加味血府逐瘀汤治疗高血压64例临床观察

目的观察加味血府逐瘀汤治疗轻中度高血压病的临床疗效.方法122例患者采用随机分组对照法,治疗组(64例)以加味血府逐瘀汤+口服常规降压药物治疗;对照组(64例)给予口服常规降压药物治疗.结果降压效果治疗组显效率25.8%,总有效率95.2%;对照组显效率12.1%,总有效率75.8%;治疗组显效率与总有效率明显高于对照组(P<0.05).结论加味血府逐瘀汤治疗轻中度高血压病疗效满意.     

益气温阳方治疗变应性鼻炎肺脾虚寒证的临床研究

目的 以西替利嗪、布地奈德鼻喷雾剂对照,评价中药益气温阳方对变应性鼻炎肺脾虚寒证患者的临床疗效.方法 多中心对照研究,分为益气温阳方组和西药对照组,样本量中药组388例,西药组173例,疗程4周.结果 益气温阳方组显效率64.95％,总有效率94.32％;西药组显效率65.90％,总有效率94.80％,2组疗效比较差异无统计学意义(P＞0.05).180 d远期疗效评价,益气温阳方组显效率62.37％,总有效率93.55％;西药组显效率53.18％,总有效率86.13％,经统计学检验,2组疗效有显著性差异(P＜0.05).结论 益气温阳方治疗变应性鼻炎肺脾虚寒证具有良好的近期疗效和远期疗效,有进一步研究和临床推广应用价值.     

家用远红外线磁疗型腰椎牵引器的临床研究

目的　观察远红外线磁疗型腰椎牵引器的临床疗效和安全性。方法　选择腰椎间盘突出症患者 60例 ,将其随机分为两组 ,每组 30例 ,实验组应用远红外线磁疗型腰椎牵引器行家庭牵引治疗 ,对照组在医院中行牵引治疗 ,比较两组的疗效。结果　实验组与对照组的总有效率分别为 80 0 %和 90 0 % ,两组总有效率间差别无显著性意义(P >0 0 5) ;实验组总显效率为 46 7% ,对照组的总显效率为 76 7% ,两组总显效率间差别有显著性意义 (P <0 0 5) ;实验过程中未发生不良反应。结论　应用远红外线磁疗型腰椎牵引器在家庭中治疗腰椎间盘突出症设备简单、安全、有效。     

“消寒痛”治疗腰痛,四肢关节痛133例临床观察

为观察自制外用涂擦剂“消寒痛”治疗腰痛、四肢关节痛的临床疗效,采用随机单盲自身前后对照与与麝香舒活灵作间对照相结合的方法进行观察,结果显示：治疗组６９例中,临床民２２例,显效２５例,有效１９便,无效３例,其有总效率为９５．６５％,总显效率为６８．１２％。对照组６４例中,临床治愈８例,显铲２２例,有效２８例,无效６是药物的有总有效率为９０．６３％,总显效率为４６．８８％。两组间综合疗效比较经统计学级     

益伤宁搽剂治疗急性闭合性软组织损伤105例临床观察

该文观察了中药益伤宁搽剂治疗急性闭合性软组织损伤，并与云南白药酊治疗该病对照观察。治疗组105例，对照组50例。通过观察治疗后临床症状及其积分变化评定疗效。结果治疗组总有效率为95.24％，临床控制显效率为74．29％；对照组的总有效率为88％，临床控制显效率为50％。经统计学处理，两组总有效率无显著性差异（P＞0.05），而临床控制显效率的差异有高度显著性（P＜0.01）。两组治疗前总积分无显著性差异（P＞0.05），而治疗后总积分治疗组明显低于对照组（P＜0．01）。表明两种药物治疗急性闭合性软组织损伤都很有效，但益伤宁搽剂的疗效优于云南白药酊。     

经纤维支气管镜肺泡灌洗抗真菌药物治疗肺部感染

目的探讨经纤维支气管镜支气管肺泡灌洗抗真菌药对肺部真菌感染的临床治疗效果。方法我院2011年1月—2012年10月共收治肺部真菌感染患者88例,随机分为2组,对照组44例运用抗真菌药物进行治疗;观察组44例在对照组治疗的基础上加用经纤维支气管镜支气管肺泡灌洗抗真菌药物进行治疗。对比2组患者的临床治疗效果。结果观察组显效率为45.45%,有效率为47.73%,临床治疗总有效率为93.18%;对照组显效率为38.64%,有效率为45.45%,总有效率为84.09%,观察组疗效明显优于对照组,差异有显著性(P<0.05)。结论对肺部真菌感染患者经纤维支气管镜支气管肺泡灌洗抗真菌药物安全、可靠,疗效显著,值得推广。     

电磁疗与药物相结合对周围性面神经麻痹的疗效分析

目的：探讨电磁疗与药物相结合疗法对周围性面神经麻痹的疗效。方法：选取90例周围性面神经麻痹患者,随机分成电磁疗与药物结合组和对照组,每组45例。对照组给予地塞米松10mg静脉注射,每日1次,维生素B1 100mg,维生素B12 50mg,肌肉注射,每日2次。电磁疗与药物相结合疗除了给予上述药物治疗外,采用TDP磁疗仪照射患侧,每日2次。根据《实用内科手册》面神经功能恢复评定标准对各组患者疗效进行评价。结果：电磁疗与药物结合组治愈28例,好转6例,显效3例,无效8例,总有效率81.1%;对照组痊愈22例,好转5例,显效6例,无效12例,有效率73.3%。电磁疗与药物结合组的有效率明显高于对照组（P〈0.05）。结论：电磁疗与药物结合疗法治疗的周围性面神经麻痹疗效优于单纯药物治疗。电磁疗与药物结合疗法疗效快,疗程短,不良反应小,是一种有效的治疗方法。     

芪贝汤治疗支气管哮喘临床研究

目的芪贝汤治疗支气管哮喘的临床研究。方法将40例患者随机分为两组。对照组26例采用静脉滴注抗菌素．糖皮质激素，茶碱类等药物；治疗组在西药常规治疗的基础上加用芪贝汤治疗。结果对照组总有效率85％，显效率50％，治疗组总有效率95％，显效率60％，经统计学处理，两组有显著性差异（p〈0．05）．结论芪贝汤治疗支气管哮喘有显著疗效。     

扩血管与缩血管药物联用治疗大咯血临床观察

目的 探讨联用扩血管与缩血管药物治疗大咯血疗效。方法 82例大咯血病人随即分为观察与对照组, 观察组联用扩血管药物与缩血管药物治疗,对照组用其中的一种。结果 观察组显效率为78．0％,总有效率 88．6％;对照组显效率56．1％,总有效率为75．6％,两组比较差异有显著性(P<0．05)。结论 联用扩血管药物与 缩血管药物治疗大咯血疗疗效更好。     

思密达治疗小儿间擦疹疗效观察

目的：观察思密达治疗小儿间擦疹的疗效。方法：将60例间擦疹患儿分为治疗组33例，对照组27例，治疗组给予思密达治疗，治疗3天后观察疗效。结果：治疗组显效率72．73％，总有效率96．97％，对照组显效率18．52％，总有效率77．78％，两组经统计学处理，疗效差异有显著意义（P＜0．05），结论：思密达是治疗小儿间擦疹的有效药物。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…