基于因子分析的疲劳性亚健康人群中医证候及证候要素特点的研究

目的：探讨疲劳性亚健康人群的中医证候及证候要素特点。方法：根据疲劳性亚健康状态中医证候研究调查表收集的资料,对四诊信息进行因子分析,提取符合要求的公因子,并对其进行中医证候诠释。结果：对64个四诊信息变量进行因子分析,共获得64个公因子,提取其中特征根值〉1的18个公因子,根据中医理论对各公因子的症状组合进行初步诠释。提示的证候要素有15个,其中病位类为肝、心、脾、肺、肾、胃、胆;病性类为气滞、热（火）、痰、湿、阴虚、阳虚、气虚、血虚。提示的常见证候有16个,虚证类为肝阴虚、心血虚、心胆气虚、肾阴虚、脾气虚、肺气虚、肾气不固;实证类为肝气郁结、肝郁化火、脾胃气滞、胃火炽盛、湿热内阻、气郁痰阻、痰湿中阻;虚实夹杂类为脾虚湿阻、肝郁脾虚。结论：基于因子分析初步提取的疲劳性亚健康人群的常见证候与证候要素,为今后进一步研究其辨证规范提供一定依据。     

482例亚健康人群90项症状清单测评结果分析

[目的]了解亚健康人群的心理卫生状况。[方法]采用90项症状清单(SCL-90)对482例亚健康人群10个因子评分及总症状指数进行自评。[结果]亚健康人群在总症状指数及躯体化、强迫、抑郁、焦虑、偏执和精神病性等6个因子评分均较常模高(<0.01)。[结论]亚健康人群存在诸多心理症状和不同程度的心理卫生问题。     

基于探索性因子分析的脾系疾病问诊症状分布及证候要素初探

目的:寻找脾系疾病问诊的症状特征与证候间的关联,探讨中医脾系疾病问诊的常见症状群。方法:采用临床流行病学方法制定脾系疾病问诊量表,运用量表在临床中进行脾系疾病样本采集,共纳入病例1 310例。数据经Epidata 3.0双遍录入核对,运用SPSS 18.0统计软件中的因子分析方法对数据进行分析。结果:重点问诊部分共提取6个公因子;一般问诊部分中寒热和汗维度提取2个公因子,头身胸腹维度提取6个公因子,饮食口味维度提取4个公因子,二便维度提取3个公因子,睡眠维度提取2个公因子,妇女维度提取2个公因子。上述不同的公因子分别对应了脾胃虚寒、湿热、肝胃不和等脾系疾病常见的证候要素。结论:脾系疾病临床证候多虚实夹杂,以本虚标实多见,脾胃虚弱、气虚、阳虚等证候要素为本,血瘀、气滞、痰浊内阻、湿热等证候要素为标。     

调查研究亚健康状态人群中心理亚健康类型的特征分析

目的 分析亚健康状态人群中心理亚健康类型的特征,为心理亚健康防治提供依据.方法 采用<个体身心健康调查量表>对广州、成都、杭州、上海等籍体检人群进行调研,对所回收的调查问卷进行数据分析和统计学处理.结果 纳入分析的2 748例亚健康人群中,心理亚健康最为常见,占57.8%,30～39岁年龄段的心理亚健康状态发生率最高,大专以上高学历人群为心理亚健康人群主要组成部分(78.4%).心理亚健康中较常见的临床症状依次是常无缘无故叹气、精神紧张、焦虑不安等,较常见的不适状态依次是急躁易怒、疲劳、抑郁苦闷等,情感问题、个人患病或受伤及劳累过度等应激事件是影响心理亚健康的主要危险因素.心理亚健康人群与健康人群、躯体亚健康人群在症状自评因子的多个因子均分比较差异有统计学意义(P<0.01),而与社会适应性亚健康人群在总症状指数(总分)及10个因子的比较差异无统计学意义(P>0.05).结论 亚健康状态中的心理亚健康以30～39岁年龄段、高学历、脑力劳动者为高发人群,而应激事件的发生是心理亚健康产生的重要诱因,因此在调治亚健康状态时,应重视心理健康教育和必要的心理治疗,减低心理应激导致的不良后果.     

820例亚健康者的SCL-90量表调查及分析

目的 分析亚健康人群的心理卫生状况。方法 采用90项症状清单（SCL-90）对820例亚健康人群（男468例，女352例）进行自评。结果 亚健康人群在总均分及躯体化、强迫、人际关系敏感、抑郁、焦虑、偏执和精神病性7个因子评分均较常模高（P〈0．01）。SCL-90分均值在男女间比较（t=5．17，P〈0．01）、不同症状严重程度组间比较（F=18.54，P〈0.05）。差异均有显著性．结论 亚健康人群存在诸多心理症状和不同程度的心理卫生问题。应用SCL-90对亚健康者心理健康状态的测定，是进行亚健康诊断和评价亚健康严重程度的有效方法。     

亚健康状态肝郁脾虚证常见症状调查研究

目的：分析亚健康状态肝郁脾虚证人群的症状分布特征。方法：运用＂亚健康状态中医证候调查问卷（3版）＂在常规体检人群中进行临床流行病学调查,获取1 397例亚健康人群的基本信息、症状信息和中医舌脉信息,通过频数与程度分析,对亚健康状态肝郁脾虚证的相关症状进行分析。结果：通过对亚健康状态肝郁脾虚证相关18个症状的分析,其中疲劳、情志抑郁、急躁易怒、喜太息、四肢无力5个症状最为常见,疲劳、急躁易怒、喜太息、情志抑郁、食后胃胀等5个症状发生程度最高。结论：疲劳、急躁易怒、喜太息、情志抑郁、食后胃胀等5个症状可作为亚健康状态肝郁脾虚证的基本症状。     

冠心病患者中医症状及体征分布特征研究

目的:探讨冠心病患者中医症状及体征的分布特征。方法:通过临床流行病学调查,应用因子分析和聚类分析等方法,对冠心病中医症状、体征分布特征进行研究。结果:本研究对冠心病患者的中医症状、体征进行探索性因子分析,共提取14个公因子;并对14个公因子进行聚类分析,聚为3类特征。结论:因子分析与聚类分析的结果与冠心病中医理论及临床表现基本一致,更直观地反映了冠心病中医证候虚实夹杂,正虚为本,邪实为标的本质,为冠心病中医证候规范化和客观化研究提供有益参考。     

某外资企业工人亚健康状态的临床亚型分析

目的 了解工人亚健康状态的常见临床表现及临床亚型.方法 运用流行病学横断面调查的方法,对东莞市某外资企业的2 580名工人进行整群抽样,采用自行设计的亚健康中医证候调查表,以文献回顾、专家讨论的方法确立亚健康的诊断标准,对调查结果进行频数分析及因子分析.结果 亚健康状态现患率为72.7%,其临床表现涉及到躯体、心理及社会等多种症状,其中疲倦乏力、头痛、头晕、容易感冒、怕热、情绪低落、时常叹气、腰背酸痛、失眠多梦等为亚健康状态的常见临床表现;根据亚健康的临床表现应用因子分析,可将亚健康分为疲劳型亚健康、失眠型亚健康、疼痛型亚健康、二便异常型亚健康、眼涩咽干型亚健康、妇女经带不调型亚健康、性亚健康、体质偏颇型亚健康、社会型亚健康、心理型亚健康等10个亚型.结论 亚健康状态的临床表现非常复杂,存在多种临床亚型.     

基于多元统计学方法的骨量肌量减少性肥胖综合征的结构特征研究

背景 骨量肌量减少性肥胖综合征（OSO）是一种严重损害老年人健康的疾病,对疾病进行临床分型可为疾病的临床诊治提供指导。基于OSO诊断变量间的相关性对OSO进行分型,并探寻OSO的结构特征,可为OSO的防治提供新的思路。 目的 探索OSO的结构特征,为实现OSO的个体化诊治提供理论依据。 方法 本研究为横断面研究。于2018年1月至2020年10月,采用随机抽样法,选取在哈尔滨医科大学附属第二医院体检中心接受健康体检、年龄≥60岁的老年OSO患者作为研究对象,采集其OSO诊断变量〔四肢骨骼肌指数,握力,体脂百分比（BF%）,腰椎1~4（L1~4）、髋部、股骨颈骨密度（BMD）,体质指数（BMI）,腰围,步速〕、社会人口学特征、生活方式、常见慢性病患病情况等方面的资料。在利用因子分析法对OSO诊断变量数据进行分析前,采用KMO检验、Bartlett's球形检验评价OSO诊断变量数据是否适合进行因子分析。通过主成分分析法,提取特征值≥1.000的成分,并运用最大方差正交旋转法得出方差最大正交旋转矩阵。根据因子正交旋转矩阵,对公因子进行命名。基于公因子得分,利用离差平方和系统聚类法生成树状结构并对患者进行分类,通过比较不同类别患者间诊断变量水平和临床特征的差异,分析OSO的结构特征。 结果 共纳入107例老年OSO患者。KMO值为0.688,Bartlett's球形检验χ2=492.374,P<0.001,表明OSO诊断变量数据适合进行因子分析;按特征根>1.000的标准可提取3个公因子（骨质疏松因子、肌肉+体脂因子、肥胖因子）,3个公因子的累积方差贡献率为81.408%,各诊断变量在所属公因子上的载荷值为0.770~0.918。聚类分析结果显示,共将OSO患者分为3类。不同类别人群四肢骨骼肌指数、握力、BF%、BMDL1~4、BMD髋部、BMD股骨颈、BMI、腰围比较,差异均有统计学意义（P<0.05）。其中第1类人群的BMDL1~4、BMD髋部、BMD股骨颈均低于其他两类人群（P<0.05）;第2类人群的BMI和腰围均低于其他两类人群（P<0.05）;第3类人群的四肢骨骼肌指数、握力和BMD均高于其他两类人群,BF%低于其他两类人群（P<0.05）。不同类别人群性别、受教育程度、个人月收入分布、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、肌酐（Cr）水平比较,差异有统计学意义（P<0.05）。第1类人群中本科以下学历者占比高于第3类人群（P<0.017）;第2类人群TC水平高于第3类人群（P<0.05）;第3类人群个人月收入≥5 000元者占比,以及UA、Cr水平均高于其他两类人群,女性占比低于其他两类人群（P<0.05或P<0.017）。 结论 可从骨质疏松、肌肉与体脂、肥胖3个方面对OSO诊断变量进行概括和解释;OSO患者具有不同的结构特征。应用多元统计学方法研究OSO患者的结构特征,有助于实现对不同类型OSO患者的个体化管理。     

空运进驻高原急性高原病症状因子分析

目的：探讨经空运进驻高原时,发生急性高原病（AMS）的主要症状之间的潜在联系。方法：采用随机抽样方法抽取307人作为高原研究组,运用症状调查表调查急性高原病（AMS）的主要症状及评分,运用WinSAS6．11统计软件对症状及评分进行因子分析。结果：提取的三个公因子分别为脑型AMS公因子、肺型AMS公因子和轻型AMS公因子,其解释脑型AMS公因子的主要症状为：恶心、呕吐、食欲减退、头痛;解释肺型AMS公因子的主要症状为：气急、胸闷、乏力、呼吸困难;解释轻型AMS公因子的主要症状为：心悸、烦燥不安、睡眠障碍、咳嗽。结论：运用因子分析加斜交旋转提取的三个公因子模型能够较好的解释空运进驻高原发生的各型AMS。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.