持续气道正压通气治疗对OSAHS患者胰岛素抵抗的影响

目的 通过观察持续气道正压通气(CPAP)治疗对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的胰岛素抵抗(1R)的影响,以验证OSAHS是否为引起患者IR增加的独立危险因素.方法 选择30例OSAHS患者,其呼吸暂停/低通气指数(AHI)为(38.9±16.0),体重指数(BMI)(27.1±2.5)kg/m2.通过3个月的CPAP治疗,观察治疗前后反映IR的稳态模式评估(HOMA)指数变化.结果 在BMI无明显改变的情况下,3个月的CPAP治疗后HOMA指数较治疗前明显降低[(2.04±1.78)vs(3.53±2.76),P<0.01].结论 CPAP治疗可显著改善OSAHS患者的IR,提示OSAHS是IR的独立危险因素.     

持续气道正压通气治疗对OSAHS患者胰岛素抵抗的影响

目的观察持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的胰岛素抵抗（IR）的影响,以验证OSAHS是否为引起患者IR增加的独立危险因素.方法选择60例OS-AHS患者,其呼吸暂停/低通气指数（AHI）为38.9±16.0;体重指数（BMI）为（27.1±2.5）kg/m2;经3个月的CPAP治疗,观察治疗前后反映IR的稳态模式评估（HOMA）指数变化.结果在BMI无明显改变的情况下,3个月的CPAP治疗后HOMA指数较治疗前明显降低（2.04±1.78 vs 3.53±2.76,P〈0.01）.结论 CPAP治疗可显著改善OSAHS患者的IR.     

持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病患者胰岛素敏感性的影响

目的 探讨CPAP,即持续气道正压通气治疗,对于OSAHS症,即阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病患者胰岛素敏感性的影响.方法 方便选择2012年1月—2016年1月该院睡眠中心收治92例OSAHS伴2型糖尿病患者,对AHI、LSaO2,即呼吸暂停低通气指数、夜间最低血氧饱和度的数据进行记录,并用稳态模式评估(HOMA)指数评估胰岛素的敏感性,经过CPAP治疗2周后,复查以上相关指标比较前后差异.结果 经过CPAP治疗2周后,AHI与LSaO2明显得到改善.结论 持续气道正压通气可以改善阻塞性睡眠呼吸暂停低通气综合征伴2型糖尿病患者的夜间低血氧的现象,并增加胰岛素的敏感性.     

CPAP对合并OSAHS的2型糖尿病患者脂联素水平的影响

【目的】探讨持续气道正压通气（CPAP）对合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的2型糖尿病患者胰岛素抵抗（IR）及血清脂联素水平的影响。【方法】选择本院合并OSA HS的2型糖尿病患者48例,通过3个月的CPAP治疗,观察治疗前后反映 IR的稳态模式评估（HOMA ）指数及血清脂联素水平的变化。【结果】CPAP治疗3个月后,患者的 HOMA指数较治疗前明显降低（3．58＆#177;0．76 vs 1．92＆#177;0．69）,血清脂联素水平较前升高（5．42＆#177;1．35 vs 8．24＆#177;1．83）,且两组相比较差异均有显著性（均 P ＜0．01）。【结论】CPAP治疗可显著改善合并OSAHS的2型糖尿病患者的IR及血清脂联素水平。     

持续正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病30例

目的研究持续正压通气（CPAP）治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并2型糖尿病的作用。方法对30例OSAHS合并2型糖尿病患者使用CPAP治疗12周（每晚5～7h）,在治疗前后对患者进行空腹血糖、糖化血红蛋白、空腹胰岛素检测。结果患者应用CPAP治疗后空腹血糖、糖化血红蛋白、胰岛素抵抗指数均下降,差异有统计学意义,空腹胰岛素无明显变化。结论CPAP治疗OSAHS合并2型糖尿病患者胰岛素抵抗改善,血糖水平降低,是一种有效的治疗方法。     

持续气道正压通气治疗对阻塞性睡眠呼吸暂停低通气综合征患者胰岛素抵抗的影响

目的探讨经鼻持续气道正压通气（nCPAP）对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者胰岛素抵抗（IR）的影响。方法研究20例中重度OSAHS患者CPAP治疗前后多导睡眠图（PSG）监测主要指标与空腹血糖（FPG）、空腹胰岛素（Fins）关系，并设正常对照组20例。结果@OSAHS患者呼吸暂停低通气指数（AHI）、Fins显著高于对照组（P〈0．01），胰岛素敏感性指数（ISI）、最低脉氧饱和度（LSPO2）显著低于对照组（P〈0．01）；（2）CPAP治疗6个月后，AHI、Fins较治疗前显著下降（P〈0．01），ISI、LSPO2较治疗前显著提高（P〈0．01）。结论OSAHS低氧可产生IR；nCPAP治疗能显著改善OSAHS患者IR。     

CPAP治疗对2型糖尿病合并OSAHS患者夜间血糖的影响

目的:评价短期的持续气道正压通气(continuous positive airway pressure,CPAP)治疗对2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者稳态模型胰岛素抵抗指数(HOMA-IR)及夜间血糖水平的作用。方法:收集2012年至2013年郑州大学人民医院内分泌科53名2型糖尿病合并OSAHS住院患者。给予动态血糖监测、多导睡眠图监测及CPAP治疗。CPAP治疗前后测定空腹血糖、胰岛素,评估HOMA-IR。CPAP治疗前后HOMA-IR及夜间血糖采用配对t检验分析。结果:夜间血糖治疗后[(6.53±0.73)mmol/L]低于治疗前[(7.73±1.17)mmol/L],平均血糖波动幅度治疗后[(0.36±0.17)mmol/L]低于治疗前[(0.58±0.22)mmol/L],HOMA-IR治疗后[(2.13±0.78)mmol/L]低于治疗前[(2.58±0.90)mmol/L],差异均有统计学意义(P均<0.05)。结论:2型糖尿病合并OASHS患者经过短期CPAP治疗后稳态模型胰岛素抵抗指数及夜间血糖水平均降低。     

持续气道正压通气治疗OSAHS的疗效评价

目的 :评价临床上应用自动持续气道正压 (Auto- CPAP)通气治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效。方法:对 4 0例 OSAHS患者使用 Auto- CPAP呼吸机进行压力滴定治疗 ,比较治疗前后呼吸暂停指数 (AI)、呼吸紊乱指数 (AHI)及最低血氧饱和度 (L Sa O2 )。结果:治疗后 AHI、AI、L Sa O2 较治疗前明显改善(P均 <0 .0 0 1)。 结论 :Auto CPAP通气是一种治疗 OSAHS的有效的方法     

持续气道正压通气在2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征患者的治疗效果观察

目的:探讨持续气道正压通气(CPAP)联合降糖药物治疗对糖尿病合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血糖的影响。方法:将35例糖尿病合并OSAHS患者随机分为对照组20例和CPAP治疗组15例。比较两组药物治疗的改变情况和血糖监测等指标变化。结果:治疗12周后,CPAP组与对照组各项血糖指标均优于治疗前(P<0.05),且CPAP组更明显。治疗后CPAP组血糖控制达标率高于对照组(84.6%vs45%,P<0.05),血糖波动情况明显优于对照组,且降糖药种类明显少于对照组。结论:CPAP联合药物治疗对糖尿病合并OSAHS患者疗效好于单纯药物治疗。对糖尿病合并OSAHS患者,CPAP治疗可以减少服用降糖药的品种,血糖控制好于对照组。     

CPAP对2型糖尿病合并阻塞性睡眠呼吸暂停综合征治疗观察

目的 观察持续气道正压通气(continuous positive airway pressure,CPAP)对2型糖尿病合并阻塞性睡眠呼吸暂停综合征患者的治疗过程中的血糖变化.方法 将40例2型糖尿病合并阻塞性睡眠呼吸暂停综合征患者随机分为治疗组(25例)及对照组(15例),两组均使用胰岛素强化治疗控制血糖,配合饮食控制及运动.治疗组在降糖基础上联合应用CPAP治疗.治疗3月后观察治疗组及对照组患者血糖变化.结果 经过3个月的治疗,治疗组患者空腹血糖、餐后血糖、糖化血红蛋白(HbA1c)及呼吸紊乱指数(AHI)较治疗前下降(P＜0.05),对照组空腹血糖、餐后血糖、糖化血红蛋白(HbA1c)及呼吸紊乱指数较治疗前下降(P＜0.05),组间比较治疗组较对照组血糖、呼吸紊乱指数下降更显著(P＜0.01).结论 CPAP 治疗对2型糖尿病合并阻塞性睡眠呼吸暂停综合征患者有利于改善其高血糖状态.     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.