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目的分析临床少见的脂质沉积性肌病(LSM)临床特点和肌肉活检特征。方法收集我院LSM患者19例,分析临床表现、肌电图、肌酶、肌力等以及肌活检时组织结构和酶组化染色特点。结果LSM临床表现为四肢近端肌萎无力,运动不持久。肌力大多在III级左右,其中1例肌力为V级;实验室检查肌酶均有增高,患者血脂和载脂蛋白异常;肌电图检查为肌源性损害。病理特点为皮肤厚度增加,肌肉结构清楚,肉色浅,质软,病理诊断主要靠镜下以I型肌纤维为主的肌纤维空泡,脂肪染色(SBB)阳性。结论脂质沉积性肌病的确诊手段是肌肉活检的脂肪染色,具体分型还需进行生化检测各种酶缺陷。 相似文献
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目的报道3例曾被误诊为多发性肌炎而后被确诊为成年起病的线粒体肌病的临床、MRI及病理学表现. 方法对3例病人进行临床、电生理、MRI和肌肉活检特殊染色、组织酶学等病理检查. 结果3例患者均表现为四肢近端肌无力与肌萎缩,肌酶升高,EMG示肌源性损害,MRI示近端肌肉萎缩较明显.肌肉病理学检查,MGT特染及NADH-TR和SDH组织酶学染色中发现典型的"玻碎红纤维",电镜证实肌纤维胞浆内线粒体增多.结论对临床成年起病的进行性对称性四肢近端肌无力与萎缩的患者应考虑线粒体肌病的可能;特殊染色及组织酶学在诊断线粒体肌病中起重要作用,激素治疗可能有效. 相似文献
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脂质沉积性肌病(lipid stoage myopath,LSM)是指由于肌肉中长链脂肪酸代谢障碍,致使脂质沉积在肌纤维内而引起的脂代谢异常性肌病,临床上容易误诊为多发性肌炎、肌营养不良症、重症肌无力、心肌炎等。作者收集了1998年3月至2012年5月经肌肉活检病理证实为LSM的19例的临床资料,探讨其临床和神经肌肉电生理特点。 相似文献
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糖原贮积症伴脂质贮积症 总被引:1,自引:0,他引:1
目的 探讨糖原贮积症伴脂质贮积症的临床与病理特点。方法 报告1例患者,结合文献复习,描述其临床与病理特征。结果 本病多见于婴儿或青少年女性,进行性或抒发性广泛性肌张力减低,四肢近端肌无力或萎缩,可伴有肌肉酸痛。病理特点为肌纤维出现弥温性空泡,Ⅰ型纤维受累可比Ⅱ型肌纤维明显,电镜下发现糖原和脂滴贮积于肌纤维内。结论 当患者因条件受限、无法进行生化检查时,光、电镜结合的活检肌组织形态观察有助于诊断。 相似文献
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脂质沉积性肌病15例临床及病理分析 总被引:3,自引:1,他引:2
结合肌肉病理改变,探讨脂质沉积性肌病的诊断及治疗。方法对15全LSM患者进行临床及病 镜与电镜观察。结果患者均有进行性四肢无力,血清肌酶不同程度升高,肌肉病理苏丹黑染色及电镜示肌纤维中大量脂质沉积,以Ⅰ型纤维为主,结论LSM是一组以肌无力和肌疲劳为主要表现的肌纤维内脂肪代谢障碍病。肌肉病理检查有助于确定诊断。激素治疗有效。 相似文献
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目的:报道3例曾被误诊为多发性肌炎而后被确诊为成年起病的线粒体肌病的临床、MRI及病理学表现。方法:对3例病人进行临床、电生理、MRI和肌肉活检特殊染色、组织酶学等病理检查。结果:3例患者均表现为四肢近端肌无力与肌萎缩,肌酶升高,EMC示肌源性损害,MRI示近端肌肉萎缩较明显。肌肉病理学检查,MGT特染及NADH-TR和SDH组织酶学染色中发现典型的“玻碎红纤维”,电镜证实肌纤维胞浆内线粒体增多。结论:对临床成年起病的进行性对称性四肢近端肌无力与萎缩的患者应考虑线粒体肌病的可能;特殊染色及组织酶学在诊断线粒体肌症中起重要作用,激素治疗可能有效。 相似文献
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APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES 总被引:13,自引:0,他引:13
Hong Zhao Tie-hu Ye* Zhi-yi Gong Yang Xue Zhang-gang Xue and Wen-qi HuangDepartment of Anesthesiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Department of Anesthesiology Zhongshan Hospital Fudan University Shanghai Department of Anesthesiology the First Affiliated Hospital Zhongshan University Guangzhou 《中国医学科学杂志(英文版)》2005,20(1):59-62
FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle… 相似文献
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Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle. 相似文献
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In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects. 相似文献
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Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea. 相似文献
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目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P<0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P<0.05),PaCO2均随观察时间的延长而降低(P<0.05).观察组治疗有效率为87.5%,显著高于对照组的70.0% (P <0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P<0.05),且观察组明显低于对照组(P<0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用. 相似文献
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Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine 下载免费PDF全文
Evidence obtained from randomized controlled trials (RCTs) has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine (TCM) and results have shown that there is an urgent need for higher quality RCTs on TCM. 相似文献
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刘鹏 《中医杂志(英文版)》2008,28(1):44-45
Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed. 相似文献
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Yang Xiang* Lei Li Fang Tian and Xiu-yu YangDepartment of Obstetrics & Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 《中国医学科学杂志(英文版)》2005,20(1):48-50
CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h… 相似文献