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1.
目的观察阈下剂量氯胺酮复合瑞芬太尼及异丙酚静脉全麻在乳房肿块切除术的麻醉效果.方法将60例患者随机分为两组,对照组(A组):诱导时由TCI泵维持异丙酚效应室浓度为3.0μg/ml,瑞芬太尼泵速0.2μg·kg-1·min-1,给予异丙酚预注量后静注瑞芬太尼1.0ug/kg、司可林20mg,置入喉置后维持异丙酚浓度不变,瑞芬太尼速下调至0.1μg·k-1·min-1,术中根据麻醉深度调整剂量;观察组(B组):除诱导时增加静注氯胺酮0.5mg/kg并术中维持氯胺酮6μg·kg-1·min-1外麻醉方式同A组.术中监测收缩压(SBP)、舒张压(DBP)、心率(HR)、脉搏氧饱和度(SPO2)、呼气末CO2(PetCO2)及气道吸气峰压(PIP),并记录:麻醉时间、自主呼吸恢复时间、停止麻醉到可以拔除喉罩时间、清醒时间(从停止麻醉到呼之睁眼时间)、术中有无躁动、术后VAS疼痛评分,术中的瑞芬太尼、乌拉地尔、阿托品及麻黄素总量,术后随访患者有无术中知晓、术中疼痛、梦幻感、恶心呕吐、瘙痒和术后咽痛.结果A组SBP、顾客HR诱导后与诱导前相比有显著差异(P<0.05或P<0.01),瑞芬太尼用量B组明显少于A组(P<0.05).结论阈下剂量氯胺酮复合瑞芬太尼及异丙酚静脉全麻可减少瑞芬太尼用量,并使诱导时血流动力学更加平稳  相似文献   

2.
瑞芬太尼在人工流产术中的应用   总被引:1,自引:0,他引:1  
目的观察异丙酚复合瑞芬太尼用于人工流产术的麻醉效果和对呼吸、循环系统的影响。方法40例需行人工流产术患者,ASAⅠ~Ⅱ级,按随机分为两组,一组为异丙酚组(A组),另一组为异丙酚复合瑞芬太尼组(B组),每组各20例。两组年龄、体重及手术时间比较无明显差异。A组病人异丙酚首次静注剂量为2mg/kg,B组瑞芬太尼静注剂量为0.3μg/kg,异丙酚静注剂量为2mg/kg。两组待麻醉满意后开始行人工流产术。同时观察诱导时间、苏醒时间、离院时间、并对麻醉效果进行分级评价。结果A组诱导、苏醒和离院时间明显短于B组(P<0.05),A组诱导后3min时BP下降、HR减慢、SpO2降低比B组明显(P<0.05);B组麻醉效果明显优于A组(P<0.05)。结论异丙酚复合瑞芬太尼应用于人工流产术,麻醉起效迅速、镇痛效果好,对呼吸和循环的抑制轻,宫颈松弛程度优良,病人术后苏醒快。  相似文献   

3.
目的:比较瑞芬太尼复合异丙酚静脉麻醉与异氟烷吸入麻醉用于声带息肉摘除术中,患者全身麻醉下的镇痛效果和术后苏醒质量。方法:40例声带息肉患者,随机分为瑞芬太尼复合异丙酚组(以后简称瑞芬太尼组)和异氟烷组,每组20例,观察两组患者诱导前、窥喉插管即刻及插管后5、15 min及拔管时的血流动力学变化和术毕停药苏醒情况。结果:瑞芬太尼组在全麻诱导及术中血流动力学波动小于异氟烷组(P<0.05);瑞芬太尼组术毕麻醉苏醒时间短于异氟烷组(P<0.05)。结论:瑞芬太尼复合异丙酚静脉麻醉用于支撑喉镜下声带息肉摘除术能够满足患者麻醉镇痛的要求,患者苏醒快、苏醒质量高,临床工作中可以采用。  相似文献   

4.
宋祥进 《海南医学》2012,23(5):45-46
目的 比较喉罩吸入七氟醚复合瑞芬太尼麻醉与异丙酚复合氯胺酮静脉麻醉在小儿腹股沟疝手术中应用的优劣.方法 择期腹股沟疝手术患儿40例,ASA Ⅰ级,随机分为喉罩吸入七氟醚复合瑞芬太尼组(A组)和异丙酚复合氯胺酮组(B组),每组20例.术中均保留自主呼吸,记录呼吸循环变化、诱导和苏醒时间、术中体动和术后不良反应发生率.结果 B组切皮后15min和术毕时HR明显快于A组和诱导前(P<0.05),B组患儿术中体动反应、术后不良反应发生率明显高于A组(P<0.05),在诱导时间、苏醒时间上A组较B组明显缩短(P<0.05).结论 对于腹股沟疝手术患儿,喉罩吸入七氟醚复合瑞芬太尼麻醉比异丙酚复合氯胺酮静脉麻醉效果更好.  相似文献   

5.
祝义军  宛泉龙  卢平 《微创医学》2007,2(4):266-268
目的观察瑞芬太尼复合异丙酚全凭静脉麻醉应用于老年患者腹腔镜胆囊切除术(LC)的临床疗效及不良反应。方法ASAⅠ~Ⅱ级、择期行LC术的老年患者40例,随机分为瑞芬太尼组(R组)和异氟醚组(I组),每组20例。两组均以咪唑安定0.04mg·kg-1、异丙酚1.5mg·kg-1、芬太尼4μg·kg-1和维库溴铵0.1mg·kg-1静脉诱导后气管插管。麻醉维持:Ⅰ组用1.5%~2.5%异氟醚吸入,R组用微量泵输注异丙酚6mg·kg-1·h-1和瑞芬太尼0.2~0.5μg·kg-1·min-1,分别记录麻醉诱导前、二氧化碳(CO2)气腹后1min、5min、气腹毕和术毕的收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)、苏醒时间和镇静评分(OAAS评分)及术后不良反应等。结果CO2气腹后1min、5min,I组的HR、MAP显著高于麻醉诱导前的基础值(P<0.05),各时点的血流动力学值也明显高于R组(P<0.05),R组术中循环较稳定;R组患者清醒时间为(10.6±3.4)min,I组为(22.8±5.7)min,且R组OAAS评分明显高于Ⅰ组,两组有显著性差异(P<0.05);R组的术后躁动、恶心呕吐发生率显著低于Ⅰ组(P<0.05)。结论瑞芬太尼复合异丙酚全凭静脉麻醉用于老年患者LC术具有麻醉平稳、苏醒质量好、并发症较少的特点,是老年患者行LC术较好的麻醉方法。  相似文献   

6.
瑞芬太尼复合异丙酚静脉麻醉病人术后苏醒期的临床观察   总被引:1,自引:0,他引:1  
目的:观察瑞芬太尼复合异丙酚在施行腹部手术病人静脉麻醉术后的苏醒情况。方法:选择ASA~级40例施行腹部手术病人随机分为瑞芬太尼异丙酚组(A组)和芬太尼异丙酚组(B组),每组20例。麻醉诱导和维持用异丙酚、维库溴铵、瑞芬太尼或芬太尼。记录病人出现睫毛反射、睁眼、指令动作及拔出气管导管的时间。结果:睫毛反射时间A组(4.75±2.61)min,B组(46.50±5.66)min(P<0.01);睁眼时间A组(8.00±4.88)min,B组(54.45±37.78)min(P<0.01);指令动作时间A组(16.35±16.16)min,B组(72.95±43.03)min(P<0.01);拔管时间A组(28.70±21.27)min,B组(91.60±49.16)min(P<0.01)。结论:瑞芬太尼复合异丙酚具有麻醉性强,起效迅速、作用时间短、消除快的特点,可大大缩短病人麻醉后的复苏时间。  相似文献   

7.
唐祖恩  孙福德 《重庆医学》2008,37(24):2815-2816
目的 比较氯胺酮、咪唑安定、芬太尼复合全凭静脉麻醉与丙泊酚、咪唑安定、瑞芬太尼复合全凭静脉麻醉用于小儿扁桃体摘除术的麻醉效果.方法 选择ASAⅠ~Ⅱ级,年龄为3~9岁,行扁桃体摘除术的患儿60例.随机分成氯胺酮、咪唑安定、芬太尼组(A组)和丙泊酚、咪唑安定、瑞芬太尼(B组),每组30例.观察两组患者术中、术后的HR、BP以及术毕清醒拔管时间和不良反应.结果 A组术中HR快于B组(P<0.05)、拔管时的HR快于B组(P<0.01)、清醒拔管时间明显长于B组(P<0.01)、术后不良反应明显多于B组(P<0.05).结论 丙泊芬、咪唑安定、瑞芬太尼复合全凭静脉麻醉用于小儿扁桃体摘除术时,术中、术后的HR较慢,术毕清醒拔管时间短,不良反应少.  相似文献   

8.
目的 :比较瑞芬太尼复合异丙酚与芬太尼复合异丙酚用于无痛人流的临床效果。方法 :1 0 0例要求终止妊娠的早孕妇女随机分成芬太尼组 (A组 ,5 0例 )和瑞芬太尼组 (B组 ,5 0例 ) ,两组均先分别静注芬太尼、瑞芬太尼后静注异丙酚 1 .5mg/kg诱导 ,A组静注芬太尼 0 .0 5mg ,B组静注瑞芬太尼 0 .0 5mg ,术中静脉追加异丙酚 0 .5mg/kg ,观察SpO2 、HR、MAP变化、异丙酚总用量、镇痛效果。结果 :术中异丙酚追加量和总用药量A组显著高于B组 (P <0 .0 5 ) ,苏醒时间A组显著长于B组。呼吸循环的变化两组间无显著差异。结论 :瑞芬太尼较芬太尼用于无痛人流具有药效、安全相似 ,但镇痛强 ,苏醒较快、镇痛效果满意等优点 ,值得推广应用。  相似文献   

9.
方华  田先平 《当代医学》2008,(14):147-148
目的 比较瑞芬太尼复合丙泊酚吸入用于老年人LC手术的麻醉效果. 方法 选择60例拟行LC手术的老年病人,ASAI-Ⅱ级,随机分为瑞芬太尼复合丙泊酚组(R组,n=30)和异氟醚组(Ⅰ组,n=30).两组麻醉诱导相同,咪哇安定0.1mg·kg-1,丙泊酚1.5mg·kg-1,芬太尼3-4μg.kg-1.h-1.组持续吸入异氟醚3%-4%.两组术中持续静注阿曲库按控制肌松和呼吸,观察两组围手术期血流动力学变化、术后恢复情况及不良反应. 结果 R组术中血流动力学指标较Ⅰ组平稳,术后呼之睁眼及拔管是时问短于Ⅰ组(P<0.01),苏醒期烦躁、高血压、恶心呕吐发生率明显低于Ⅰ组(P<0.01). 结论 瑞芬太尼复合丙泊酚静脉麻醉与异氟醚吸入麻醉比较,具有血流动力学稳定,术后苏醒快,不良反应少,安全可行的优点.适用于老年患者LC手术.  相似文献   

10.
比较支撑喉镜手术中瑞芬太尼复合异丙酚和地氟醚对患者术中血流动力学变化的影响.麻醉诱导采用异丙酚1.5 mg·kg-1,瑞芬太尼1 μg·kg-1不能完全抑制气管插管反应;麻醉维持阶段瑞芬太尼0.2μg·kg-1·min-1的输注速度不能完全消除置支撑喉镜时引起的血压升高;瑞芬太尼复合地氟醚麻醉在手术开始前血压下降的程度小于复合异丙酚组;麻醉诱导期瑞芬太尼复合地氟醚要比复合异丙酚的血流动力学更加稳定.  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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