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1.
OBJECTIVE:To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease.METHODS:Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group(n=45) treated with Liandouqingmai Recipe and a standard treatment group(control group,n=56).A normal group of 16 healthy persons was additionally set up.Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire(SAQ) was adopted in studying life quality before and after treatment for two weeks.The data were analyzed with SPSS 16.0 statistic software.RESULTS:The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease.There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation(PL),pngina stability(AS),apngina frequency(AF),treatment satisfaction(TS) and disease perception(DP)] between the two groups before treatment(P>0.05).But after treatment,the scores of SAQ(PL,AS,AF,TS,DP) and NO level were higher than those in the control group,and ET-1 average level in the treatment group was lower than that in the control group.The negative relations between PL and ET-1 and between AF and ET-1 were found in this study.CONCLUSION:Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment,thus improving vascular endothelial function and life quality.Life quality is related to vascular endothelial function.  相似文献   

2.
Objective: To study the effect of Shengrnai injection (生脉注射液, SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM). Methods: One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin Ⅱ (Ang Ⅱ ), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. Results: After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8 ± 33.1 μ mol/L to 120.1 ± 50.8 μ mol/L, and ET-1 was lowered from 70.1 ± 32.1 ng/L to 46.2±21.3 ng/L, respectively (P<0.01); that of Ang Ⅱ was lowered from 81.3 ± 24.3 ng/L to 50.2 ± 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 ± 26.3% to 459.3 ± 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 ± 5% to 68 ± 6% (P<0.01), all the changes being more significant than those in the control group (all P<0.01). Conclusion: SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.  相似文献   

3.
Objective: To study the effect of Shengmai injection (生脉注射液, SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM). Methods: One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin Ⅱ (Ang Ⅱ), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. Results: After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8±33.1 μmol/L to 120.1±50.8μmol/L, and ET-1 was lowered from 70.1±32.1 ng/L to 46.2±21.3 ng/L, respectively (P〈0.01); that of Ang Ⅱ was lowered from 81.3±24.3 ng/L to 50.2±27.3 ng/L (P〈0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4±26.3% to 459.3±27.8% (P〈0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44±5% to 68±6% (P〈0.01), all the changes being more significant than those in the control group (all P〈0.01). Conclusion: SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.  相似文献   

4.
Background Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD). Although alveolar hypoxia is considered as a main cause of PH in COPD, structural and functional changes of pulmonary circulation are apparent at the initial stage of COPD. We hypothesized that an inflammatory response and oxidative stress might contribute to the formation of PH in COPD. Methods We measured the levels of interleukin-6 (IL-6) and 8-iso-prostaglandin (8-iso-PSG) in exhaled breath condensate (EBC) and serum in 40 patients with COPD only or in 45 patients with COPD combined with PH. Pulmonary arterial systolic pressure (PASP) was assessed by Doppler echocardiography and defined as PH when the value of systolic pressure was greater than 40 mmHg. Results Compared with the COPD only group, the level of IL-6 in EBC was significantly increased in all 45 patients with COPD combined with PH ((8.27±2.14) ng/L vs. (4.95±1.19) ng/L, P 〈0.01). The level of IL-6 in serum was also elevated in patients with COPD combined with PH compared with the COPD only group ((72.8±21.6) ng/L vs. (43.58±13.38) ng/L, P 〈0.01 ). Similarly, we also observed a significant increase in the level of 8-iso-PSG in both EBC and serum in the COPD with PH group, compared with the COPD only group (EBC: (9.00±2.49) ng/L vs. (5.96±2.31) ng/L, P 〈0.01 and serum: (41.87±9.75) ng/L vs. (27.79±11.09) ng/L, P 〈0.01). Additionally, the value of PASP in the PH group was confirmed to be positively correlated with the increase in the levels of IL-6 and 8-iso-PSG in both EBC and serum (r=0.477-0.589, P 〈0.05). Conclusion The increase in the levels of IL-6 and 8-iso-PSG in EBC and serum correlates with the pathogenesis of PH in COPD.  相似文献   

5.
Background Antithrombin-Ⅲ (AT-Ⅲ), the major inhibitor of thrombin in plasma, also has anti-inflammation property and might have positive effect on sepsis. The present study aimed to investigate the effects of AT-Ⅲ on inflammatory reaction and pulmonary protection in endotoxin-induced acute lung injury (ALI) rat. Methods Sixty male Sprague-Dawley rats were randomly assigned equally to normal control group, ALl group, AT-Ⅲ treatment group, AT-Ⅲ+heparin treatment group, and heparin treatment group. The pulmonary vascular permeability index (PVPI) was measured by single nuclide tracer technique. The activity of AT-Ⅲ in plasma was determined by the method of synthetic chromogenic substrata. Tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) levels in serum were determined by enzyme-linked immunosorbent assay. The expressions of lung tissue mitogen-activated protein kinases (ERK1/2, P38 and JNK MAPK) were determined by Western blotting. Results Rats had significantly improved lung histopathology in the AT-Ⅲ treatment group and heparin treatment group compared with the ALl group, The PVPI of the ALl group was 0.38±0.04, significantly higher than that of the normal control group (0.20±0.02, P 〈0.01), AT-Ⅲ treatment group (0.30±0.04, P 〈0.01) and heparin treatment group (0.28±0.04, P 〈0.01) respectively. There were no significant differences of PVPI in the ALl group and AT-Ⅲ+heparin treatment group. The activity of AT-Ⅲ in plasma in the ALl group was (76±8)%, significantly lower than that of the normal control group ((96±11)%, P 〈0.05) and AT-Ⅲ treatment group ((105±17)%, P 〈0.05) respectively. The serum levels of TNF-α and I L-6 of the ALl group were (2.770±0.373) μg/L and (1.615±0.128) ng/ml respectively, significantly higher than those of the normal control group (0.506±0.093) μg/L and (0.233±0.047) ng/ml respectively, all P 〈0.01), AT-Ⅲ treatment group ((1.774±0.218) pg/L and (1.140±0145) ng/ml respectively, all P 〈0.01) and heparin treatment group ((1.924±0.349) μg/L and (1.223±0.127) ng/ml respectively, all P 〈0.01). The lung tissue levels of phospho-ERK1/2 and phospho-P38 MAPK expressions were markedly higher in the ALl group than in the normal control group, AT-Ⅲ treatment group and heparin treatment group respectively. Conclusions AT-Ⅲ without concomitant heparin inhibited the activation of ERK1/2 and P38 MAPK, down-regulated the levels of downstream cytokines TNF-a and IL-6, relieved endothelial permeability, and improved the ALl in endotoxin-induced rats. It might be helpful to administrate AT-Ⅲ alone, not with concomitant heparin, to those patients with ALl and sepsis.  相似文献   

6.
Objective: To study the clinical effect of Fuzheng Jiedu granule (扶正解毒颗粒, FJG) and its influence on serum nitric oxide (NO), nitric oxide synthase (NOS) and rnicroelements in patients with coronary heart disease who are in long-term contact with nickel. Methods: Sixty patients were randomly divided into two groups, the treated group and the control group, 30 in each group. Conventional Western medicinal treatment was applied to both groups, but to the treated group, FJG was given additionally by oral intake, and the therapeutic course for both groups was 4 weeks. Besides, a health control group was set up with 15 healthy subjects selected from the same area, who had no history of contact with nickel. Clinical symptoms of the patients and changes in their electrocardiogram (ECG) and serum levels of NO, NOS and microelements were observed before and after treatment. Results: The total effective rate on clinical symptoms in the treated group was 93.3% and that in the control group 63.3%, comparison between the two showing significant difference (P<0. 05); the total effective rate on ECG in the two groups was 90.0% and 56.7% respectively, which also showed significant difference ( P<0. 05). After treatment, levels of serum NO, NOS, Mg, Zn and Ca increased and those of Ni, Mn and Fe decreased significantly ( P<0. 05 or P<0.01) in the treated group, while in the control group, changes in these laboratory indexes were insignificant. Conclusion: FJG could lower the blood nickel level and regulate the unbalance of microelements, help restore serum NO and NOS in persons exposed to nickel and improve the clinical symptoms of patients with coronary heart disease and in long-term contact with nickel.  相似文献   

7.
Objective: To investigate the intervention effect of Jianxin Decoction (健心汤, JXD) on the cytokine level in serum of patients with congestive heart failure (CHF). Methods: Sixty-six patients with CHF were randomly divided into the control group (n=33) and the trial group (n=33). The control group received conventional treatment, and the trial group was treated with conventional therapy plus JXD for 4weeks. Before and after treatment, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and nitrogen monoxide (NO) in serum and cardiac function were determined. Results: After treatment, the levels of TNF-α,IL-6 and NO were significantly lower than those before treatment (P<0.05, or P<0. 01) in the two groups,and the lowering degree of the indices in the trial group was more significantly reduced than that in the control group (P<0. 05). And cardiac functions in both groups were improved significantly (P < 0.05, or P <0.01). Conclusion: JXD could prevent and reverse ventricular remodeling so as to ameliorate cardiac function through regulating the levels of cytokines.  相似文献   

8.
Background Dyslipidemia caused by liver injury is a significant risk factor for cardiovascular complications.Previous studies have shown that hydrogen sulfide (H2S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide (NO),and NO/endothelial nitric oxide synthase (eNOS) pathway is the key route of NO production.The purpose of this study was to investigate whether H2S can ameliorate the high blood pressure and plasma lipid profile in Nw-nitro-L-argininemethyl ester (L-NAME)-induced hypertensive rats by NO/eNOS pathway.Methods Thirty-six 4-week old Sprague-Dawley (SD) male rats were randomly assigned to 6 groups (n=6):control group,L-NAME group,control + glibenclamide group,control + NaHS group,L-NAME + NaHS group,and L-NAME + NaHS + glibenclamide group.Measurements were made of plasma triglycerides (TG),low-density lipoprotein (LDL),high-density lipoprotein (HDL),total cholesterol (CHO),glutamic-pyruvic transaminase (ALT) levels after 5 weeks.Then measurements of NO level and proteins expression of eNOS,P-eNOS,AKT,P-AKT were made in liver tissue.Results After 5 weeks of L-NAME treatment,the blood pressure,plasma TG ((1.22±0.12) mmol/L in L-NAME group vs.(0.68±0.09) mmol/L in control group; P <0.05) and LDL ((0.54±0.04) mmol/L in L-NAME group vs.(0.28±0.02) mmol/L in control group; P <0.05) concentration were significantly increased,and the plasma HDL ((0.26±0.02) mmol/L in L-NAME group vs.(0.69±0.07) mmol/L in control group; P <0.05) concentration significantly decreased.Meanwhile the rats treated with L-NAME exhibit dysfunctional eNOS,diminished NO levels ((1.36±0.09) mmol/g protein in L-NAME group vs.(2.34±0.06) mmol/g protein in control group; P <0.05) and pathological changes of the liver.H2S therapy can markedly decrease the blood pressure ((37.25±4.46) mmHg at the fifth week; P <0.05),and ameliorate the plasma TG ((0.59±0.06) mmHg),  相似文献   

9.
Objective:To investigate the effects of Modified Sanhuang Decoction(加味三黄汤,MSD)enema on the serum tumor necrosis factor alpha(TNF-α)and colonic mucosa interleukin-1β(IL-1β),interleukin-6(IL-6)levels in experimental ulcerative colitis(UC)rats.Methods:Forty-five male Wistar rats were randomly divided into 4 groups:normal group(n=12),model group(n=11),salazosulfapyridine(SASP)group(n=11)and MSD group(n=11).The UC model was induced by 2,4,6-trinitrobenzene sulfonic acid(TNBS)/ethanol solution.Rats in the normal group and model group were clystered with 0.9%normal saline,while in the SASP group and MSD group were clystered with SASP and MSD enema,respectively.After drug administration(10 mL/kg body weight,for 7 days),colonic gross changes and colonic mucosa histology were observed,serum TNF-αand colonic mucosa IL-1β,IL-6 levels were tested by enzyme linked immunosorbent assay and radioimmunoassay,respectively.Results:As compared with the normal group,the experimental UC rats,the colonic mucosal damage index scores(CMDIs),histopathological scores(HS)and the serum TNF-a and colonic mucosa IL-1β,IL-6 levels significantly increased(P0.05 or P0.01).In the MSD and SASP groups,the ulcer area significantly reduced,and edema disappeared.The CMDIs,HS,the serum TNF-a and colonic mucosa IL-1β,IL-6 levels in the MSD and SASP groups significantly decreased(P0.05 or P0.01)compared with the model group.The CMDIs in the MSD group were lower than that in the SASP group(P0.05),but there were no significant differences in HS,serum TNF-αor colonic mucosa IL-1β,IL-6 levels between the MSD and SASP groups.Conclusion:MSD enema can improve colonic mucosa impairment and decrease serum TNF-αand colonic mucosa IL-1β,IL-6 levels in experimental UC.  相似文献   

10.
Objective:To investigate effect of Chaiqin Chengqi Decoction(柴芩承气汤,CQCQD) on changes of neuronal acetylcholine receptor alpha 7(nAChRα7) of peritoneal macrophages in acute pancreatitis(AP).Methods:Eighteen Kunming mice were equally randomized into the control group,AP group and CQCQD treatment group.AP was induced by two intraperitoneal injections of 4 g/kg L-arginine at 1 h apart,while control mice received saline injections.At 72 h after the first injection of L-arginine,mice in the treatment group were intragastrically administered 0.1 mL/10 g CQCQD every 2 h for 3 times,whilst mice in the other two groups received the same amount of saline feeding.Mice were sacrificed by cervical dislocation 2 h after the last feeding of either CQCQD or saline.Peritoneal macrophages were collected for determination of nAChRα7 mRNA and protein expression.Serum was collected for detection of interleukin-6(IL-6),IL-10 and acetylcholine(ACh)levels,and pancreas was for histopathology analysis.Results:The CQCQD treatment significantly ameliorated the severity of AP as evidenced by reducing the pancreatic histopathology score(4.5 ± 0.5 vs.6.2 ± 1.7,P0.05)and the serum IL-6 levels(1228.31419.2 pg/mL vs.1589.6 ±337.3 pg/mL,P0.05).The mRNA and protein expression of nAChRα7 of the peritoneal macrophages in the AP group were similar to the control group(P0.05),but were significantly up-regulated after the CQCQD treatment(P0.05).The serum ACh levels in the AP group were significantly lower than those in the control group(3.1 ± 0.6 μg/mL vs 4.8 ± 0.7 μg/mL P0.05),but were significantly increased after the CQCQD treatment(5.6±1.5 μg/mL vs 3.1 ±0.6 μg/mL,P0.05).Conclusion:CQCQD is protective against L-arginine-induced AP through mechanisms involving nAChR α 7 of peritoneal macrophages.  相似文献   

11.
肺癌患者外周血单个核细胞分泌IL-1、IL-4、IL-6水平的研究   总被引:1,自引:0,他引:1  
目的研究肺癌患者外周血单个核细胞(PBMCs)分泌IL-1、IL-4、IL-6的水平,及根治手术对其影响.方法分别采用生物学方法及酶联免疫方法测定40例肺癌手术前、14例肺癌根治手术前后、30例正常对照者及22例肺部良性疾病者细胞因子的水平.结果肺癌组分泌IL-1、IL-4、IL-6(分别为0.566±0.102,7.918±5.071pg/ml,3.499±2.088)均低于正常对照组(分别为0.640±0.123,19.297±10.685pg/ml,5.372±0.113,均P<0.01),且相互间无相关性.根治手术后产生IL-1、IL-4水平明显提高(分别为t=5.067,P<0.01;t=2.244,P<0.05).结论检测PBMCs分泌IL-1、IL-4水平对肺癌的诊断有较好的敏感性和特异性,联合检测意义更大,且对监测疗效,提示预后也有重要的临床意义.  相似文献   

12.
目的 探讨IL-4基因启动子C589T,IL-4R基因E375A、C406R、Q576R和IL-13基因Arg110Gln位点多态性与儿童哮喘发生的相关性.方法 采用聚合酶链反应-限制性片段长度多态性分析(PCR-PFLP)方法检测122名哮喘儿童、144名健康儿童各个多态性位点的基因型,采用SPSS 13.0进行统计学分析.结果 IL-4R基因E375A、C406R这两个位点的基因型及等位基因频率分布在哮喘组与正常对照组均存在显著性差异(P<0.05),哮喘组E375A位点等位基因A频率显著高于正常对照组;C406R位点的等位基因C频率分布在哮喘组显著高于正常对照组.IL-13基因Arg110Gln位点Gln等位基因携带者(GlnGln+ArgGln)的频率在哮喘组显著高于对照组.结论 IL-4R基因E375A和C406R位点可能与儿童哮喘的发病存在关系,其中,A和C等位基因可能分别是易感等位基因,而IL-13基因Gln携带者可能更易罹患哮喘.  相似文献   

13.
目的:检测卵巢过度刺激综合征(0HSS)大鼠体内IL-1、IL-6、IL-10的变化,探讨OHSS的发病机制.方法:将Wistar雌性清洁大鼠随机分成生理盐水组和OHSS组.卵巢过度刺激组皮下注射孕马血清促性腺激素(PMSG)10 IU,每日1次,连续4天,第5天皮下注射100 IU人绒毛膜促性腺激素(HCG)一次建立OHSS模型;对照组皮下注射生理盐水每天1次,连续5天.HCG注射后48 h,取大鼠血、卵巢测IL-1、IL-6、IL-10(酶联免疫法).结果:OHSS组血和卵巢IL-1均高于对照组,有显著差异(P<0.05);两组血IL-6、IL-10含量极低,无法测出.OHSS组卵巢IL-10含量显著降低,有统计学意义(P<0.05).结论:大鼠OHSS全身症状可能与主要由IL-1介导的炎症相关,而IL-6和IL-10参与卵巢局部炎症.  相似文献   

14.
目的 探讨卵泡液中细胞因子白细胞介素2(IL-2)、IL-12、IL-18与体外受精-胚胎移植妊娠结局的关系.方法 接受体外受精-胚胎移植助孕治疗的妇女117例,其中妊娠妇女59例,未妊娠妇女58例,应用酶联免疫吸附试验检测卵泡液中IL-2、IL-12、IL-18的浓度.结果 妊娠组卵泡液中IL-2的浓度为(36.73±18.53)pg/ml、IL-12的浓度为(0.52±0.88)pg/ml、IL-18的浓度为(76.10±69.06)pg/ml;未妊娠组卵泡液中IL-2的浓度为(40.89±22.83)pg/ml、IL-12的浓度为(1.59±1.58)pg/ml、IL-18的浓度为(131.80±162.35)pg/ml.未妊娠组IL-12和IL-18浓度均明显高于妊娠组(P<0.05),未妊娠组IL-2浓度虽较妊娠组升高,但差异无统计学意义(P>0.05).结论 IL-12、IL-18在接受体外受精-胚胎移植助孕治疗的非妊娠妇女中明显升高,考虑与体外受精-胚胎移植妊娠结局负相关.  相似文献   

15.
目的探讨幽门螺杆菌(Hp)密度与血清白细胞介素6(IL-6)、IL-8和肿瘤坏死因子α(TNF-α)水平的关系。方法随机选择2011年1月至2013年12月在海南省农垦总医院消化内科接受胃镜检查的门诊患者134例,采用化学发光法检测IL-6水平,放射免疫法测检测IL-8和TNF-α水平,病理学诊断Hp密度及胃黏膜炎症分期。结果 134例受检患者中病理诊断Hp感染83例,阳性率为61.94%(83/134);Hp感染密度1级41例、2级29例、3级13例。慢性胃炎轻度18例、中度50例、重度15例。活动期炎症66例,炎症静止期共17例,其中轻度9例、中度5例、重度3例。Hp阳性炎症活动期IL-6、IL-8和TNF-α水平高于静止期(P<0.05);重度组IL-6、IL-8和TNF-α水平高于轻度组和中度组,差异有统计学意义(P<0.05);不同Hp密度组间IL-6、IL-8和TNF-α水平比较差异有统计学意义(P<0.05)。结论 Hp感染可引起IL-6、IL-8和TNF-α水平升高,后者可能参与Hp阳性胃黏膜炎症的发生、发展过程。  相似文献   

16.
OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of interleukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five groups according to the random number table: a normal group (GroupⅠ), an external dampness group (GroupⅡ), an internal dampness group (Group Ⅲ), and an external and internal dampness group (GroupⅣ). Twenty days after the model made, IL-2 and IL-8 levels were detected by radioimmunoassay method. RESULTS: The IL-2 and IL-8 levels among groups were significant (F=3.102, P<0.05; F=2.657, P<0.05, respectively). The level of IL-2 in Group Ⅱ and Group Ⅲ were higher than that in GroupⅠ(P<0.05, P<0.01, respectively), especially higher in the Group Ⅲ compared with GroupⅡ (P<0.05). The lev- el of IL-8 in Group Ⅲ were higher than those inGroupⅠ, GroupⅡ and GroupⅣ (P<0.05, P<0.01, P< 0.05, respectively). In the GroupⅢ, the 24-hour wa ter and body weight were higher than that in the GroupⅣ (all P<0.05), and spontaneous movemen frequency was higher than those in GroupⅡ and GroupⅣ (P<0.05). CONCLUSION: Immune activation and inflammato ry reaction might be easily caused by externa danpness other than internal dampness.  相似文献   

17.
COPD患者外周血几项免疫指标的变化   总被引:5,自引:0,他引:5  
为了探讨COPD患者外周血可溶性白细胞介素2受体(sIL-2R)、白细胞介素-8(IL-8)、免疫球蛋白、T淋巴细胞亚群水平变化,用ELISA法检测COPD患者30例,对照组30例,血清sIL-2R,IL-8;免疫散射速率法测IgG,IgA;单克隆抗体免疫组化萤光染色法测CD^ 3,CD^ 4,CD^ 8,并进行分析。结果COPD患者sIL-2R,IL-8,CD^ 8增高;IgG,IgA,CD^ 3,CD^ 4,CD^ 4/CD^ 8比值均降低,具有较显著性差异,提示COPD患者免疫功能低下。  相似文献   

18.
目的 探讨急性扁桃体炎患者血清中的白细胞介素-2、可溶性白细胞介素-2受体和白细胞介素-6水平。方法 采用放射免疫法(RIA)和双抗体夹心酶联免疫吸附测定法(ELISA),测定了25例急性扁桃体炎患者、20例健康人血清中白细胞介素-2、可溶性白细胞介素-2受体和白细胞介素-6的水平。结果 急性扁桃体炎患者血清中白细胞介素-2、可溶性白细胞介素-2受体和白细胞介素-6的水平均高于健康人(P<0.05)。结论 三种细胞因子参与了急性扁桃体炎的病理过程。  相似文献   

19.
目的阐明失血性休克白介素1(IL-1)、白介素6(IL-6)和肿瘤坏死因子(TNF-α)活性变化,探讨失血性休克免疫调节机制.方法采用放射免疫分析法对9例失血休克和12例普通失血对照进行血清IL-1、IL-6和TNF-α活性检测.结果失血休克组IL-1、IL-6和TNF-α活性较对照组明显增高(P<0.001),IL-1、IL-6与TNF-α活性正相关(r=0.78,P<0.01).结论休克过程有免疫因素介导,IL-1、IL-6和TNF-α活性变化可作为判断病情和疗效的一种手段.  相似文献   

20.
目的 探讨原发性肾病综合征 ( PNS)患者发病期及缓解期的细胞免疫状态。方法 分别采用单克隆抗体致敏红细胞检测法、白介素 2 ( IL - 2 )生物活性检测法和受体的放射性配体结合法 ,对 39例 PNS患者及 2 5例正常对照的外周血淋巴细胞亚群、IL - 2活性及高亲和力白介素 2受体 ( IL - 2 R)的表达进行检测。结果  PNS组2 2例发病期患者的 T淋巴细胞 ( CD3 )、辅助淋巴细胞 ( CD4)、抑制淋巴细胞 ( CD8)以及 IL - 2、IL - 2 R均显著低于对照组 ( P<0 .0 5 ) ;17例缓解期患者的 CD3 、CD4、IL - 2、IL - 2 R高于发病期组 ,但低于对照组 ,且与后两组的上述各项指标均有显著性差异 ( P<0 .0 5 )。结论  PNS患者发病期细胞免疫功能低下 ,缓解期有所恢复 ,但仍未达正常水平。缓解期细胞免疫功能低下可能是 PNS易于复发的原因之一。  相似文献   

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