性分析我院2005年1月~2015年1月365例人工心脏瓣膜置换术患者的临床资料,其中男135例,女230例,年龄16~72岁,平均(51.2±10.7)岁。二尖瓣置换术244例,其中生物瓣膜置换术12例;主动脉瓣置换术65例;二尖瓣主动脉瓣双瓣置换术56例;同期采用Devega或Kay法行三尖瓣成形术235例,行左房附壁血栓清除术91例。结果术后早期病死率3.01%,死因为低心排血量综合征3例,严重心律失常4例,呼吸衰竭2例,肾功能衰竭2例;术后早期并发症发生率5.75%,低心排血量综合征3例,心律失常8例,急性肾功能不全3例,呼吸功能不全2例,术后开胸止血5例;心功能改善至Ⅰ级197例,Ⅱ级145例,Ⅲ级23例。结论术前有效治疗,选择合适手术时机,缩短手术及体外循环时间,提高手术技巧是降低心脏瓣膜置换术后病死率和并发症的重要因素。  相似文献   

9.
目的 总结80例心脏瓣膜疾病的外科治疗经验。方法 80例患者中行二尖瓣置换术43例,二尖瓣成形术5例,主动脉瓣置换术12例,双瓣置换术12例,单瓣膜置换+冠状动脉搭桥术4例,二尖瓣成形+主动脉瓣置换术1例,带瓣人工血管置换术(Bentall术)2例,三尖瓣置换术1例,同期三尖瓣成形18例,血栓取出术13例,左房缩缝+左心耳结扎3例。结果 死亡3例,死亡率为3.7%,死亡原因为左室破裂、低心排并肾衰、心律紊乱各1例,低心排3例,心律紊乱10例,心包积液1例,术中二次转机2例,二次剖胸止血1例。结论 提高手术疗效,降低死亡率,应重视围术期处理及心脏功能的支持、保护,提高手术质量,减少手术并发症。  相似文献   

10.
目的 回顾分析近年蚌埠医学院第一附属医院 ≥ 68岁高龄心脏瓣膜疾病手术患者,总结外科及围手术期临床经验。 方法 选择蚌埠医学院第一附属医院2016年3月-2017年9月间,单中心接受手术的 ≥ 68岁高龄心脏瓣膜患者为研究对象,其中男性16例,女性9例。其中,风湿性心脏瓣膜病18例,感染性心内膜炎2例,老年退行性瓣膜病变5例。行二尖瓣置换术(mitral valve replacement,MVR)14例,主动脉瓣置换术(aortic valve replacement,AVR)5例,双瓣膜置换术(double valve replacement,DVR)2例,二尖瓣置换术+冠状动脉旁路移植术(coronary artery bypass graft,CABG)2例,主动脉瓣置换术+升主动脉置换术+冠状动脉旁路移植术1例,主动脉瓣置换术+二尖瓣成形术1例。合并手术包括三尖瓣成形术11例,左房血栓清除+左心耳切除1例,左房黏液瘤切除术1例。 结果 全组体外循环时间(126.2±57.2)min,主动脉阻断(72.3±48.2)min,术后呼吸机辅助(15.24±6.91)h,术后监护(49.12±18.82)h,术后住院(9.5±4.2)d。手术死亡1例(4%),各类手术并发症11例(44%),其中心律失常7例,肺部感染2例,切口裂开1例,活动性出血1例。术后患者心功能显著改善,活动能力不同程度改善。术后随访时间1~18个月,死亡1人,二尖瓣置换患者术后7月死于严重肺部感染,其余23例患者均存活,生活质量均显著改善。 结论 充分的围手术期处理、良好的心肌保护及完善的术中操作,老年心脏瓣膜病外科治疗是安全和有效的。   相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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