冠状动脉旁路移植术45例临床分析

目的报告冠状动脉旁路移植手术治疗冠心病的临床结果及体会。方法回顾性分析冠状动脉旁路移植手术45例临床资料。应用体外循环9例,非体外循环36例。总搭桥144支,平均搭桥3.2支,其中双乳内动脉搭桥2例、左乳内动脉搭桥38例、＂Y＂型桥8例、序贯搭桥5例。结果全组无手术死亡,术后患者心绞痛症状均有缓解或消失。结论合理的选择患者和手术方式、充分的术前准备、良好的心肌保护以及围术期治疗是开展冠状动脉旁路移植手术保证安全和疗效的关键因素。     

非体外循环冠状动脉旁路移植手术91例

目的 总结91例非体外循环冠状动脉旁路移植术（OPCAB）的手术经验。方法 2002年4月～2007年4月，采用非体外循环冠状动脉旁路移植手术治疗冠心病91例，男83例，女8例，年龄36～80岁，其中二支血管病变13例，三支血管病变78例，合并左主干病变15例，均在非体外循环、心脏不停跳下进行冠状动脉旁路移植术，8例搭桥4支，67例搭桥3支，16例搭桥2支。89例应用左乳内动脉吻合前降支，15例应用桡动脉吻合后降支，其余均采用大隐静脉吻合。8例应用主动脉内球囊反搏（IABP）。结果 全组91例共行冠脉搭桥265支，平均2．91支／人，全组死亡1例，全组无出血和脑部并发症发生。结论 非体外循环冠状动脉旁路移植手术是安全可行的手术方式，可避免体外循环的并发症．手术效果满意。     

13例冠状动脉旁路术的临床分析

目的 报告13例冠状动脉旁路术的临床体会。方法 体外循环下手术9例。非体外循环心脏跳动下手术4例,其中3例同期行心肌激光血运重建术,单支病变2例、双支病变3例、三支病变7例、左主干病变1例。平均每例搭桥2.3支。结果 全组无手术死亡,术后心绞痛消失11例,减轻2例。结论 冠状动脉旁路术是安全的手术,非体外循环心脏跳动下冠状动脉旁路术可减少术后输血及并发症,患者术后恢复快。     

冠状动脉旁路移植术56例报道

目的总结分析56例冠状动脉旁路移植术(CABG)的临床经验.方法 1999年10月～2003年11月,我院对56例冠心病患者行冠状动脉旁路移植术.左主干病变4例,单支病变3例,双支病变13例,三支病变36例.全部胸骨正中切口,42例在体外循环下进行,17例在非体外循环下进行.乳内动脉搭桥26根,大隐静脉搭桥128根,人均搭桥2.8支.结果全组死亡1例,其余患者痊愈出院,术后心绞痛完全消失或明显减轻.随访2～48个月效果良好.结论 CABG是治疗冠心病的一种安全有效的方法,合理选择病人,妥善围手术期管理,术中良好的心肌保护及不断提高外科操作技术是提高手术成功率的关键.     

重症冠心病非体外循环冠状动脉旁路移植术及围术期处理

目的总结重症冠心病在非体外循环心脏不停跳下行冠状动脉旁路移植术(OPCABG)的经验.方法 20例重症冠心病者,全部采用OPCABG,选用乳内动脉、桡动脉、大隐静脉作为移植血管材料.共搭桥64支,平均3.2支.术中使用CTS心脏固定器.加强围手术期处理.结果全组无围术期急性心肌梗塞,无死亡病例.术后心绞痛症状全部缓解,住院天数为19～45天,平均25.2天.结论非体外循环冠状动脉搭桥手术安全、有效,可用于多支病变或/和危重急症患者.主动脉内球囊反搏是治疗冠心病严重并发症和围手术期心衰很有效的辅助装置.合理的围术期处理对手术效果很重要.     

重症冠心病非体外循环冠状动脉旁路移植术及围术期处理

目的总结重症冠心病在非体外循环心脏不停跳下行冠状动脉旁路移植术(OPCABG)的经验.方法 20例重症冠心病者,全部采用OPCABG,选用乳内动脉、桡动脉、大隐静脉作为移植血管材料.共搭桥64支,平均3.2支.术中使用CTS心脏固定器.加强围手术期处理.结果全组无围术期急性心肌梗塞,无死亡病例.术后心绞痛症状全部缓解,住院天数为19～45天,平均25.2天.结论非体外循环冠状动脉搭桥手术安全、有效,可用于多支病变或/和危重急症患者.主动脉内球囊反搏是治疗冠心病严重并发症和围手术期心衰很有效的辅助装置.合理的围术期处理对手术效果很重要.     

冠状动脉旁路移植术治疗冠心病25例

目的 :回顾冠状动脉旁路移植术 ( CABG)治疗冠心病的早期效果和经验。方法 :2 5例冠心病病人92 %为多支冠状动脉病变。 1 0例左室射血分数 ( EF)≤ 45 % ,其中 4例 <30 %。所有患者均有心绞痛症状 ,CCS ～ 级。 1 0例在非体外循环、心脏不停跳下手术 ,余为低温体外循环 ( CPB)下手术。 1 4例采用左乳内动脉与左前降支搭桥 ,余均为大隐静脉桥 ,人均搭桥 3.0 8支。同期行激光心肌血管重建术 ( TMLR) 3例。结果 :2 5例 CABG临床效果良好 ,无手术死亡。术后 96%的患者心绞痛症状完全消失。结论 :CABG是一种治疗冠心病安全和有效的方法 ,近期临床效果满意。     

非体外循环冠状动脉旁路移植135例围手术期处理

目的:总结非体外循环冠状动脉旁路移植的围手术期处理经验。方法:对135例冠心病患者施行非体外循环冠状动脉旁路移植手术,其中单支病变15例,双支病变21例,三支病变99例。有经皮冠状动脉腔内支架治疗史1例。结果:每例行非体外循环冠状动脉旁路移植1～5支,平均3.1支。死亡1例(0.74%),围手术期并发症发生率15.5%(21/135)。结论:提高围术期处理技巧对提高冠状动脉旁路移植手术成功率、减少并发症具有重要意义。     

冠状动脉搭桥970例

目的总结我院970例行冠状动脉搭桥手术(CABG)患者的临床资料,分析手术中的难点,总结围术期处理的要点,以提高CABG的疗效。方法1997年5月至2004年11月共行CABG 970例,其中停跳下行CABG 394例,不停跳下行CABG 382例,单纯激光心肌血运重建术(TMLR)30例,CABG TMLR 50例,CABG 瓣膜手术67例,CABG 室壁瘤手术41例,CABG 左房黏液瘤切除术2例,CABG 室间隔穿孔修补术2例,CABG 升主动脉成形术1例,CABG 纵隔内肿瘤切除术1例。结果平均冠状动脉搭桥数量为(2．8±1．0)支。住院期间死亡37例,病死率为3．8%。术后心绞痛症状明显缓解,生活质量较术前大为提高。结论合理地开展CABG是治疗冠心病的有效手段。     

非体外循环冠状动脉旁路移植术的临床应用

目的:探讨非体外循环冠状动脉旁路移植术(OPCAB)的手术经验及临床应用。方法:回顾分析我院自2004年3月-2007年12月采用非体外循环不停跳下进行冠状动脉旁路移植术治疗冠心病37例的临床资料,全组均应用左乳内动脉吻合前降支,2例患者术前及术中应用主动脉内球囊反搏(IABP)临时辅助。结果:全组37例共行冠脉搭桥109支,平均2.94支/人,3例搭桥4支,29例搭桥3支,5例搭桥2支。全组死亡1例,全组无出血和脑部并发症发生。结论:非体外循环冠状动脉旁路移植手术是安全可行的手术方式,可避免体外循环的并发症,手术效果满意。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…