人工流产等因素与输卵管性不孕关系的临床研究

目的 探讨人工流产及不孕年限、盆腔炎史、阑尾炎史、输卵管妊娠史和沙眼衣原体感染等是否为输卵管性不孕的危险因素.方法 采用病例对照研究方法,调查对象分为双侧输卵管阻塞不孕者（病例组154例）,双侧输卵管通畅不孕者（对照组170例）,面对面调查收集资料,内容包括年龄、教育程度、职业、不孕年限、人工流产史、月经史、妊娠史、盆腔炎病史、阑尾炎病史等,资料单因素及采用非条件Logistic回归分析.结果 单因素分析显示,病例组有人工流产史94例（61.0％）,对照组有人工流产史95例（55.9％）,2组间差异无统计学意义（P＞0.05）.不孕年限、盆腔炎史、阑尾炎史、输卵管妊娠史和沙眼衣原体感染所占比例比较,2组间差异有统计学意义（P＜0.05）.非条件Logistic回归分析盆腔炎史（OR：4.378）、输卵管妊娠史（OR：3.026）、沙眼衣原体感染（OR：5.041）、阑尾炎史（OR：4.912）是输卵管性不孕的危险因素.人工流产史与盆腔感染有关（OR：1.534）.结论 人工流产不增加输卵管性不孕的危险性,但应避免人工流产并发症如盆腔炎以及输卵管妊娠、沙眼衣原体感染等的发生,以减少输卵管不孕.     

海南省92例肺结核耐药的危险因素分析

目的 探讨海南省92例肺结核发生耐药的相关危险因素。方法 收集海南省92例耐药的肺结核患者(耐药组)和120例非耐药的肺结核患者(非耐药组)的临床资料(性别、年龄、居住地、初/复治、治疗过程是否中断、结核病诊断治疗史、第一次是否在结核病定点医疗机构就诊)进行统计学处理,把有统计学意义的因素进行多因素非条件Logisitic回归分析,探讨肺结核发生耐药的相关危险因素。结果 肺结核耐药的发生与患者的性别、年龄无关(P>0.05),与居住地、初/复治、治疗过程是否中断、有结核病诊断治疗史,第一次在非结核医疗定点机构就诊有关(P<0.01);多因素非条件Logisitic回归分析显示,居住地为农村(OR=2.467 95%CI=1.309~4.650)、复治(OR=4.046 95%CI=2.274~7.199)、治疗过程曾经中断(OR=5.195 95%CI=2.877~9.381)、有结核病诊断治疗史(OR= 7.792 95%CI=4.206~14.436)和第一次在非结核医疗定点机构就诊(OR=5.495 95%CI=3.038~9.938)是产生耐多药结核病的危险因素。结论 居住地为农村、复治、曾经中断治疗、有结核病诊断治疗史、第一次在非结核病定点医疗机构就诊的肺结核患者易出现耐药性。     

输卵管妊娠发病的高危因素探讨

目的探讨输卵管妊娠发病的高危因素。方法回顾性分析输卵管妊娠患者的临床资料,与同期收治的早期宫内妊娠者（12周以内）的临床资料进行比较。结果输卵管妊娠的发生与盆腔炎性疾病（PID）、多次宫腔操作史、既往输卵管妊娠史、不孕史及宫内节育器的关系密切,与年龄和产次无关。结论盆腔炎性疾病（PID）、多次宫腔操作史、既往输卵管妊娠史、不孕史及宫内节育器是形成输卵管妊娠的高危因素。     

输卵管妊娠保守性手术后重复异位妊娠发生的多因素分析

【目的】探讨输卵管妊娠保守性手术后重复异位妊娠发生的高危因素。【方法】回顾分析1999年1月至2004年1月,收治于广东省人民医院及中山大学附属第一医院经保守性手术治疗确诊为输卵管妊娠的有生育要求的330例患者,追踪生育结局18～72个月。据生育结局分为重复性异位妊娠组与非异位妊娠组,采用多重logistic回归分析13项临床变量与生育结局间的关系,探讨引起保守治疗术后重复性异位妊娠发生的危险因素。运用Pearson/Spearman相关性分析探讨两次异位妊娠发生部位的相关性。【结果】①70/330（21.2%）患者重复发生异位妊娠,经腹腔镜手术的43/249例（17.3%）,经开腹手术的27/81例（33.3%）。②影响重复性异位妊娠发生的危险因素有：不孕史（OR=0.359）、盆腔炎史（OR=0.347）、异位妊娠史（OR=0.152）、输卵管手术史（OR=0.410）、输卵管粘连（OR=0.187）、输卵管伞端闭锁（OR=0.333）、开腹手术（OR=0.424）。P值均〈0.05。尚未发现年龄、阑尾炎史、流产次数、输卵管妊娠部位、破裂与否、盆腔积血量对重复性异位妊娠结局有显著性影响。③Pearson／Spearman相关性分析显示P〉0．05，表示两次异位妊娠部位无相关性。【结论】①重复性异位妊娠的发生受盆腔整体环境及患者特点影响，并不倾向于发生在原输卵管妊娠侧。②积极防治盆腔病变、治疗不孕症、选择腹腔镜手术是预防重复性异位妊娠发生的重要手段。     

输卵管妊娠保守性手术后重复异位妊娠发生的多因素分析

 【目的】探讨输卵管妊娠保守性手术后重复异位妊娠发生的高危因素。【方法】回顾分析1999年1月至2004年1月,收治于广东省人民医院及中山大学附属第一医院经保守性手术治疗确诊为输卵管妊娠的有生育要求的330例患者,追踪生育结局18～72个月。据生育结局分为重复性异位妊娠组与非异位妊娠组,采用多重logistic回归分析13项临床变量与生育结局间的关系,探讨引起保守治疗术后重复性异位妊娠发生的危险因素。运用Pearson/Spearman相关性分析探讨两次异位妊娠发生部位的相关性。【结果】①70/330（21.2%）患者重复发生异位妊娠,经腹腔镜手术的43/249例（17.3%）,经开腹手术的27/81例（33.3%）。②影响重复性异位妊娠发生的危险因素有：不孕史（OR=0.359）、盆腔炎史（OR=0.347）、异位妊娠史（OR=0.152）、输卵管手术史（OR=0.410）、输卵管粘连（OR=0.187）、输卵管伞端闭锁（OR=0.333）、开腹手术（OR=0.424）。P值均〈0.05。尚未发现年龄、阑尾炎史、流产次数、输卵管妊娠部位、破裂与否、盆腔积血量对重复性异位妊娠结局有显著性影响。③Pearson／Spearman相关性分析显示P〉0．05，表示两次异位妊娠部位无相关性。【结论】①重复性异位妊娠的发生受盆腔整体环境及患者特点影响，并不倾向于发生在原输卵管妊娠侧。②积极防治盆腔病变、治疗不孕症、选择腹腔镜手术是预防重复性异位妊娠发生的重要手段。     

输卵管性不孕因素与术后预后相关性研究

目的探讨影响输卵管性不孕患者术后预后的术前不孕因素。方法对263例输卵管性不孕患者的临床资料进行回顾性分析,研究患者年龄、不孕时间、盆腔炎病史、生育史（继／原发不孕）、异位妊娠史、盆腹腔手术史、输卵管通畅程度对术后预后的影响。结果263例患者中,术后不孕者有174例,不孕率66．2％。继发／原发不孕、异位妊娠史、盆腹腔手术史术后不孕及成功妊娠患者不孕率差异均无统计学意义（均P〉0．05）,年龄、不孕时间、流产史、盆腔炎病史以及输卵管通畅程度方面两者术后不孕率差异均有统计学意义（均P〈0．05）：多因素Logistic回归分析显示,盆腔炎病史、输卵管阻塞或通而极不畅和流产≥3次是术后不孕的独立危险因素。结论输卵管性不孕患者术前不孕因素与术后预后相关。     

输卵管性不孕的主要危险因素探讨--Logistic回归分析

目的：通过对输卵管不孕妇女的月经、生育、生殖道感染状，既往手术情况等进行调查、分析，了解输卵管性不孕的病因和危险因素，对其预防和治疗提供帮助。方法：对2000年9月至2001年2月在我院就诊的257例不孕妇女和同期在我院进行产前检查的241例孕妇的各项对生育力有不良影响的因素进行分析。结果：经Logistic回归分析发现，产后感染（包括流产后感染）、盆腔炎、异位妊娠是输卵管性不孕的主要危险因素（OR分别为7．87、6．52、5．95），结核病史、阑尾手术、宫内节育器避孕和人工流产也是不孕症的危险因素（OR分别为3．54、1．64、2．02、0．92），月经紊乱对不孕的发生有不利影响。结论：盆腔感染、异位妊娠、结核病史、阑尾手术、宫内节育器避孕和人工流产是输卵管性不孕的主要危险因素，应注意预防和治疗盆腔感染，减少盆腔手术的干扰和创面损伤，避免非意愿妊娠，采用口服避孕药等具有保护作用的避孕方法。     

凶险性前置胎盘发生的相关因素分析

目的 分析凶险性前置胎盘(PPP)的相关因素。方法 选取2017年4月至2019年3月我院PPP产妇121例为研究对象,另根据1∶1配对原则选取同期非前置胎盘正常产妇121例作为参照,回顾性分析其临床资料,通过制定调查问卷收集患者一般情况(年龄、居住地、文化程度)、孕期情况(系统产检、孕早期是否工作)、孕产史(孕次、既往流产次数、既往剖宫产次数、早产史、胎盘前置史)、妊娠方式(剖宫产、阴道分娩),分析PPP发病危险因素,并进行多因素Logistic回归分析。结果 年龄≥35岁、居住地农村、孕早期参加工作、孕次2次、既往流产次数1次、既往剖宫产次数1次产妇PPP所占比例高于正常产妇(P0.05);既往流产次数1次(OR=3.654,95%CI:1.954～6.932,P0.05)、既往剖宫产次数1次(OR=3.709,95%CI:1.593～8.634,P0.05)、年龄≥35岁(OR=3.753,95%CI:1.386～10.164,P0.001)是PPP发生的独立危险因素。结论 既往流产次数多、既往剖宫产次数多、年龄高是PPP发生的独立危险因素。临床应加强健康宣教,避免流产次增加而损伤子宫内膜,对流产次、剖宫产次较多,年龄较大产妇进行有效管理,加强诊断与预防工作,降低PPP发病率。     

影响药物流产的多因素分析

目的探讨影响药物流产失败的因素。方法随机选择400例应用米非司酮序贯并用米索前列醇药物流产的妇女,统计其年龄、孕产次、既往分娩方式、孕周、孕囊大小、子宫内膜厚度、子宫位置、盆腔炎症;记录流产成功、流产失败;行Logistic回归分析识别可能的影响因素。结果药物流产失败与既往自然分娩史(OR=0.150,95%CI 0.074~0.302)、孕周较小(OR=0.128,95%CI 0.019~0.879)、子宫内膜厚度较厚(OR=2.193,95%CI 1.109~4.338)、子宫位置后倾后屈(OR=2.876,95%CI 1.383~5.981)以及慢性盆腔炎症(OR=2.889,95%CI 1.370~6.091)有关。结论药物流产失败与既往分娩史、孕周、子宫位置、内膜厚度、慢性盆腔炎有关。临床中医生除了严格掌握其适应证和禁忌证外,还要结合上述因素进行综合考虑,以提高药物流产成功率及安全性。     

人工流产女性生殖道感染及其相关因素分析

目的了解人工流产女性生殖道感染(RTIs)的患病情况并分析其影响因素。方法对新乡市妇幼保健院2002年7月至2005年7月收治人工流产的女性300例进行常规妇科检查、取阴道分泌物检测阴道清洁度、滴虫、念珠菌、淋球菌、衣原体等,并对其婚姻状况、流产史、初次性交年龄等相关情况进行调查,记录有关数据,分析统计结果。结果流产史(OR=6.496,95%C:I 4.047-10.351)、初次性交年龄(OR=0.804,95%C:I 0.746-0.868)、配偶健康状况(OR=1.340,95%C:I 0.609-1.960)、婚姻状况(OR=1.212,95%C:I 0.617-1.699)等因素和RTIs呈正相关(P<0.05),卫生措施(OR=0.709,95%CI:0.557-0.902)和RTIs呈负相关,统计分析存在显著性差异(P<0.05)。结论未婚、既往有流产史、初次性交年龄较小、配偶健康状况欠佳可能是RTIs的危险因素;个人卫生措施可能是RTIs的保护因素。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.