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1.
目的:探讨持续方式与间断方式吸入糖皮质激素对咳嗽变异性哮喘(CVA)儿童的肺功能和炎性介质的影响。方法:将90例咳嗽变异性哮喘儿童按随机数字表分为观察组45例和对照组45例,对照组患儿采用间断方式吸入糖皮质激素治疗,200μg/次,仅在症状发作时使用,最长使用时间不能长于1个月;观察组患儿采用持续吸入布地奈德治疗,200μg/次,1次/d,连续治疗6个月。治疗前、治疗6个月后进行咳嗽症状评分,采用肺功能检测仪测定第1秒用力呼气容积(FEV_1)、呼气峰流速(PEF)和最大呼气中段流速(MMEF),采用酶联免疫吸附试验(ELISA)法测定血清炎性因子[肿瘤坏死因子(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)],测定诱导痰中嗜酸性粒细胞(Eos)数目。结果:两组患儿治疗后咳嗽评分均较治疗前明显降低,观察组明显低于对照组,差异均有统计学意义(P<0.05)。对照组和观察组患儿治疗后FEV_1为(95.4±12.4)%和(109.6±11.5)%、PEF为(90.3±8.8)%和(105.6±10.0)%、MMEF为(1.98±0.40)L/s和(2.48±0.38)L/s,均较治疗前明显升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。对照组和观察组治疗后TNF-α为(902.3±112.2)ng/L和(511.8±103.4)μg/L、IL-4为(80.2±10.5)μg/L和(50.6±7.4)μg/L、IL-8为(326.8±106.8)μg/L和(232.2±105.3)μg/L,较治疗前明显降低,IL-10为(16.66±3.10)μg/L和(25.75±4.21)μg/L,较治疗前明显升高,且观察组治疗后TNF-α、IL-4、IL-8明显低于对照组,IL-10明显高于对照组,差异均有统计学意义(P<0.05)。对照组和观察组治疗后Eos为(6.2±2.2)%和(4.5±1.6)%,均较治疗前明显降低,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。结论:持续吸入糖皮质激素能更好改善CVA患儿咳嗽症状及肺功能,减轻炎性反应,提高临床综合疗效。  相似文献   

2.
林秀玲  刘和平 《海南医学》2016,(13):2124-2126
目的:探讨孟鲁司特钠对儿童咳嗽变异型哮喘(CVA)的临床疗效及其对患儿血清免疫球蛋白E (IgE)以及白介素-4(IL-4)的影响。方法将2013年1月至2015年2月我院儿科收治的98例CVA患儿以数表法随机分为观察组(n=49)与对照组(n=49),对照组给予布地奈德气雾剂治疗,观察组在对照组基础上加用孟鲁司特钠治疗,比较两组患儿的临床疗效,以及治疗前后患儿血清IgE及IL-4水平的变化情况。结果观察组患儿的治疗总有效率为95.9%(47/49),显著高于对照组的67.3%(33/49),差异有显著统计学意义(P<0.01);观察组患儿的咳嗽缓解时间和咳嗽消失时间分别为(3.82±1.11) d和(6.46±1.38) d,均显著短于对照组的(6.02±1.14) d和(10.23±1.50) d,差异均有显著统计学意义(P<0.01);治疗后观察组IgE为(148.2±43.5) KU/L,IL-4为(67.6±11.7) ng/mL,均显著低于治疗前的(277.4±44.2) KU/L与(90.4±12.2) ng/mL,对照组治疗后IgE为(168.3±42.9) KU/L,IL-4为(75.4±12.1) ng/mL,均显著低于治疗前的(278.3±43.6) KU/L与(91.0±12.4) ng/mL,且治疗后观察组的IgE及IL-4水平均明显低于对照组,差异均有统计学意义(P<0.05)。结论孟鲁司特钠用于CVA患儿的治疗能够有效降低IgE、IL-4水平,抑制Ⅰ型变态反应,从而更加快速的缓解患儿临床症状,疗效确切,安全可靠,值得推广应用。  相似文献   

3.
多靶点治疗难治性成人肾病综合征疗效观察   总被引:1,自引:0,他引:1  
目的:探讨多靶点治疗对难治性成人肾病综合征(RNS)患者肾功能的影响。方法选取2012年5月至2014年5月我院肾内科收治的78例RNS患者作为研究对象,采用数字随机表法分为对照组和观察组各39例,均给予常规治疗,观察组给予泼尼松+霉酚酸酯+他克莫司治疗,对照组给予泼尼松+环磷酰胺,治疗前后检测两组患者24 h尿蛋白定量、血清白蛋白(ALB)、血肌酐(Scr)水平,以及白细胞介素-8(IL-8)、尿白细胞介素-6(IL-6)及T淋巴细胞水平。评估两组患者的疗效及用药安全性。结果观察组患者治疗有效率为71.79%(28/39),明显高于对照组的41.03%(16/39),差异具有统计学意义(P<0.05);观察组患者治疗后24 h尿蛋白定量、Scr水平明显低于对照组[(0.71±0.82) g/24 h vs (1.30±1.06) g/24 h、(70.26±9.66)μmol/L vs (76.27±10.28)μmol/L],ALB明显高于对照组[(36.87±6.29) g/L vs (32.04±5.28) g/L],差异均具有统计学意义(P<0.05);观察组患者治疗后的IL-6、IL-8水平均明显下降,且低于对照组[(42.34±9.37) pg/ml vs (63.68±8.23) pg/ml、(59.86±9.85) pg/ml vs (81.06±5.29) pg/ml],差异均具有统计学意义(P<0.05);观察组患者治疗后的CD3+、CD4+、CD4+/CD8+均明显高于对照组[(63.39±5.29)%vs (58.67±6.07)%、(36.11±5.16)%vs (31.05±5.97)%、(1.53±0.71)%vs (1.27±0.86)%],差异均具有统计学意义(P<0.05)。观察组和对照组的不良用药反应率分别为25.64%(10/39)和30.77%(12/39),差异无统计学意义(χ2=0.25,P>0.05)。结论泼尼松+霉酚酸酯+他克莫司多靶点治疗RNS能够改善肾功能,维持机体免疫功能,提高临床疗效。  相似文献   

4.
目的:观察替硝唑口服联合荆芥水煎液外用治疗阴道滴虫病的疗效,并探讨其对患者血清白介素(IL)-2、IL-4和IL-10水平的影响。方法平行设计选取2013年1月至2016年1月铜川市人民医院南院和西安交通大学第一附属医院妇产科符合阴道滴虫病的患者随机分为对照组和观察组,每组60例。对照组予替硝唑口服治疗,观察组在对照组治疗的基础上予荆芥水煎液阴道外用,治疗14 d。观察两组患者临床症状和体征改善的所需时间;显微镜检查阴道分泌物悬液;酶联免疫法检测患者治疗前后的血清IL-2、IL-4和IL-10水平;随访3个月以观察复发情况。结果观察组患者的总有效率为90.0%(55/60),明显高于对照组的73.3%(44/60),差异有统计学意义(P<0.05);两组患者治疗前后血清IL-2、IL-4和IL-10浓度水平比较,差异均有统计学意义(P<0.05);观察组治疗前后血清IL-2、IL-10浓度差值明显多于对照组[(6.5±2.7) pg/mL vs (3.6±1.7) pg/mL,(6.8±2.6) pg/mL vs (2.6±0.9) pg/mL],差异均有统计学意义(P<0.05),而观察组治疗前后血清IL-4浓度差值稍多于对照组,但差异无统计学意义(P>0.05);随访3个月,对照组复发率为18.3%(4/60),明显高于观察组的6.7%(11/60),差异有显著统计学意义(P<0.01)。结论替硝唑口服联合荆芥水煎液外用能够治疗阴道滴虫病,症状改善与复发率方面明显优于单一使用抗滴虫药物,其可能通过抗滴虫治疗与局部调节炎症反应从而提高疗效。  相似文献   

5.
目的 观察康复新液联合美沙拉嗪治疗溃疡性结肠炎的临床效果.方法 选择2012年1月至2014年1月河北北方学院附属第三医院消化科收治且符合入组条件的78例溃疡性结肠炎患者,按照数字表法随机分为对照组与观察组各39例,对照组与观察组均予以美沙拉嗪口服治疗,每次1 g,每日3次,持续治疗30 d为一个疗程,观察组另增加康复新液灌肠治疗,每日1次,持续治疗30 d为一个疗程.比较两组患者治疗一个疗程后的临床疗效、疾病复发率、药物副作用,并观察其对患者炎性细胞因子、凝血参数的影响.结果 治疗后观察组患者的临床治疗总有效率为97.44%(38/39),明显高于对照组的84.62%,(33/39)两组疗效比较差异有统计学意义(P<0.01);跟踪随访12个月,观察组患者的疾病复发率为15.38%(6/39),明显低于对照组的48.72%(19/39),两组比较差异有显著统计学意义(P<0.01);治疗后,观察组患者的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平显著低于对照组[(133.4±20.3)ng/mL vs(191.5±22.6)ng/mL、(75.1±7.2)ng/mL vs(116.2±8.6)ng/mL],差异具有显著统计学意义(P<0.01),而白细胞介素-1(IL-1)、白细胞介素-8(IL-8)、纤维蛋白原(Fib)则低于对照组[(0.51±0.19)ng/mL vs(0.83±0.19)ng/mL、(0.45±0.08)ng/mL vs(0.63±0.12)ng/mL、(2.60±0.15)g/L vs(3.01±0.24)g/L],血小板体积(MPV)指标值高于对照组[(9.92±0.41)fl vs(8.76±0.35)fl],差异均有统计学意义(P<0.05).结论 康复新液联合美沙拉嗪治疗溃疡性结肠炎的疗效优于单纯美沙拉嗪治疗,其能有效改善血液流变学状态与局部炎症反应,疾病复率低,安全可靠.  相似文献   

6.
目的探讨抗结核感染免疫疗法治疗肺结核的疗效及对免疫功能和生活质量的影响。方法回顾性分析2012年5月至2014年12月在华北石油管理局总医院治疗的70例结核分枝杆菌阳性的初治肺结核患者的临床资料,按照治疗方法不同分为对照组和观察组,各35例。对照组给予0.3 g异烟肼、1.5 g吡嗪酰胺、0.75 g乙胺丁醇口服,静脉滴注0.6 g利福平,每日1次。观察组在对照组基础上给予静脉滴注0.08 g胸腺五肽,每日1次。两组患者均治疗16周。观察两组患者的临床疗效,治疗前后的肺功能、免疫功能、炎性因子和生活质量。结果 (1)疗效:观察组阴转率为82.9%(29/35),对照组为71.4%(25/35),组间比较差异无统计意义(P>0.05);观察组病灶吸收率为85.7%(30/35),对照组为82.9%(29/35),组间比较差异无统计意义(P>0.05)。(2)肺功能:治疗后,观察组第一秒用力呼气量、第一秒用力呼气量占用力肺活量比值、用力呼气25%时瞬间流速、用力呼气50%时瞬间流速高于对照组[(1.92±0.32)L比(1.62±0.24)L,(74.31±2.13)%比(67.82±1.63)%,(73.82±11.33)L/s比(65.14±12.61)L/s,(80.21±9.73)L/s比(72.12±11.12)L/s],差异有统计学意义(P<0.01)。(3)免疫功能:治疗后,观察组IgG高于对照组[(11.22±2.63)g/L比(9.73±2.74)g/L],IgE低于对照组[(107.92±56.24)ng/L比(223.53±34.82)ng/L],差异有统计学意义(P<0.05)。(4)炎性因子:治疗后,观察组白细胞介素(IL)-6、IL-8、肿瘤坏死因子α低于对照组[(86.72±9.95)μg/L比(99.24±10.81)μg/L,(0.31±0.14)μg/L比(0.38±0.11)μg/L,(90.53±22.32)ng/L比(102.73±20.82)ng/L],差异有统计学意义(P<0.05)。(5)生活质量:治疗后,观察组生活质量评分低于对照组[(16±6)分比(24±7)分],差异有统计学意义(P<0.05)。结论抗结核感染免疫疗法治疗肺结核能明显缓解临床症状,改善患者肺功能和生活质量,提高机体免疫功能。  相似文献   

7.
目的:探讨早期高流量血液滤过联合微创置管引流术在重症急性胰腺炎腹腔间室综合征治疗中的应用价值。方法选择2010年1月~2014年10月在广东省茂名市人民医院接受治疗的重症急性胰腺炎腹腔间室综合征患者98例,按照随机数字表法分为联合组与对照组。对照组在传统对症支持治疗的基础上行早期高流量血液滤过治疗,联合组在对照组治疗的基础上行微创置管引流治疗。观察两组患者治疗前后白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、血钾(K+)、血铬(Cr)、血尿素氮(BUN)、胃肠黏膜pH、平均动脉压(MAP)、呼吸频率(R)、心率(HR)等指标及预后情况。结果联合组治疗后IL-6[(173.82±6.82)pg/mL]、IL-10[(27.59±2.31)pg/mL]、TNF-α[(29.13±2.76)pg/mL]、CRP [(202.65±10.83)mg/L]均显著低于对照组治疗后 IL-6[(207.82±6.27)pg/mL]、IL-10[(50.38±4.02)pg/mL]、TNF-α[(61.98±4.87)pg/mL]、CRP [(235.76±11.72)mg/L],差异均有统计学意义(均P<0.05)。联合组治疗后血K+[(4.11±0.65)mmol/L]、血Cr[(385.87±11.85)mmol/L]、BUN[(14.02±2.75)mmol/L]均显著低于对照组治疗后血K+[(4.78±0.76)mmol/L]、血Cr[(406.20±11.54)mmol/L]、BUN[(17.03±2.84)mmol/L],差异均有统计学意义(均P<0.05)。联合组治疗后胃肠黏膜pH(7.30±0.35)与对照组治疗后胃肠黏膜pH(7.26±0.31)比较,差异无统计学意义(P>0.05)。联合组治疗后R[(22.76±1.96)次/min]、HR[(88.76±5.92)次/min]均显著低于对照组治疗后R[(25.15±1.87)次/min]、HR[(93.63±5.87)次/min],MAP[(117.98±6.82)mmHg]显著高于对照组治疗后MAP[(108.78±6.77)mmHg],差异均有统计学意义(均P<0.05)。联合组存活率(73.47%)显著高于对照组存活率(51.02%),差异有统计学意义(P<0.05)。结论早期高流量血液滤过联合微创置管引流术治疗重症急性胰腺炎腹腔间室综合征效果显著,值得应用于临床。  相似文献   

8.
目的探究标准大骨瓣开颅术对重型创伤性颅脑损伤(STBI)患者围术期炎性应激及代谢状态的影响。方法将自2010年3月至2014年9月河北省沧州中西医结合医院神经外科收治的208例STBI致颅内出血患者按照随机数字表法分为标准组和对照组,各104例。标准组行标准大骨瓣开颅手术,对照组行传统大骨瓣开颅手术,根据格拉斯哥昏迷评分法(GCS)预后评分标准进行预后分级,测定两组患者的血清神经元特异性烯醇化酶(NSE)和炎性因子[白细胞介素(IL)-2、IL-4、肿瘤坏死因子α(TNF-α)]水平,并对比其术后恢复情况及平均住院时间。结果标准组患者术后GCS评分≥4分患者比例(62.5%,65/104)显著高于对照组(38.5%,40/104),差异有统计学意义(P<0.05);标准组患者术后的血清NSE、TNF-α和IL-2水平较术前显著降低[(19.4±1.8)μg/L比(25.5±2.2)μg/L,(19.4±2.0)μg/L比(37.1±3.1)μg/L,(22.8±1.5)μg/L比(36.0±2.8)μg/L],差异有统计学意义(P<0.05);IL-4水平较术前显著增高[(15.8±2.3)μg/L比(5.7±2.0)μg/L],差异有统计学意义(P<0.05);IL-2/IL-4比值也较术前显著降低(1.8±0.5比7.7±1.2),差异有统计学意义(P<0.05);术后标准组患者的血清NSE、TNF-α和IL-2水平低于对照组(P<0.05);标准组平均住院时间为显著短于对照组[(39±5)d比(48±6)d],差异有统计学意义(P<0.01)。结论 STBI所致颅内血肿患者在标准大骨瓣手术治疗下其临床疗效显著提升,患者神经功能出现缺陷的可能大大降低,并能显著提高患者的生活质量。  相似文献   

9.
目的探讨沙美特罗氟替卡松对慢性阻塞性肺疾病(COPD)患者外周血及痰液中炎性因子水平的影响。方法选择2014年5~11月天门市第一人民医院收治的处于COPD稳定期的30例患者作为COPD组,另取30例健康志愿者为对照组。进行药物治疗前,比较对照组和COPD组血清中炎性因子水平;进行药物治疗则采用COPD患者自身对照,观察记录其采用沙美特罗氟替卡松吸入剂治疗前后外周血及痰液中炎性因子水平的变化。结果治疗前,COPD组患者白细胞介素(IL)8、肿瘤坏死因子α(TNF-α)、IL-10、IL-17高于对照组[(41±9)μg/L比(34±6)μg/L,(21±9)μg/L比(13±8)μg/L,(45±10)ng/L比(31±3)ng/L,(209±41)μg/L比(171±35)μg/L],差异有统计学意义(P<0.01)。治疗后,COPD患者外周血中IL-8、TNF-α、IL-10与IL-17水平均低于治疗前[(32±4)μg/L比(41±9)μg/L,(13±7)μg/L比(21±9)μg/L,(26±6)ng/L比(45±10)ng/L,(163±28)μg/L比(209±41)μg/L],差异有统计学意义(P<0.01)。治疗后,COPD患者痰液中IL-8、TNF-α、IL-10与IL-17均低于治疗前[(62±4)μg/L比(87±9)μg/L,(26±6)μg/L比(45±8)μg/L,(24±3)ng/L比(38±8)ng/L,(83±18)μg/L比(118±13)μg/L],差异有统计学意义(P<0.01)。结论 COPD稳定期患者使用沙美特罗氟替卡松治疗能有效降低外周血及痰液中炎性因子水平,减轻炎症现象,改善症状,对患者生活品质的提高有积极作用。  相似文献   

10.
目的分析孟鲁司特治疗老年支气管哮喘患者的疗效及对细胞因子的影响。方法选取2013年3月至2015年3月枣庄矿业集团中心医院收治的老年支气管哮喘患者84例,依据抽签法分成观察组与对照组,各42例。对照组予以常规抗支气管哮喘治疗,观察组在对照组的基础上加用孟鲁司特治疗,睡前口服,每次10 mg,每日1次,疗程为两个月。治疗两个月后,观察两组患者的临床疗效,比较细胞因子水平[白细胞介素(IL)4、IL-10、γ干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)]、临床症状缓解时间、肺功能变化[用力肺活量(FVC)、第一秒用力呼气量(FEV1)、呼气流量峰值(PEF)]、不良反应发生情况。结果治疗后,观察组的总有效率显著高于对照组[95.24%(40/42)比80.85%(34/42)],差异有统计学意义(P<0.05)。治疗前,两组患者的IL-4、IL-10、IFN-γ、TNF-α水平比较差异无统计学意义(P>0.05)。治疗后,两组患者的IL-4、TNF-α水平较治疗前降低,且观察组的IL-4、TNF-α水平低于对照组[(4.56±0.37)ng/L比(5.12±0.34)ng/L,(4.36±0.53)μg/L比(5.41±0.50)μg/L];IL-10、IFN-γ水平较治疗前升高,且观察组的IL-10、IFN-γ水平高于对照组[(11.34±1.27)ng/L比(9.87±1.24)ng/L,(21.58±2.24)ng/L比(19.73±2.28)ng/L],差异有统计学意义(P<0.05)。观察组的喘息、咳嗽、胸闷缓解时间均低于对照组[(3.82±0.47)d比(4.35±0.42)d,(7.31±1.20)d比(8.15±1.23)d,(4.78±0.56)d比(5.94±0.51)d],差异有统计学意义(P<0.05)。治疗前,两组患者的FVC、FEV1、PEF水平比较差异无统计学意义(P>0.05);治疗后,两组患者的FVC、FEV1、PEF水平均高于治疗前,且观察组的FVC、FEV1、PEF水平均高于对照组[(3.67±0.35)L比(3.41±0.33)L,(2.87±0.23)L比(2.64±0.25)L,(7.84±1.08)L/s比(7.31±1.01)L/s],差异有统计学意义(P<0.05)。观察组的总不良反应发生率为26.19%(11/42),与对照组地23.81%(10/42)比较,差异无统计学意义(P>0.05)。结论孟鲁司特治疗老年支气管哮喘患者的疗效确切,能够明显改善患者的肺功能并调节细胞因子水平。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

16.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

17.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

18.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

19.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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