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1.
白内障不同切口术后角膜散光及角膜内皮细胞的变化   总被引:1,自引:0,他引:1  
目的 研究距角膜缘不同距离切口对非超声乳化小切口白内障人工晶体植入术后角膜散光及角膜内皮细胞变化的影响.方法 96例(96只眼)白内障患者按切口距角膜缘距离随机分为A、B和C 3组.在角膜上方部位行反眉弓形切口的非超声乳化小切口白内障人工晶体植入术.分别于术前及术后1周、1个月、3个月用角膜地形图仪测量平均角膜散光度,用角膜内皮显微镜测量角膜内皮细胞计数.比较3组的平均角膜散光度和角膜内皮细胞平均密度及细胞平均丢失率.结果 A、B、C组的平均角膜散光度在术后1周时分别是(2.08±0.96)、(1.36±0.83)、(1.69±0.85)D,差异有统计学意义(P=0.007),术后1、3个月差异无统计学意义(P>0.05).3组的角膜内皮细胞密度及角膜内皮细胞丢失率在术后差异无统计学意义(P>0.05).结论 切口所处位置距角膜屈光中心的距离越远,术后早期平均角膜散光度越小.白内障手术切口与术后角膜内皮细胞丢失无直接关系.  相似文献   

2.
目的:观察双手微小切口超声乳化白内障吸除术的临床疗效。方法:83例(92只眼)白内障患者随机分为对照组43例(48只眼)与治疗组40例(44只眼)。对照组采用常规超声乳化吸除术,治疗组采用双手微小切口超声乳化白内障吸除术,观察术中平均超声乳化能量、时间、术后视力及手术并发症,比较术后角膜内皮细胞密度。结果:两组患者术中超声乳化能量及时间比较有显著性差异(P〈0.05);术后1 d裸眼视力,治疗组明显优于对照组,有显著性差异(P〈0.05);术后1 w及1个月视力,两组比较无显著性差异(P〉0.05);术后第1周,治疗组平均角膜内皮密度明显高于对照组,有显著性差异(P〈0.05);术后第1个月平均角膜内皮密度则无显著性差异(P〉0.05);两组术后并发症的发生率相当。结论:双手微小切口超声乳化白内障吸除术具有安全、有效、微创等特点,为白内障患者的首选手术方式。  相似文献   

3.
目的:探讨超声乳化术与现代囊外摘除术对硬核性白内障角膜内皮的影响。方法选择我院自2012年1月-2014年1月收治的44例硬核性白内障患者,随机分为观察组22例(28眼)与对照组22例(27眼),全部患者术前均予详细的全身及眼部检查,观察组患者行超声乳化技术治疗,对照组患者行现代囊外摘除术。结果治疗后,两组患者角膜内皮细胞密度、平均细胞面积、六角形细胞比与术前比较,差异具有显著性(P〈0.05);观察组患者角膜内皮细胞密度、平均细胞面积、六角形细胞比及细胞丢失率与对照组比较,差异具有显著性(P〈0.05);患者术后视力恢复情况比较,差异具有显著性(P〈0.05);术后并发症发生比较,无显著性差异(P〉0.05)。结论超声乳化术可有效改善患者视力,适用于硬核性白内障患者的治疗。但超声乳化术对角膜内皮细胞的损伤程度高于现代囊外摘除术。  相似文献   

4.
目的观察不同浓度肾上腺素对高度近视并发白内障患者超声乳化白内障吸除术后角膜内皮细胞的影响,探讨术中应用。肾上腺素的合理浓度。方法选取高度近视并发白内障患者90例(90眼),随机分为3组(每组30眼),分别于灌注液中加入0.1mL、0.2mL及0.5mL肾上腺素,每组30眼,均行白内障超声乳化吸除联合人工晶体植入手术,于术前及术后1周采用非接触型角膜内皮显微镜行角膜内皮细胞密度及六角形细胞比例检查。结果3组术前角膜内皮细胞密度及六角形细胞比例比较,差异无统计学意义(P〉0.05)。3组术后1周角膜内皮细胞密度分别为(2495.24±326.08)mm^-2、(2457.45±355.12)mm^-2、(2425.38±312.68)mm^-2,六角形细胞比例分别为(47.85±12.01)mm^-2、(45.20±9.43)mm^-2、(44.35±8.13)mm^-2。3组术后角膜内皮细胞密度及六角形细胞比例均较术前减少,其差异均有统计学意义(P〈0.05)。术后各组间比较,随加入肾上腺素浓度增加,角膜内皮细胞密度及六角形细胞比例逐渐下降,组间差异无统计学意义(P〉0.05)。结论高度近视并发白内障患者角膜内皮细胞对手术损伤及肾上腺素毒性损害的耐受性降低,在有效维持术中瞳孔散大状态的同时,选用浓度较低的肾上腺素,可减少对角膜内皮细胞的损害。  相似文献   

5.
目的探讨小切口非超声乳化与超声乳化手术治疗白内障的临床效果。方法白内障患者83例(96眼)分为小切口非超声组和超声乳化组,每组48眼。小切口非超声组行小切口非超声乳化摘除手术,超声乳化组行超声乳化吸出术。对两组患者术后1d角膜水肿情况、术后并发症及视力恢复情况。结果与超声乳化组相比,小切口非超声组角膜水肿0级患者比率明显提高(P〈0.05)。两组患者后囊破裂、前方出血以及虹膜损伤等并发症的发生率无差异(P〉0.05)。术后视力恢复情况无明显差异性(P〉0.05)。结论小切口非超声乳化手术操作简单,能够取得同超声乳化手术等同的手术效果。  相似文献   

6.
目的:观察3.2 mm透明角膜小切口白内障超声乳化吸除折叠人工晶体植入术和5.5 mm巩膜隧道切口白内障超声乳化吸除硬性PMMA人工晶体植入术对角膜内皮细胞的影响。方法:应用Noncon-ROB06000型(日本)非接触式角膜内皮显微镜对两种不同切口白内障超声乳化吸除病例的术前和术后不同时间角膜内皮细胞进行细胞密度和形态学的检查。结果:两种不同切口术后1、2、3个月角膜内皮细胞密度及形态改变两组间没有显著性差异(P>0.05);两组间术后不同时间角膜内皮细胞其损失比较经统计学分析差异无显著性(P>0.05)。结论:3.2 mm透明角膜小切口白内障超声乳化折叠人工晶体植入术是一种快捷、可靠的手术方式并不增加对角膜内皮细胞的损伤程度。  相似文献   

7.
糖尿病性白内障术后角膜内皮细胞的变化   总被引:1,自引:0,他引:1  
目的:观察糖尿病性白内障患者超声乳化术后角膜内皮细胞形态学的变化,探索糖尿病患者术后角膜内皮细胞的变化规律及影响因素。方法:随机选取28例(32眼)非胰岛素依赖型糖尿病合并老年性白内障患者行经透明角膜切口的白内障超声乳化吸除术联合折叠式人工晶体植入术。所有患者于术前、术后3月分别行角膜中央区和手术切口区内皮细胞观察,检测其细胞密度、六角形细胞比例和变异系数。结果:白内障超声乳化术后角膜内皮细胞密度和六角形细胞比例均呈现逐渐下降趋势,变异系数渐增加。术后切口区内皮细胞密度低于中央区,有显著性差异。六角形细胞比例低于中央区,变异系数高于中央区。结论:白内障超声乳化术中,糖尿病患者角膜内皮受到超声因素和机械因素的双重损伤。手术切口区内皮细胞丢失明显大于中央区,所以对于白内障患者尤其合并糖尿病者,在超声因素(能量、时间)损伤的基础上,应注意机械因素的作用;并且这种创伤对角膜内皮的影响可能更大。  相似文献   

8.
目的 探讨超声乳化白内障吸除手术对角膜内皮细胞的影响。方法 对 6 80例 (6 80只眼 )老年性白内障患者行超声乳化白内障吸除手术。术前根据晶体核混浊的程度分为 1~ 4级 ,术后观察角膜水肿等情况。使用角膜内皮显微镜观察手术前后角膜内皮细胞的平均密度、六边形细胞所占百分率。结果 术后 0~ 1级角膜水肿者内皮细胞平均密度、六边形细胞所占百分率比较 ,差异无显著意义 (P >0 .0 5 ) ,2级角膜水肿者内皮细胞平均密度、六边形细胞所占百分率与术前比较 ,差异有显著意义 (P <0 .0 5 )。角膜水肿于术后 2~ 5d消退。结论 白内障手术的最佳时机应选择在晶体核硬度尚未达到过硬时 ,以减轻手术对角膜内皮细胞的损伤。  相似文献   

9.
探讨0.7 mm与2.65 mm切口治疗年龄相关性白内障的术后视觉质量。方法:选取年龄相关性白内障患者90例(130眼)。采用随机数字表法分为A组共46例(65眼)、B组共44例(65眼)。A组行2.65 mm切口同轴白内障超声乳化术,B组行0.7 mm切口双手白内障超声乳化术。在患者术后1d、1周、1个月进行随访,收集并分析两组术眼的裸眼远视力、角膜散光值、角膜细胞等情况。结果:两组术后1d、术后1周及术后1个月裸眼视力差异均无统计学意义(F=3.14,P=0.11);随着时间的推移,两组角膜散光值先升高后下降,差异具有统计学意义(F=4.72,P=0.03);两组术后1个月角膜散光值差异无统计学意义(P>0.05);B组术后1个月细胞密度、内皮细胞数、六角形细胞比例均高于A组,差异具有统计学意义(P<0.05);两组均无明显并发症发生。结论:0.7 mm微切口双手白内障超声乳化手术具有角膜内皮细胞丢失率低,视功能术后恢复较快等优点,值得临床推广使用。  相似文献   

10.
[目的]比较超声乳化白内障吸除术术前与术后的中央及中间带角膜内皮细胞计数和厚度,评估超声乳化白内障吸除术后引起的视线区域角膜损伤程度.[方法]随机选择2012年5月至12月行超声乳化自内障吸除联合人2C-晶状体植入术的患者52例(60眼),术前及术后2个月采用SP.2000P非接触角膜内皮计和OrbscanⅡ角膜地形图检测角膜中央及距中心3mm处的上方、下方、鼻侧及颞侧角膜内皮细胞计数及角膜厚度.[结果]超声乳化白内障吸除术前中央与中间带角膜内皮细胞计数比较差异无统计学意义(P〉0.05).术后2个月中央部及颞侧中间带角膜内皮细胞计数较术前显著降低(P=0.034,P〈0.001),颞侧中间带角膜厚度较术前显著增厚(P=0.041).[结论]中央角膜内皮细胞计数不能完全评估整体角膜的损伤程度,检测中央及中间带不同区域的角膜内皮细胞计数与厚度变化,可有效地评估白内障超声乳化手术对整个视线区域角膜的损伤程度.  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

19.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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