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1.
Lung cancer continues to be the leading cause of cancer-related death in the world, which is classically subgrouped into two major histological types: Non-small cell lung cancer (NSCLC) (85% of patients) and small-cell lung cancer (SCLC) (15%). Tumor location has been reported to be associated with the prognosis of various solid tumors. Several types of cancer often occur in a specific region and are more prone to spread to predilection locations, including colorectal cancer, prostate cancer, ga...  相似文献   

2.
Objective The aim of this review was to overview the current practice of gastric cancer treatment including surgery and other adjuvant modalities.Data sources The review was based on data obtained from the published articles and main guidelines in the East and West.Study selection Articles with high level of evidence or current best evidence in each issue were selected to be reviewed.Results Although varied adjuvant modalities have been proved to be benefit for treating gastric cancer,surgery is still the most important treatment strategy against gastric cancer.Actively adapting to new technology is important but it should be balanced with an effort to establish sound scientific rationale that adheres to oncologic principles.Conclusions Future treatment of gastric cancer will be focused on tailored,personalized therapy.For achieving it,collaboration across disciplines is essential.Also the philosophy of caring for the patients with gastric cancer should be rooted in the realization of true patient benefit regardless of who is providing the care.With these philosophies,we can shift the scientific and technological advances toward triumph over gastric cancer.  相似文献   

3.
Multiple primary cancers (MPC) are specific malignant tumors type,manifesting as more than one primary tumor diagnosed in the same patient,either simultaneously or sequentially.The diagnostic criteria include:the cancer must be clearly malignant as determined by histological evaluation;each cancer must be geographically separate and distinct;and the possibility that the second tumor represents a metastasis should be excluded.1 The mechanism of pathophysiology remains poorly understood but cancer survivors are at increased risk of second cancer.With increased availability of methods with greater sensitivity for screening organs susceptible to cancers,there may be an increase of frequency in the identification of multiple malignities in the coming years.The association of multiple myeloma with solid tumors is rare.In this study,we presented a multiple myeloma case accompanying to lung,colon and gastric cancer.  相似文献   

4.
Estrogen and progesterone receptor (ER and PR) contents of 40 breastcancer patients were determined with immunofluorescent staining.Thedifferentiation of cancer cells was evaluated on the basis of histological andultrastructural changes.It was found that there was a positive correlation of ERand PR contents with the cellular differentiation of breast cancer,and the lattercould be used to estimate the status of hormone receptors.Breast cancer is a malignant disease with heteropathological characteristics.In handling a breast cancerpatient,both the status of hormone receptors and the cellular differentiationshould be considered and the treatment varied with each pa(?)ent.For those witha well-differentiated cancer and rich hormone receptors,endocrine therapy shouldmainly be administered,while for those with a poorly-differentiated cancer and afew hormone receptors,chemotherapy would be of choice.  相似文献   

5.
Objective: To explore the affecting factors of liver cancer recurrence after hepatectomy. Methods: The BP artificial neural network - Cox regression was introduced to analyze the factors of recurrence in 1 457 patients. Results: The affecting factors statistically significant to liver cancer prognosis was selected. There were 18 factors to be selected by uni-factor analysis, and 9 factors to be selected by multi-factor analysis. Conclusion: The 9 factors selected can be used as important indexes to evaluate the recurrence of liver cancer after hepatectomy. The artificial neural network is a better method to analyze the clinical data, which provides scientific and objective data for evaluating prognosis of liver cancer.  相似文献   

6.
Relationship between cancer and thromboembolic disease,the research has been going on for more than a century.Armand trousseau in 1865 first reported the formation of venous thrombosis prone patients with gastric cancer.It will be cancer patients with early migratory superficial phlebitis thrombosis as trousseau syndr  相似文献   

7.
Objective To investigate the influence of the mass screening on the status of the prostate cancer (PCa), we compared the cases of PCa detected by the mass screening and the cases diagnosed at a conventional ordinary urologic outpatient. Methods Using a SPSS analysis system, We compared 67 cases of prostate cancer detected by mass screening and 358 cases diagnosed at the outpatient of various hospitals in Changchun in terms of age distribution, clinical stages, level of serum prostate special antigen (PSA), pathological stage and treatment modality. Results The annual average incidence of PCa during 1999 to 2001 increased 4.72 times when compared to the 1986 to 1989's. In the screening group, the cases with clinical stage T2 and T1 accounted for 59.7%. In the clinical group, it was only 28.0%, and mostly detected incidentally. Furthermore, in the screening group the percentage of the cases beyond 20 ng/ml PSA and of poorly differentiated carcinoma were much lower compared to the clinical group. These differences between them were statistically significant. The number of radical prostatectomy in the screening group increased 15.3% compared with that of the clinical group. Conclusion Only the mass screening can really reveal the actual prevalence of prostate cancer. It can markedly raise the number of prostate cancer, especially the cancer in the early stage.  相似文献   

8.
The cases of aberrant retroesophageal right subclavian artery (ARRSA) with esophageal cancer are rare. The treatment could be a challenge. We present a case of ARRSA with esophageal cancer infiltration and a successful surgical treatment.  相似文献   

9.
Carcinoma of the lung and multiple primary tumors   总被引:1,自引:0,他引:1  
Objective To assess the incidence of multiple primary malignancies combined with lung and other organs. Methods All patients who were consecutively treated for lung cancer from December 1964 to December 1992 were retrospectively analyzed regarding the occurrence of simultaneous primary tumor elsewhere in the body. Results Of 1019 patients reviewed, 21 (2.1%) had associated carcinoma of other organs. In these 21 patients, the incidence of associated aerodigestive tract cancer was 71% and cancer of other organs was 29%. Five patients had simultaneous cancer with the lung cancer and 16 metachronous lung cancer associated with cancer of other organs. Conclusions Multiple primary tumors in patients with carcinoma of the lung is not a rare phenomenon. Surveillance programs for detection of second primary tumors should focus on this group of patients. Surgeons should be aware of the possibility of double cancer, and the patient’s condition and stage of the carcinoma must be taken into consideration in the determination of operative indications and method.  相似文献   

10.
MGb_2 is a monoclonal antibody againstgastric cancer.It can be well localized in thetumour tissue and has been successfully used inthe radioimmunoimaging in the patients withgastric cancer.The conjugate of MGb_2 withchemotherapeutic drug mitomycin C(MMC)al-so shows highly selective cytotoxic effect uponhuman gastric cancer cells in vitro.Whether  相似文献   

11.
[目的]运用代谢组学方法,研究胃火炽盛证引起的口腔疾病患者的尿液代谢物变化及黄连解毒汤对其干预作用,探索胃火炽盛证引起的口腔疾病患者尿液中的潜在标志物。[方法]按照诊断标准、纳入标准、排除标准等纳入胃火炽盛证引起的口腔疾病患者58例作为口腔疾病患者组,所有患者服用黄连解毒汤5d后为黄连解毒汤干预组,另外纳入健康对照组10例。利用超高效液相色谱-静电场轨道阱质谱联用(ultra performance liquidchromatography coupled with orbitrap tandem mass spectrometry, UHPLC-Orbitrap MS)法对口腔疾病患者黄连解毒汤干预前和干预后,以及健康对照组的尿液进行分析,采用主成分分析(principal component analysis, PCA)和正交偏最小二乘法-判别分析(orthogonal partial least squares-discriminantanalysis, OPLS-DA)处理数据,区分代谢轮廓并寻找可能的生物标记物。[结果]健康对照组和口腔疾病患者组初步鉴定38个差异代谢物,口腔疾病患者组黄连解毒汤干预前和干预后初步鉴定出36个差异代谢物。3组中鉴定出α-N-苯乙酰基-L-谷氨酰胺等10种化合物可能与黄连解毒汤干预胃火炽盛证引起的口腔疾病的作用机制和代谢途径有关,分别为癸酰肉碱、α-N-苯乙酰基-L-谷氨酰胺、反-2,顺-4-癸二烯酰肉毒碱、异亮羟基脯氨酸、3-氨基己酸、10,20-二羟基二十碳酸、菊蒿醇B、Sterebin A、亮菌素和L-谷氨酰胺。推测黄连解毒汤治疗胃火炽盛证口腔疾病主要涉及的代谢通路为三聚氰胺、天冬氨酸和谷氨酸代谢,D-谷氨酰胺和D-谷氨酸代谢等。[结论]本研究首次从代谢组学角度研究了健康对照组和胃火炽盛证口腔疾病患者组,以及胃火炽盛证口腔疾病患者黄连解毒汤干预前和干预后尿液中代谢模式差异,证实黄连解毒汤可以显著修复胃火炽盛证引起的口腔疾病患者尿液中的内源性小分子代谢紊乱。  相似文献   

12.
目的通过检测赣南地区非综合性唇腭裂(NSCL/P)患者与正常人血浆内源性代谢产物的变化,探讨基于核磁共振(NMR)的代谢组学方法在临床实践中的可行性。方法分别收集17例NSCL/P患者和16例正常人对照组的血浆样品,测定NSCL/P患者血浆的一维1H-NMR图谱,采用主成分分析法(PCA)分析NMR数据,以鉴别NSCL/P组和正常对照组血浆中内源血浆代谢产物的变化,获得NSCL/P患者的特征代谢物。结果 NSCL/P组和正常对照组间的血浆代谢产物存在明显差别。与正常对照组相比,NSCL/P患者血浆中的缬氨酸、苯丙氨酸和酪氨酸的含量升高;NSCL/P患者血浆中的丙氨酸、胆碱、磷酰胆碱等代谢物的含量降低。结论采用基于NMR的代谢组学技术能较好地反映赣南地区NSCL/P患者血浆的代谢变化,通过1H-NMR代谢图谱获得NSCL/P的特征代谢物,可以初步探讨NSCL/P的代谢机制,表明了该技术在临床应用中具有很大的潜能。  相似文献   

13.
[目的]探讨气阴两虚型非小细胞肺癌肠道菌群、代谢组学和蛋白组学的基本特征。[方法]选择气阴两虚型非小细胞肺癌患者13例作为患者组,选择健康志愿者15名作为健康对照组,收集两组粪便标本,用16S rDNA技术检测肠道微生态。采集两组血清标本,通过液相色谱-质谱联用技术比较两组代谢组学和蛋白质组学差异。最后通过WGCNA软件对多组学结果进行联合分析。[结果]两组间存在6种显著差异菌,20种差异蛋白(上调5个,下调15个),11种差异代谢物(负离子模式下2个,正离子模式下9个),差异菌群、差异蛋白与差异代谢物间存在相关性,联合分析发现差异物质与癌症通路相关。[结论]气阴两虚型非小细胞肺癌具有特异的肠道菌群、蛋白质和代谢物,与肿瘤的发生发展密切相关。  相似文献   

14.
  目的  研究2型糖尿患者与健康者血清和粪便的代谢组学差异,分析差异代谢物与2型糖尿病之间的相关性。  方法  选择2018年1月至2019年3月在昆明医科大学第二附属医院内分泌科住院的2型糖尿病患者53例,以及同期常规体检健康对照人群30例,采用超高效液相色谱-四级杆飞行时间质谱技术对两组研究对象的血清代谢物及30例糖尿病患者与对照组的粪便代谢物进行非靶向和靶向的代谢组学研究。应用Spearman相关性分析方法对血清和粪便中的差异代谢物与2型糖尿病相关指标的相关性进行分析。  结果  在2型糖尿病组与健康对照组血清样本中鉴定出15个差异代谢物,在粪便样本中鉴定出的差异代谢物则有6个。其中,糖尿患者血清中的谷氨酰胺、壬二酸、癸二酸及3-羟基癸二酸等二羧酸类羟基化衍生物明显低于健康对照组,差异有统计学意义(P < 0.01),而琥珀酰乙酰乙酸、缬氨酸、亮氨酸、葡萄糖、乳酸的含量则高于对照组,差异有统计学意义(P < 0.01),并且琥珀酰乙酰乙酸、乳酸与糖化血红蛋白、餐后2 h血糖及空腹血糖浓度具有较强的正相关性,而壬二酸、癸二酸及二羧酸类羟基化衍生物与血糖浓度则具有较强的负相关;在粪便代谢物中,去氧胆酸和鹅去氧胆酸等胆汁酸与受检者的血糖浓度也有着一定的正相关性,并且单变量分析结果显示,与健康对照组相比糖尿病患者血清中的去氧胆酸和鹅去氧胆酸均显著性升高,差异有统计学意义(P < 0.05)。  结论  2型糖尿患者的血清代谢组学与健康者具有明显的差异,这些差异代谢物与糖尿病的发生和发展具有较强的关联性。在粪便代谢组学中,糖尿患者的胆汁酸水平与血糖的浓度变化也密切相关。  相似文献   

15.
目的 应用核磁共振氢谱(nuclearmagnetic resonancc1H,1H NMR)和偏最小二乘法.判别分析(partial least square-discriminant analysis,PLS-DA)研究鼻咽癌(NPC)患者血清中代谢物的代谢组变化.方法 健康人血清10例和鼻咽癌患者血清2l例,采用...  相似文献   

16.
目的探讨血管内皮生长因子(VEGF)在胃癌诊断中的价值。方法用时间分辨荧光免疫分析(TRFIA)技术对92例胃癌、36例胃良性病变(10例胃溃疡和26例胃炎)和92例正常人血浆VEGF含量进行测定,分析不同临床病理特性与VEGF含量的相关性,并用受试者工作特征(ROC)曲线分析VEGF对胃癌诊断的临床价值。结果血浆VEGF含量在胃癌和胃良性病变组呈非正态分布,与正常对照组相比,胃癌和胃良性病变组都显著增高,但胃良性病变组增高幅度不及胃癌组;血浆VEGF含量与性别、年龄、肿瘤位置(胃窦、胃体、幽门)、组织类型、分化程度及肿瘤分级无相关性,与TNM分期、有无淋巴结和远处转移显著相关;以217.79 pg/mL为临界值,血浆VEGF诊断胃癌的灵敏度为40.2%,特异性为93.7%,诊断准确率为69.9%。结论血浆VEGF含量与胃癌的临床病理特性相关,检测血浆VEGF含量对胃癌诊断有一定价值。  相似文献   

17.
目的探讨基于1H-NMR的模式识别方法应用于慢性心力衰竭(CHF)血清代谢组学研究的可行性。方法应用1H-NMR技术对9例CHF患者和6例健康人血清进行检测,对所得数据分别采用主成分分析法(PCA)和正交信号校正偏最小二乘法(OPLS)进行模式识别分析,确定CHF患者与健康人血清差异代谢物,比较两种模式识别方法判别能力。结果 CHF患者与健康人血清1H-NMR图谱有明显差异。其中PCA模式识别法未能将CHF组和健康对照组区分开,而用OPLS模式识别方法两组可明显区分。结论 1H-NMR技术是研究CHF代谢组学的有效技术手段,CHF患者血清代谢组与健康人存在明显差异。OPLS模式识别法明显优于PCA法,能够去除非实验因素的影响,提高分类效果。  相似文献   

18.
目的 采用代谢组学方法分析阵发性心房颤动患者血清中低分子代谢物的变化。方法 采用气相色谱-质谱联用技术(GC-MS)检测15例阵发性心房颤动患者(病理组)和同期20例健康者(对照组)血清中代谢物,采用正交偏最小二乘法(OPLSA)的方法比较两组代谢谱的变化。结果 对照组和病例组的代谢谱分离趋势明显,利用Wiley和NIST质谱库及本课题组建立的标准品谱库鉴定了29个具有统计学意义的差异代谢物。并对29个差异代谢物进行了ROC曲线绘制,计算ROC曲线下的面积,得出甘油曲线下的面积为0.937,丝氨酸曲线下的面积为0.853,天冬氨酸曲线下的面积为0.933,苏氨酸曲线下的面积为0.823,色氨酸曲线下的面积为1。结论 心房颤动患者血清中低分子代谢产物与正常人存在差异,心房颤动患者血清中甘油、丝氨酸、天冬氨酸、苏氨酸以及色氨酸可能成为心房颤动诊断标志物。  相似文献   

19.
邓雪松  何滔 《中外医疗》2011,30(11):29+31-29,31
目的 探讨胃癌患者及健康者血清IL-2水平变化.方法 选取初次住院的早期胃癌患者共26例纳入本项研究.采集并分离所有受试者血清标本,ELISA方法检测血清IL-2水平.结果 早期胃癌患者血清IL-2水平较正常健康人显著降低,差异具有统计学意义.结论 血清IL-2水平可反映胃癌患者细胞免疫功能变化,这可能是肿瘤细胞发生免...  相似文献   

20.
目的 检测基质金属蛋白酶抑制因子-2在食管癌患者血清中的蛋白水平及其临床意义.方法 通过对100例血浆样本,包括50例食管癌患者、50例健康人,采用酶联免疫吸附试验进行检测,测定基质金属蛋白酶抑制因子-2蛋白的血清浓度,检验其诊断食管癌的敏感性和特异性.结果 酶联免疫吸附试验检测结果显示,食管癌患者血清中基质金属蛋白酶抑制因子-2蛋白浓度显著低于正常对照人群(P<0.01).当cutoff值定为107.5 ng/mL时,基质金属蛋白酶抑制因子-2检测食管癌的敏感性为70%,特异性为94%.结论 检测血清中基质金属蛋白酶抑制因子-2的蛋白水平有助于食管癌的诊断.  相似文献   

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