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1.
目的:评价介入治疗应用于儿童Legg-Perthes病的治疗效果。方法:股动脉插管,経旋股内外动脉,将溶栓,扩血管及改善微循环药物直接注入股骨头供血动脉。结果:血管造影及DSA显示治疗后血管计数较治疗前增多。临床及X片进行随访,髋部疼痛及关节功能障碍均有不同程度的改善和减轻。X片可见股骨头明显修复。结论:初步总结表明,本法对股骨头的血供起到了改善作用。对治疗儿童早期Legg-Perthes病是一种安全有效的方法。  相似文献   

2.
股骨头缺血坏死的介入疗效观察   总被引:1,自引:0,他引:1  
目的:评价介入治疗股骨头缺血坏死的疗效.方法:对58例股骨头缺血坏死患者采用介入插管的方法,超选择进入到股骨头营养血管旋股内、外侧动脉和闭孔动脉,造影观察其血液供应情况后,注入溶栓药物、扩血管药物及改善微循环药物,术后再次造影观察对比股骨头供血改变情况,并于12~36个月摄X线、CT片与术前X线、CT片进行比较,对比观察股骨头骨质改变情况.结果:治疗前后血管造影对照显示治疗后血管增多,股骨头染色增强,12~36个月后X线、CT片显示骨密度增高者占96.56%,临床症状明显改善.结论:通过介入方法治疗股骨头缺血坏死是一种安全有效的治疗方法,能在临床上广泛应用.  相似文献   

3.
股骨头坏死的介入治疗   总被引:5,自引:0,他引:5  
叶伟龙  陈忠  吴小红 《河北医学》2010,16(7):854-855
目的:探讨股骨头缺血性坏死(ANFH)的介入治疗效果。方法:对12例ANFH患者的12髋先常规行股动脉DSA,后在股骨头的供血动脉旋股内、外侧动脉内灌注溶栓、扩血管药物,即在每支血管内注入稀释后的罂粟碱25mg、尿激酶25万u、低分子右旋糖酐80mL、血栓通0.15mg;术后每日静脉滴注低分子右旋糖酐500mL、血栓通0.3mg及肝素钠4500 u,连用5d,治疗后行股骨头X线平片及/或CT随访半年以评估疗效。结果:术后患者患髋疼痛症状明显减轻,关节功能不同程度改善,股骨头X线平片及/或CT随访1-6个月(平均4.5个月)示FicatⅠ、Ⅱ期患者介入治疗后股骨头修复明显。结论:股骨头供血动脉内的介入治疗是一种疗效肯定、安全的方法。  相似文献   

4.
凌冰  陈东民  王海  乔风雷  惠本军 《当代医学》2009,15(17):343-344
目的评价介入治疗股骨头缺血性坏死(ANFH)的疗效。方法对38例ANFH的患者采用介入插管的方法,先常规行股骨头的供血动脉旋股内、外动脉和闭孔动脉造影,观察血液供应情况后,每支血管分别灌注溶栓并给予扩血管药物及改善微循环药物,术后再次造影,观察对比股骨头供血改变情况,并于1~20个月摄X线平片或\和CT及MRI随访以评估疗效。结果术后血管造影显示所有患者股骨头区血管增多,股骨头染色增强。随访1~20个月(平均10.5个月)影像检查示股骨头缺血性坏死Ⅱ期以内的患者介入治疗后股骨头得以修复。临床症状明显改善。结论介入治疗ANFH是一种安全有效的治疗方法。  相似文献   

5.
目的 探讨通过血管内给药治疗股骨头缺血性坏死的临床效果及本方法的可行性。方法 对35例股骨头无菌坏死的患者,分别进行了经股动脉插管,将血管扩张药、溶栓药及抗凝药、及改善微循环药物直接注入缺血坏死股骨头的供血动脉:旋股内动脉,旋股外动脉及闭孔动脉,治疗后口服维生素D及钙片。结果 经治疗的35例46髋患者中疼痛消失或缓解占9r7.82%,X线、CT复查均有不同程度的骨质修复,新骨形成。血管造影显示股骨头供血动脉增粗,细小动脉侧支循环增多。结论 经股动脉血管内介入治疗股骨头缺血性坏死对改善局部血液循环,缓解临床症状,恢复髋关节功能,促进新骨形成及死骨修复起了重要作用,是一种安全有效的治疗方法。  相似文献   

6.
股骨头缺血性坏死介入治疗的临床应用   总被引:1,自引:0,他引:1  
目的:探讨股骨头缺血性坏死(ANFH)经旋股内、外动脉及闭孔动脉灌注溶通术的治疗效果。方法:将扩张血管、溶栓及改善微循环的药物直接注入缺血坏死股骨头的供血动脉旋股内、外侧动脉及闭孔动脉,7~10d后行第二次或第三次治疗。结果:疼痛缓解和改善是本组病例最有效的反应,影像学检查均有不同程度的骨质修复及新骨形成。结论:介入治疗股骨头缺血性坏死能明显改善血供状况,血管再通率高,症状明显改善,疗效显著。  相似文献   

7.
申东峰 《实用医技杂志》2007,14(27):3714-3716
目的:评价介入治疗股骨头缺血坏死的疗效,探索股骨头缺血坏死的治疗方法。方法:对28例股骨头缺血坏死患者采用介入插管的方法,超选择进入到股骨头营养血管旋股内、外侧动脉和闭孔动脉,造影观察其血液供应情况后,注入溶栓药物、扩血管药物及改善微循环药物,术后再次造影观察对比股骨头供血改变情况,并于12个月~36个月摄X光片与术前相片对比观察股骨头骨质改变情况。结果:治疗前后血管造影对照显示治疗后血管增多,股骨头染色增强,12个月~36个月后平片显示骨密度增高者占97.2%,临床症状明显改善。结论:通过介入方法治疗股骨头缺血坏死是一种安全有效的治疗方法,能在临床上广泛应用。  相似文献   

8.
儿童股骨头缺血性坏死(Perthes病)是骨科难治之症,股骨头骨骺血运受阻是产生Perthes病的重要原因。本病多见于4~8岁儿童,由于48岁儿童只有一条外骺动脉供血股骨头,因此,增加股骨头血运被认为是治疗Perthes病有效方法。我院设计了旋骨外侧血管升支的髂嵴支和髂前下嵴支双骨膜瓣转移治疗Perthes病,2004-2006年,临床应用22例,疗效满意。现将有关护理报告如下:  相似文献   

9.
介入法治疗股骨头缺血坏死20例   总被引:3,自引:0,他引:3  
目的:探讨介入法治疗股骨头缺血性坏死(avascular necrosis of femur head,ANFH)的临床应用价值。方法:20例ANFH患者,全部病例均经X线、CT及MRI检查证实。经股动脉行Seldinger法穿刺插管,先行血管造影,再将导管超选择至病变股骨头供血动脉,灌注一定量溶栓及扩血管药物行介入治疗,术后血管造影观察病变股骨头供血情况,1周后所有病例行第2次介入治疗,方法同前,并随访临床疗效。结果:术后血管造影示股骨头供血动脉均不同程度增粗、增多,血供较术前丰富;随访发现患者关节疼痛缓解率达95%。结论:介入法是治疗ANFH的有效手段,具有重要的临床应用价值。  相似文献   

10.
目的:探讨动脉融通术介入治疗非创伤性股骨头缺血坏死的临床意义。方法回顾分析31例53髋非创伤性股骨头缺血坏死经动脉融通术药物介入治疗前后的股骨头血供及疼痛症状改善情况的疗效。结果疗效评分显示治疗后3、6个月疗效优良率明显高于治疗前。治疗后患侧股骨头分支小血管增粗增多,股骨头血供改善、染色较治疗前部分显著增强。结论动脉融通术介入治疗能明显改善病患坏死股骨头血供、缓解疼痛症状,特别对于早期患者可取得较为满意的疗效。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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