肌电图引导A型肉毒杆菌素治疗特发性眼睑痉挛临床对照研究

目的探讨肌电图引导对提高A型肉毒杆菌素治疗特发性眼睑痉挛的有效性及安全性。方法回顾性分析2004年3月至2007年5月间连续治疗的78例特发性眼睑痉挛患者,其中特发性眼睑痉挛男性30例,女性48例,平均年龄51.1岁,平均病程3.8年。将78例患者随机分为机电引导组和非机电引导组,治疗采取A型肉毒杆菌素眼轮匝肌局部多点注射。每一点注射0.1m（L含毒素2.5U）。结果机电引导组和非机电引导组比较,完全和明显缓解率分别为94.9%和82.1%;眼睑闭合不全、睑外翻和上睑下垂等副作用总发生率分别为30.77%（12例）和64.13%（25例）。结论肌电图引导可明显提高A型肉毒杆菌素治疗特发性眼睑痉挛的疗效及减少副作用。     

局部注射A型肉毒毒素治疗特发性眼睑痉挛临床研究

目的 观察眼睑局部注射A型肉毒杆菌毒素治疗特发性眼睑痉挛的临床疗效.方法 选取特发性眼睑痉挛患者55例.所有患者均采取眼睑局部多点注射A型肉毒杆菌毒素,浓度为2.5 U/0.1 mL,每点注射剂量:2.5~5 U(其中初次治疗和第二次治疗每点注射2.5 U,随着病程延长,治疗剂量增加).记录治疗的疗效、维持时间与不良反应.结果 A型肉毒杆菌毒素眼睑局部注射治疗特发性眼睑痉挛,痉挛症状2~6天完全缓解,有效率为100%.效果通常持续3~6个月不等.治疗55例未出现上睑下垂、复视、溢泪等并发症.结论 A型肉毒杆菌毒素眼睑局部注射治疗特发性眼睑痉挛起效迅速、无创伤、简便易行.     

A型肉毒毒素治疗眼睑痉挛

目的 通过对38例眼睑痉挛患者的治疗,分析A型肉毒毒素治疗眼睑痉挛的疗效.方法 根据病情需要采用A型肉毒毒素分别注射于上下眼睑,有残存痉挛的可以在2周后重复注射.结果 38例(40只眼)患者均于注射后1～2 d内症状开始缓解,1～2周明显好转.其中,完全缓解16例(17只眼);明显缓解19例(20 只眼);部分缓解2例(2只眼).结论 A型肉毒毒素局部注射治疗眼睑痉挛简单易行、毒副作用小、疗效确切、患者易于接受,但是复发率高.     

阿霉素联合A型肉毒毒素治疗睑痉挛的远期疗效

目的:评价阿霉素联合A型肉毒毒素局部注射治疗特发性眼睑痉挛的长期有效性和安全性。方法:对22例眼睑痉挛患者应用浓度0.5mg/ml的阿霉素和小剂量A型肉毒毒素交替注射于眼睑周围,观察其作用时间和安全性。结果:所有患者经过数次注射后取得了较好的短期和长期疗效。每一注射间歇期的疗效相当,但作用持续时间差异有统计学意义(P<0.05)。治疗副作用很轻且为暂时性。结论:局部注射阿霉素联合A型肉毒毒素比单纯使用用肉毒毒素疗效好,缓解痉挛时间长,是治疗眼睑痉挛的首选方法。     

A型肉毒毒素治疗眼睑痉挛60例分析

目的：观察A型肉毒毒素治疗特发性眼睑痉挛的疗效。方法：对60例特发性眼睑痉挛进行局部多点注射A型肉毒毒素，评价其疗效。结果：60例眼睑痉挛，完全缓解27例(45％)，明显缓解29例(48．33％)。起效时间平均1～3天，缓解时间平均4．19月。无全身反应及过敏反应，局部反应轻微，短暂可逆。结论：A型肉毒毒素局部注射足治疗特发性眼睑痉挛的．种安全、有效、简便、易行的方法。     

A型肉毒杆菌毒素治疗特发性眼睑痉挛的临床疗效

目的探讨A型肉毒毒素（BTXA）对特发性眼睑痉挛的临床疗效。方法根据纳入标准,选择26例患者作为观察对象,根据病情,采用BTXA眼睑眉弓下肌肉进行1点或多点注射,每点剂量为2.5～3 U。结果完全缓解16例（61%）,明显缓解8例（30%）,部分缓解2例（7%）。结论局部注射A型肉毒毒素（BTXA）治疗特发性眼睑痉挛,副作用小、方法简单、刺激性小并且维持有效时间长,可作为治疗特发性眼睑痉挛的首选治疗手段。     

肉毒毒素治疗儿童痉挛型脑瘫拇指内收畸形的临床疗效分析

目的 探讨A型肉毒毒素对痉挛型脑性瘫痪拇指内收畸形的疗效.方法 50例脑性瘫痪患儿随机分为两组,观察组采用A型肉毒毒素肌肉注射和手传统中医按摩、拇指矫形器固定及上田法训练,对照组采用手传统中医按摩、拇指矫形器固定和上田法训练.结果 经过3mo治疗,两组总有效率分别为96.0%和78.0%,观察组明显优于对照组(χ2=7.16,P＜0.01),且观察组拇指腕掌外展活动度明显改善,与对照组相比差异有显著性(t=5.20,P＜0.01).结论 A型肉毒毒素肌肉注射对脑性瘫痪拇指内收畸形的疗效较好.     

A型肉毒毒素联合CO_2点阵激光的眼周年轻化疗效观察

目的研究A型肉毒毒素联合CO2点阵激光治疗眼周皱纹的临床效果。方法将我院58例患者抽签随机分为观察组与对照组,观察组患者采取A型肉毒毒素联合CO2点阵激光治疗,对照组仅行CO2点阵激光治疗,比较两组治疗后临床效果、患者满意度及不良反应。结果观察组总有效率86.21%,显著高于对照组的58.62%(P0.05);观察组2例患者术后2只眼睛少量分泌物,1例1只眼轻微红肿,可自行缓解,对照组未见不良反应出现,观察组不良反应发生率10.34%,对照组为0.00%,组间比较差异无统计学意义(χ2=2.072,P0.05)。结论 A型肉毒毒素联合CO2点阵激光治疗眼部皱纹、松弛效果显著,A型肉毒毒素可显著改善动态皱纹,辅以CO2点阵激光使疗效更为显著,联合应用具有可行性。     

中西医结合治疗特发性眼睑痉挛

目的：观察玉真散加味内服及眼周围穴位注射A型毒杆菌毒素治疗特发性眼睑痉挛的疗效。方法：作眼周围穴位A型肉毒杆菌毒素注射，同时内服中药。结果：完全缓解率为67．74%；明显缓解率为27．42%；部分缓解率为4．84％。总有效率为100％。结论：本法是一种安全高效、简便易行的方法。     

A型肉毒毒素对眼睑痉挛的疗效观察

[背景 ]观察A型肉毒毒素对原发性眼睑痉挛和面肌痉挛的治疗效果 .[病例报告 ]多点局部注射A型肉毒毒素治疗原发性眼睑痉挛 2 6例及合并面肌痉挛的眼睑痉挛 13例 .结果 ,症状在 1～ 3d内缓解 ,5d内明显缓解 ,2个星期内缓解最明显 ,有效率为 10 0 % ,原发性眼睑痉挛的有效作用时间为 10～2 3周 ,平均 16周 .合并面肌痉挛的眼睑痉挛的平均有效作用时间为 14周 .[讨论 ]局部注射A型肉毒毒素是治疗原发性眼睑痉挛和面肌痉挛的一种方法     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.