氯氮平对人体姿态平衡的效应

目的探讨氯氮平对人体姿态平衡的效应.方法研究组(17例精神分裂症病人)用氯氮平治疗,入组时和治疗第28天时分别评定简明精神病量表,治疗第3天评定药物副反应量表,氯氮平治疗第3天(100mg/d)和第28天[(315±63)mg/d]分别检测人体姿态平衡试验;对照组不服精神药物的26例正常人检测人体姿态平衡试验.结果 (1)研究组第3天的路径总长比对照组的明显为长(P ＜ 0.01);研究组第3天的Romberg路径比较对照组明显为大(P ＜0.01).(2)研究组第28天的Romberg路径比较第3天的明显为小(P ＜0.05),其余的平衡试验参数在第28天与第3天之间无显著差异.结论 (1)氯氮平抑制了本体感觉反射性的微小姿势控制功能;(2)氯氮平引起的姿态平衡损害随时间推移而发生耐受,唯视觉代偿的平衡功能可能随氯氮平的增量而下降.     

利培酮对人体姿态平衡的效应

目的 探讨利培酮对人体姿态平衡的效应。方法 对病例组 (39例精神分裂症病人 )用利培酮治疗,于治疗第 3天和第 28天分别进行人体平衡实验;对 26例不服精神药物的对照组 (正常人 )进行人体姿态平衡实验。结果 (1)病例组第 3天测定的路径总长(795. 49±159. 67)和Romberg路径比 (1. 14±0. 18)较对照组(679. 01±110. 26; 1. 03±0. 14)的明显为大; (2)病例组第 3天的路径总长和Romberg路径比较第 28天的明显为大; (3)病例组第 28天的平衡实验所有参数与对照组的均无显著差异; (4)平衡实验参数与精神病症状均无明显相关性。结论 (1)利培酮 1mg/d治疗第 3天可抑制本体感觉反射性的微小姿势控制功能; (2)利培酮(3. 6±0. 9)mg/d治疗 1个月时,平衡功能损害已完全耐受; (3)利培酮治疗之初的平衡功能损害与精神分裂症无关。     

利培酮对人体姿态平衡的效应

目的探讨利培酮对人体姿态平衡的效应.方法对病例组(39例精神分裂症病人)用利培酮治疗,于治疗第3天和第28天分别进行人体平衡实验;对26例不服精神药物的对照组(正常人)进行人体姿态平衡实验.结果 (1)病例组第3天测定的路径总长(795.49±159.67)和Romberg路径比(1.14±0.18)较对照组(679.01±110.26;1.03±0.14)的明显为大;(2)病例组第3天的路径总长和Romberg路径比较第28天的明显为大;(3)病例组第28天的平衡实验所有参数与对照组的均无显著差异;(4)平衡实验参数与精神病症状均无明显相关性.结论 (1)利培酮1mg/d治疗第3天可抑制本体感觉反射性的微小姿势控制功能;(2)利培酮(3.6±0.9)mg/d治疗1个月时,平衡功能损害已完全耐受;(3)利培酮治疗之初的平衡功能损害与精神分裂症无关.     

齐拉西酮联合小剂量氯氮平治疗难治性精神分裂症的疗效研究

目的:研究齐拉西酮联合小剂量氯氮平在控制难治性精神分裂症患者的疗效。方法:选取难治性精神分裂症患者70例,采用随机数字表的方法,分为研究组和对照组。对照组给予氯氮平传统剂量口服;研究组给予齐拉西酮口服同时联合小剂量的氯氮平口服,应用PANSS量表评估两组治疗效果。结果:治疗后研究组PANSS量表各因子评分以及总分明显低于对照组,差异有统计学意义(P<0.05)。治疗后研究组总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组患者不良反应总发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:齐拉西酮联合小剂量氯氮平在控制难治性精神分裂症患者的病情中治疗效果较好,不良反应发生率较低。     

瑞波西汀合并氯氮平治疗精神分裂症阴性症状的随机双盲对照研究

目的 观察瑞波西汀合并氯氮平治疗精神分裂症阴性症状的疗效和不良反应。方法 筛选出114例慢性精神分裂症患者，采用随机双盲法，将其分为研究组（瑞波西汀＋氯氮平）（n=57）和对照组（安慰剂＋氯氮平）（n=57），实验期间，氯氮平剂量不变，瑞波西汀为8mg（装入空胶囊两粒）／日，安慰剂与瑞波西汀等量（淀粉胶囊两粒）／日。在治疗前及治疗后4．8、12周末分别以阳性和阴性症状量表总分、阴性因子分评定疗效和不良反应量表评定不良反应。结果 治疗12周末，研究组PANSS总分、阴性因子分及一般精神病理分均低于治疗前（P＜0．05或P＜0．01），与对照组比较，差异有统计学意义（P＜0．05或P＜0．01）；阴性因子中除交流缺乏自发性和流畅性外各项症状评分均低于对照组（P＜0．05或P＜0．01）。结论 瑞波西汀合并氯氮平治疗精神分裂症阴性症状安全有效。     

氯氮平合并氟西汀治疗慢性精神分裂症阴性症状的对照研究

目的 :评价氯氮平合并氟西汀治疗慢性精神分裂症阴性症状的疗效和副作用。 方法 :将符合CCMD -3的 78例慢性精神分裂症患者随机分为研究组 (氯氮平 氟西汀组 )和对照组 (氯氮平组 ) ,采用阳性症状和阴性症状量表 (PANSS)、阴性症状量表 (SANS)和副反应量表 (TESS)分别于治疗前、治疗后 4、8、12周末进行疗效及副反应评定。 结果 :治疗 8周后研究组PANSS总分、阴性因子分、SANS总分及分量表分均比治疗前明显下降 ,且阴性因子分显著低于对照组。治疗后 4周、8周、12周末TESS评分 ,研究组低于对照组且治疗后低于治疗前 ,比较均有显著性差异。 结论 :氯氮平合并氟西汀能明显改善慢性精神分裂症的阴性症状 ,且副作用较少     

阿力哌唑联合氯硝西泮与氯氮平治疗精神分裂症兴奋症状的效果观察

目的观察比较阿力哌唑联合氯硝西泮与单一使用氯氮平治疗精神分裂症兴奋症状的疗效及安全性。方法住院患者分成两组,研究组阿力哌唑联合氯硝西泮针剂注射1周后改口服;对照组氯氮平口服。治疗前、治疗后,以1、3、7、14、28天的(PANSS)量表作为疗效评定标准,以副反应量表(TESS)评定不良反应。结果阿力哌唑联合氯硝西泮肌肉注射7天,兴奋因子减分率为34.83%(有效),2周50.9.1%(显效),其控制兴奋症状的疗效与氯氮平相当。结论阿力哌唑联合氯硝西泮肌肉注射,能有效控制兴奋状态,且不良反应少,安全易接受。     

齐拉西酮与氯氮平治疗精神分裂症的对照研究

目的:了解齐拉西酮治疗精神分裂症疗效和安全性.方法:将80例患者随机分为研究组和对照组,研究组给予齐拉西酮治疗,对照组给予氯氮平治疗,两组疗程均为6周.分别于治疗前及治疗第1、3、6周进行阳性和阴性症状量表(PANSS)评定,副反应采用不良反应量表(TESS)评定.结果:研究组有效率85.0%;对照组有效率80.0%.两组有效率相比无统计学差异(χ2 =0.35,P>0.05),研究组不良反应发生率更低.结论:齐拉西酮治疗精神分裂症疗效可靠,不良反应更少.     

莲子清心糖合并氯氮平治疗精神分裂症临床疗效分析

目的:探讨中药方剂莲子清心糖合并氯氮平与单用氯氮平治疗对精神分裂症患者社会功能的影响。方法:对70例精神分裂症患者随机分成两组,治疗组予莲子清心糖合用氯氮平、对照组予氯氮平治疗,共6周。用阳性、阴性症状量表(PANSS)、临床疗效总评量表(CGI)、不良反应量表(TESS)、社会功能缺陷筛选量表(SDSS)分别评定患者疗效、不良反应及社会功能。结果:两组PANSS分值前后差异均有显著性,两组间差异无显著性;临床疗效评定治疗组治愈率明显高于对照组(P<0.01);治疗组不良反应于治疗4周后和社会功能缺陷于治疗6周后分值明显低于对照组(P<0.01)。结论:莲子清心糖合并氯氮平治疗精神分裂症能提高疗效、减轻不良反应,能明显提高精神分裂症患者的社会功能。     

盐酸二甲双胍辅助氯氮平治疗难治性精神分裂症时对患者体重及血糖的影响

目的:观察盐酸二甲双胍在辅助氯氮平治疗难治性精神分裂症时对患者体重及血糖的影响。方法:将78例用氯氮平治疗的难治性精神分裂症患者随机分为研究组(二甲双胍+氯氮平)和对照组(氯氮平)。毎4周观察一次患者体重和血糖,疗程12周。结果:第4周起研究组患者体重明显低于对照组(P<0.05),第8周时P<0.01。对照组患者空腹血糖于第8周显著高于研究组(P<0.05),第12周时P<0.01。结论:二甲双胍对氯氮平治疗难治性精神分裂症时对患者产生的不良反应,即体重增加及血糖升高有一定的控制作用,无明显的不良反应,安全有效,值得辅助应用。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.