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1.
目的探讨电针对抑郁症患者血清细胞因子的影响.方法采用放射免疫分析法测定电针组30例、麦普替林组31例抑郁症患者治疗前、治疗第2、4、6周末血清白细胞介素1,2,6和肿瘤坏死因子水平,并与正常组10人进行对比.结果抑郁症患者治疗前血清IL-1β,IL-6、TNF-α水平非常明显地高于正常人.相关性分析发现,血清IL-1β,TNF-α水平与HAMD抑郁量表总分呈显著正相关.IL-1β与认知障碍症状群,TNF-α与绝望症状群,IL-6水平与焦虑/躯体化因子分有明显的正相关性.经电针和四环类抗抑郁药麦普替林治疗,随着抑郁症状的缓解,以上细胞因子水平也逐渐下降,至第6周末基本恢复正常.两治疗组之间无明显差别.结论细胞因子在抑郁症的发病过程中起一定作用,电针对细胞因子的抑制作用是电针治疗抑郁症的机制之一.  相似文献   

2.
目的观察电针治疗肝郁脾虚型抑郁症的治疗效果,以及电针治疗对血清细胞因子的影响。方法选出的60例抑郁症患者分为两组,一组为电针组,另一组为药物组(各30例)。电针组给予电针针刺穴位治疗;药物组给予百忧解胶囊治疗。记录并观察以上两组患者治疗前后汉密顿抑郁量表(HAMD)评分及血清细胞因子白细胞介素(IL)-1β、IL-2、IL-6、肿瘤坏死因子-α(TNF-α)的变化。结果治疗第3周,发现针刺组使抑郁症患者的HAMD总分显著减少;第6周时,针刺组的HAMD因子分析改善明显优于药物组(P0.05)。针刺组能比药物组更加明显地降低IL-1β、IL-2、IL-6、TNF-α的高表达水平。结论针刺治疗可以通过调节血清细胞因子水平而发挥治疗抑郁症的作用,最终有效改善抑郁症患者的HAMD评分。  相似文献   

3.
成人Still病患者血清细胞因子水平及与病情活动性的关系   总被引:4,自引:0,他引:4  
目的:观察成人Still病患者血清细胞因子水平的变化,以及与病情活动性的关系。方法:18例成人Still病患者接受糖皮质激素治疗前及治疗1个月后,采用双抗体夹心ELISA法测定血清白介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子(TNF)-α和可溶性IL-2受体(sIL-2R)水平,以及检测红细胞沉降率(ESR)、血清C-反应蛋白(CRP)和血清IgG、IgA和IgM水平。结果:所有患者在病情活动期,红细胞沉降率(ESR)和血清CRP、IL-1β、IL-6、IL-8、TNF-α和sIL-2R水平均显著增高,而IgG、IgA、IgM水平无显著升高。经泼尼松治疗1个月后,患者体温正常、关节痛和皮疹消失,ESR和血清CRP、IL-6、TNF-α和sIL-2R水平显著下降,IL-1β和IL-8水平无显著性变化。经直线相关分析,IL-6、TNF-α和sIL-2R水平与ESR、CRP均有相关性,且与IL-6的相关系数(r=0.62,0.58)为最高。结论:成人Still病患者在病情活动期血清免疫球蛋白水平无明显变化,而血清IL-1β、IL-6、IL-8、TNF-α和sIL-2R等细胞因子水平显著升高,且IL-6、TNF-α和sIL-2R水平与病情活动性相关,可作为病情活动性指标。  相似文献   

4.
目的:探讨血清白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)与脑卒中后抑郁的相关性,并对音乐疗法在治疗卒中后抑郁的作用进行研究。方法:选取100例在我院住院治疗脑卒中患者,在住院后10天,应用汉密尔顿抑郁量表对患者进行分组:抑郁组,56人,HAMD 评分>17分;非抑郁组,44人,评分≤17分。对两组患者检测血清 IL-6、TNF-α含量并统计分析。对纳入抑郁组的患者再随机平均分为2组进行治疗,PSD 常规治疗组,28人,应用常规抗抑郁药治疗;PSD 音乐治疗组,28人,在常规抗抑郁药物基础上加用音乐治疗。在治疗1个月后,对两组患者进行疗效分析。结果:抑郁组患者血清 IL-6、TNF-α含量较非抑郁组患者明显升高,差异有统计学意义(P<0.05);在常规抗抑郁药物基础上加用音乐治疗的患者抑郁改善明显由于单纯药物治疗,差异有统计学意义(P<0.05);结论:血清 IL-6、TNF-α水平与脑卒中后抑郁存在相关性;音乐疗法对 PSD患者的治疗有改善作用。  相似文献   

5.
目的:探讨度洛西汀对抑郁症患者血清细胞因子水平的影响。方法:采用放射免疫分析法测定82例抑郁症患者治疗前、治疗第6周末血清白细胞介素2(IL-2)和肿瘤坏死因子(TNF-α)水平。结果:抑郁症患者治疗前血清IL-2和TNF-α水平明显高于治疗后。相关性分析发现,血清IL-2,TNF-α水平与HAMD抑郁量表总分呈显著正相关。经度洛西汀治疗后,随着抑郁症状的缓解,以上细胞因子水平逐渐下降。结论:细胞因子在抑郁症的发病过程中起一定作用,度洛西汀对细胞因子的抑制作用是治疗抑郁症的机制之一。  相似文献   

6.
目的:探讨度洛西汀对抑郁症患者血清细胞因子水平的影响.方法:采用放射免疫分析法测定82例抑郁症患者治疗前、治疗第6周末血清白细胞介素2(IL-2)和肿瘤坏死因子(TNF-α)水平.结果:抑郁症患者治疗前血清IL-2和TNF-α水平明显高于治疗后.相关性分析发现,血清IL-2,TNF-α水平与HAMD抑郁量表总分呈显著正相关.经度洛西汀治疗后,随着抑郁症状的缓解,以上细胞因子水平逐渐下降.结论:细胞因子在抑郁症的发病过程中起一定作用,度洛西汀对细胞因子的抑制作用是治疗抑郁症的机制之一.  相似文献   

7.
目的:探讨孕妇血清及羊水中白细胞介素1β(IL-1β)及肿瘤坏死因子-α(TNF-α)与胎儿宫内发育迟缓(IUGR)的关系。方法:采用酶联免疫吸附法(ELISA)检测正常足月孕妇及IUGR孕妇血清及羊水中IL-1β及TNF-α水平,并进行比较分析。结果:IUGR组与正常分娩组孕妇血清中IL-1β、TNF1-α水平比较,无统计学意义(P>0.05);而IUGR组羊水中IL-1β明显低于对照组,TNF-α则明显高于对照组,均存在显性差异(P<0.01);在预测IUGR方面,羊水中TNF-α水平变化较IL1β更有价值。结论:羊水中IL-1β及TNF-α水平变化与IUGR的发生密切相关。  相似文献   

8.
目的 研究心衰患者血清TNFα和IL-6水平,观察不同病因和心功能改善后TNFα和IL-6水平变化。方法 采用酶联免疫吸附实验57主衰患者治疗前后和20例健康体检者血清TNFα和IL-6水平。结果 中重度心衰组患者血清TNFα明显高于对照组和轻中度心衰组(P<0.01),所有心衰患者血清IL-6水平均明显高于对照组(P<0.01)。且中重度心患者高于轻中度肾衰患者(P<0.01),不同病因心衰患者血清TNFα和IL-6水平差异不显著(P>0.05)。经治疗心功能改善后,中重度心衰组患者血清TNFα和TL-6水平明显降低(P<0.05)。结论 中重度心衰患者血清TNFα和IL-6水平升高,且随着心功能改善而降低,细胞因子水平与心衰病因无关。  相似文献   

9.
细胞因子活性与小儿肺炎关系的探讨   总被引:3,自引:0,他引:3  
目的:探讨小儿肺炎的发病及病情变化与细胞因子活性的关系。方法:采用化学发光酶免疫分析法检测47例肺炎患儿(其中单纯性肺炎40例,重症肺炎7例)及40例正常健康儿童血清白细胞介素1β(interleukin1β,IL-1β)、白细胞介素8(interleukin-8,IL-8)和肿瘤坏死因子α(tumor necrosis factor-α,TNFα)的水平。结果:入院第1天肺炎患儿血清IL-8、TNFα含量高于正常健康儿童(P<0.01),重症肺炎组血清IL-8含量高于单纯性肺炎组(P<0.01)。治疗过程中,单纯性肺炎患儿随病情的减轻IL-8、TNFα含量逐渐下降(P<0.01);而重症肺炎患儿则随病情的加重IL-1β、IL-8和TNFα含量明显升高,与治疗前比差异显著(P<0.01)。结论:血清IL-1β、IL-8和TNFα水平的变化与肺炎患儿病情的严重程度有关;连续检测血清IL-1β、IL-8和TNFα水平对肺炎患儿病情及预后的估计有一定的价值。  相似文献   

10.
冯斌  陈实 《四川医学》2001,22(8):736-737
目的 探讨新生儿缺氧缺血性脑病(HIE)血清白介素-6(IL-6)、肿瘤坏死因子-α(INF-α)与新生儿行为神经测定(NBNA)的相关性。方法 采用ELISA法测定30例HIE患儿血清IL-6、TNF-α水平,及20项NBNA。同期26例健康足月新生儿脐血IL-6、TNF-α及NBNA作对照。结果 HIE组血清IL-6、TNF-α水平明显高于对照组(P<0.01),二者与NBNA有一定的相关性(r分别为0.356,0.638)。结论 肿瘤坏死因子-α可作为HIE的早期诊断、评价脑损伤程度及判断预后的指标之一。血清IL-6的升高仅提示可能存在缺氧缺血性脑损伤,不能判断其损伤程度和预后。  相似文献   

11.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

12.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

13.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

14.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

15.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

16.
A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care(~'4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.  相似文献   

17.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

18.
Journal of Nanjing Medical University (English Edition) JNMU, sponsored by Nanjing Medical University, was established in 1987. It is a bimonthly comprehensive English medical journal published locally and abroad.Since 2007, Journal of Nanjing Medical University (English Edition )was granted Elsevier the full publishing and distribution rights worldwide for the Electronic Edition, excluding the People's Republic of China.  相似文献   

19.
Objective To measure Derpl and Blot5 allergen levels in asthmatics' homes in Hongkong.Methods Seventy houses were enrolled for a mite indoor environment study. Dust samples were obtained from two sites of each patients' house: bed and floor. Derpl and Blot5 levels were quantified by a two-site monoclonal antibody-based ELISA technique.Results The levels of Derpl allergens found in bed (geometric mean (GM) 3.43 μg/g of dust; 95%CI, 1.89-4.96 μg/g)and on the floor (GM 1.12 μg/g of dust; 95%CI, 0.71-1.53 μg/g) indicated significant differences (P=0.005). However, the levels of Blot5 allergens found in bed (GM 19.00 μg/g of dust; 95%CI, 0.89-38.90 μg/g) and on the floor (GM 6.14 μg/g of dust; 95%CI, 0.40-11.90 μg/g) showed no statistically significant difference. In addition, in regards to the exposure index for Derpl and Blot5 allergens found in bed and on the floor, 17.6% in bed and 8.6% on the floor had levels of Blot5 ≥ 10 μg/g of dust, higher than those obtained for Derp1 (7.2% and 0% in bed and on the floor respectively, P< 0.05); higher percentages in bed and on the floor (25.0% and 35.7%) were observed for levels of Blot5 =0 μg/g of dust as compared with Derpl in bed and on the floor (4.3% and 14.5% respectively, P< 0.05).Conclusions Derpl and Blot5 are the major allergens found in this regional study, Blot5 is a more potent allergen in Hongkong, probably reflecting the high level of exposure to Blomia tropicalis (Bt). Bt and Dermatophagoides pteronyssinus (Dp) allergens should be included for precise diagnosis and effective immuno-therapeutic treatment of mite allergy in Hongkong.  相似文献   

20.
ANTI-PROLIFERATION EFFECT OF ORIDONIN ON HL-60 CELLS AND ITS MECHANISM   总被引:4,自引:0,他引:4  
Objcetive To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism. Methods HL-60 cells in vitro in culture medium were given different concentrations of oridonin. The inhibitory rate of cells were measured by microculture tetrazolium (MTT) assay, cell apoptotic rate was detected by flow cytometry (FCM), morphology of cell apoptosis was observed by hoechst 33258 fluorescence staining, and the activity of telomerase was detected using telomere repeat amplification protocol (TRAP) PCR-ELISA before and after apoptosis occurred. Results Oridonin could decrease telomerase activity, inhibit growth of HL-60 cells, and cause apoptosis significantly. The suppression was both in time- and dose-dependent manner. Marked morphological changes of cell apoptosis including condensation of chromatin and nuclear fragmentation were observed clearly by hoechst 33258 fluorescence staining especially after cells were treated 48-60 hours by oridonin. Conclusions Oridonin has apparent anti-proliferation and apoptotic effects on HL-60 cells in vitro, decreasing telomerase activity of HL-60 cells may be one of its most important mechanisms. These results will provide strong laboratory evidence of oridonin for clinical treatment of acute leukemia.  相似文献   

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