氧化应激对心衰大鼠心肌细胞凋亡的影响及卡维地洛的干预作用

目的:研究氧化应激对心衰心肌细胞凋亡的影响及卡维地洛的疗效.方法:构建心衰人鼠模型,随机分为心衰组,卡维地洛组.药物干预4周,测心功能指标、氧化代谢指标、心肌细胞凋亡率(AI).结果:心衰氧化应激与AI相关,AI与心功能恶化和度平行并与左心室质量指数(LVMl)有关,(P均＜0.05);卡维地洛改善心功能,纠正氧化失恒,降低LVMI、右心室质量指数(RVMI),AI下降(P均＜0.05).结论:氧化应激促进心肌细胞凋亡,细胞凋亡参与心室重构并提示心衰预后.卡维地洛改善心功能,机制可能与其抗氧化应激、抗细胞凋亡、逆转心室重构有关.     

卡维地洛防治急性心肌梗死后左心室重构的临床研究

目的:为比较卡维地洛与卡托普利防治急性心肌梗死(AMI)后左心室重构的效果.方法:将122名AMI患者随机分为卡维地洛组52例,卡托普利组50例,常规治疗组20例,分别于治疗后1周、6个月采用心脏多普勒超声测定室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室舒张末内径(LVDd),计算左室重量指数(LVMI),同时测定左室射血分数(LVEF)及舒张早期左室充盈最大速率(E峰)与心房收缩期最大速率(A峰).结果:卡维地洛组和卡托普利组与常规治疗组比较均可使IVST、LVPWT变薄(P＜0.01),LVDd缩小(P＜0.01),LVMI降低(P＜0.01).卡维地洛组和卡托普利组均可增加LVEF、降低A/E峰比值,与常规治疗组比较1周时P＜0.05,6个月时P＜0.01.结论:卡维地洛具有良好的防治AMI后左室重构效果.     

卡维地洛对冠心病心力衰竭患者心室重构和心功能的影响

目的　探讨卡维地洛对冠心病心力衰竭患者心室重构及心功能的影响。方法　冠心病心力衰竭患者 80例 ,左室射血分数≤ 45 % ,心功能Ⅱ～Ⅲ级 ,常规治疗基础上随机分为治疗组和对照组 ,治疗 6个月 ,观察卡维地洛对心室重构、心功能的影响。结果　经过 6个月治疗 ,与对照组相比 ,卡维地洛组左室射血分数明显升高 (P <0 .0 1) ,左室收缩末容量指数、左室舒张末容量指数、左室重量指数均显著降低 (P <0 .0 1)。结论　在常规治疗的基础上 ,应用卡维地洛能显著改善冠心病心力衰竭患者的心功能 ,改善心室重构     

卡维地洛和美托洛尔对左室舒张功能及心室重塑影响的对比观察

目的探讨卡维地洛与美托洛尔两种不同类型的β-受体阻滞剂对充血性心力衰竭患者左室舒张功能和心室重塑的影响。方法将68例充血性心力衰竭患者在常规治疗心力衰竭(心衰)基础上随机分为卡维地洛组(A组35例)和美托洛尔组(B组33例),应用超声心动图分别于治疗前、治疗6个月后、12个月后测量左心室舒张早期充盈峰速度(E峰)、左心室舒张晚期充盈峰速度(A峰)、E/A、左心室舒张早期充盈峰减速时间(EDT)、E波流速积分(Ei)以及室间隔厚度(IVS)、左室后壁厚度(IVPW)、左室重量指数(LVMI)、左室球径指数(LVGI)。结果随访59例(A组30例、B组29例)发现:①治疗6个月时,两组的E峰、A峰、E/A、LVMI、LVGI均较治疗前差异有高度显著性(P<0.01);A组LV-MI、LVGI较B组显著减少(P<0.05或0.01)。②治疗12个月时两组的E峰、A峰、E/A、LVMI、LVGI、IVS、LVPW均较治疗前明显改善(P<0.01或0.05);A组的E峰、LVMI、LVGI、LVPW较B组差异有显著性(P<0.01或0.05)。结论卡维地洛在改善左心室舒张功能和心室重塑方面较美托洛尔更显著,治疗充血性心力衰竭更有优势。     

卡维地洛治疗高血压并慢性心力衰竭的疗效观察

目的:观察卡维地洛对高血压并慢性心力衰竭(CHF)患者的心功能影响及临床疗效.方法:选择高血压并高心病或冠心病82例,心功能Ⅱ～Ⅳ级的患者,随机分为两组,常规组(40例),给与控制血压、利尿、转换酶抑制剂(ACEI)、洋地黄治疗.卡维地洛组(42例),在常规治疗基础上加用卡维地洛(20mg Bid×180天).结果:卡维地洛组临床显效率(57.1%),总有效率(92.8%),较常规组显著提高(P＜0.05).卡维地洛组与常规组治疗前后,心率、血压、左室舒张末期直径、左室收缩末期直径、左室射血分数、心输出量、E/A、等容舒张期时间均有显著改善(卡维地洛组P＜0.01,常规组P＜0.05),且卡维地洛组上述指标改善更明显(P＜0.01或P＜0.05).结论:卡维地洛显著改善高血压并慢性心力衰竭患者的心功能,是一种安全有效的治疗方法.     

辛伐他汀改善急性心肌梗死后心室重塑与心功能的实验研究

目的:观察辛伐他汀对急性心肌梗死后大鼠心室重塑及心功能的影响,并探讨其可能的机制.方法:结扎大鼠冠状动脉前降支造成心肌梗死模型,给予辛伐他汀干预.8周后,测定心脏重量指数、血流动力学指标、心肌及血液中总-氧化氮合酶(NOS)、诱导型一氧化氮合酶(iNOS)活性,并与假手术组比较.结果:心肌梗死组大鼠右室重量指数(RVWI)、左室重量指数(LVWI)升高(P<0.01),外周动脉压(APS)、舒张压(APD)均降低,心率增快(P<0.01).左室收缩压(LVSP)和心室收缩期室内压上升速率( dp/dtmax),心室舒张期室内压下降速率(-dp/dtmax)下降(P<0.01),左室舒张末压(LVEDP)升高(P<0.01).血清和心肌NOS、iNOS活性下降(P<0.01).辛伐他汀干预组较心肌梗死组(M组)RVWI、LVWI下降(P<0.01),APS、APD、LVSP、 dp/dtmax、-dp/dtmax均回升(P<0.01),LVEDP回落(P＜0.01);血清和心肌NOS、iNOS活性升高.结论:辛伐他汀减轻左室重塑,改善心功能.     

卡维地洛与美托洛尔对慢性心力衰竭患者长期疗效比较

目的:观察两种β受体阻滞剂卡维地洛与美托洛尔对慢性充血性心力衰竭(CHF)的长期疗效.方法:慢性充血性心力衰竭患者65例,随机分为卡维地洛组32例,美托洛尔组33例,随访6个月,比较两组的心功能改善情况.结果:卡维地洛组及美托洛尔用药后两组患者左心室舒张末期内径(LVEDd)、左心室收缩期内径(LVEDs)、右心室内径(RVD)、左心房内径(LAD)显著缩小(均为P＜0.01);左心室射血分数(LVEF)显著增加(卡维地洛组P＜0.01,美托洛尔组P＜0.05),且卡维地洛对LVEDs、RVD、LVEF的改善作用更优于美托洛尔(LVEDs、RVD均为P＜0.01,LVEF为P＜0.05).结论:卡维地洛及美托洛尔均能明显改善心功能,提高生活质量,且卡维地洛疗效优于美托洛尔.     

卡维地洛对糖尿病伴急性心肌梗死患者心功能不全的疗效观察

目的 评价卡维地洛治疗糖尿病伴心肌梗死患者心功能不全的疗效和安全性.方法 将66例糖尿病心肌梗死合并心力衰竭的患者,随机分为卡维地洛组和对照组,在同对照组一样控制血糖,治疗心肌梗死合并心功能不全,卡维地洛组在治疗组的标准用药基础上从小剂量开始用卡维地洛,逐步增加至目标剂量进行治疗,测定两组治疗前、后临床心功能分级、血压、心率、左心室功能及肾功能和血糖、血脂水平.结果 两组治疗后左室舒张末期内径(LVEDd)、左室收缩末期内径(LVEDs)均减小(P＜0.05),左心室射血分数(LVEF)及心输出量(CO),短轴缩短率(FS)均有提高(P＜0.05或P＜0.01),但舒张功能均无改善(P＞0.05).结论 卡维地洛治疗糖尿病伴心肌梗死患者心功能不全安全、有效,同时能改善糖代谢和肾功能.     

卡维地洛对老年充血性心力衰竭患者心功能和细胞因子的影响

目的:观察卡维地洛对老年充血性心力衰竭(CHF)患者心功能的改善和对细胞因子的影响.方法:老年CHF患者45例随机分为心力衰竭常规治疗组(n=22)和卡维地洛治疗组(n=23),后者在常规抗心力衰竭治疗基础上加用卡维地洛,疗程6个月.两组治疗前和治疗3个月、6个月分别测定左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)和6 min步行距离.测定健康对照组(n=30)和两组心衰患者治疗前和治疗6个月血浆肿瘤坏死因子(TNF-α)、白细胞介素(IL)-1β和IL-6的浓度.结果:老年CHF患者用卡维地洛治疗6个月后,LVEDD、LVESD、LVEF和6min步行距离的改善均优于常规治疗组(P＜0.01,P＜0.05).心衰患者3种细胞因子血浆浓度均高于对照组(P＜0.001),卡维地洛治疗后细胞因子的下降明显优于常规抗心力衰竭治疗(P＜0.01).结论:卡维地洛可明显改善老年CHF患者心功能,提高运动耐量,改善左室重构,降低细胞因子TNF、IL-1和IL-6的浓度.     

重组人脑利钠肽联合硝酸甘油对慢性心力衰竭患者心室重构及心功能的影响

目的探讨重组人脑利钠肽联合硝酸甘油对慢性心力衰竭患者心室重构及心功能的影响。方法将2016年5月至2018年2月收治的98例慢性心力衰竭患者,按随机双盲法分为对照组49例及观察组49例。对照组给予硝酸甘油治疗,观察组在此基础上给予重组人脑利钠肽治疗。比较两组患者心室重构指标及心功能指标。结果治疗后4周,两组左室舒张末期内径(LVEDD)、左室间隔厚度(IVST)及左室质量指数(LVMI)均升高(P<0.05),但观察组上述指标低于对照组,差异有统计学意义(P<0.01);治疗后4周,两组左室内径缩短率(LVFS)、左室射血分数(LVEF)、左室舒张时间(IVRT)均升高(P<0.05),且观察组高于对照组,差异有统计学意义(P<0.01)。结论重组人脑利钠肽联合硝酸甘油治疗慢性心力衰竭,能够有效抑制心室重构,改善患者心脏舒缩功能,值得临床推广。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.