Meta—analysis在病因流行病学中的运用

很早以前,统计学就认识到对多个独立研究结果加以综合的必要性。60年代后期,医学文献中开始有了对多个独立研究统计量进行合并的报道。1976年,G.V.Glass 将合并统计量的文献综合研究方法称为“Meta-analysis”［1］。80年代末此法传入我国,有后分析、二次分析等汉译名。本文就Meta-analysis 在病因流行病学研究中的运用作一简单介绍。1 Meta-analysis 的工作步骤1） 制定试验设计：根据研究目的确定本次Meta-analysis 所分析的因素、文献查找方法、单个研究的入选标准、效应尺度的综合方法等。2） 查找文献,收集研究信息：可借助计…     

我国“循证”冠名杂志刊载干预类系统评价/Meta分析的统计学现状调查

目的：调查我国“循证”冠名杂志发表的干预类系统评价/Meta 分析统计学软件和统计学分析方法现状。方法以《中国循证医学杂志》、《循证医学》、《中国循证儿科杂志》、《中国循证心血管医学杂志》4本杂志官方网站为数据来源,根据纳入排除标准,纳入干预类的系统评价/Meta分析/荟萃分析/系统综述,检索时间截止2011年12月31日。2名研究者独立提取资料,并输入Excel软件分析。结果共纳入干预类系统评价/Meta分析487篇,RevMan为最常用的统计学软件（445篇,91．38％）,其次为Stata（13篇,2．67％）。92．81％（452篇）系统评价/Meta 分析使用1种统计软件,1．64％（8篇）使用2种统计软件,5．54％（27篇）未报告使用的统计软件。统计学分析方法的描述和执行情况存在结果部分和方法学部分的报告率不等,尤其体现在敏感性分析、亚组分析和发表偏倚的评价,且其本身的报告比例并不高。结论调查显示RevMan是目前我国干预类系统评价/Meta分析的首选统计软件;正确地执行敏感性分析、亚组分析及评估发表偏倚可有效地避免各种偏倚。     

Meta-分析的研究进展

医学文献的Meta 分析 (Meta analysis)是建立在临床流行病学和循证医学基础上的一种新的研究方法[1] 。近年来 ,Meta 分析在国内医学领域的应用已逐渐展开 ,本文就其历史、定义、目的、步骤方法、存在问题等作一综述。1　Meta 分析的历史回顾对分散的研究结果进行合并的努力由来已久。早在190 4年 ,统计学家KarlPearson在其血清接种抗伤寒的预防作用的研究中 ,正式报道了从不同的样本中合并数据的技术[2 ] ,Pearson提出的合并研究的原因至今仍被Meta 分析沿用 :“许多研究 ,由于样本数太少而难以明确其结果。”首次治疗干预效果的Meta …     

57例围产儿死亡原因分析

５７例围产儿死亡原因分析牟尚敏（安徽省合肥市第二人民医院２３００１１）关键词：围产医学；围产保健；围产儿死亡中图法分类号：Ｒ７１４．７１９８１年中华医学会全国围产医学专题学术会议规定：围产儿死亡是以死胎、死产及早期新生儿死亡进行统计。其围产儿标准是：...     

Meta分析在非医学领域的应用

目的：揭示近10年Meta分析在非医学领域的研究主题,为Meta分析相关科研人员的选题和今后研究方向提供参考。方法：采用共词聚类分析法,通过CNKI检索2008-2017年核心期刊、CSSCI和CSCD中非医学领域的Meta分析的文献,统计文献的高频主题词。利用Bicomb 2.0软件构建高频关键词矩阵,并导入SPSS 22.0进行共词聚类分析。结果：目前Meta分析在非医学领域主要应用于为心理健康、老年人、教育等社会问题提供支持决策,提升农作物产量与企业经济效益等方面。结论：近10年Meta分析在非医学领域的研究主要集中于社会问题、农业和企业效益3个方面。     

中国传统医学发展面临的机遇、挑战及对策

传统医学是传统中医学、印度医学及阿拉伯医学等传统医学体系以及各种形式的民间疗法的统称。通常情况下，涉及非洲、拉美、东南亚和（或）西太平洋地区时使用“传统医学”一词；而涉及欧洲和（或）北美（及澳大利亚）时称为“补充和替代医学”一词；     

舍曲林治疗强迫症的Meta分析

目的：进一步了解舍曲林（左洛复）治疗强迫症的疗效。方法：对3项公开发表的论以及1项自己研究论的结果作Meta分析。结果：综合检验：Z．6，P＜0．01，说明左洛复对强迫症治疗前后的量表评分有明显性的降低；d＝0．875，提示这种治疗效应较大。结论：左洛复对强迫症有明显的治疗作用，而且效应较大。     

全科医生小词典——询证医学、Meta分析、价-效医学

循证医学（evidence based medicine,EBM）：即遵循证据的医学,循证医学创始人之一DavidSackett教授在2001年将循证医学的定义重新修订为“慎重、准确和明智地应用当前所能获得的最佳研究依据,同时结合医生的个人专业技能和多年临床经验,考虑病人的价值和愿望,将三者完美地结合制定出病人的治疗措施”。循证医学是一门新兴交叉临床医学基础学科,其核心思想是重视证据,将最佳研究结果和临床相结合。认为搜集所有质量可靠的同类研究进行系统评价所得的证据最为可靠。     

Meta分析简介：同类研究结果综合再分析的统计方法

Ｍｅｔａ分析简介──同类研究结果综合再分析的统计方法胡克震（卫生事业管理系）虽然，尝试、探索对同类单个研究结果进行综合再分析的历史，可追溯到本世纪初、中期，如ＦｉｓｈｅｒＲＡ早年提出的方法现仍见应用。但作为专门方法，引入＂ｍｅｔａ－ａｎａｌｙｓｉｓ＂...     

基于Web of Science的Meta分析在医学信息学领域中的应用

目的：探讨Meta分析在医学信息学领域的研究前沿,并对其跨学科属性进行分析,为科研人员提供借鉴和参考。方法：以Web of Science核心合集中医学信息学领域发表的Meta分析相关文献为研究对象分析学科领域分布,利用Netdraw建立学科共现网络探讨跨学科属性。对高频被引论文进行双向聚类分析,分析当前该领域的研究前沿。结果：近5年医学信息领域中Meta分析研究涉及最多的学科有卫生保健科学与服务、数学与计算生物学等,研究前沿主要集中在网状Meta分析的方法学研究、诊断性试验Meta分析方法、基于互联网和医疗信息技术干预模式对疾病或健康结局影响的系统评价和Meta分析、Meta分析的统计学方法及统计模型构建与模拟等5个方面。结论：医学信息学领域Meta分析研究的跨学科属性和5个研究前沿,为后续研究指明了方向。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.