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1.
目的:分析草酸艾司西酞普兰与盐酸帕罗西汀对抑郁症的临床治疗效果及安全性。方法选取46例抑郁症患者,随机分为草酸艾司西酞普兰组(实验组)与盐酸帕罗西汀(对照组)(n=23)。实验组给予口服草酸艾司西酞普兰治疗,对照组给予口服盐酸帕罗西汀治疗,2组均进行为期8周的治疗。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,不良反应量表(TESS)评定药物不良反应和安全性,同时记录在治疗前和治疗后2、4、8周末患者的HAMD和TESS评分,比较草酸艾司西酞普兰和盐酸帕罗西汀对于抑郁症患者的治疗效果。结果实验组治愈总有效率为87.96%。对照组总有效率为91.30%,差异无统计学意义。2组治疗后从第2周末开始HAMD评分均较治疗前低,实验组从治疗后第2周末开始HAMD评分明显较对照组低,实验组的不良反应发生率显著低于对照组,差异均有统计学意义(P<0.05)。结论草酸艾司西酞普兰对于抑郁症的治疗效果与盐酸帕罗西汀的治疗效果相当,但草酸艾司西酞普兰治疗起效快,不良反应较少,耐受性高,适宜于长期治疗。  相似文献   

2.
目的:探讨草酸艾司西酞普兰治疗脑卒中后抑郁的临床疗效及安全性.方法:对88例符合脑卒中后抑郁诊断标准的患者.随机分成两组,分别给予草酸艾司西酞普兰与盐酸文拉法辛进行为期8周的治疗.采用汉密尔顿抑郁表(HAMD)评价疾病的严重程度及评定临床疗效.副反应量表(TESS)评估药物的不良反应.结果:治疗后草酸艾司西酞普兰组与盐酸文拉法辛组在汉密尔顿抑郁量表(HAMD)减分率无明显差异.草酸艾司西酞普兰组有效率为75%,盐酸文拉法辛组有效率为77.3%.两组疗效比较无显著性差异(P>0.05).副反应量表(TESS):草酸艾司西酞普兰组不良反应少.结论:草酸艾司西酞普兰不仅能有效控制脑卒中后抑郁症状,而且不良反应少.对脑卒后抑郁患者是一种较为理想的抗抑郁药物.  相似文献   

3.
目的:观察盐酸文拉法辛与草酸艾司西酞普兰对抑郁障碍患者快感缺失的疗效对比。方法:将入院患者根据随机数字表法分为盐酸文拉法辛组(26例,75~225 mg/d)和草酸艾司西酞普兰组(27例,10~20 mg/d),疗程均为8周。在入组时收集一般资料、Snaith快感缺失量表(SHAPS)、汉密尔顿抑郁量表24项(HAMD-24),并于治疗2、4、6、8周末评定HAMD-24,于2、8周末评定SHAPS,同时评定副反应量表(TESS)。结果:草酸艾司西酞普兰组和盐酸文拉法辛组相比,所有患者经治疗8周后,两种药物对HAMD评分改善均有显著作用(P<0.01),两种药物间对HAMD的改善差异无统计学意义(P>0.05);治疗8周后,研究组患者SHAPS评分有显著统计学意义(P<0.01)。结论:草酸艾司西酞普兰和盐酸文拉法辛对抑郁障碍患者疗效相似,对相应症状具有明显改善作用;但盐酸文拉法辛对快感缺失的疗效较草酸艾司西酞普兰好。  相似文献   

4.
目的:观察草酸艾司西酞普兰联合小剂量氨磺必利治疗以躯体症状为主老年抑郁症的疗效和安全性。方法:采用随机数字表法将符合《国际疾病分类(第10版)》(ICD-10)抑郁症诊断标准的85例老年抑郁症患者分为研究组43例(采用草酸艾司西酞普兰联合氨磺必利治疗)和对照组42例(采用草酸艾司西酞普兰组),疗程8周。于治疗前和治疗后第1、2、4、6、8周末采用汉密尔顿抑郁量表17项版(HAMD-17)及症状自评量表(SCL-90)躯体化因子分评定并比较两组疗效及采用不良反应量表(TESS)评定安全性和不良反应。结果:治疗1周末,研究组的HAMD-17总评分与治疗前比有统计学差异性(P<0.05),治疗2周后,两组HAMD-17总评分与治疗前比较差异均有统计学意义(P<0.05)。治疗4周末,研究组HAMD-17和SCL-90躯体化因子总评分均较对照组低,比较差异有统计学意义(P<0.05);两组痊愈率及总有效率差异均有统计学意义(P<0.05)。研究组与对照组总体的不良反应发生率差异无统计学意义(P>0.05)。结论:草酸艾司西酞普兰联合小剂量氨磺必利治疗以躯体症状为主的老年抑郁症的疗效优于单纯草酸艾司西酞普兰治疗疗效,但其安全性等同。  相似文献   

5.
目的:探讨草酸艾司西酞普兰治疗脑卒中后抑郁的临床疗效及安全性。方法:对112例符合脑卒中后抑郁诊断标准的患者。随机分成两组,分别给予草酸艾司西酞普兰与盐酸舍曲林进行为期12周的治疗。应用抑郁量表评价疾病的严重程度及评定临床疗效。副反应量表(TESS)评估药物的不良反应。结果:治疗后草酸艾司西酞普兰组与盐酸舍曲林组用抑郁量表评定其治疗效果相当。草酸艾司西酞普兰组有效率为78.6%,盐酸酸舍曲林组效率为76.8%,两组疗效比较无显著性差异(P >0.05)。副反应量表(TESS):草酸艾司西酞普兰组不良反应少。结论:草酸艾司西酞普兰能改善脑卒中后抑郁症状,并且耐药性好,安全,不良反应少。  相似文献   

6.
《右江医学》2018,(1):71-74
目的探讨草酸艾司西酞普兰联合富马酸喹硫平在治疗难治性抑郁症方面的临床疗效和安全性。方法将70例在门诊和住院收集的符合要求的难治性抑郁症患者,随机分成两组,每组35例,研究组服用草酸艾司西酞普兰联合小剂量富马酸喹硫平,对照组单用草酸艾司西酞普兰,观察期共8周。并于治疗前和治疗后的第2、4、6、8周均采用17项汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评价各组的疗效,同时使用副反应量表(TESS)评定治疗期间的不良反应。结果治疗后两组HAMD、HAMA的评分较治疗前均显著下降(P<0.01);同期研究组各项评分结果较对照组下降更显著(P<0.001),第8周研究组和对照组有效率分别是82.86%、60.0%,两组间疗效差异有统计学意义(P<0.01)。两组药物不良反应发生率差异无统计学意义(P>0.05)。结论对于难治性抑郁症,草酸艾司西酞普兰联合小剂量富马酸喹硫平与单用艾司西酞普兰相比,起效较快,并能改善夜眠和焦虑症状,且安全性较好。  相似文献   

7.
目的:比较逍遥散加减联合草酸艾司西酞普兰片与单独使用草酸艾司西酞普兰片治疗抑郁症的疗效及安全性。方法:将确诊为抑郁症的60例患者随机分为治疗组(逍遥散加减联合草酸艾司西酞普兰片组)30例,对照组(草酸艾司西酞普兰片组)30例,用汉密尔顿抑郁量表(HAMD)在治疗前及治疗后2、4、6、8周评定疗效,用不良反应量表(TESS)评定安全性。结果:治疗组有效率为93.33%,对照组为83.33%,两组比较,差异有统计学意义(P〈0.05);治疗后2、4、6、8周,治疗组HAMD评分均低于对照组,差异有统计学意义(P〈0.05);治疗组出现不良反应4例,对照组出现12例,两组比较,差异有统计学意义(P〈0.05)。结论:逍遥散加减联合草酸艾司西酞普兰片治疗抑郁症起效快,疗效好,不良反应少。  相似文献   

8.
目的:对比分析国产草酸艾司西酞普兰和进口草酸艾司西酞普兰在抑郁症治疗中的应用效果和安全性。方法:将选取接诊的抑郁症患者60例按顺序编号并随机分组,得对照组(进口草酸艾司西酞普兰治疗)和观察组(国产草酸艾司西酞普兰片治疗)各30例,对比两组疗效。结果:治疗后观察组的HAMD评分与对照组比较,差异无统计学意义(t=0.57;P>0.05);观察组的治疗有效率和不良反应率和对照组比较,差异无统计学意义(χ~2=1.87,2.39;P>0.05);观察组的治疗成本为(2 562.17±134.28)元,显著低于对照组,差异有统计学意义(t=13.74,P<0.05)。结论:国产草酸艾司西酞普兰和进口药物治疗抑郁症的效果类似,且国产药物的治疗成本相对更低,具有更高的临床应用价值。  相似文献   

9.
目的:比较度洛西汀与艾司西酞普兰治疗脑卒中后抑郁的临床疗效及安全性。方法:按诊疗顺序将收治的126例脑卒中后抑郁患者分为对照组和研究组,每组各63例。研究组给予度洛西汀口服治疗,对照组口服艾司西酞普兰治疗,疗程均为8周。于治疗前和治疗2、4、8周采用汉密尔顿抑郁量表(HAMD)评定疗效,不良反应量表(TESS)评定不良反应。结果:治疗8周后研究组临床有效率87.53%,对照组临床有效率为85.78%,两组疗效差异无统计学意义(P>0.05);治疗第2周末,研究组HAMD总分低于对照组(t=2.26,P<0.05),其中睡眠障碍,焦虑/抑郁因子评分与对照组有显著性差异(P<0.01);研究组不良反应发生率为19.52%,对照组不良反应发生率为20.75%,两组不良反应发生率差异无统计学意义(P>0.05)。结论:度洛西汀与艾司西酞普兰治疗脑卒中后抑郁的临床疗效相当,不良反应少,但度洛西汀起效时间比艾司西酞普兰快。  相似文献   

10.
艾司西酞普兰与氟西汀治疗老年抑郁的对照研究   总被引:1,自引:0,他引:1  
目的评价草酸艾司西酞普兰与氟西汀治疗老年抑郁症的临床疗效及安全性。方法将62例老年抑郁症患者随机分为艾司西酞普兰组31例,氟西汀组31例,观察6周。于治疗前和治疗1周、2周、4周、6周末采取汉密尔顿抑郁量表评定疗效,不良反应量表评定不良反映。结果艾司西酞普兰组显效率77.4%,氟西汀组77.2%,两组比较差异无统计学意义(P0.05);艾司西酞普兰组不良反应发生率35.48%,氟西汀组51.62%,两组比较差异没有统计学意义(P0.05)。结论艾司西酞普兰与氟西汀治疗老年抑郁症疗效相当,但艾司西酞普兰起效比氟西汀起效更快更安全,适合作为老年抑郁患者的一线用药。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

20.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

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