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1.
目的 探讨全心尖切面心肌背向散射积分参数评价存活心肌的临床价值.方法 研究22例冠心病(CAD)患者和18例冠状动脉造影术(QCA)正常患者全心尖切面所测左室16个节段背向散射积分参数,比较CAD组中室壁运动异常节段心肌、对照组心肌的背向散射周期变异幅度(CVIB)、标化平均背向散射积分(AII%)、标化CVIB(CVIB%)值.测量CAD患者PCI术前1周内,术后2周、3月室壁运动计分指数(WMSI)、左室射血分数(EF)及IBS参数(CVIB、CVIB%及AII%),分析存活节段、坏死节段IBS参数的变化.结果 CAD组中室壁运动异常节段心肌与对照组心肌的IBS参数有显著性差异(P<0.05),PCI术后2周、3月EF、WMSI与术前相比有显著性差异(P<0.05).存活节段与坏死节段的CVIB、AII%、CVIB%有显著性差异(P<0.05).存活节段PCI术前IBS值与术后2周、术后3月相比,CVIB、CVIB%术后明显升高(P<0.01),而AII%显著减小(P<0.01),术后2周与术后3月相比,CVIB、AII%、CVIB%无显著性差异(P>0.05).坏死节段的CVIB、AII%、CVIB%术前、术后2周、3月无显著性差异(P>0.05).结论 全心尖切面所测CVIB、AII%、CVIB%值能够敏感、客观地评价存活心肌.  相似文献   

2.
目的探讨应变率成像(SRI)及背向散射积分(IBS)技术在综合评价风湿性二尖瓣狭窄(MS)患者左心室局部收缩功能中的价值。方法应用SRI及IBS技术测量30例MS患者(MS组)和30例健康志愿者(对照组)左心室各壁基底段和中间段收缩期峰值应变(Ss)、收缩期峰值应变率(SRs)及左心室心肌IBS参数。测量心脏左室整体收缩功能指标,即左心室射血分数(EF)和短轴缩短率(FS)。结果MS组左心室壁各节段Ss、SRs均小于对照组相应节段(P<0.05,P<0.01),MS组室间隔及左心室后壁心肌的IBS标准化值(IBS%)显著增大(P<0.01),IBS心动周期变异幅度(CVIB)及变异率(CVIB%)减小(P<0.01),2组间心脏左心室整体收缩功能比较差别无统计学意义(P>0.05)。结论SRI及IBS技术能够准确评价风湿性MS患者左心室局部收缩功能的变化。  相似文献   

3.
目的应用多普勒组织成像(DTI)技术测定二尖瓣环运动速度定量分析生理和病理(心肌缺血)状态下左室收缩和舒张功能。方法对268例确诊急性心肌梗死(AMI)患者和93例年龄匹配的正常人(对照组)的二尖瓣环运动速度进行测量,分别在心尖四腔、心尖二腔和心尖长轴切面上测量二尖瓣环后间隔、侧壁、前壁、下壁、前间隔和后壁的收缩期运动峰值速度(VS)、舒张早期运动峰值速度(VE)和VE与舒张晚期峰值速度(VA)的比值(VE/VA)。结果与对照组相比,AMI组DTI可敏感地定量显示出收缩和舒张峰值速度显著下降;DTI收缩和舒张速度指标之间、收缩速度与左室射血分数之间以及舒张功能参数VE/VA均值与二尖瓣血流频谱E/A比值之间存在高度相关性。结论应用DTI技术测定二尖瓣环运动速度能够较准确的评价急性心肌梗死患者的左室收缩和舒张功能。  相似文献   

4.
目的应用实时三平面组织同步显像(TSI)技术评价正常人左心室内心肌收缩的同步性。方法应用实时三平面TSI技术同步采集20例健康志愿者心尖4腔观、2腔观及左室长轴观图像,脱机后进行后处理分析:(1)创建TSI彩色编码表示的左心室表面模型半定量反映心肌节段达峰时间(TTP);(2)定量测量3个心尖切面观左心室6个基底段和6个中间段TTP,并将各测值进行比较。结果 (1)TSI表面模型显示左心室各心肌节段彩色编码多为均匀一致的绿色,少数心尖段为黄色或红色。(2)左心室各心肌节段TTP差异均无显著性意义(均P>0.05)。结论正常人左心室内心肌收缩具有同步性;TSI技术可对心肌收缩的同步性作直观、定量地评价。  相似文献   

5.
目的 利用速度向量成像技术评价正常大鼠心尖四腔观与短轴心肌运动的相关性。方法 选取18只 10周龄SD大鼠,用速度向量成像技术测量大鼠心尖四腔观左心室及胸骨旁短轴二尖瓣水平的侧壁段,以及后 间隔段的收缩期纵向峰值速度(Vs)、舒张期纵向峰值速度(Vd)、纵向峰值应变(SR)、收缩期纵向峰值应变 率(SRs) 和舒张期纵向峰值应变率(SRd),分析两个切面相应室壁心肌运动之间的相关性。结果 胸骨旁短 轴二尖瓣水平侧壁段与心尖四腔观左心室侧壁基底段的Vd呈正相关(r =0.566,P <0.05)。胸骨旁短轴二尖瓣 水平侧壁段与心尖四腔观左心室侧壁中段的Vd、SRs和SRd呈正相关(r =0.521、0.540和0.592,均P <0.05)。 胸骨旁短轴二尖瓣水平后间隔段与心尖四腔观左心室后间隔基底段的Vd、SRs呈正相关(r=0.614和0.627,均 P <0.05)。胸骨旁短轴二尖瓣水平后间隔段与心尖四腔观左心室后间隔中段的Vs、Vd、SR、SRs和SRd均呈正 相关(r =0.536、0.937、0.530、0.639和0.621,均P <0.05)。结论 速度向量成像技术可用于评价大鼠心尖四 腔观的室壁心肌运动。  相似文献   

6.
组织多普勒成像评估冠心病心脏舒缩功能的临床研究   总被引:3,自引:1,他引:2  
目的:了解组织多普勒成像(DTI)技术在评估冠心病(CAD)心肌舒缩功能方面的应用。方法:应用超声心动图DTI技术测量正常人和冠心病患者心尖二腔观二尖瓣环、左室前壁及下壁心肌的基段、中段及心尖段收缩期、舒张早、晚期峰值运动速度(分别为S、E、A)、内外膜峰值度差(ΔV)及峰值速度阶差(MVG)、E/A比值、等容收缩期(IVC)及等容舒张期心肌运动频谱持续时间(IVR)等一系列参数,并进行比较。结果:冠心病组二尖瓣环、左室前壁及下壁收缩期、舒张早期各测量参数均低于正常,舒张晚期无明显变化,E/A比值减小,ΔV及MVG减小,IVC、IVR明显延长(P<0.05,P<0.01)。结论:DTI技术可实时、准确地反映心肌舒缩运动状况,为进一步了解局部及整体心肌功能提供更多信息。  相似文献   

7.
高海燕  唐立  穆玉明 《农垦医学》2011,33(5):400-402
目的:探讨背向散射积分技术在原发性高血压患者左室心肌与主动脉重构的应用价值.方法:67例原发性高血压(EH)患者与30例正常者,分别测定室间隔(IVS)心肌和主动脉根部(A0)背向散射积分(IBS)、IBS周期变异幅度(CVIB),左心室质量指数(LVMI),舒张末期IVS厚度(IVSTd)和主动脉根部(AOD)径线....  相似文献   

8.
目的采用定量组织多普勒速度成像技术(QTVI)分析新生儿左室壁各节段心肌长轴方向的收缩功能。方法应用QTVI测量30例足月儿和30例早产儿有无临床心功能不全表现,通过标准心尖左室四腔观、两腔观切面获得的左心室的4个室壁(侧壁、室间隔、前壁、下壁)基底段、中间段、心尖段心肌运动速度曲线,分别测量各节段心肌纵向收缩期峰值速度(Vs),然后进行对比分析。结果新生儿左室壁各节段Vs呈梯度变化,基底部瓣环处速度最高,中间部次之,心尖部最低,各节段之间存在显著差异。足月儿左室壁各节段Vs高于早产儿。结论QTVI技术能定量评价新生儿左室壁各节段心肌运动速度,足月儿左心室心肌运动速度高于早产儿。  相似文献   

9.
目的探讨多普勒组织技术(DTI)及背向散射积分技术(IBS)在检测早期糖尿病心脏病变左室收缩功能异常病理基础方面的临床价值。方法 36例糖尿病患者及25例健康人,应用DTI分别测量左室6个壁收缩期峰值速度(Sa),应用IBS分别测量室间隔及左室后壁的校正背向散射积分(IBS%)及其周期变异幅度(CVIB)。并计算有统计学差异的IBS与DTI参数之间的相关关系。结果与对照组比较,糖尿病组左室壁平均Sa显著减低(P<0.05),下壁及前间隔Sa均显著低于对照组(P<0.01);糖尿病组室间隔IBS%显著增高(P<0.05),左室后壁CVIB显著减低(P<0.01)。间隔的IBS%与前间隔Sa及左室壁平均Sa呈显著负相关(分别为r=-0.524,P<0.01;r=-0.506,P<0.01),与下壁Sa呈显著负相关(r=-0.383,P<0.05);左室后壁CVIB与下壁Sa及左室壁平均Sa皆呈显著正相关(分别为r=0.469,P<0.01;r=0.415,P<0.01)。结论 DTI及IBS技术能够无创检测出早期糖尿病心脏病变左室收缩功能异常病理基础。  相似文献   

10.
目的探讨正常人心肌等容收缩期多普勒组织成像特点及其临床价值。方法应用多普勒组织成像(DTI)对30例正常人心肌进行检测。于标准胸骨旁左室长轴观、心尖左室长轴观、两腔观和四腔观,将取样容积分别置于左室前间隔、后壁、前壁、下壁、后间隔和侧壁的基底段和中段处内膜下心肌层,获取6个壁共16个取样点的组织多普勒图像,在每一个取样点的DTI图像上测量等容收缩期正向波、负向波的峰值速度(VIVC1,VIVC2),持续时间(TIVCI,TIVC2),速度时间积分(VTIIVC1,VTIIVC2),并计算等容收缩期正、负向波峰值速度的差值DIVC(DIVC:VIVC1-VIVC2)。结果正常人左心室六个壁等容收缩期心肌各位点DTI频谱通常呈正向为主的正负双向型坡。除后壁外(包括纵向和横向)每个壁基底段、中段的VIVC1〉VIVC2,TIVC1〉TIVC2,VTIIVC1〉VTIIVC2(P〈0.05),同一节段不同壁之间及同一壁不同节段间的VIVC1比较以及VIVC2比较差异多无统计学意义(P〉0.05)。结论正常心肌等容收缩期多普勒组织成像具有明显特点,应用其可对多种心脏疾病予以评价,因而具有重要临床意义。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

19.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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