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1.
原发性甲状腺功能亢进症722例外科手术治疗体会   总被引:1,自引:0,他引:1  
目的 探讨甲状腺功能亢进症(甲亢)外科手术治疗的术前准备方法 及术后并发症预防.方法 经手术次全切除甲状腺病理检查确诊的722例原发性甲亢患者,术前准备均给予口服他巴唑、卢戈氏液、谷维素、维生素B1治疗,如心率〉90次/min、心电图无完全性房室传导阻滞者加服心得安控制心率;术后72 h内每日用0.9%氯化钠100 ml+地塞米松15 mg静脉滴注,连续用3 d,术后不再口服卢戈氏液.结果 722例全部治愈,无一例死亡及甲亢危象发生,无术中、术后大出血.随访5年内,无一例复发.结论 术前口服他巴唑和卢戈氏液及辅以谷维素、维生素B1、心得安做术前准备,术后使用地塞米松能有效预防甲亢术后严重并发症发生.  相似文献   

2.
目的探讨甲状腺功能亢进症(甲亢)患者术前术后不口服碘剂的可行性。方法将56例甲亢患者按是否口服碘剂随机分为实验组(术前术后不口服碘剂组)29例和对照组(术前术后口服碘剂组)27例,比较两组间手术时间、出血量、术后踊、术后甩、住院时间和并发症发生率的差异。结果实验组的手术时间、出血量、术后FT3、术后FT4及住院时间分别为(96.32±8.38)min、(74.21±6.32)mL、(3.96±1.02)pmol/L、(9.88±1.86)pmol/L、(9.58±0.34)d,对照组的手术时间、出血量、术后FL、术后nj及住院时间分别为(85.63±3.97)min、(70.00±7.18)mL、(4.08±0.93)pmol/L、(9.68±1.74)pmol/L、(28.13±1.48)d,两组间手术时间、出血量、术后FT3、术后FT4均无显著性差异(P〉0.05),二组间住院时间有非常显著性差异(P〈0.01),两组患者均未发生甲状腺危象。结论甲亢患者术前术后不El服碘剂是安全可行的。  相似文献   

3.
目的探讨原发性甲状腺功能亢进合并分化型甲状腺癌患者的围手术期处理方法。方法选取26例原发性甲状腺功能亢进合并分化型甲状腺癌(术前诊断为甲状腺癌)患者,入院时游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)高于正常者或规则服抗甲状腺药物〈2个月者16例,于术前服用大剂量丙基硫氧嘧啶(600 mg/d)3~4周;3~4周后停用丙基硫氧嘧啶,改为复方碘溶液10滴口服,3次/d,共10~15 d;于术前1次、术后连续3 d予地塞米松10 mg静脉点滴。入院时仍在规则服药治疗甲亢(时间〉2个月)且血FT3和FT4正常者6例,术前停止口服抗甲状腺药物,给予复方碘溶液10滴口服,3次/d,共10~15 d,既往有甲亢病史、经内科规则治疗后治愈者4例,未予特殊处理。结果 26例患者均顺利通过了围手术期。结论合并甲亢的分化型甲状腺癌患者经过适当的处理,可限期手术并顺利通过围手术期。  相似文献   

4.
目的:探讨甲状腺功能亢进的介入栓塞治疗方法及临床疗效.方法:5例药物治疗效果不佳的甲亢患者,使用海藻微粒和明胶海绵颗粒行双侧甲状腺上动脉栓塞.结果:5例增粗的甲状腺上动脉均栓塞,腺体染色消失.栓塞后临床随访1~6个月,术前FT3 102.4~151.2pmol/L(参考值:FT3 3.18~9.22pmol/L),FT4 221.45~312.7pmol/L(参考值:FT4 8.56~25.6pmol/L),术后FT3降至4.12~9.11pmol/L,FT4降至17.54~25.2pmol/L.B超检查,甲状腺肿大小术前3.4~5.8cm,术后缩小至2.0~4.6cm.临床症状逐渐缓解,未闻及明显颈部血管杂音,并发症经对症处理后也消失.结论:介入治疗是甲亢治疗的一种安全有效的新方法.  相似文献   

5.
朱郧鹤  骆磊  孙鹏  任亮萍  王淇  吴国 《海南医学》2016,(11):1768-1769
目的:探讨血管活性肠肽(VIP)与甲亢发生、发展的病理生理过程关系。方法选取2012年6月至2015年6月在湖北医药学院附属人民医院确诊的168例甲亢患者为观察组,60例同时期在我院体检中心体检合格的健康人作为对照组,对所有参与的研究对象进行空腹采静脉血3 mL,并分离血清。检测观察组接受131I治疗前后以及对照组血清游离甲状腺原氨酸(FT3)、离甲状腺素(FT4)及血管活性肠肽(VIP)浓度的变化,并对观察组的VIP水平与甲亢关系做直线回归分析。结果甲亢患者治疗后,FT3、FT4和VIP均下降[(5.32±1.40) pmol/L、(15.05±5.42) pmol/L、(184.4±21.7) pmol/L],与治疗前[(10.08±2.34) pmol/L、(29.09±5.46) pmol/L、(421.1±79.6) pmol/L]比较差异均有统计学意义(P<0.05),与对照组[(5.72±1.62) pmol/L、(16.46±3.16) pmol/L、(179.3±16.3) pmol/L]比较差异均无统计学意义(P>0.05)。观察组血清VIP水平与FT3、FT4水平均呈负相关(r=-0.3998、r=-0.3871,P<0.05)。结论 VIP在甲亢患者131I治疗前后的含量有明显变化,解释了甲亢患者出现消化道症状的部分机理。  相似文献   

6.
目的分析地塞米松等药物在甲状腺功能亢进(甲亢)患者围手术期的应用。方法分析198例围手术期应用地塞米松等药物的应用方法、不良反应和治疗处理。结果本组术前应用地塞米松后,FT3、FT4均较前显著下降(P〈0.05)。其中,15例出现用药后低血钾性四肢麻痹,2例出现甲亢危象前兆,9例术后出现短暂性口唇和四肢麻木,对症处理后均迅速恢复,余均恢复正常。结论甲亢手术具有较大的难度和危险性,应用地塞米松等药物能缩短术前准备,提高手术成功率,减少术后并发症。  相似文献   

7.
患女,45岁,发现下腹部包块1个月,1个月前曾停经1次,查体:下腹正中偏右侧扪及一包块,如拳头大小,质硬,活动一般,轻压痛,表面不规则。实验室检查:促甲状腺激素(TSH)0.006μmol/L,三碘甲状腺原氨酸(T3)1.11nmol/L,甲状腺素(T4)112.7nmol/L,游离三碘甲状腺原氨酸(FT3)3.17pmol/L,游离甲状腺素(FT4)23.60pmol/L。  相似文献   

8.
患者女,39岁。以“心慌1月,巩膜黄染5d”之主诉于2013年5月20日入院。1月前患者因心慌就诊,查总甲状腺素(巩)172.4nmol/L,游离T4(FT4)19.97pmol/L,游离三碘甲状腺原氨酸(FT3)6.78pmol/L,促甲状腺激素(TSH)0.032mIU/L,甲状腺过氧化物酶抗体(TPOAb)770.1IU/ml。  相似文献   

9.
目的:探讨小剂量他巴唑治疗甲状腺功能亢进症的临床疗效。方法选取雅安市第二人民医院收治的46例甲状腺功能亢进症患者,随机均分为对照组(大剂量他巴唑治疗,初始剂量:10 mg/次,3次/d,后改为10 mg/次,1次/d)和观察组(小剂量他巴唑治疗,剂量:15 mg/次,1次/d)。比较2组治疗前后血清游离三碘甲腺原氨酸FT 3、血清游离甲状腺素FT 4、促甲状腺激素TSH水平的变化、治疗总有效率和不良反应发生率的差异。结果观察组患者治疗后血清FT 3、FT 4、TSH水平和治疗总有效率分别为(10.95±1.23)μmol/L、(21.33±3.28)μmol/L、(0.27±0.05)mU/L、91.3%,与对照组比较差异无统计学意义;观察组不良反应发生率为17.4%,显著低于对照组的47.8%(P<0.05)。结论小剂量他巴唑治疗甲亢疗效确切,和大剂量比较无明显差异,小剂量他巴唑不良反应少。  相似文献   

10.
甲状腺疾病核素显像与甲状腺功能测定研究   总被引:2,自引:0,他引:2  
目的研究甲状腺摄高锝酸盐(99mTcO4-)显像与甲状腺功能测定对甲状腺疾病的诊断价值。方法空腹采静脉血,测定血清促甲状腺素(TSH)和甲状腺激素含量;静脉注射显像剂前、后测定注射器的放射性计数,注射30min后作甲状腺显像并计算甲状腺摄99mTcO4-率。根据受检者临床表现及血清TSH、游离三磺甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物抗体(TPOAb)含量及部分病理结果,分为甲状腺腺瘤组71例、单纯性甲状腺肿组24例、Grave’s病组200例、慢性淋巴细胞性甲状腺炎(HT)甲状腺功能亢进(甲亢)组21例和HT甲状腺功能减退(甲减)组29例,另设对照组95例,进行相关性分析。结果对照组甲状腺摄99mTcO4-率为(1.10±0.75)%,血清TSH为(1.50±0.98)μU/L、FT3为(6.34±1.84)pmol/L、FT4为(12.60±3.06)pmol/L。甲状腺腺瘤组甲状腺摄99mTcO4-率为(2.50±1.02)%,血清TSH为(1.47±0.61)μU/L、FT3为(7.11±1.04)pmol/L、FT4为(13.10±2.84)pmol/L。单纯性甲状腺肿组甲状腺摄99mTcO4-率为(2.80±0.98)%,血清TSH为(2.69±1.44)μU/L、FT3为(8.29±1.42)pmol/L、FT4为(11.5±2.23)pmol/L。Grave’s病组甲状腺摄99mTcO4-率为(7.40±4.97)%,血清TSH为(0.17±0.21)μU/L、FT3为(17.40±2.31)pmol/L、FT4为(2.80±3.04)pmol/L。HT甲亢组甲状腺摄99mTcO4-率为(6.10±4.69)%,血清TSH为(0.31±2.46)μU/L、FT3为(15.40±7.34)pmol/L、FT4为(22.90±15.44)pmol/L。HT甲减组甲状腺摄99mTcO4-率为(1.70±1.00)%,血清TSH为(35.80±17.41)μU/L、FT3为(4.57±1.41)pmol/L、FT4为(5.99±2.83)pmol/L。对照组与甲状腺腺瘤组、单纯性甲状腺肿组、HT甲减组甲状腺摄99mTcO4-率的差异有显著性(P<0.05),与Grave’s病组、HT甲亢组的差异亦有显著性(P<0.01);对照组与甲状腺腺瘤组、单纯性甲状腺肿组甲状腺激素含量的差异无显著性(P>0.05),与Grave’s病组、HT甲亢组、HT甲减组的差异有显著性(P<0.01)。甲状腺腺瘤组、Grave’s病组、HT甲减组甲状腺摄99mTcO4-率与甲状腺激素含量相匹配。甲状腺腺瘤组、Grave’s病组甲状腺摄99mTcO4-率均高于正常值;前者甲状腺激素含量正常,后者异常。单纯性甲状腺肿组、HT甲亢组甲状腺摄99mTcO4-率与甲状腺激素含量不匹配。两组摄99mTcO4-率均增高;单纯性甲状腺肿组甲状腺激素含量正常,HT甲亢组异常。HT甲亢组和HT甲减组甲状腺摄99mTcO4-率与甲状腺激素含量呈“分离现象”。结论甲状腺摄99mTcO4-率显像能反映甲状腺的位置、大小、形态、甲状腺及其包块的摄取情况,结合甲状腺血清学指标,其在甲状腺疾病的诊断、鉴别诊断、治疗及随访中均具有重要的临床价值。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

16.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

17.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

18.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

19.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

20.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

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