复方守宫散联合放疗化疗治疗局部晚期非小细胞肺癌90例

目的观察复方守宫散联合放化疗治疗局部晚期非小细胞肺癌（non-small cell lung cancer,NSCLC）的近期疗效及耐受性。方法对90例局部晚期NSCLC患者实施常规放疗,并同步行吉西他滨、顺铂化疗及口服复方守宫散治疗,中位随访期为18（5～27）个月。结果NSCLC缓解率为15．6％,部分缓解率为70．0％,有效率为85．6％,稳定率和进展率分别为5．6％和8．9％;胸痛、血痰、气短和上腔静脉综合征改善率分别为89．7％、92．1％、89．5％和89．6％;因放化疗引起的放射性肺炎、放射性食管炎和白细胞减少发生率分别为14．4％、18．9％、32．1％;卡氏评分增高〉10分占78％,增高或减少〈10分者占17r％,减少〉10分占5％。结论复方守宫散联合放化疗治疗局部晚期NSCLC能明显缓解患者的近期临床症状,提高生活质量,并且对机体产生的不良反应小。     

复方守宫散对S180荷瘤小鼠镇痛作用研究

目的:研究复方守宫散对S180荷瘤小鼠的镇痛作用。方法:采用小鼠热板法和扭体法致痛模型来评价复方守宫散的镇痛作用。结果:复方守宫散可以明显延长荷瘤小鼠舔后足的时间和显著减少扭体反应的次数。结论:复方守宫散具有明显的镇痛作用。     

国产甲地孕酮改善晚期癌症患者恶病质的临床探讨

目的：探讨国产甲地孕酮佳迪胶囊对晚期癌症患者恶病质的治疗作用。方法：将92例晚期癌症恶病质病人,随机分为治疗组和对照组各46例,治疗组每日口服甲地孕酮160mg,对照组每日口服安慰剂1片,连用1个月,观察两组病人摄食量、体重及KPS评分变化。结果：治疗组病人摄食量增加者为71．74％,体重增加者为67．39％,KPS评分提高者为54．35％;对照组病人摄食量增加者为10．87％,体重增加者为6．52％,KPS评分提高者为15．22％;两组间有显著性差异（P＜0．05）。结论：甲地孕酮可改善病人食欲、增加体重及提高KPS评分,在一定程度上能延缓癌症恶病质发展,改善病人生存质量。     

复方守宫散中铅、镉、铜含量分析

目的：测定抗肿瘤药物复方守宫散中微量金属元素铅（Pb）、镉（Cd）、铜（Cu）的含量.方法：采用湿法消化,火焰原子吸收分光光度法测定.结果：复方守宫散中含金属元素Pb、Cd、Cu,含量高低依次为：Pb〉Cu〉Cd.结论：复方守宫散每日服用量中Pb、Cd、Cu含量均远低于人体正常摄入量,属安全用药范围.     

沙利度胺改善晚期癌症恶病质综合征的临床研究

目的 观察沙利度胺改善晚期癌症恶病质综合征的临床疗效。方法 收集2021年1月至2022年5月收治的80例晚期癌症恶病质综合征患者进行前瞻性研究,按随机数字表法分为观察组和对照组,各40例,对照组给予甲地孕酮+肠内营养乳剂营养支持治疗,观察组在对照组基础上给予沙利度胺治疗,比较两组体质量、Karnofsky功能状态(KPS)评分、食欲、肿瘤病人主观整体营养评分(PG-SGA)、血红蛋白(HGB)、白蛋白(ALB)、前白蛋白(PA)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平以及不良反应。结果 观察组治疗后体质量、KPS评分均高于对照组(均P <0.05),观察组治疗后食欲VAS评分高于对照组,PG-SGA评分低于对照组,差异均有统计学意义(均P>0.05),观察组治疗后HGB、ALB、PA水平均高于对照组(均P <0.05),观察组治疗后TNF-α、IL-6水平均低于对照组(均P<0.05),两组总不良反应发生率差异无统计学意义(P> 0.05)。结论 沙利度胺治疗晚期癌症恶病质综合征患者的效果较好,可通过提高血清HGB、ALB、PA水平,降低炎症反应,进而提高体质量、食欲和营养状况。     

复方守宫散对S180小鼠抗肿瘤作用研究

目的:研究复方守宫散(SGS)对S180小鼠的抗肿瘤作用研究。方法:昆明种小鼠,制备成S180荷瘤小鼠模型,模型制备成功后随机分成模型组、复方守宫散(SGS)高、中、低剂量组(29.25、19.50、9.75 g·kg-1)和复方环磷酰胺组(0.52 g·kg-1)。除模型组外,其余各组分别每天灌胃给药1次,连续14 d,实验结束后,摘眼球取血,剥离肿瘤,计算抑瘤率;HE染色观察肿瘤组织病理学改变;ELISA法检测血清中TNF-α含量。另取造模成功的S180荷瘤小鼠,按照各组设定的剂量连续灌胃给药10 d,停药,每天观察并记录小鼠死亡数,计算SGS对小鼠的生命延长率。结果:SGS可改善S180荷瘤小鼠的一般活动情况,对荷瘤小鼠肿瘤有抑制作用,可延长荷瘤小鼠的生命;SGS可提高荷瘤小鼠TNF-α水平;病理学检查表明给药组瘤体普遍小于模型对照组,瘤内有大片状坏死,坏死面积较大,坏死区及周围可见大量炎症细胞浸润。结论:复方守宫散具有一定的抗肿瘤作用。     

复方蟾酥散外敷治疗癌痛60例临床观察

目的 观察复方蟾酥散外敷治疗癌性疼痛的临床疗效。方法 临床研究采用随机分组、单盲给药、疼痛局部外敷方法，以蟾酥膏为对照组，比较2组不同药物作用的疼痛缓解度、镇痛有效率、平均止痛起效时间和持续时间、生活质量以及安全性。结果治疗组和对照组镇痛总有效率分别为93.3％、80．0％，镇痛持续时间分别为16．5h、12.4h，卡氏评分提高稳定率分别为90．0％、76．7％，治疗组在以上各方面优于对照组，差异有显著性意义；二者在平均止痛起效时间和安全性评定方面无明显差别。结论 复方蟾酥散外敷是治疗癌性疼痛的安全、有效药物。     

肿瘤恶病质研究概述

肿瘤恶病质是一组症状和体征 ,包括营养不良、厌食、虚弱、组织消耗和器官功能障碍等 ,常见于晚期转移的恶病质 ,也可以发生于局限性疾病患者。恶病质与肿瘤负荷、病期和细胞类型间无恒定的关系 [1 ] 。恶病质影响着手术、化疗、放疗的实施 ;许多肿瘤患者死于营养不良和机体的消耗 ,若不治疗肿瘤 ,癌症恶病质常导致患者死亡。因此 ,加强这方面的研究有着重要的意义。现将有关中西医的研究概述如下。1　西医对恶病质的机制、治疗的认识肿瘤恶病质发生机理十分复杂 ,仍未能满意解释 ,一般认为与肿瘤能量消耗增加、摄入不足、中间代谢紊乱、谷…     

癌症恶病质的中医药治疗研究进展

恶病质目前并没有明确的定义,一般认为是机体的综合代谢变化过程,多见于慢性消耗性疾病,如恶性肿瘤、AIDS和终末期肾衰等。癌症恶病质综合征发病机制复杂,至今尚未完全阐明。恶病质是诸多肿瘤并发症发生的基础,肿瘤患者出现恶病质,不仅对放疗、化疗的反应性差,降低患者生存期,也严重影响患者的生活质量。西医治疗重点在增加营养摄入,抑制肌肉蛋白和脂肪降解,改善患者食欲,提高生活质量。中医药在肿瘤恶病质的治疗中有着极为广阔的发展前景。本文就近年来肿瘤恶病质中医药治疗研究进展,综述如下。     

碎岩散联合化疗治疗气虚阳微型食管癌43例临床观察

目的：观察碎岩散联合化学疗法对气虚阳微型中晚期食管癌的临床疗效。方法：将71例气虚阳微型中晚期食管癌患者随机分为两组,治疗组43例采用碎岩散联合LFP方案治疗,对照组28例采用单纯LFP化疗治疗,观察3个疗程。结果：治疗组有效率72．1％,对照组有效率35．7％,治疗组优于对照组（P〈0．01）。治疗组治疗后一般状况、症状体征及生活质量评分、毒副反应、近期生存率,治疗组均优于对照组（P〈0．05）。结论：碎岩散联合LFP化疗可明显改善气虚阳微型中晚期食道癌患者临床症状,提高生存质量,延长生存期,且能减轻LFP化疗的毒副反应。     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

A preliminary screening study on the associated proteins in human psoriasis vulgaris by serum proteomics technologies

Objective：To investigate the optimum screening conditions of associated proteins in human psoriasis vulgaris by serum proteomics technique, and to screen the different expression proteins related with psoriasis vulgaris. Methods：Serum samples of peripheral blood were collected from newly diagnosed psoriasis vulgaris patients in the clinic, and 20 matched healthy persons. Serum albumin IgG was removed by filtering with ProteoExtract Albumin/IgG. After comparative proteomics analysis the different protein spots were identified using 2-DE and MS. Results ：Electrophoresis figures with high resolution and reproducibility were obtained. Three different expression proteins were found only in the serum from psoriasis vulgaris patients, while nine other different proteins expressing from healthy volunteers. Conclusion：The protein expression was different in the serum between the psoriasis vulgaris patients and healthy volunteers. It was hoped that we could find the biomarkers related to psoriasis vulgaris by using proteomics.     

A CASE OF HUGE GASTRIC DISOPYROBEZOAR

PYTOBEZOARS are common bezoars in gastrontestinal tract, commonly seen in stomach and mall intestine,1but huge disopyrobezoars are     

Acupuncture Treatment of Chest Bi Syndrome

CASE HISTORY A male,a retired officer of 61 years old,paid his first visit on May 12,2006.The patient stated that 2 weeks before he suddenly got paroxysmal precordial choking pain,with irregular attacks.Each attack would last several seconds to several minutes.The attack was accompanied with heavy oppressed sensation in the precordial region,palpitation,lassitude,and in severe cases,sweating,which was once diagnosed by a hospital as'coronary heart disease'.Recalling the case history,the patient said that several days before he got angry with others because of some affairs in work,and he was not so used to the life pattern since he had just retired from his busy working post.At usual times,he was quick tempered and peevish.In recent days,he had poor appetite,and loose stool.     

Instructions to Contributors

The English edition of Chinese Journal of Integrative Medicine is edited and published by the Chinese Journal of Integrated Traditional and Western Medicine Press.Original scientific papers of advanced clinical and experimental medicine in the field of complementary/alternative medicine or integrative medicine are expected.     

Development Is A High Level Inheritance for China Time-honored Brand Products

<正>As culture is the soul of a nation,the three books,"History of Chinese Philosophy,""History of Chinese Culture"and"History of Chinese Science and Technology"have demonstrated the superiority of our great Chinese culture,and its significant impact in the field of international culture.Both core value and practical value of the Chinese culture are very clear,reflected in the views of universe,nature,life,health,disease,and therapy and related considerations,concepts,and technical methods.