动态血压监测与心脑血管疾病的关系及用药指导

<正> 高血压病是一种严重危害人体健康的常见病,也是导致心脑血管疾病的“元凶”。动态血压监测(ABPM)是高血压病的一项诊断新技术,它能更好地监测高血压并发症的发生和发展。 ABPM反映的血压水平,昼夜节律状况与心脑肾靶器官损害程度之间有较好的相关性。血压越高,血压昼夜节律消失者更容易发生并发症。临床资料报导已证明高血压病人与急性心血管事件,如心肌梗塞、心脏性猝死,脑卒中等都有明显而相似的昼夜节律性,如在清晨,血压迅速上升接近峰值,而心血管事件发生率也     

24小时动态血压监测在老年高血压患者中的应用

无创性动态血压监测(ABPM)可以24h连续监测血压,了解血压昼夜节律的变化,已广泛应用于高血压的诊断、治疗、预后判断等方面.如何有效的控制高血压患者的血压,是减少心、肾等靶器官损害的关键.为此,我们对96例老年高血压患者的血压进行了动态监测,旨在探讨老年高血压病患者24h动态血压波动规律及范围,现将检测结果报告如下.     

老年患者动态血压临床监测分析与意义探讨

目的探讨动态血压监测对老年高血压病诊断及预后判断的意义。方法对34例于本科门诊或病房经观察偶测血压、确诊为高血压病的老年患者实施动态血压监测,对确定无疑的高血压病患者动态血压指标进行分析研究。结果老年单纯收缩期高血压病占全部高血压病的12．5％;单纯收缩期高血压病患者的靶器官损害发生率明显高于非单纯收缩期高血压病患者。非单纯收缩期高血压病例中,血压昼夜节律消失组靶器官损害发生率亦显著高于血压昼夜节律存在组。结论动态血压监测是正确诊断高血压病的必要选择,老年高血压病中单纯收缩期高血压病患者及血压昼夜节律消失者占较大比例,并有更加严重的靶器官损害。     

老年高血压病的特点及24 h动态血压检查的意义(附170例报告)

目的 探讨24h动态血压监测对老年高血压病诊断及预后判断的意义。方法 对170例于该科门诊或病房经观察偶测血压，按1999年WHO高血压分类标准确诊为高血压病的老年患者实施24h动态血压监测，根据动态血压结果，剔除白大衣性高血压厦诊断依据不充分的患者。将确定无疑的高血压病患者定为老年组，另取经动态血压监测确诊为高血压病中青年患者59人作为对照组，通过观察靶器官损害发生率，高血压病类型构成及血压昼夜节律等指标进行分析研究。结果 老年单纯收缩期高血压病（ISH）占全部高血压病的12．5％。单纯收缩期高血压病患者的靶器官损害发生率明显高于非单纯收缩期高血压病患者，非单纯收缩期高血压病例中，血压昼夜节律消失组靶器官损害发生率亦显著高于血压昼夜节律存在组。结论 动态血压监测是正确诊断高血压病的必要选择，老年高血压病中ISH患者厦血压昼夜节律消失者占较大比例，并有高于中青年高血压患者的靶器官损害率。     

老年高血压病患者动态血压昼夜节律与颈动脉硬化的关系

目的探讨老年高血压病患者血压昼夜节律与颈动脉粥样硬化间的关系.方法采用无创动态血压仪对90例老年高血压患者进行24h动态血压监测,并按动态血压结果分为勺形与非勺形组;同时采用B型超声诊断仪测量患者颈动脉内膜-中层厚度(IMT)及动脉粥样斑块.结果非勺形组患者IMT(1.14±0.17mm)较勺形组患者IMT(1.01±0.19mm)增厚(t=3.55,P＜0.01);非勺形组患者颈动脉粥样斑块发生率(55.56%)较勺形组患者(28.89%)明显增加(X2=6.54,P＜0.05).结论老年高血压患者血压昼夜节律影响颈动脉粥样硬化及斑块的形成.     

血压昼夜节律及心率变化对原发性高血压患者靶器官损害预测分析

目的探究血压昼夜节律及心率变化对原发性高血压患者靶器官损害预测分析。方法选取本院2014年3月到2016年2月收治患原发性高血压患者88例作为研究对象,根据患者血压昼夜节律变化及心率变化分为无变化组和变化组,每组44例。观察两组患者脉搏波传导速度(pulse wave velocity PWV)、左室重量指数(left ventricular mass index LVMI)、尿白蛋白与肌酐比值(albumin creatinine ratio ACR)、动态血压监测(ambulatory blood pressure monitor ABPM),对比预测患者血管、肾、心脑等靶器官损害。结果变化组各项指数均高于无变化组,组间对比显示具有统计学意义(P0.05)。结论血压昼夜节律及心率变化对原发性高血压患者的左室肥厚、肾等靶器官具有较大损害,且PWV、LVMI、ACR及ABPM指标可有效预测靶器官损害程度。     

老年高血压病的临床特点分析(附170例报告)

目的:探讨24h动态血压监测对老年高血压病诊断及预后判断的意义。方法:对170例于本科门诊或病房经观察偶测血压,按1999年WHOISH高血压分类标准,确诊为高血压病老年患者实施24h动态血压监测,根据动态血压结果,剔除白大衣性高血压〔1〕,及诊断依据不充分的患者。将确定无疑的高血压病患者动态血压指标进行分析研究。结果:老年单纯收缩期高血压病占全部高血压病的12.5%。单纯收缩期高血压病患者的靶器官损害发生率明显高于非单纯收缩期高血压病患者,非单纯收缩期高血压病例中,血压昼夜节律消失组靶器官损害发生率亦显著高于血压昼夜节律存在组。结论:动态血压监测是正确诊断高血压病的必要选择,老年高血压病中单纯收缩期高血压病患者及血压昼夜节律消失者占较大比例,并有更加严重的靶器官损害。     

动态血压监测评价高血压病靶器官损害的进展

目的综述动态血压监测(ABPM)评价高血压病靶器官损害的进展。方法对24h动态值、血压昼夜节律、血压变异性、24h血压负荷等与高血压靶器官损害之间的相关性加以分析整果展现ABPM在上述方面评价高血压病靶器官损害的最新成果。结论24h动态血压均值与心发症的相关性较偶测血压为优;夜间血压降低减弱或消失的高血压病人与较高的心血管意外发生率血压变异性与心血管损坏的严重性相关,而不依赖于血压水平;血压负荷是比血压水平更为精确的危险预测脂标。ABPM诸指标与高血压病病人心、脑、肾损害有较好的相关性,可作其预测因子和具。     

动态血压监测在老年高血压合并靶器官损害中的应用价值

目的 探讨动态血压监测(ABPM)在老年高血压病患者合并靶器官损害(TOD)中的应用价值.方法 采用24h动态血压监测仪,对130例老年高血压病患者进行监测,分为TOD组77例和非TOD组53例,以24h、白天、夜间血压均值,血压昼夜节律及变异性值为指标进行分析.结果 (1)TOD组24h、日间、夜间血压均值较非TOD组升高,两组差异均有统计学意义(P＜0.01);(2)TOD组以非杓型血压为主,非TOD组以杓型血压为主,两者差异有显著性意义(χ2=37.52,P＜0.01);(3)日间及夜间收缩压变异性大,两组差异有显著统计意义(P＜0.01),两组舒张压变异性无统计意义(P＞0.05).结论 血压均值、昼夜节律及其变异性与TOD密切相关,ABPM对诊断老年高血压合并靶器官损害患者有一定的预测价值.     

老年高血压病脉压与颈动脉粥样硬化的关系

目的:研究老年高血压病患者脉压与颈动脉粥样硬化的关系。方法:选择74例老年高血压患者作为研究对象,并与21例年龄、性别与之无统计学差异的健康者作为对照,对所有患者行血压监测,作颈动脉血管超声测量颈总动脉内膜-中层厚度、颈总动脉内径,局限性的内膜-中层增厚≥1.3mm定义为斑块。结果:老年高血压病患者随着脉压的增大,颈总动脉内径、平均颈总动脉IMT及斑块的发生率显著增高;高血压病患者内膜-中层厚度明显增厚,且随着斑块严重程度的增加,内膜-中层厚度逐渐增厚;直线相关分析显示:脉压与内膜-中层厚度及斑块明显正相关,内膜-中层厚度与斑块正相关。结论:颈动脉内膜-中层厚度是老年高血压病动脉粥样硬化的早期表现,脉压在评估早期动脉硬化方面有着重要意义。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.